LOCUS       NM_177595               3201 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus mohawk homeobox (Mkx), mRNA.
ACCESSION   NM_177595 XM_974986
VERSION     NM_177595.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3201)
  AUTHORS   Wang,Y., Qin,Q., Wang,Z., Negri,S., Sono,T., Tower,R.J., Li,Z.,
            Xing,X., Archer,M., Thottappillil,N., Zhu,M., Suarez,A., Kim,D.H.,
            Harvey,T., Fan,C.M. and James,A.W.
  TITLE     The Mohawk homeobox gene represents a marker and osteo-inhibitory
            factor in calvarial suture osteoprogenitor cells
  JOURNAL   Cell Death Dis 15 (6), 420 (2024)
   PUBMED   38886383
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3201)
  AUTHORS   Lynch,C.A., Acosta,S.A., Anderson,D.M., Rogers,G.E.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     The Transcription Factor Mohawk Facilitates Skeletal Muscle Repair
            via Modulation of the Inflammatory Environment
  JOURNAL   Int J Mol Sci 25 (9), 5019 (2024)
   PUBMED   38732238
  REMARK    GeneRIF: The Transcription Factor Mohawk Facilitates Skeletal
            Muscle Repair via Modulation of the Inflammatory Environment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3201)
  AUTHORS   Ono,Y., Schlesinger,S., Fukunaga,K., Yambe,S., Sato,T., Sasaki,T.,
            Shukunami,C., Asahara,H. and Inui,M.
  TITLE     Scleraxis-lineage cells are required for correct muscle patterning
  JOURNAL   Development 150 (10) (2023)
   PUBMED   37246520
REFERENCE   4  (bases 1 to 3201)
  AUTHORS   Mechakra,A., Lin,J., Yang,Y., Du,X., Zhang,J., Ewetse,P.M., Zhou,F.
            and Alakpa,E.
  TITLE     Mohawk impedes angiofibrosis by preventing the differentiation of
            tendon stem/progenitor cells into myofibroblasts
  JOURNAL   Sci Rep 12 (1), 20003 (2022)
   PUBMED   36411329
  REMARK    GeneRIF: Mohawk impedes angiofibrosis by preventing the
            differentiation of tendon stem/progenitor cells into
            myofibroblasts.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3201)
  AUTHORS   Adachi,Y., Higuchi,A., Wakai,E., Shiromizu,T., Koiwa,J. and
            Nishimura,Y.
  TITLE     Involvement of homeobox transcription factor Mohawk in
            palatogenesis
  JOURNAL   Congenit Anom (Kyoto) 62 (1), 27-37 (2022)
   PUBMED   34816492
  REMARK    GeneRIF: Involvement of homeobox transcription factor Mohawk in
            palatogenesis.
REFERENCE   6  (bases 1 to 3201)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
  REMARK    GeneRIF: Mohawk can repress transcription through recruitment of
            the Sin3A/HDAC co-repressor complex
REFERENCE   7  (bases 1 to 3201)
  AUTHORS   Takeuchi,J.K. and Bruneau,B.G.
  TITLE     Irxl1, a divergent Iroquois homeobox family transcription factor
            gene
  JOURNAL   Gene Expr Patterns 7 (1-2), 51-56 (2007)
   PUBMED   16824806
  REMARK    GeneRIF: Irxl1 is a newly identified highly divergent member of the
            Irx gene family with specific expression patterns in embryogenesis.
REFERENCE   8  (bases 1 to 3201)
  AUTHORS   Liu,H., Liu,W., Maltby,K.M., Lan,Y. and Jiang,R.
  TITLE     Identification and developmental expression analysis of a novel
            homeobox gene closely linked to the mouse Twirler mutation
  JOURNAL   Gene Expr Patterns 6 (6), 632-636 (2006)
   PUBMED   16426902
  REMARK    GeneRIF: The developmental expression pattern indicates that Irxl1
            is a good candidate gene for the Twirler gene.
REFERENCE   9  (bases 1 to 3201)
  AUTHORS   Anderson,D.M., Arredondo,J., Hahn,K., Valente,G., Martin,J.F.,
            Wilson-Rawls,J. and Rawls,A.
  TITLE     Mohawk is a novel homeobox gene expressed in the developing mouse
            embryo
  JOURNAL   Dev Dyn 235 (3), 792-801 (2006)
   PUBMED   16408284
  REMARK    GeneRIF: Mohawk is an important regulator of vertebrate
            development.
REFERENCE   10 (bases 1 to 3201)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856607.1, AK034675.1, CD544112.1 and BY644476.1.
            
