LOCUS       NM_001100681            6680 bp    mRNA    linear   ROD 17-DEC-2023
DEFINITION  Rattus norvegicus PBX homeobox 1 (Pbx1), transcript variant 2,
            mRNA.
ACCESSION   NM_001100681 XM_001072172 XM_001072218 XM_001072250
VERSION     NM_001100681.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6680)
  AUTHORS   Jia D, Han J, Cai J, Huan Z, Wang Y and Ge X.
  TITLE     Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic
            shock-induced kidney damage by inhibiting NF-kappaB activation
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (1), 119571 (2024)
   PUBMED   37673222
  REMARK    GeneRIF: Mesenchymal stem cells overexpressing PBX1 alleviates
            haemorrhagic shock-induced kidney damage by inhibiting NF-kappaB
            activation.
REFERENCE   2  (bases 1 to 6680)
  AUTHORS   Alankarage D, Szot JO, Pachter N, Slavotinek A, Selleri L, Shieh
            JT, Winlaw D, Giannoulatou E, Chapman G and Dunwoodie SL.
  TITLE     Functional characterization of a novel PBX1 de novo missense
            variant identified in a patient with syndromic congenital heart
            disease
  JOURNAL   Hum Mol Genet 29 (7), 1068-1082 (2020)
   PUBMED   31625560
REFERENCE   3  (bases 1 to 6680)
  AUTHORS   Slavotinek A, Risolino M, Losa M, Cho MT, Monaghan KG,
            Schneidman-Duhovny D, Parisotto S, Herkert JC, Stegmann APA, Miller
            K, Shur N, Chui J, Muller E, DeBrosse S, Szot JO, Chapman G,
            Pachter NS, Winlaw DS, Mendelsohn BA, Dalton J, Sarafoglou K,
            Karachunski PI, Lewis JM, Pedro H, Dunwoodie SL, Selleri L and
            Shieh J.
  TITLE     De novo, deleterious sequence variants that alter the
            transcriptional activity of the homeoprotein PBX1 are associated
            with intellectual disability and pleiotropic developmental defects
  JOURNAL   Hum Mol Genet 26 (24), 4849-4860 (2017)
   PUBMED   29036646
REFERENCE   4  (bases 1 to 6680)
  AUTHORS   Wang J, Qu D, An J, Yuan G and Liu Y.
  TITLE     Integrated microarray analysis provided novel insights to the
            pathogenesis of glaucoma
  JOURNAL   Mol Med Rep 16 (6), 8735-8746 (2017)
   PUBMED   28990066
REFERENCE   5  (bases 1 to 6680)
  AUTHORS   Le Tanno P, Breton J, Bidart M, Satre V, Harbuz R, Ray PF, Bosson
            C, Dieterich K, Jaillard S, Odent S, Poke G, Beddow R, Digilio MC,
            Novelli A, Bernardini L, Pisanti MA, Mackenroth L, Hackmann K,
            Vogel I, Christensen R, Fokstuen S, Bena F, Amblard F, Devillard F,
            Vieville G, Apostolou A, Jouk PS, Guebre-Egziabher F, Sartelet H
            and Coutton C.
  TITLE     PBX1 haploinsufficiency leads to syndromic congenital anomalies of
            the kidney and urinary tract (CAKUT) in humans
  JOURNAL   J Med Genet 54 (7), 502-510 (2017)
   PUBMED   28270404
REFERENCE   6  (bases 1 to 6680)
  AUTHORS   Ferretti E, Schulz H, Talarico D, Blasi F and Berthelsen J.
  TITLE     The PBX-regulating protein PREP1 is present in different
            PBX-complexed forms in mouse
  JOURNAL   Mech Dev 83 (1-2), 53-64 (1999)
   PUBMED   10381567
REFERENCE   7  (bases 1 to 6680)
  AUTHORS   Piper DE, Batchelor AH, Chang CP, Cleary ML and Wolberger C.
  TITLE     Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the
            hexapeptide and a fourth homeodomain helix in complex formation
  JOURNAL   Cell 96 (4), 587-597 (1999)
   PUBMED   10052460
REFERENCE   8  (bases 1 to 6680)
  AUTHORS   Knoepfler PS, Calvo KR, Chen H, Antonarakis SE and Kamps MP.
