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Previous release (v1)
2026-01-18 13:20:31, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_001085369 2765 bp mRNA linear ROD 23-JUN-2025
DEFINITION Rattus norvegicus kinesin family member 2C (Kif2c), transcript
variant 1, mRNA.
ACCESSION NM_001085369
VERSION NM_001085369.2
KEYWORDS RefSeq; RefSeq Select.
SOURCE Rattus norvegicus (Norway rat)
ORGANISM Rattus norvegicus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
REFERENCE 1 (bases 1 to 2765)
AUTHORS Shrestha,R.L. and Draviam,V.M.
TITLE Lateral to end-on conversion of chromosome-microtubule attachment
requires kinesins CENP-E and MCAK
JOURNAL Curr Biol 23 (16), 1514-1526 (2013)
PUBMED 23891108
REMARK Erratum:[Curr Biol. 2013 Dec 2;23(23):2440-1]
REFERENCE 2 (bases 1 to 2765)
AUTHORS Tanenbaum,M.E., Macurek,L., van der Vaart,B., Galli,M.,
Akhmanova,A. and Medema,R.H.
TITLE A complex of Kif18b and MCAK promotes microtubule depolymerization
and is negatively regulated by Aurora kinases
JOURNAL Curr Biol 21 (16), 1356-1365 (2011)
PUBMED 21820309
REFERENCE 3 (bases 1 to 2765)
AUTHORS Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
TITLE Defining the membrane proteome of NK cells
JOURNAL J Mass Spectrom 45 (1), 1-25 (2010)
PUBMED 19946888
REFERENCE 4 (bases 1 to 2765)
AUTHORS Honnappa,S., Gouveia,S.M., Weisbrich,A., Damberger,F.F.,
Bhavesh,N.S., Jawhari,H., Grigoriev,I., van Rijssel,F.J.,
Buey,R.M., Lawera,A., Jelesarov,I., Winkler,F.K., Wuthrich,K.,
Akhmanova,A. and Steinmetz,M.O.
TITLE An EB1-binding motif acts as a microtubule tip localization signal
JOURNAL Cell 138 (2), 366-376 (2009)
PUBMED 19632184
REFERENCE 5 (bases 1 to 2765)
AUTHORS Parra,M.T., Gomez,R., Viera,A., Llano,E., Pendas,A.M., Rufas,J.S.
and Suja,J.A.
TITLE Sequential assembly of centromeric proteins in male mouse meiosis
JOURNAL PLoS Genet 5 (3), e1000417 (2009)
PUBMED 19283064
REFERENCE 6 (bases 1 to 2765)
AUTHORS Zhu,C., Zhao,J., Bibikova,M., Leverson,J.D., Bossy-Wetzel,E.,
Fan,J.B., Abraham,R.T. and Jiang,W.
TITLE Functional analysis of human microtubule-based motor proteins, the
kinesins and dyneins, in mitosis/cytokinesis using RNA interference
JOURNAL Mol Biol Cell 16 (7), 3187-3199 (2005)
PUBMED 15843429
REFERENCE 7 (bases 1 to 2765)
AUTHORS Holmfeldt,P., Zhang,X., Stenmark,S., Walczak,C.E. and Gullberg,M.
TITLE CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is
essential for bipolar spindle formation
JOURNAL EMBO J 24 (6), 1256-1266 (2005)
PUBMED 15775983
REFERENCE 8 (bases 1 to 2765)
AUTHORS Cassimeris,L. and Morabito,J.
TITLE TOGp, the human homolog of XMAP215/Dis1, is required for centrosome
integrity, spindle pole organization, and bipolar spindle assembly
JOURNAL Mol Biol Cell 15 (4), 1580-1590 (2004)
PUBMED 14718566
REFERENCE 9 (bases 1 to 2765)
AUTHORS Andrews,P.D., Ovechkina,Y., Morrice,N., Wagenbach,M., Duncan,K.,
Wordeman,L. and Swedlow,J.R.
TITLE Aurora B regulates MCAK at the mitotic centromere
JOURNAL Dev Cell 6 (2), 253-268 (2004)
PUBMED 14960279
REFERENCE 10 (bases 1 to 2765)
AUTHORS Sperry,A.O. and Zhao,L.P.