            On Oct 25, 2007 this sequence version replaced NM_177595.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034675.1, BC137728.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BB856607.1         2-159
            159-1225            AK034675.1         137-1203
            1226-1575           CD544112.1         207-556
            1576-3167           AK034675.1         1551-3142
            3168-3201           BY644476.1         362-395
FEATURES             Location/Qualifiers
     source          1..3201
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 4.53 cM"
     gene            1..3201
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="mohawk homeobox"
                     /db_xref="GeneID:210719"
                     /db_xref="MGI:MGI:2687286"
     exon            1..158
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            159..425
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1302
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="iroquois homeobox protein-like 1"
                     /codon_start=1
                     /product="homeobox protein Mohawk"
                     /protein_id="NP_808263.2"
                     /db_xref="CCDS:CCDS37728.1"
                     /db_xref="GeneID:210719"
                     /db_xref="MGI:MGI:2687286"
                     /translation="

MNTIVFNKLGGAVLFEDRGTPDRERGSRTFSGFLDNPHTGPEVGIPDGPPLKDNLSLRHRRTGARQNGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDGDSCSEDGENPPRNHMNEEGYSTPAHHTVIKGESSAIKAGGRPESRAAEDYVSPPKYKSSLLNRYLNDSLRHVMATSTAMMGKTRRRNHSGSFSSNEFEEELVSPSSSETEGTFVYRTDTPDIGSTKGDSAANRRGPSKDDTYWKEINAAMALTNLAQGKDEVQGTTTSCIIQKSSHIAEVKTVKLPLVQRF"

     misc_feature    289..387
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BIA3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    order(451..465,469..471,526..528,544..546,583..585,
                     589..594,601..606,610..618,622..627)
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(457..459,466..468,592..594,601..606,613..615)
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    502..618
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     misc_feature    706..786
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BIA3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    964..1143
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BIA3.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            426..585
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..742
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..1078
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1112
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..3201
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3168..3173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="hexamer: AATAAA"
     polyA_site      3189
                     /gene="Mkx"
                     /gene_synonym="9430023B20Rik; Irxl1"
                     /note="major polyA site"
ORIGIN      

