LOCUS       NM_001030044            1455 bp    mRNA    linear   ROD 16-JUL-2023
DEFINITION  Rattus norvegicus iroquois homeobox 5 (Irx5), mRNA.
ACCESSION   NM_001030044 XM_574208
VERSION     NM_001030044.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Liu D, Pattabiraman V, Bacanamwo M and Anderson LM.
  TITLE     Iroquois homeobox transcription factor (Irx5) promotes G1/S-phase
            transition in vascular smooth muscle cells by CDK2-dependent
            activation
  JOURNAL   Am J Physiol Cell Physiol 311 (2), C179-C189 (2016)
   PUBMED   27170637
  REMARK    GeneRIF: Irx5 plays an important role in VSMC G1/S-phase cell cycle
            checkpoint control.
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Bonnard C, Strobl AC, Shboul M, Lee H, Merriman B, Nelson SF,
            Ababneh OH, Uz E, Guran T, Kayserili H, Hamamy H and Reversade B.
  TITLE     Mutations in IRX5 impair craniofacial development and germ cell
            migration via SDF1
  JOURNAL   Nat Genet 44 (6), 709-713 (2012)
   PUBMED   22581230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   He W, Jia Y and Takimoto K.
  TITLE     Interaction between transcription factors Iroquois proteins 4 and 5
            controls cardiac potassium channel Kv4.2 gene transcription
  JOURNAL   Cardiovasc Res 81 (1), 64-71 (2009)
   PUBMED   18815185
  REMARK    GeneRIF: Interaction between transcription factors Iroquois
            proteins 4 and 5 controls cardiac potassium channel Kv4.2 gene
            transcription across the left ventricular wall of rodent hearts.
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow
            RL and Wong RO.
  TITLE     Genetic control of circuit function: Vsx1 and Irx5 transcription
            factors regulate contrast adaptation in the mouse retina
  JOURNAL   J Neurosci 28 (10), 2342-2352 (2008)
   PUBMED   18322081
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Beisvag V, Lehre PK, Midelfart H, Aass H, Geiran O, Sandvik AK,
            Laegreid A, Komorowski J and Ellingsen O.
  TITLE     Aetiology-specific patterns in end-stage heart failure patients
            identified by functional annotation and classification of
            microarray data
  JOURNAL   Eur J Heart Fail 8 (4), 381-389 (2006)
   PUBMED   16753336
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Rosati B, Grau F and McKinnon D.
  TITLE     Regional variation in mRNA transcript abundance within the
            ventricular wall
  JOURNAL   J Mol Cell Cardiol 40 (2), 295-302 (2006)
   PUBMED   16412459
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham
            V, Zhang X, Bruneau BG, Birch DG, Hui CC, McInnes RR and Cheng SH.
  TITLE     The Iroquois homeobox gene, Irx5, is required for retinal cone
            bipolar cell development
  JOURNAL   Dev Biol 287 (1), 48-60 (2005)
   PUBMED   16182275
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Costantini DL, Arruda EP, Agarwal P, Kim KH, Zhu Y, Zhu W, Lebel M,
            Cheng CW, Park CY, Pierce SA, Guerchicoff A, Pollevick GD, Chan TY,
            Kabir MG, Cheng SH, Husain M, Antzelevitch C, Srivastava D, Gross
            GJ, Hui CC, Backx PH and Bruneau BG.
  TITLE     The homeodomain transcription factor Irx5 establishes the mouse
            cardiac ventricular repolarization gradient
  JOURNAL   Cell 123 (2), 347-358 (2005)
   PUBMED   16239150
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from DQ109812.1.
            
            On Aug 5, 2005 this sequence version replaced XM_574208.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ109812.1, AW252100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19p11"
     gene            1..1455
                     /gene="Irx5"
                     /note="iroquois homeobox 5"
                     /db_xref="GeneID:498918"
                     /db_xref="RGD:1565518"
     CDS             1..1455
                     /gene="Irx5"
                     /note="iroquois homeobox protein 5"
                     /codon_start=1
                     /product="iroquois-class homeodomain protein IRX-5"
                     /protein_id="NP_001025215.1"
                     /db_xref="GeneID:498918"
                     /db_xref="RGD:1565518"
                     /translation="

MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFVNARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDLEGPEAGGTEQKAAAGCERLQGPLSPAGKETEGSLSDSDFKESPSEGRHDDLPRPPRAGEPSPAGPATARLAEDAGPHYPAGAPAPGPHPSAGELPPGSGGSSVIHSPPPPPPPPPAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIGGQTLGGSRASPAPAPARSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTAGPGSHFNGLNQTVLNRADVLAKDPKMLRSQSQLDLCKDSPYELKKGMSDI"

     misc_feature    order(346..351,355..357,415..417,433..435,472..474,
                     478..483,490..495,499..507,511..516)
                     /gene="Irx5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(352..354,481..483,490..495,502..504)
                     /gene="Irx5"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    391..507
                     /gene="Irx5"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    <667..1233
                     /gene="Irx5"
                     /note="large tegument protein UL36; Provisional; Region:
                     PHA03247"
                     /db_xref="CDD:223021"
     exon            1..246
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     exon            247..652
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
     exon            653..1455
                     /gene="Irx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atgtcctacccgcagggctacttgtaccagccgtccgcctcgctggcgctctactcgtgccccgcatacagcaccagcgtcatttcggggccccgcacggatgagctcggccgctcttcttcgggctccgcattctcgccctacgctggctccactgccttcacggctccctcgccgggctacaactcgcacctccagtacggtgccgatcccgcggctgcggccgccgccgccttctcgtacgtgggctctccctatgaccacactcccggtatggcgggttccttgggatatcacccttacgccgcacctctgggctcctatccttatggggatcccgcgtaccggaagaacgccactcgggacgccactgccactctcaaggcctggctcaatgagcaccgaaagaacccgtatcccactaagggcgagaagatcatgctggccatcatcaccaaaatgaccctcacccaggtgtccacctggttcgtcaacgcgcgccggcgcctcaagaaagagaacaagatgacgtggacgccacggaaccgcagcgaggacgaggaggaggaggagaacattgatctggaaaagaacgacgaggacgagccacagaagcccgaggacaagggcgacctcgagggccccgaagcaggaggaacagagcagaaggcggctgcgggctgcgaacggctgcaggggccgctcagccccgccggcaaggaaactgaaggcagcctcagcgactcggattttaaagagtcgccctccgaaggccgccacgatgacctgcccaggcccccgcgtgcaggcgagccctccccggctgggcccgcaactgcgcgtctggcggaggatgcgggtcctcactaccctgcgggtgcgccggcgcccggcccgcacccatcagccggagagttgccccccggctcgggcggatcctcggtcatccactcaccaccgccacctccgccaccgcctccggccgtgctagccaagcccaaactgtggtctctggcagagatagccacatcctcggacaaggtcaaggacgggggcggagggagcgagggctctccgtgcccaccgtgccccgggcccataggcgggcaaacccttggaggcagccgcgcttctcctgctccggcgcccgcacgctcaccctcggcgcagtgtccctttcctggcgggaccgtgctgtcccggcctctctactacacggcgcccttctatccgggctacacgaactatggctccttcggacatcttcacggccacccagggccagggccaggccctacagcgggtcctggctctcatttcaatggattaaaccagacggtgttgaatcgtgcggacgttttggctaaagacccgaaaatgttgcggagtcagtctcagctagacctgtgcaaagactccccctatgaattgaagaaaggtatgtccgacatttaa

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