  TITLE     Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an
            interaction surface disrupted in oncoprotein E2a-Pbx1
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14553-14558 (1997)
   PUBMED   9405651
REFERENCE   9  (bases 1 to 6680)
  AUTHORS   Chang CP, Jacobs Y, Nakamura T, Jenkins NA, Copeland NG and Cleary
            ML.
  TITLE     Meis proteins are major in vivo DNA binding partners for wild-type
            but not chimeric Pbx proteins
  JOURNAL   Mol Cell Biol 17 (10), 5679-5687 (1997)
   PUBMED   9315626
REFERENCE   10 (bases 1 to 6680)
  AUTHORS   Shen WF, Rozenfeld S, Lawrence HJ and Largman C.
  TITLE     The Abd-B-like Hox homeodomain proteins can be subdivided by the
            ability to form complexes with Pbx1a on a novel DNA target
  JOURNAL   J Biol Chem 272 (13), 8198-8206 (1997)
   PUBMED   9079637
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000244.1, BC161983.1 and BC098847.1.
            
            On Aug 5, 2017 this sequence version replaced NM_001100681.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC161983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132307, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               JACYVU010000244.1  11308676-11308810   c
            136-1973            BC161983.1         1-1838
            1974-5415           JACYVU010000244.1  11033938-11037379   c
            5416-6680           BC098847.1         1-1265
FEATURES             Location/Qualifiers
     source          1..6680
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q24"
     gene            1..6680
                     /gene="Pbx1"
                     /note="PBX homeobox 1"
                     /db_xref="GeneID:304947"
                     /db_xref="RGD:1308213"
     exon            1..585
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    311..313
                     /gene="Pbx1"
                     /note="upstream in-frame stop codon"
     CDS             395..1438
                     /gene="Pbx1"
                     /note="isoform b is encoded by transcript variant 2;
                     pre-B-cell leukemia transcription factor 1; pre-B-cell
                     leukemia homeobox 1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform b"
                     /protein_id="NP_001094151.1"
                     /db_xref="GeneID:304947"
                     /db_xref="RGD:1308213"
                     /translation="

MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGGYPSPCYQPDRRIQ"

     misc_feature    518..1090
                     /gene="Pbx1"
                     /note="PBC domain; Region: PBC; pfam03792"
                     /db_xref="CDD:427507"
     misc_feature    1094..1276
                     /gene="Pbx1"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(1094..1108,1112..1114,1172..1174,1190..1192,
                     1229..1231,1235..1240,1247..1252,1256..1264,1268..1273)
                     /gene="Pbx1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(1100..1102,1109..1111,1238..1240,1247..1252,
                     1259..1261)
                     /gene="Pbx1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     exon            586..659
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..904
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1095
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1231
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1391
