LOCUS       NR_174480               3666 bp    RNA     linear   ROD 02-MAY-2024
DEFINITION  Mus musculus RAS protein activator like 3 (Rasal3), transcript
            variant 7, non-coding RNA.
ACCESSION   NR_174480
VERSION     NR_174480.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3666)
  AUTHORS   Olivier,J.F., Langlais,D., Jeyakumar,T., Polyak,M.J., Galarneau,L.,
            Cayrol,R., Jiang,H., Molloy,K.R., Xu,G., Suzuki,H., LaCava,J.,
            Gros,P. and Fodil,N.
  TITLE     CCDC88B interacts with RASAL3 and ARHGEF2 and regulates dendritic
            cell function in neuroinflammation and colitis
  JOURNAL   Commun Biol 7 (1), 77 (2024)
   PUBMED   38200184
  REMARK    GeneRIF: CCDC88B interacts with RASAL3 and ARHGEF2 and regulates
            dendritic cell function in neuroinflammation and colitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3666)
  AUTHORS   Saito,S., Cao,D.Y., Victor,A.R., Peng,Z., Wu,H.Y. and
            Okwan-Duodu,D.
  TITLE     RASAL3 Is a Putative RasGAP Modulating Inflammatory Response by
            Neutrophils
  JOURNAL   Front Immunol 12, 744300 (2021)
   PUBMED   34777356
  REMARK    GeneRIF: RASAL3 Is a Putative RasGAP Modulating Inflammatory
            Response by Neutrophils.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3666)
  AUTHORS   Muro,R., Nitta,T., Kitajima,M., Okada,T. and Suzuki,H.
  TITLE     Rasal3-mediated T cell survival is essential for inflammatory
            responses
  JOURNAL   Biochem Biophys Res Commun 496 (1), 25-30 (2018)
   PUBMED   29291408
  REMARK    GeneRIF: Collectively, Rasal3 controls the magnitude of
            inflammatory responses through the survival of both naive T cells
            and activated T cells in vivo.
REFERENCE   5  (bases 1 to 3666)
  AUTHORS   Saito,S., Kawamura,T., Higuchi,M., Kobayashi,T.,
            Yoshita-Takahashi,M., Yamazaki,M., Abe,M., Sakimura,K., Kanda,Y.,
            Kawamura,H., Jiang,S., Naito,M., Yoshizaki,T., Takahashi,M. and
            Fujii,M.
  TITLE     RASAL3, a novel hematopoietic RasGAP protein, regulates the number
            and functions of NKT cells
  JOURNAL   Eur J Immunol 45 (5), 1512-1523 (2015)
   PUBMED   25652366
  REMARK    GeneRIF: results suggest that RASAL3 plays an important role in the
            expansion and functions of NKT cells in the liver by negatively
            regulating Ras/Erk signaling
REFERENCE   6  (bases 1 to 3666)
  AUTHORS   Muro,R., Nitta,T., Okada,T., Ideta,H., Tsubata,T. and Suzuki,H.
  TITLE     The Ras GTPase-activating protein Rasal3 supports survival of naive
            T cells
  JOURNAL   PLoS One 10 (3), e0119898 (2015)
   PUBMED   25793935
  REMARK    GeneRIF: Rasal3 is required for in vivo survival of peripheral
            naive T cells, contributing to the maintenance of optimal T cell
            numbers.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3666)
  AUTHORS   Yu,X., Bauer,K., Koczan,D., Thiesen,H.J. and Ibrahim,S.M.
  TITLE     Combining global genome and transcriptome approaches to identify
            the candidate genes of small-effect quantitative trait loci in
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 9 (1), R3 (2007)
   PUBMED   17244351
REFERENCE   8  (bases 1 to 3666)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485616.11.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               CT485616.11        25328-25853         c
            527-660             CT485616.11        21562-21695         c
            661-739             CT485616.11        21357-21435         c
            740-801             CT485616.11        21189-21250         c
            802-869             CT485616.11        20293-20360         c
            870-996             CT485616.11        19766-19892         c
            997-1095            CT485616.11        19582-19680         c
            1096-1632           CT485616.11        18620-19156         c
            1633-1777           CT485616.11        18094-18238         c
            1778-1922           CT485616.11        17347-17491         c
            1923-2159           CT485616.11        16310-16546         c
            2160-2361           CT485616.11        16013-16214         c
            2362-2480           CT485616.11        15795-15913         c
            2481-2871           CT485616.11        14670-15060         c
            2872-3025           CT485616.11        14318-14471         c
            3026-3089           CT485616.11        13608-13671         c
            3090-3666           CT485616.11        12931-13507         c
FEATURES             Location/Qualifiers
     source          1..3666
                     /organism="Mus musculus"
                     /mol_type="transcribed RNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.55 cM"
     gene            1..3666
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /note="RAS protein activator like 3"
                     /db_xref="GeneID:320484"
                     /db_xref="MGI:MGI:2444128"
     misc_RNA        1..3666
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /product="RAS protein activator like 3, transcript variant