TITLE Kinesin-related proteins in the mammalian testes: candidate motors
for meiosis and morphogenesis
JOURNAL Mol Biol Cell 7 (2), 289-305 (1996)
PUBMED 8688559
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAXUCZ010000005.1 and FN805204.1.
On Mar 12, 2015 this sequence version replaced NM_001085369.1.
Transcript Variant: This variant (1) represents the longest
transcript and encodes the longest isoform (1).
Sequence Note: This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR26360181.494204.1,
SRR26360181.1607998.1 [ECO:0000332]
RNAseq introns :: mixed sample support SAMEA5760383,
SAMEA5760386 [ECO:0006172]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-2 JAXUCZ010000005.1 135899211-135899212 c
3-515 FN805204.1 1-513
516-630 FN805204.1 517-631
631-703 FN805204.1 633-705
704-719 JAXUCZ010000005.1 135889321-135889336 c
720-736 FN805204.1 720-736
737-832 JAXUCZ010000005.1 135888713-135888808 c
833-887 JAXUCZ010000005.1 135886935-135886989 c
888-1050 JAXUCZ010000005.1 135886685-135886847 c
1051-1141 JAXUCZ010000005.1 135883836-135883926 c
1142-1205 JAXUCZ010000005.1 135883556-135883619 c
1206-1297 JAXUCZ010000005.1 135883387-135883478 c
1298-1440 JAXUCZ010000005.1 135882436-135882578 c
1441-1645 JAXUCZ010000005.1 135881451-135881655 c
1646-1756 JAXUCZ010000005.1 135881173-135881283 c
1757-1824 JAXUCZ010000005.1 135878312-135878379 c
1825-1930 JAXUCZ010000005.1 135877889-135877994 c
1931-2035 JAXUCZ010000005.1 135877692-135877796 c
2036-2765 JAXUCZ010000005.1 135873925-135874654 c
FEATURES Location/Qualifiers
source 1..2765
/organism="Rattus norvegicus"
/mol_type="mRNA"
/strain="BN"
/db_xref="taxon:10116"
/chromosome="5"
/map="5q36"
gene 1..2765
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/note="kinesin family member 2C"
/db_xref="GeneID:171529"
/db_xref="RGD:620239"
exon 1..146
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
CDS 86..2251
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/note="isoform 1 is encoded by transcript variant 1;
kinesin-like protein KIF2C; mitotic centromere-associated
kinesin; kinesin-related protein 2"
/codon_start=1
/product="kinesin-like protein KIF2C isoform 1"
/protein_id="NP_001078838.1"
/db_xref="GeneID:171529"
/db_xref="RGD:620239"
/translation="
MESLHARLFPGLSINIQRSNGLIHSANISTVNLEKSCVSVEWTEGGTTKGKEIDIDDVAAINPELVQLLPLRPKDSLPLQENVTIPKQKRKSVNSKIPGPKEGLRSRSTRISTVSEVRIPAQENEMEVELPVSTNSRKPFPIHSHPRPSCSTVTELPLLMISEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSEIRIKRAQEYDNSFPNWEFARMIKEFRVTMDCNPLTVTDPIEEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRSLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSKQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRAKGRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPSGEQAVQMETEEMDASSHGASLTGNEEEELSSQMSSFNEAMTQIRELEERAMEELREIIQQGPSWLELSEMTDQPDYDLETFVNKAESALTQQAKQAKHFSALQEVIKALRLAMQLEEQASKQINSKKRHQ"
misc_feature 845..1831
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/note="Kinesin motor domain, KIF2-like group; Region:
KISc_KIF2_like; cd01367"
/db_xref="CDD:276818"
misc_feature order(869..871,1115..1117,1124..1126,1130..1141,
1547..1549)
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:276818"
misc_feature order(1691..1693,1700..1702,1709..1711)
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/note="microtubule interaction site [polypeptide binding];
other site"
/db_xref="CDD:276818"
exon 147..241
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 242..343
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 344..392
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 393..515
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 516..635
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 636..736
