LOCUS       NM_198610               2017 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus immunoglobulin superfamily, member 21 (Igsf21), mRNA.
ACCESSION   NM_198610 XM_131808
VERSION     NM_198610.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Botella-Lopez,A., Garcia-Lopez,R., Pombero,A. and Martinez,S.
  TITLE     Radial glia fibers translate Fgf8 morphogenetic signals to generate
            a thalamic nuclear complex protomap in the mantle layer
  JOURNAL   Brain Struct Funct 224 (2), 661-679 (2019)
   PUBMED   30470893
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Tanabe,Y., Naito,Y., Vasuta,C., Lee,A.K., Soumounou,Y.,
            Linhoff,M.W. and Takahashi,H.
  TITLE     IgSF21 promotes differentiation of inhibitory synapses via binding
            to neurexin2alpha
  JOURNAL   Nat Commun 8 (1), 408 (2017)
   PUBMED   28864826
  REMARK    GeneRIF: IgSF21 interacts with neurexin2alpha to induce presynaptic
            differentiation of inhibitory synapses, and mice lacking IgSF21
            exhibit deficits in inhibitory synaptic transmission
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   da Silva,S., Hasegawa,H., Scott,A., Zhou,X., Wagner,A.K., Han,B.X.
            and Wang,F.
  TITLE     Proper formation of whisker barrelettes requires periphery-derived
            Smad4-dependent TGF-beta signaling
  JOURNAL   Proc Natl Acad Sci U S A 108 (8), 3395-3400 (2011)
   PUBMED   21300867
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB867903.1 and BC055811.1.
            
            On May 1, 2010 this sequence version replaced NM_198610.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055811.1, AK137439.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BB867903.1         2-28
            28-2017             BC055811.1         1-1990
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 71.09 cM"
     gene            1..2017
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="immunoglobulin superfamily, member 21"
                     /db_xref="GeneID:230868"
                     /db_xref="MGI:MGI:2681842"
     exon            1..510
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    354..356
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="upstream in-frame stop codon"
     CDS             441..1847
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="immunoglobin superfamily, member 21"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 21 precursor"
                     /protein_id="NP_941012.1"
                     /db_xref="CCDS:CCDS18851.1"
                     /db_xref="GeneID:230868"
                     /db_xref="MGI:MGI:2681842"
                     /translation="

MQAAPSLRRASCLLLAAILDLARGYLTVNIEPLPPVVAGDAVTLKCNFKTDGRMREIVWYRVTDGGTIKQKIFTFDAMFSTNYSHMENYRKREDLVYQSTVRLPEVRISDNGPYECHVGIYDRATREKVVLASGNIFLNVMAPPTSIEVVAADSPAPFSRYQAQNFTLVCIVSGGKPAPMVYFKRDGEPIDAVPLTELPAASSGPVQDSRPFRSLLHRDVDDTKMQKSLSLLDTEYRAGRPYTERPARSLTQDPSLFVQPTTENIPETVVSREFPRWVHSAEPVYFLRHSRTPGSDGTVEVRALLTWTLNPQIDNEALFSCEVKHPALSMPMQAEVTLVAPKGPKIMMTPSRARVGDTVRILVHGFQNEVFPEPMFTWTRVGSRLLDGSAEFDGKELVLERVPAELNGSMYRCTAQNPLGSTDTHTRLIVFENPNIPRGTEDSRGSASGPAGVRLTLVLALTVILELT"