                     7"
                     /db_xref="GeneID:320484"
                     /db_xref="MGI:MGI:2444128"
     exon            1..526
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..2943
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_001400382.1"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            527..660
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            661..739
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            740..801
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            802..869
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            870..996
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1095
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1632
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1777
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1922
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2159
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2361
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2480
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2871
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3025
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3026..3089
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3090..3666
                     /gene="Rasal3"
                     /gene_synonym="A430107D22Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gaggaaggaagctaggcacagtacagacggctgctggttctggactggccaggaaatcaaggtaagggagggtgtacgtgtggcatcctcaagtatgttcctggaggcgaagctgagaagagaccagggaagatgaagccagaatgtgggcagacaatgttcagaaccttttggtctcgcagcagagactcctccgccatggacccaccgttgcagagtgaagaagattcccaaacgcagccctcgctgccctctccgctgacatcctaccgctggcacactggaggcagtggggaaaaggctgctggagggttccgctggggccgctttgcaggctggggaagggccctgagccatcaggagcccatggtgaacagccagccagcccccagatctctgtttcgtcgggtcctctctgcaccccctaaggagtcacggtccaatcgcctccggttttccaagaccctgtggggaaggcacaagaacgtggcaccactggaacccaagccaaatccgaaggccccagagctggagttggtagcagacccagatctacccgttgcacagatccctgagcctcccaccccggacatgcctgtttggaacattgatggctttacccttctcgaaggaaagctggtgatgctcggtgaggaggagggtcctcgccaaatccgagtgggaagcgccagttcagagaacagcatgcaggcagctttggggaacctcaaggatgcagttcggacccctggaaaaactgagccggaagctgctggttccaaccaggtccacaatgttcggttactcaagaggctgaaggagaagaaaagagccaagtcagaactgggagcctacacccctcgagatggacctcccagtgccctcggttccagagaatcgctggccacactctctgagctggacctaggtgctgagagggacgtgagagtctggccactgcatcctagcctcttgggggagccctactgcttccaggtaacctgggcaggtgggagcctctgtttctcatgtcgctcgagcgctgagagagaccgttggattgaggaccttcgtcggcagttccagccgagccaggacaacgtggagcggcaagagatgtggctgacggtgtgggtgcacgaggccaaagggctaccccgagcaactgtacccggagtgcgtgcggagctgtggttggatggcgcgctattggcgcgcactgccccccgtgccggcccaggccaactcttctgggctgaacgcttccacttcgaggcgttgccacctgcccgtcgcctgtcgctgcggttgcgcagcgcaggcccggcaggggcaaccgtgggcagggtggtgctggagctggacgaggtgagcatcccccgcgcgcctgccgcgggcctagagcgctggttcccggtgcttggggcgccggcaggtgcggtgctacgagcgcggatcagggtgcgttgtctgcgcgtgctgccgtcggagcgctataaggagctggccgagttcctcaccttccactacgcgcgcctgtgcggggcgctggagccggcgctgtctgctcaggccaaagaggagctggcagcagccatggtgcgcgtgctacgagccactggccgagcgcaggcattggtgacagacctaggaaccgcagagctggcacgctgtggaggccgtgaagcactgctattccgagaaaataccttagccacaaaggccattgatgaatacatgaaactggtggcacaggagtacctccaggacaccctggggcaggttgtgcggtgtctctgtgcctccactgaggactgtgaagtggaccccagcaagtgcccaacaccagagctgccaaaacaccaagctagactgcgagacagctgtgaggaggtttttgaaaacatcatccattcttacaactgtttcccagcagagctgggctccgtgttctcaagttggcgtgaagcatgcaaagcacgaggctctgaggccctgggcccccggctggtgtgtgcttccctcttcctgaggcttttatgccctgccatcttggcacctagcctctttggcctggcaccagagcacccagccccaggcccagccagaactcttacactcatcgccaaggtcatccagaacctcgccaactgtgccccgtttggtgagaaggaagcctacatggcgtttatgaatagcttcctggaagatcatggaccagccatgcaacacttcctggaccaggtagctacggtggatgcagataccacacccagtggctaccagggaagtggagacctggcccttcagttagcagttcttcatgtccagctctgcacaatctttgccgaacttgaccagaaaacccaagatagcttggaaccactacccaccatccttcgagccattgaggaaggccggcctgtcccagtgtctgtaccaatgcgtcttccccggatctccactcaggtccaatccagcttcttttcaggggagaaacccggcttcctggcaccccgagacctccccaagcacactcccctcatttccaagagtcaatctctgcgcagctttcaaggggcaggaagctgggccagtcggcggccagatgaggagcggccccagaggcggccgcggccagtgctgcgcacacagagcgtccctgccagacgtcctacccaccgtcgcccttctgcaggttccaagccgcggcccaaaggctccctacgcatgggccccgcgccttgcggacgggcctggactagggcttctgcctcgctacctcggaagccatcggtaccatggcagcgccaaatggaccagccgggggaccgataccaaactacgggaacgcaccgaccagtgggcaagcagagatacaatgtgaggtggctatattccgcgaggcacagaaagctctgtcccttctggtggagtcgttgagtacccaagtccaagccttgaaggagcagcaggagcacttccgctgtcagctgcaggatctgtactccagactgggagctggtatctcaaagttggattctaagggtggtctcccaagcaacggaagccacaggctgaaaagtctggaacagcgcctgactgagatggaatgttctcaggaccagctgagggatagcctccaaagcctgcaacttctttcaaaaacaccaggatctcggagccagcccctgcctctcaaagcaccatgtgtcaatggagctgatctgtcaatgggcacttgagcatttcaccccactccatatatggtctggaagccaagagagccactacagaggattttctgactgcctcagcccttcatggccttcagtgggggacagagtgggaggtgtcaatcactctggtaactgtgaggttgcccagtaaatccatttcagaaaatcaccggtttctctgcccctacaaatgattaatacaagagaatgcccagttctccattcaggtctcccaaattcatacctaatttgaagtctcctgaagttggaaataatgagcagatcctcacaattggtgtgatctaaggttgtcactttaagagactccattctctcctctgtaaagtgtatctaaaaattctccacatagtggaaaactcttagttaaaggtattcaataaagggtattgatcatttttggggggaa

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