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 737..832
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 833..887
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 888..1050
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1051..1141
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1142..1205
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1206..1297
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1298..1440
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1441..1645
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1646..1756
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1757..1824
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1825..1930
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 1931..2035
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
exon 2036..2765
/gene="Kif2c"
/gene_synonym="KRP2; MCAK"
/inference="alignment:Splign:2.1.0"
ORIGIN
ggcggcgttaacacagctcagtatctgcagagtcgtggtttctaaacttcttgcatttgcgttacccgttgctgtttccgagtccatggagtcgcttcacgcacgattgtttcccggtctctccatcaacattcaacgcagcaatgggttaattcacagcgccaatataagcacggtgaacttggagaaatcctgtgtttcagtggaatggaccgaaggaggtaccacaaagggcaaagagattgacattgacgatgtggctgccataaacccagagcttgtacagcttcttcccttacgaccgaaggacagtctgccactgcaggagaacgtaaccatcccaaagcaaaaacgcaagtccgtcaactccaaaattccaggtccaaaagaaggccttcgaagtcgttccactcgcatatccactgtctccgaagttcgaatccctgctcaggagaatgaaatggaggtggagctgcctgtgtccacaaactctcgcaagccatttcccattcacagccaccctaggccctcctgctccacagtgacagaattaccgttgttgatgatcagcgaggaggcagaagagcaagcccactccacccgaagcacctcttctgcaaaccctgggaattcagttcggaggaaatcatgtattgtgaaggagatggagaaaatgaagaacaagcgagaagagaagagggcccagaactcggagataagaataaagcgagctcaggaatatgacaacagctttccaaactgggaatttgcccggatgattaaggagtttcgggttactatggactgtaatcctctcactgtgacagaccctattgaagaacacaggatctgtgtctgtgtcaggaaacgcccactgaataaacaagaactggccaagaaagaaatcgatgtgatttctgttcccagcaagtgtctcctcctggtgcatgaacccaagctgaaagtggacttaacgaagtacctggagaaccaggctttttgcttcgactttgcctttgatgaaactgcttccaatgaggtcgtctacaggttcacagcaaggccactggtacagacgatttttgaaggggggaaagcaacgtgctttgcctatgggcagacaggcagtggaaagacacacacaatgggtggagacctgtctggtaaaagtcagaatgcatctaaagggatctacgcaatggcttcccgggatgtcttccttctgaagaatcagcctcgctaccggagcttaaacctggaagtttatgtgacgttcttcgagatctacaatgggaaggtatttgatctgctcaacaagaaggccaagttacgtgtgctggaggacagcaagcagcaggtgcaggttgtggggctgcaggagtacctggttacctgtgccgatgatgtcatcaagatgatcaacatgggcagcgcctgcaggacttcgggacaaacatttgccaactccaattcctcccgctcccacgcctgcttccagattcttcttcgagctaaagggagattacacggcaaattctctttggtggatctggcagggaatgaacgaggagccgacacgtctagtgctgaccgacagactcgcatggagggtgcagaaattaacaagtctctcctggctctgaaggaatgcatccgggcgctgggacagaacaaggctcataccccattccgtgagagcaagctgactcaggtgctgagggactccttcattggggagaactcgaggacatgcatgatcgccatgatctcaccggggataagctcctgtgaatacactttaaacacactgagatacgcagacagagtcaaggagctgagcccccacagcgggcccagtggagaacaggcagtccagatggagacagaggagatggacgccagctctcatggggcctctctgacaggcaatgaagaggaggagctgtcctcccagatgtccagctttaatgaagccatgactcagatcagggagctggaagagagggccatggaagagctcagagagatcatacagcaaggaccaagctggcttgagctctctgagatgacggatcagccagactatgacttggagaccttcgtgaacaaggcagaatctgccctgacacagcaggctaagcaggctaagcacttctcagcccttcaagaagtcatcaaggccctacgcctggccatgcaactggaagaacaggctagcaaacaaataaacagcaagaaacggcaccaatgatgacttcaaataaagatctgtttggtatcacactagcctcttcccctccccagaaaacttcgggcacctctggctttggttagggcctgagtggacaggttttggtaaatgtcaagtacagggcgtcaagccctggaaagcttggggagaggccatgttcttttcctcagtttggatcaggaagaaggaactttaatgactgtgcttcctctcctccctgtcaggagtgctgtttgatagtttcctggtacagcatccagctgctggtagagaagcttcgagatgcaggctctggcagagaagcagtgcttgtccggctcctgctgcctctggctgccagcatcaatcacctttagtctgagcgctctcgtgttttatactttcagaaaaaaggttttgagacctctttgtttttgtttttgaagcctaagaaaatctctagttcttgctttttatgtatttatatgttgcacctaacaataaagaaaaaaaaaacattttgtgtgattatcag
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]