LOCUS       NM_001105885            2706 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus homeo box D4 (Hoxd4), mRNA.
ACCESSION   NM_001105885 XM_001064107 XM_221521
VERSION     NM_001105885.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2706)
  AUTHORS   Nishiyama,A., Xin,L., Sharov,A.A., Thomas,M., Mowrer,G., Meyers,E.,
            Piao,Y., Mehta,S., Yee,S., Nakatake,Y., Stagg,C., Sharova,L.,
            Correa-Cerro,L.S., Bassey,U., Hoang,H., Kim,E., Tapnio,R., Qian,Y.,
            Dudekula,D., Zalzman,M., Li,M., Falco,G., Yang,H.T., Lee,S.L.,
            Monti,M., Stanghellini,I., Islam,M.N., Nagaraja,R., Goldberg,I.,
            Wang,W., Longo,D.L., Schlessinger,D. and Ko,M.S.
  TITLE     Uncovering early response of gene regulatory networks in ESCs by
            systematic induction of transcription factors
  JOURNAL   Cell Stem Cell 5 (4), 420-433 (2009)
   PUBMED   19796622
REFERENCE   2  (bases 1 to 2706)
  AUTHORS   Horan,G.S., Ramirez-Solis,R., Featherstone,M.S., Wolgemuth,D.J.,
            Bradley,A. and Behringer,R.R.
  TITLE     Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4
            genes show more complete homeotic transformations and a
            dose-dependent increase in the number of vertebrae transformed
  JOURNAL   Genes Dev 9 (13), 1667-1677 (1995)
   PUBMED   7628700
REFERENCE   3  (bases 1 to 2706)
  AUTHORS   Horan,G.S., Kovacs,E.N., Behringer,R.R. and Featherstone,M.S.
  TITLE     Mutations in paralogous Hox genes result in overlapping homeotic
            transformations of the axial skeleton: evidence for unique and
            redundant function
  JOURNAL   Dev Biol 169 (1), 359-372 (1995)
   PUBMED   7750651
REFERENCE   4  (bases 1 to 2706)
  AUTHORS   Zappavigna,V., Renucci,A., Izpisua-Belmonte,J.C., Urier,G.,
            Peschle,C. and Duboule,D.
  TITLE     HOX4 genes encode transcription factors with potential auto- and
            cross-regulatory capacities
  JOURNAL   EMBO J 10 (13), 4177-4187 (1991)
   PUBMED   1756725
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001105885.1.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               JAXUCZ010000003.1  80021886-80022280
            396-473             JAXUCZ010000003.1  80032400-80032477
            474-509             JAXUCZ010000003.1  80033179-80033214
            510-1008            JAXUCZ010000003.1  80035301-80035799
            1009-1838           JAXUCZ010000003.1  80036696-80037525
            1839-2706           JAXUCZ010000003.1  80038081-80038948
FEATURES             Location/Qualifiers
     source          1..2706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..2706
                     /gene="Hoxd4"
                     /note="homeo box D4"
                     /db_xref="GeneID:288153"
                     /db_xref="RGD:1309690"
     exon            1..395
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            396..473
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            474..509
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..1008
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1838
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    1250..1252
                     /gene="Hoxd4"
                     /note="upstream in-frame stop codon"
     CDS             1412..2167
                     /gene="Hoxd4"
                     /codon_start=1
                     /product="homeobox protein Hox-D4"
                     /protein_id="NP_001099355.1"
                     /db_xref="GeneID:288153"
                     /db_xref="RGD:1309690"
                     /translation="

MAMSSYMVNSKYVDPKFPPCEEYLQGGYLGEQGADYYGSGAQGSDFQPPGLYPRPDFGEQPFGGGGPGPGSALPARGHGQEPSGPGSHYSAPGEPCPAPPPAPLPGARACSQPTGPKQPPPGTALKQPAVVYPWMKKVHVNSVNPNYTGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQIKIWFQNRRMKWKKDHKLPNTKGRSSSSSSSCSSSAAPSQHLQPMAKDHHTDLTTL"

