LOCUS       NM_001100901            2135 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus syntrophin, alpha 1 (Snta1), mRNA.
ACCESSION   NM_001100901 XM_001064932 XM_342548
VERSION     NM_001100901.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2135)
  AUTHORS   Kim JE, Yeo SI, Ryu HJ, Kim MJ, Kim DS, Jo SM and Kang TC.
  TITLE     Astroglial loss and edema formation in the rat piriform cortex and
            hippocampus following pilocarpine-induced status epilepticus
  JOURNAL   J Comp Neurol 518 (22), 4612-4628 (2010)
   PUBMED   20886625
REFERENCE   2  (bases 1 to 2135)
  AUTHORS   Lanciotti A, Brignone MS, Camerini S, Serafini B, Macchia G, Raggi
            C, Molinari P, Crescenzi M, Musumeci M, Sargiacomo M, Aloisi F,
            Petrucci TC and Ambrosini E.
  TITLE     MLC1 trafficking and membrane expression in astrocytes: role of
            caveolin-1 and phosphorylation
  JOURNAL   Neurobiol Dis 37 (3), 581-595 (2010)
   PUBMED   19931615
REFERENCE   3  (bases 1 to 2135)
  AUTHORS   Cheng J, Van Norstrand DW, Medeiros-Domingo A, Valdivia C, Tan BH,
            Ye B, Kroboth S, Vatta M, Tester DJ, January CT, Makielski JC and
            Ackerman MJ.
  TITLE     Alpha1-syntrophin mutations identified in sudden infant death
            syndrome cause an increase in late cardiac sodium current
  JOURNAL   Circ Arrhythm Electrophysiol 2 (6), 667-676 (2009)
   PUBMED   20009079
REFERENCE   4  (bases 1 to 2135)
  AUTHORS   Wu G, Ai T, Kim JJ, Mohapatra B, Xi Y, Li Z, Abbasi S, Purevjav E,
            Samani K, Ackerman MJ, Qi M, Moss AJ, Shimizu W, Towbin JA, Cheng J
            and Vatta M.
  TITLE     alpha-1-syntrophin mutation and the long-QT syndrome: a disease of
            sodium channel disruption
  JOURNAL   Circ Arrhythm Electrophysiol 1 (3), 193-201 (2008)
   PUBMED   19684871
REFERENCE   5  (bases 1 to 2135)
  AUTHORS   Ueda K, Valdivia C, Medeiros-Domingo A, Tester DJ, Vatta M,
            Farrugia G, Ackerman MJ and Makielski JC.
  TITLE     Syntrophin mutation associated with long QT syndrome through
            activation of the nNOS-SCN5A macromolecular complex
  JOURNAL   Proc Natl Acad Sci U S A 105 (27), 9355-9360 (2008)
   PUBMED   18591664
REFERENCE   6  (bases 1 to 2135)
  AUTHORS   Thomas GD, Shaul PW, Yuhanna IS, Froehner SC and Adams ME.
  TITLE     Vasomodulation by skeletal muscle-derived nitric oxide requires
            alpha-syntrophin-mediated sarcolemmal localization of neuronal
            Nitric oxide synthase
  JOURNAL   Circ Res 92 (5), 554-560 (2003)
   PUBMED   12600881
REFERENCE   7  (bases 1 to 2135)
  AUTHORS   Hagiwara Y, Sasaoka T, Araishi K, Imamura M, Yorifuji H, Nonaka I,
            Ozawa E and Kikuchi T.
  TITLE     Caveolin-3 deficiency causes muscle degeneration in mice
  JOURNAL   Hum Mol Genet 9 (20), 3047-3054 (2000)
   PUBMED   11115849
REFERENCE   8  (bases 1 to 2135)
  AUTHORS   Adams ME, Kramarcy N, Krall SP, Rossi SG, Rotundo RL, Sealock R and
            Froehner SC.
  TITLE     Absence of alpha-syntrophin leads to structurally aberrant
            neuromuscular synapses deficient in utrophin
  JOURNAL   J Cell Biol 150 (6), 1385-1398 (2000)
   PUBMED   10995443
REFERENCE   9  (bases 1 to 2135)
  AUTHORS   Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC
            and Solimena M.
  TITLE     The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ
            domains of beta2-syntrophin and nNOS in pancreatic beta-cells
  JOURNAL   Eur J Cell Biol 79 (9), 621-630 (2000)
   PUBMED   11043403
REFERENCE   10 (bases 1 to 2135)
  AUTHORS   Peters MF, Kramarcy NR, Sealock R and Froehner SC.
  TITLE     beta 2-Syntrophin: localization at the neuromuscular junction in
            skeletal muscle
  JOURNAL   Neuroreport 5 (13), 1577-1580 (1994)
   PUBMED   7819523
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169101.1.
            
