LOCUS       NM_001025770            2481 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus centrosomal protein 41 (Cep41), transcript
            variant 1, mRNA.
ACCESSION   NM_001025770 XM_575421
VERSION     NM_001025770.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Ishikawa,H., Thompson,J., Yates,J.R. 3rd and Marshall,W.F.
  TITLE     Proteomic analysis of mammalian primary cilia
  JOURNAL   Curr Biol 22 (5), 414-419 (2012)
   PUBMED   22326026
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Lee,J.E., Silhavy,J.L., Zaki,M.S., Schroth,J., Bielas,S.L.,
            Marsh,S.E., Olvera,J., Brancati,F., Iannicelli,M., Ikegami,K.,
            Schlossman,A.M., Merriman,B., Attie-Bitach,T., Logan,C.V.,
            Glass,I.A., Cluckey,A., Louie,C.M., Lee,J.H., Raynes,H.R.,
            Rapin,I., Castroviejo,I.P., Setou,M., Barbot,C., Boltshauser,E.,
            Nelson,S.F., Hildebrandt,F., Johnson,C.A., Doherty,D.A.,
            Valente,E.M. and Gleeson,J.G.
  TITLE     CEP41 is mutated in Joubert syndrome and is required for tubulin
            glutamylation at the cilium
  JOURNAL   Nat Genet 44 (2), 193-199 (2012)
   PUBMED   22246503
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Jakobsen,L., Vanselow,K., Skogs,M., Toyoda,Y., Lundberg,E.,
            Poser,I., Falkenby,L.G., Bennetzen,M., Westendorf,J., Nigg,E.A.,
            Uhlen,M., Hyman,A.A. and Andersen,J.S.
  TITLE     Novel asymmetrically localizing components of human centrosomes
            identified by complementary proteomics methods
  JOURNAL   EMBO J 30 (8), 1520-1535 (2011)
   PUBMED   21399614
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Andersen,J.S., Wilkinson,C.J., Mayor,T., Mortensen,P., Nigg,E.A.
            and Mann,M.
  TITLE     Proteomic characterization of the human centrosome by protein
            correlation profiling
  JOURNAL   Nature 426 (6966), 570-574 (2003)
   PUBMED   14654843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC098832.1.
            
            On Aug 30, 2012 this sequence version replaced NM_001025770.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098832.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2481              BC098832.1         3-2483
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2481
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="centrosomal protein 41"
                     /db_xref="GeneID:500069"
                     /db_xref="RGD:1562034"
     exon            1..107
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    29..31
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="upstream in-frame stop codon"
     CDS             65..1084
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     centrosomal protein of 41 kDa; testis specific gene A14;
                     testis specific, 14; testis-specific gene A14 protein;
                     centrosomal protein 41kDa"
                     /codon_start=1
                     /product="centrosomal protein of 41 kDa isoform 1"
                     /protein_id="NP_001020941.1"
                     /db_xref="GeneID:500069"
                     /db_xref="RGD:1562034"
                     /translation="

MSDSPIDGSPQPEPDYRYKKDELFKRIKVTTFAQLVIQVASLSDQTLEVTAEEIQRLEDSDSATSEADTDIAAKTNGKGSPEEQSPSPVQFINSTGAGDASRSTLQSVISGVGELDVDKGLVKKEEPSGKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILEYKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLVTGSLPASCQQALPFGSVRKRPGPKMPALPAENKWRFTPEDLKKIECYLEADQGPANNPSRLNQNNSAGRDLKVPAGRGGQNLPTGCPTSHSNSRTLNSGHLQGKPWK"