     misc_feature    1868..2038
                     /gene="Hoxd4"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            1839..2706
                     /gene="Hoxd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cattctgctttcccagagcctcaccccctctttttctaacctttgtctctgcagaggtgggctctagtcgccggctgcgggatcgcgtggtccgcagcggcctgggctcccgccgcgactccacggcacctcgccccgggtcgcgatcagggccgcctccggagtcggcggggagcccggaaggagccccgggcgccgagccacccgcagccgctcacactcctgcggagagccgaccgcctgcttccacaaggcgacccgggccgcgcacttcccaccggaccccttcagcaacatgagcccaaacctgcggccgacggtaagcgcagccccgcagcgccggatggatcccagcggtggcccgggccgaccgaccgcagctccgcaccctccgggggactaaaaacttgaagctggacatgagcgcctgaggaaaccaccattctgtgatccgtctgtaggttctcctgcaggtttcggagcaccaggaattatcagggagaaccattctcaacagtctcagcccggggaggctccgtggccgcaaacagcgcctgccgcagggtctgcagcagcagtagcagcagaagcagcagcagcagcggatccgaaagtctggcggggctgagggcccaggaaggtaaatgctcgaattctaggaggactagtcttggccactaacttggctcaggttttgttgaagagtatcccttttgcctttttcaaaactccttttctgctgctaaaggcctttgcttctttttgggaaataccacttgataagggggcgggagatttgtattctgagaaggggcaataaagccgccatctctggggtgaaagaaattcctcatcttttcttttcctttttttaaaaaagaaggtactggttgctcagctgcttggtggcccccatcctggcagtgggaggatgaggggactcattactacaaattgtcaccgagcctacctgcaccatctctgaacaccaggcttggggagttcctgtaggagaattcactcttctttgaactatgcccattctgggggctgcttcaggcgatggtgagtgaggagggcatgggaggttagcaaagtcagtggaagacaaaagcgaagattatctgctgcaaattggggtctcggggatagaatcaaaactatattaacatctgtcagggactctcaaatgtggcatggcaagtcacttgattacacgtatgttatttagttaaatttgtgaaaattatgagatgctcaccaacccggtgataaacatgctctcttcctattggctggcctggtcacatggccgcccaactttattcagttgacagcaagtaggagggcccaatggaaggagaaaaaagacaacacgagaaaaattagtattttctaccttctgaaattaatggccatgagttcgtatatggtgaactctaagtacgtggaccccaagtttcctccgtgcgaggaatatttgcagggtggctacctaggcgagcagggagccgactactacggcagcggtgcacagggctccgacttccagcccccggggctctacccacggcccgacttcggtgagcaacccttcggaggcggcgggcccgggcctggctcagcgctgcccgcgcggggtcacggacaggagccgagcggcccgggaagtcactacagtgccccgggagagccgtgcccagcgcccccgcctgcgcccctgcctggcgctcgggcctgcagccagcccaccggccccaagcagccgccccccgggacagcactcaagcagcccgctgtggtctacccttggatgaagaaggtgcatgtgaattcggtgaaccccaactacaccggcggggagcccaagcgttcccggacggcctacaccagacagcaagtcctagaactggaaaaggaatttcattttaacaggtatctgaccaggcgccgtcggattgaaatcgctcacaccctgtgtctttctgagcgccagatcaagatctggttccagaaccggaggatgaagtggaaaaaagatcacaaactgcccaacaccaagggcagatcttcttcttcctcatcttcctgctcctcttcagctgcccccagccagcatttgcagccaatggccaaggaccaccatacggacctgacgaccttatagaagtgggaaccctgggcccattccttcttgcactccaggttgaggcgaagctgcgggtgcaggcggggcctgctgtcacctcactgggctctaaggtactgtgggggtggacctgggacccgcaggttaccatcctgcctgagggcagccccctccctaaagtggggaagggtgggagggagggcgggcttctttaaatagattatcaaacggcaggagctactgagaacataaacccttggtgagtcattaaactcctgaaaatctctgctgttggattttgaatttgcaaatgaaggtcggaggcttcaccccagtgtgaaccgggatgttctcctccgcaccacccctccagggagctgcgtggcatagtaactgtgggggagttgaggcagaaggccagcacccagtgctaggtgcttccactgcaagcaggagagctgagtcagaagctcagaactttctgaataatctatagaatttcttctgtgataaaaagaaatgttttgctcccagtggcccatgcccaaagaaataaa

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