            On or before Sep 14, 2008 this sequence version replaced
            XM_001064932.1, XM_342548.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2135
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2135
                     /gene="Snta1"
                     /note="syntrophin, alpha 1"
                     /db_xref="GeneID:362242"
                     /db_xref="RGD:1307068"
     exon            1..402
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1610
                     /gene="Snta1"
                     /note="syntrophin, acidic 1"
                     /codon_start=1
                     /product="alpha-1-syntrophin"
                     /protein_id="NP_001094371.1"
                     /db_xref="GeneID:362242"
                     /db_xref="RGD:1307068"
                     /translation="

MASGRRAPRTGLLELRSGAGSGAGGERWQRVLLTLAEDALTVSPADGEPGPEPEPAQLNGAAEPGAASPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQALKKTGKEVVLEVKYMKEVSPYFKNSAGGTSVGWDSPPASPLQRQPSSPGPQPRNLNEAKHVSLKMAYVSRRCTPTDPEPRYLEICAADGQDTLFLRAKDEASARSWAGAIQAQISTFIPWVKDELQALLTATGTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYCSLPQTREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCNLSVHIDKGFTLWAAEPGATRAVLLRQPFEKLQMSSDDGMSLLFLDFGGAEGEIQLDLHSCPKTMVFIIHSFLSAKVTRLGLLA"

     misc_feature    348..596
                     /gene="Snta1"
                     /note="PDZ domain of syntrophins, and related domains;
                     Region: PDZ_syntrophin-like; cd06801"
                     /db_xref="CDD:467262"
     misc_feature    order(381..401,435..437,444..446,534..536,546..548,
                     555..560)
                     /gene="Snta1"
                     /note="peptide binding site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:467262"
     misc_feature    <726..902
                     /gene="Snta1"
                     /note="Syntrophin Split Pleckstrin homology (PH) domain;
                     Region: PHsplit_syntrophin; cd01258"
                     /db_xref="CDD:269960"
     misc_feature    984..1295
                     /gene="Snta1"
                     /note="PH domain; Region: PH; pfam00169"
                     /db_xref="CDD:459697"
     exon            403..588
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..793
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1001
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1002..1132
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1329
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1517
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..2099
                     /gene="Snta1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggcggctggctctgctgccccgccgccctctgccctgggcgctgggtcggagcgggccgggtacggcgggaccgggcgagcgcagcgtactgggacttcgaggcgaagatggcgtcaggcaggcgcgctccgcgcaccgggttgctagaactgcgctccggggcgggctccggggcgggtggtgagcggtggcagcgggtgttgctcactctggcggaggacgcgctgaccgtgagccccgccgacggcgagcccggcccggagcccgagcccgcgcagctcaacggcgccgctgagcccggcgcggcgtccccacagctgccagaggcgctgctgctccagcggcgccgcgtgacggtgcgcaaggccgacgccggcgggctcggcatcagcatcaagggaggccgggaaaacaagatgcctattctcatttccaagatcttcaaggggctggcagcagaccagacggaggccctctttgtcggcgatgccatcctctctgtgaatggtgaagatttgtcctctgccacccatgatgaagcagtacaggccctcaagaagacgggcaaggaggttgtgttggaggttaagtatatgaaggaggtctcaccgtatttcaagaattctgctggtgggacctccgttggctgggactcacctcctgcctcgcctcttcagcgtcagccttcttcccctggcccccaaccccggaacctcaatgaggccaaacatgtatctttgaagatggcgtatgtctcaaggaggtgtacccccactgacccggagcccaggtatctggagatctgtgcagcagatggccaggacactctcttcttgagggccaaggatgaggccagtgcaaggtcatgggcaggtgccatccaagctcagatcagcacatttataccttgggtcaaggatgagctgcaggcgctgctgacagccacaggtacagctgggagccaggacatcaagcagattggctggctcacggaacagttgcccagtgggggtacagcaccaaccctggccctgctgactgagaaggagctgctcctctactgctctctcccccagactcgagaggccctgagcaggccggcccgcactgccccgctcattgccaccaggctggtgcactcaggcccttccaagggctcagtgccctatgatgcagagctctcctttgccctgcgcacgggtacacgccacggtgtggacactcacctgttcagtgtggagtcgccgcaggagctggcagcctggacccgacagttggtggatggctgtcaccgggctgctgaaggtgtgcaagaagtgtctacagcctgcacgtggaatggccgtccctgcaacctatccgtgcacattgacaagggcttcacactgtgggcagctgagccaggagcaacccgagctgtgctgctccgacagccctttgagaaacttcagatgtcatcagatgatggcatgagtctccttttcctggactttgggggtgctgaaggagagatccagctggacctgcattcgtgtcccaaaaccatggtctttatcatccactctttcctgtctgccaaggtcacccgcttggggctcttggcctagaagttgtcaggtgaactaggcctgaagaggaacgttcatcttgtgacctgacccgtccttctgctgactgcctgctcatctgtgggctgagggaagggagaggaggggaactagggcctcagagaccaacctgaggaagcagaactcagacctgggacagtgagtctggcttgtgatggggcagccttcctactgctcacctccaccagtgcctttcgaagagagatattttgtgtacacagaagccattccgaggctgggacctgaccctgtggggatccatcccatctccagtcaacagcagagctgccacgcctcctggaggcccctaagccaccctgagatctctgcagatggagtcttctgggtcagtggcaagaggaggaagaggagcctttctgttcactctcccttgggccctgagggctgtctgggctctctcctcctctctctccttcctcttgataataaacagcctgtgagcacataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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