     sig_peptide     441..512
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     mat_peptide     513..1844
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /product="Immunoglobulin superfamily member 21.
                     /id=PRO_0000223339"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7TNR6.1)"
     misc_feature    528..830
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    564..578
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand B [structural motif]; Region: Ig strand
                     B"
                     /db_xref="CDD:409353"
     misc_feature    606..620
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    684..686
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNR6.1); glycosylation site"
     misc_feature    738..749
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    777..794
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    807..818
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     misc_feature    933..935
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNR6.1); glycosylation site"
     misc_feature    <1554..1736
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Immunoglobulin domain; Region: Ig; cl11960"
                     /db_xref="CDD:472250"
     misc_feature    1563..1577
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand C [structural motif]; Region: Ig strand
                     C"
                     /db_xref="CDD:409353"
     misc_feature    1623..1637
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand E [structural motif]; Region: Ig strand
                     E"
                     /db_xref="CDD:409353"
     misc_feature    1659..1661
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q7TNR6.1); glycosylation site"
     misc_feature    1665..1685
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand F [structural motif]; Region: Ig strand
                     F"
                     /db_xref="CDD:409353"
     misc_feature    1710..1721
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="Ig strand G [structural motif]; Region: Ig strand
                     G"
                     /db_xref="CDD:409353"
     exon            511..623
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            624..745
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            746..864
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            865..980
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1455
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1541
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1734
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1773
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..2000
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="hexamer: ATTAAA"
     polyA_site      2000
                     /gene="Igsf21"
                     /gene_synonym="Gm141"
                     /note="major polyA site"
ORIGIN      

gagcgcggggcagagcgcggcggcgcgggcagagcttcggctccaaactccgccactgccgccacggatccgactccggccgccgtggccgcctatcgcagccaaccagccgggagcagctgcgcgccccagccaggtccggtgcagcccggagcagccagtgcgtctggtgcagcccggagcatcctattacagcccagagtagcctggtggtgcagcccggagcatcccggtacagcccagagcagccccgggtagcctggcggccgggctacagtagcatggggacctcccctcggctctcctcgcctctcgtcaccgccacggccggcggcccgggtcacaagcgcttctgagcccatggcgaggggacccaccgccgccactgcgatcgctgccgccgccgccgcctcggccagcgccgccagcttctggacaccatgcaagctgctccaagcctccgccgcgcttcctgcctgctgctcgccgcgattctggacctggcacgcggctacctgacagtcaacattgagccccttccccctgtggtggctggggacgcagtgaccctgaagtgtaacttcaagacagacggccgtatgcgtgagatcgtgtggtaccgggtgacagatggcggcaccatcaagcagaagatcttcacgtttgacgccatgttctccacgaactactcgcacatggagaattaccgcaagagggaggaccttgtgtatcagtccaccgtgaggctgcccgaggtccggatctcagacaatggtccctatgagtgccacgtgggtatctacgaccgagccacgagggagaaggtggtcctcgcctcaggcaacatcttcctcaatgtcatggctcctcccacctccatcgaagtcgtggctgctgactcccctgccccctttagccggtaccaggcccagaacttcacactggtctgcatcgtgtcaggagggaagccggcgcccatggtttatttcaaacgggacggggagccgatagatgccgtgcccctgacagaactgccagcagccagctctggcccagtccaggacagcaggcccttccgaagccttctgcaccgagacgtggatgataccaaaatgcaaaagtcactgtcccttctggacactgaataccgggctggacgtccctacacggagcgccccgcgcgcagcctgacccaggaccccagcctcttcgtgcagcccaccacggaaaacatcccagagacagtggtgagccgagagttcccccgttgggtacacagcgccgagccggtctacttcctgcgccacagccgcaccccaggcagcgatggcacggtggaggtgcgggccctgctcacctggaccctcaacccgcagatcgacaatgaggccctcttcagctgtgaggtcaagcacccagcgctgtccatgcccatgcaggcggaggtcacgctggttgctcccaaaggacccaaaatcatgatgacgcccagcagagcccgggttggggacacagtgaggatcctagtccacggatttcagaatgaggtcttcccagaacccatgttcacgtggacgagagtgggcagccgcctcctggatggcagtgccgagtttgacgggaaggagcttgtgctggagcgggttcctgccgagctcaacggctccatgtaccgctgcactgcccagaaccccctgggctccactgatacacacactcggctcatcgtgttcgaaaacccaaatatcccaagaggaacagaggactcccgtggttctgcttccggccccgctggcgtccggctcaccctggtgcttgccctgacagtgatcctggagctcacgtgaagatgctgcctcctcccgatgctccagccgcccggcatctctgcgatcgattttcatttcttttctaaactatttccagtcttgttcttagtctcggcccatgtcttggcttcctcactgggtttaattaaacaaacagaccaattttccccaaaaaaaaaaaaaaaaaa

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