gggccgcgcgcatcagtctgggtaaataaagcagagacgactccggtggccccggtgaacgcgtcggagcctgagccgagaacatgcggtggggatgggagtgtgcctagtccagagacaggagtgtcagccgctggctgccgattccgcggccacagaacccgagccctgctgcggagctcctggtggactccgaggctctgccgcaaggccgcgcgtccctgccagcccccaatcatgaacaccatcgtcttcaacaagctcgggggagccgtgctttttgaagaccgaggcactccagatcgggaacgtggcagccggacgttcagtggtttcctggacaatccacacacagggccggaggtgggcataccagacggcccgcccctcaaggacaacctcagcctgagacaccggaggacaggggcccggcagaatggagggaaggtaaggcataagcgacaggccctgcaagacatggcgcgtcctcttaagcagtggctttacaagcaccgtgacaacccgtaccctacgaagactgagaagatactcttggccctaggctcgcagatgacgctagtgcaggtgtcaaattggttcgctaatgctagacgtcggctgaagaacactgtccggcagccagatttaagttgggccttaagaataaagttatacaacaagtatgttcagggcaacgctgaacggctgagtgtgagcagcgatggcgactcctgctctgaagatggagaaaatcccccaagaaatcacatgaacgaagaaggctacagcacccccgcccaccacactgtgattaaaggggaaagctcagcgataaaagctggcggcagaccggagtcgagggctgccgaggattatgtgtcaccgcccaagtataagagcagcttgttgaaccgttaccttaacgactccttgagacatgtcatggccaccagcactgccatgatggggaaaacaaggcgaaggaaccattcggggtcttttagctccaacgaatttgaagaagagttggtgtctccatcatcatcagaaactgaaggcacctttgtctatcgcacagacaccccggacatcggatctactaagggtgacagtgctgctaacagaaggggaccaagcaaagatgacacatactggaaggagatcaatgcagccatggccttaacaaaccttgcccaaggaaaagatgaagtgcaggggacgaccaccagttgcatcatccagaagtcttcccacatagcagaagtaaagacagtcaagctgccactggtgcagcgcttctagagtggccaggaagtgctgagctgtcagtgggttgtttgtttgtttgtgtttgtttttacctaaatcctcatcctaagagccaaagcagaggtgaagaggactcccttaaaactcctgagttcaactatcgtaaatatatcagttgcttctataaaaagacatataagttataaaaactcattttaatcaaaaatattaacttatttttatgttactgaaactatgcataaagtatctgcattaccattacagtaagtgccttgctccctgaggtaagccccaacgtgggcacagtgaagagctgtgcctcaaaccatcaatgccaacacttgctagactgcatcattcccactggtccaggacagaagccaatcgccgaaagcccatgaaacaatttcattcattcacatgttcaaacttggaaatctgttcagcccagatgaggtgatcttttctttcttttttctttccttttctttttctttttctctttctttttctttcctctttcttttttttttttcttttccttaacttccggtgtgatggtgagaattttatgtgtgggttttgtttgcatatcagttagtgcatccaaaatgaaaggtgctgcaggaccacatgatgcatacacttaagaagagatgctttcaaactactttaatattgtaatgcagtcaaggattgttttcccaagcactgctggaaagtatcccaatgccctttacaactaattgggattttttttccctgaagctttaaaaagagtcttattatataaatctttgaaattttttcctgtgtaaagctaaacctaaagtttagttttaaatcataatcttgtttgcattagagctcagggttcctgtgtgatggaagccgctttcatgtggagtgagtaaaagctttttatttggttcatttcaaatcccaattcagatggacaatttgtattgcaatgagaacaagacaacgaagaaaaaatctgtgtgtgtatatacatatacatgcagaaaaattgatttcttaaaaatttaaaatgtacgggtagcaaaatatgttcatgtagcatagactgtttagtctctgatttttgccagataggacattcaaatagaaattaagtgaagtcttgcattaaaagaaagaaagtcttgtttctaaatgtcactaccacagagtgagagcaatcgctatcaagaaagaaaagtcttttccatcaagcattaacatcctcccctgcctgggaagactgcaaaccagaggaatgtggagatgcccagtagaaaaggaaatctggagatggcctataaaacagagcaaacgttcaacagcaaagtaaaaaagactaggctatcgggggaatttttttctggttatgtaatgtattttctaattgttttaggctggaaagcatttttgcaagtgtgaatgacatctggtttcacagcacatgctgacgtttttttctttattttacaaaatgcttttaatgccaaagttaatctggttgctgagcagacatgacggccttgatggccctcgtaggacactttctcctgtatcatagcatagtggggtgggggttatctagtgtaatgaagataatttgatatgaaaatattttgtacgtatatttttactttgttttctcaagtgctgttggcagttgcagttgccctaggtgagatgtgtcagtgctgactgtatgaatggatgaagtattgggttcttctcgtgcagccagccaagtggggatcactacaagacaagcctgcccagatgtgcatgaggcagtgagaagcaagaacgaatacttcactctttctcatactattataagttattctggtattaaatattttaataaaagtgttcttgttttaacatattgtgatt

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