     misc_feature    230..361
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM37.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    248..250
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    257..259
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    287..289
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99NF3; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    302..304
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    323..325
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); phosphorylation site"
     misc_feature    470..727
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Rhodanese-like domain; Region: Rhodanese;
                     pfam00581"
                     /db_xref="CDD:425764"
     misc_feature    638..640
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="active site residue [active]"
                     /db_xref="CDD:238089"
     misc_feature    911..1081
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q4KM37.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    989..991
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:Q99NF3; propagated from
                     UniProtKB/Swiss-Prot (Q4KM37.1); methylation site"
     exon            108..169
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            170..239
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            240..384
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            385..536
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            537..604
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            605..719
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            720..935
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
     exon            936..2481
                     /gene="Cep41"
                     /gene_synonym="Tsga14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ccttttttataaaatttaaaactctgcttaaggctttggcttgatctcgtatctccaagcagccatgtcagacagtcccattgacggctcgcctcagccagaaccagattatagatacaaaaaagatgaacttttcaagagaataaaagttaccacttttgcccagctggtcattcaagttgcttccctgtcagatcaaacactggaagtgacagctgaggagatccaaagactcgaagacagtgattctgcaacgtcagaggctgacactgacattgctgccaagaccaatgggaaagggagccctgaggaacagtcgcccagccctgtccagttcatcaacagcacgggagcaggggacgccagccgctccactctgcagagcgtcatcagtggcgttggggaactggatgtagacaaagggctcgtaaagaaagaagagcccagtggcaaagacaagccttatcccgactgtcccttcctgctgctagatgtgcgtgacagagattcttatcagcagtgtcacattgtcggggcctacagttaccccattgcaactctatccaggacaatgaacccctattcaaacgatattcttgagtataaaaatgctcatggcaagatcatcatcttgtacgatgacgacgagaggctagccagccaggcagccaccaccatgtgcgagcgcgggtttgaaaacctcttcatgctttccgggggtctgaaagtcttagctcagaagtttccggaaggactggtcactggttccctgccagcctcttgccaacaggcccttccttttggttctgtccggaaacgacctggccccaaaatgccagccctgccagctgagaacaagtggagatttaccccagaagacttaaaaaagatagaatgttacctggaagcggaccagggaccagccaacaaccctagccgactgaaccagaataactctgctggaagagacttgaaggtgcctgccggccggggtggccaaaacctgcccaccggctgtcctaccagccactcgaactcccgaacactcaacagtggtcacctgcaaggcaaaccctggaagtgaaggcctgtgttgtttagtcaaataaatgtcccctccttttggaacccccaacactcccaacttggtccttttcagaactgctgtagggaaacagccatgctactcgggctggaccaggcccacttctcactgtcttagctcccttcccttcattcaggaaggattttgacagctgaccacgaaagccagaggcttgacaggcaggctctagttgctttccctatttgtttacacaagattcatgtcttttgaaactgaataggaaaaaagaaagatactttcttttaaataaggtccagcctgtttggtctgtaaccagtgttgttctttaaataattcagtcacatctgctgctgtgttcttcccagccagcttttttcattcactgttgatttctgaaaaattctccaggtgggcctggccttggccactgtccccaggggcacagatgagttcttggttcctgcagcccacaggccccacactgggccaggtggctggctgagtcttagctctctatgtgctggcgctgcaggctctacgtgctgcaggctctacgtgctgcaggctctacgtgctgcaggctctatgtgctgcaggctctgctgggcacttgaagctgaggggtgatccgtgagcatgggtccatcttactggtttagcagaaaaactctctgcaaaatgatcccctccttaaatggtttcccgggaccagaaagctgtgtgctcagctgtcctcaccagaagaccccagtattctacaggtctatgctgagaaccctgcccgggaggccgctgcagctgtccccttcattatgagccttatatcaattaaaatttcccattgcctgatttgagtcccgcgatagtagatggatagaaatcacggtcatttgaaagcttcactttgacaaggggacacacaggtgaggaggactcgtgagtcctttgtcagggctgacaaccccttaagcccttgcttaaaatacagtattagtctaattgagtaattagtgcaatttcctgcttgcttttcattctcacgactgagctgtgattagaagtctgtgattatagattctggttttggccggaatttcgaatcggcattaattgaattgctagatgactgacatccattctatttaattgggggaacaaaagacctcaggtaaggatgaggcccatgaagtcataggcaaggacgagccttgttcatttttatggtctgtgatcgtagctctgataagggactgaagaataaattgtgcgctttgtcatggcaaccagcttctgaaaagccagctgaaaattgcctatccttaggtagttattgctggtgggtaagattcgccttagcagtacgatttcttcaccactttaaaaaaaaaaaaaaa

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