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1481
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..6655
                     /gene="Pbx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggagcccatttctgccttgcacaggagatcggactgaaaaacccaaaggcagctctgatttcttttcgccaagtgggaaggtggtttatttttcttgcttttttggagtcaacacccttccccaccagcccttatccccaccctcaccccgcaaccccttcacgccccctccccctccccatcctcccaccatcctctaaagaggcaaagagattttttttttcccttttggtcttcttcttcttcttcttcttctttttttttttaaaccctggtccctgtttatcctgaaaaggatttgaagacagcttgaaggataaaaagcctcggtgcttcccaggcgccgagccgaggagccgaagaggaagagccggggctgccggagccttcagagatggacgagcagccgaggctgatgcattcccacgctggggtcgggatggccggacaccccggcctgtcccagcacttgcaggatggggccggagggaccgagggggagggcgggaggaagcaggacatcggggacattttacagcaaattatgaccatcacagaccagagtttggatgaagcgcaggccagaaaacatgctttaaactgccacagaatgaagcctgccttgtttaatgtgttgtgtgaaatcaaagaaaaaacagttttgagtattcggggagcccaagaagaggagcccacagacccccagctcatgcgactggacaacatgctgctagcagaaggggtggcggggcctgagaagggcggaggctcggcagcggcagcggcagcagcggcagcttctgggggtgcaggttcagacaactcagtggagcattccgattacagagccaaactctcacagatcagacaaatctaccacacagagctggagaagtatgaacaggcatgcaatgaattcaccacccacgtgatgaacctccttcgggagcaaagccggaccagacccatctctccgaaggagatcgagcggatggtcagcattattcaccgcaagttcagctccatccagatgcagctgaagcaaagcacgtgcgaggcagtcatgatcctgcgctcccggtttctggatgcgaggcggaagagacggaatttcaacaagcaagccacagaaattctgaatgaatatttctattcccatctcagcaacccttaccccagtgaggaagccaaagaggagttagccaagaagtgcggcatcacagtctcccaggtatcaaactggtttggaaataagcgaatccggtacaagaagaacataggtaaatttcaagaggaagccaatatttatgctgccaaaacggctgtcactgccaccaatgtgtcagcccatggaagccaagctaactcgccctccactcccaactcagcgggtggatacccttcgccatgttatcagccagacaggaggatacagtgacggactcgcagccagtcagatgtacagtccgcagggcatcagtgctaatggaggttggcaggatgctactaccccttcatcagtgacctcccctacagaaggccctggcagtgttcactctgatacctccaactgatctcccagcaatcgcatcccggctgaccctgtgccgcagttggggcaggggcaggagggagggtttctctcccaacgctgaagcggtcagactggaggtcgaagcaatcagcaaacacaataagagtctccttctcttctcttctttgggatgctatttcagccaatctggacacttctttatactctcttccctttttttctgggtagaagccacccttccctgcctccagctatcagactggttctgtcatcttccctggcccccgctctctgttatagactccctggttcctgccttctattatttcactgaaggattttttccccccacaattagagaaatttaaaaaggaaagacaaattacaaagaaacaataaacgcgtttgtatgttttcatgctggtggtttgaggagccaaatttacctcacgaggagccctcatccctacattgacaggcaatccttctgtttcccttgttactcttactacctcttagcaggaatacaccacactgccctactcattccaggccaccctatctccatttcccccttctttctgggaacaatcctgatttcttcctctcctttctggccccaggtgtttgctagggactgccatacctgggcttctaaaggtgccacatgtcccagtgtagctccatcaggttgagtcctaggcaggaagtctagcagcggaggacacaaggaatggcaaaggcaggactcctaccagctttctcatcctcttagaaacagttcttggtctcagaggcacagtctatggtgaccattcgaccattcaatttgcagaacctcaggcaagccaggtctaagagaggcgtcctgatgaggctgtttataaagagtgaaggatctcatcctgaaaggcttcactgtcccttcatagacatgtgcacacatacacaacatacaggtggacacatgcacaacctcacagctttgcttcgcaggatgctactaacctttcatcagtgacctcccctgtagaaggccctggcagtgtttactgatacctcccaaatggtctcccaacaatcaagtcctatacagacttacactagtgatcatagtactctatctggtgagcccgagagagaagcggtatgtggctggggcttttaggacccactaacatgtacttactacagtcagatgtacaggacttggttaacatgcaggtcaggattcaagtgtaaaccgtcttcattcctaccacctctgcagctctcagggagccacacacaggacttccaatgtctatgacagatttgaacgctttgtttgtgtttttattatgttatctttccaaaatattatagtcaaccatggtcttgattctggctttccctccagagaagagaacggtataggtatacggttaacttttactaattacttggaagacattgaatcatagagtaagggtgatgaattttttttttttttgttgtcgttgaaataatcacggtgatctatctatatgccaagggattgacagaaaatataagttgctagaaaggtagtcttgcttttgatatgaacttaaattctccagatgagtctgccagccataaagatggcagctttaccagtaggttaagtgacaagtggccagatatctttggagcctcatgcacttcctctgtaaaatgggaattggtatacttggctcaccaaggggcttgtaagacaccccccccaaaaaagctggttttgtttatatttaatctccaggtctgatggtcaggaaaagcaatgtctctatgccaaacatttcatgctaagtcagaacgatacatggttttcttcttctaatctctgcttgttatccagaccttggtgccatcgtagtaatgacagagtgctgtgtcagaggctttctgctctgatttggttttgctccatttgtcttcttaggatagagaggagattcaaagctagaggagtagaacctggttttattagtttcaacttgaatccagttatgaggctctgcaagtccttgtccctatcacaactcttctgcttcagggactcccaggaagaagtacaagagcttgagggctgagagacaagcccacagcaccacacacattccacaatactacagtgataaatgggaaacacgcttcatgtgtgttcggaggagtcaggcttgtatactggaaacctgaggggaccgagtatttgaagataatgcagaacagaattatttggcaaatgaaaatttgtctagctgacccgttactagaaagactgtcatcaaacctgagccatgcatagatctttgtccttgtggcaagaatatattgaaaccattaacagaagcatggctggatcacatcatgtaacatggagcaaattgtaagaattgctgaagggctctcttgaaaacaagaatgaccccagctgtggattgaacacatgaagggacatgagtggatcgtgctgcaatagtaccatcctcaaagcttgcttctctccaggcagtagctgcacagagagacccacccagcacttgattaggccgcctttagctccaacacatagccagtggtctgacatccatgctcactgctgcctccaacatggcagccaccagatctctgttgtcaagcaaggctagggaaaactggcagtccccagatagaattggaatgagtgtggcctttagaaactcagctccccaggatttcagatcaggtcaatgctatagactccccatttaaaaaacaaactgtgtcccagaatttcttcgtattctctaagtacgagtgtgagtgctctgtttccaacagcagcaattccctcctgagaaatggcgttgccgtgtataccttggtttaccatcacctcttcctgctggagtagaatggacttctgggtagctgttaagcccacagacaccttctctccatttcctcccctgtggtagtagtacttaattattaatattattatttttatttcggttgctttttcctcacacttatcttcgcttctttcttcctcctctttatttttttctgcccagaaaaacctgacttcgataccaaaaaaagataaaactacagaaactcaaattaaaaaaaaaaaatcttaggaaaaaaagaatgcaaaaaaaaaaaaaaaaactcaacaattctttcagctttattaacatttttccattgtttcttgcgacttgtgtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcagataaagaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaaaaagttttaaaaatgaccctcatagcacgcaaaacaggaaggggaagcgtcccttctctctgtaacaatacacatcattcctgcaaatgttttttaacaccgaactacctatgttcctcatttctcccgtttttcttttttattttctcgcatttgtgaattagttcaagaatgctagaaaagtgtcaaggtgtgtacatccatttcttctttcatgatgtttaaaagtgaccgtaattcattttgtaaactaaaaaaggaaaaaaaaaaggaaaaaaaaaagaaaaaaaggaaaaaaaaaggttggaatagtgaacataataggttcaacctaacacattatgtttattaattttgacccagaaatgaattcttctctttattcctgctcttaaaaatacagaaaaagaaagttttgttttgtcttctttttggttttgtttatttgaggggggggtgctccttttccgctgttgggtttatgggtcttactaggtttgttccttacatatgtgtacagggtgatgtgaaaagagacagctaggagagaaggctgcttctcccctctgctttgctgcagtcaatgtcaaaaccaacgataaagcccacggccacatgcccctgctctcttgcatgccagggtgtgtggcactctgcagtccccgagataatgaggcagggacttccttccttaaatactcaccgagtctgtccaggggatttcttacattgaaaacaaaagcgcttgttgattctgaatgtcccaatcaagggctttctttctccctgactaacatcaacagtccacaggaagctcccaacaaggtgggatctctctccaggtagaactctacaggcagtactgccatggaagccgatgttacccagtacagtagatccgtgaagcccaccctgggcccatcttcttgggatccagattcccacattctggacgcagtgtggatgaagttaggagccagggtcacggctgggatttgaatactaagaagctgtcttttaatctgggtgcacttgtcgctcacctctggtgaggttaactctaaaatgccaggtgggcttcaccagaacgtttgtcacggtcttagggaaaaagaaggccatgtggttggacagacactcagtttcagacattgctcatgcagacactcaagtgttcagaaagcagacagaattcccgccagatgcatgaagaagggaagccacagtcccgggtctctgctgtaggaagcattccacctagagacagtttagctcttgtttctatgtcctgggagatgaaaggcagccttttcacgtcacctctgtgctctccagcctagctcaaagctttctggaaacttttattttatttttttttgtaaactttttctttccctttcattaaaataaaatatcgaatgttttccctctttcttcttccctctggggggtttcattttgaagtgtgttcctttggttgttggttttattccccccccccccgcattttcttttcttttcttttttctttattattgagagtataaacctgcaaagctcggttctactttggttttgaaagtttaagctttttctgcttctgtgcgagcacaggcctctgtcccctttgattccagctgaactttttgtgttctctaatgatactaacacgatgtaggttttacagtctcctaatttgtactggtaatgcagattccaaataaatagtttcttttgttgcaaaaaatataaaaaaaaaaaaaaaaaaaaaaaaaa

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