2025-08-21 21:57:06, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_144881 2857 bp mRNA linear ROD 12-JUN-2024 DEFINITION Mus musculus hedgehog acyltransferase (Hhat), mRNA. ACCESSION NM_144881 VERSION NM_144881.5 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (bases 1 to 2857) AUTHORS Asciolla,J.J. and Resh,M.D. TITLE Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane JOURNAL Cell Rep 29 (13), 4608-4619 (2019) PUBMED 31875564 REMARK GeneRIF: Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane. REFERENCE 2 (bases 1 to 2857) AUTHORS Iulianella,A., Sakai,D., Kurosaka,H. and Trainor,P.A. TITLE Ventral neural patterning in the absence of a Shh activity gradient from the floorplate JOURNAL Dev Dyn 247 (1), 170-184 (2018) PUBMED 28891097 REFERENCE 3 (bases 1 to 2857) AUTHORS Yun,K. and Perantoni,A.O. TITLE Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal ureter-bladder connection JOURNAL Differentiation 94, 1-7 (2017) PUBMED 27923152 REFERENCE 4 (bases 1 to 2857) AUTHORS Kurosaka,H., Trainor,P.A., Leroux-Berger,M. and Iulianella,A. TITLE Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling JOURNAL PLoS One 10 (3), e0120821 (2015) PUBMED 25799573 REMARK Publication Status: Online-Only REFERENCE 5 (bases 1 to 2857) AUTHORS Callier,P., Calvel,P., Matevossian,A., Makrythanasis,P., Bernard,P., Kurosaka,H., Vannier,A., Thauvin-Robinet,C., Borel,C., Mazaud-Guittot,S., Rolland,A., Desdoits-Lethimonier,C., Guipponi,M., Zimmermann,C., Stevant,I., Kuhne,F., Conne,B., Santoni,F., Lambert,S., Huet,F., Mugneret,F., Jaruzelska,J., Faivre,L., Wilhelm,D., Jegou,B., Trainor,P.A., Resh,M.D., Antonarakis,S.E. and Nef,S. TITLE Loss of function mutation in the palmitoyl-transferase HHAT leads to syndromic 46,XY disorder of sex development by impeding Hedgehog protein palmitoylation and signaling JOURNAL PLoS Genet 10 (5), e1004340 (2014) PUBMED 24784881 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 2857) AUTHORS Abe,Y., Kita,Y. and Niikura,T. TITLE Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog JOURNAL FEBS J 275 (2), 318-331 (2008) PUBMED 18081866 REFERENCE 7 (bases 1 to 2857) AUTHORS Li,C., Xu,X., Nelson,D.K., Williams,T., Kuehn,M.R. and Deng,C.X. TITLE FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis JOURNAL Development 132 (21), 4755-4764 (2005) PUBMED 16207751 REFERENCE 8 (bases 1 to 2857) AUTHORS Coumoul,X., Shukla,V., Li,C., Wang,R.H. and Deng,C.X. TITLE Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA interference JOURNAL Nucleic Acids Res 33 (11), e102 (2005) PUBMED 15987787 REMARK Publication Status: Online-Only REFERENCE 9 (bases 1 to 2857) AUTHORS Chen,M.H., Li,Y.J., Kawakami,T., Xu,S.M. and Chuang,P.T. TITLE Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates JOURNAL Genes Dev 18 (6), 641-659 (2004) PUBMED 15075292 REFERENCE 10 (bases 1 to 2857) AUTHORS Nelson,D.K. and Williams,T. TITLE Frontonasal process-specific disruption of AP-2alpha results in postnatal midfacial hypoplasia, vascular anomalies, and nasal cavity defects JOURNAL Dev Biol 267 (1), 72-92 (2004) PUBMED 14975718 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL365317.22, AC115917.11 and AC105325.11. On Dec 21, 2021 this sequence version replaced NM_144881.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK028230.1, SRR7345562.2403635.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-259 AL365317.22 1786-2044 260-389 AL365317.22 13224-13353 390-457 AL365317.22 24076-24143 458-571 AL365317.22 31401-31514 572-766 AL365317.22 45546-45740 767-1000 AL365317.22 46671-46904 1001-1172 AL365317.22 55896-56067 1173-1323 AL365317.22 79075-79225 1324-1359 AC115917.11 160126-160161 c 1360-1561 AC115917.11 93557-93758 c 1562-1706 AC115917.11 51609-51753 c 1707-2857 AC105325.11 114657-115807 c FEATURES Location/Qualifiers source 1..2857 /organism="Mus musculus" /mol_type="mRNA" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="1" /map="1 97.55 cM" gene 1..2857 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="hedgehog acyltransferase" /db_xref="GeneID:226861" /db_xref="MGI:MGI:2444681" exon 1..259 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" misc_feature 155..157 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="upstream in-frame stop codon" exon 260..389 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" CDS 299..1798 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="skinny hedgehog protein" /codon_start=1 /product="protein-cysteine N-palmitoyltransferase HHAT" /protein_id="NP_659130.2" /db_xref="CCDS:CCDS15628.1" /db_xref="GeneID:226861" /db_xref="MGI:MGI:2444681" /translation="
MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL"
misc_feature 314..364 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 500..550 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 569..763 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); Region: Essential for palmitoylation of SHH. /evidence=ECO:0000250|UniProtKB:Q5VTY9" misc_feature 692..742 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 752..1642 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="membrane-bound O-acyltransferase family; Region: MBOAT; cl00738" /db_xref="CDD:445070" misc_feature 785..847 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1046..1129 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1160..1246 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1406..1456 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1466..1513 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1598..1660 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" misc_feature 1703..1759 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1); transmembrane region" exon 390..457 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 458..571 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 572..766 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 767..1000 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1001..1172 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1173..1323 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1324..1359 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1360..1561 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1562..1706 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" exon 1707..2857 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /inference="alignment:Splign:2.1.0" regulatory 2836..2841 /regulatory_class="polyA_signal_sequence" /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="hexamer: AATAAA" polyA_site 2857 /gene="Hhat" /gene_synonym="2810432O22Rik; AP-2CRE; Skn; Tg(TFAP2A-cre)1Will" /note="major polyA site" ORIGIN
attcctttggggaccggaagaatcctggagcctgaggttctggtgggaccctgtgtaatgattcggctccagtaaatgtacagagccctggccaatcctgcgttcgggaacccgggcacaacatctcaggccaggcgctcacccccgcggcctctgacccgcgctgtgctcgcgagtccctcccgggccgcggctcagcgcggcggggtgcagggacgccttctctcccgctcgcccagctctgcacactgcgatccagaaactctccacactacactgggaagcagagactccagctatgctgcccgggtgggaactgactctctgcctgcttgtttccttgggtttccacttccgctctttctatgaagtttacaaagtctccagagagcatgaagaggaactggatcaagaatttgagctggagatggacactctatttggaggactgaagaaggacccgactgattttgagtggaacttctggatggaatgggggaagcggaggctggtgtggctcttcattggccatatggctgtgtctcagttggccacgttactcacaaagaagcacagaccctggattgtcatggtctatggaatgtgggcctgctggtgtgtgctgggggcgccaggcgtggtcatggtccttctccacagcaccatcgcgttctgcgtggctcagttccgatccgtgctcctgtcctggctgtgttctctccttctgctctccaccctaaggctgcaaagtgtggaggaagttaagagaaggtggtacaagacagagaacgagtattacctgctccagtttacgctcactgttcgctgcctgtactacaccagcttcagcctggagctgtgccggcagcctccgtctgcacaacctactccatctgcgcaaggtgcctcccattcctacccgtggctgctgacctacgtcttctattatcccgtcttccacaacgggcccatccttaacttcccggagttcttcagacagatgcagcagccagagctcaactctctgcagcacagcctctgcattgtagccaagggcctgggtcgtctgctctgctggtggtggctggctgaactgatggtacacctcatgtacatgcatgccctctacagcagcgcccccctcctggagagcgtttcctgctggaccttaggaggactggcgctggcccaagtgctcttcttctatgtgaagtacctggtgctctttggtgtcccggctctgctcatgcgcctggatggactcacgccaccacctcttccccgctgcgtgagcaccatgttcagttttaccgggatgtggaggtattttgatgttggactacacaatttcttaatcaggtatgtgtacatcccactgggcgggtcccagcatggcctgttggggacactgctttctactgcaacaacgtttgcgttcgtgagctactggcatggtagctatgaggacctctggtgctgggcagcgctcaactggctgggagtcactgtggagagtggggtccggaggctgctagagacaccctgtgtccgggagactttggcccggcacctctccccacaagcccaccatcgactgcacgctctgcttgccgcctgctctacctccatgctcatcctcttcaacctggtgttcctcgggggaattcaagttgggaaaacctactggaacaggatcttcctgcaagggtggccatgggtgactctgtctgtcctgggattcctgtactgctattctcacgtggacattgcttgggctcagacatacacagttctttaactgtgtatggctgctgggccagctcagcctccaagggacatggcatttcatcctgatctctcattctgagaccatcctcaaaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggactaccttccactcatcttctaatgaagacgcttcattccaggactggcagcttcatcaatcacagtaaatacacaactcaaacttctagctctggagcctcagagatttgtcgcgtcccccccagaagcttcctgacgcacaaggtacagtccagagcagtctcaggttttcctgactatacctgtgatatttgttcccatgaacctgcttgtttttttttttttttcttctctaccaaagcttaggtgtggcagatgtgtgttttgatatggaagtcctggttagggataggcttgccatccttgggatgtctttctgagaaattctgagatactttgatgtctcctttctatgtgctgccctgggggctctggactaaccttcgcatgaatggtccttagacaggggatcagcagaaccatttcacatttcaagtggcccagctagagtgggtgatgtgcagctggggctttacaaagagttctgtaacttgaactttattggagagtccacacagggctgctgctttctgagacttgtagccatggaggaacatggtggttcctctcacagctgttctgcacagaagtggagtttaaaagccagagaataagatgtccacatgcaggtggtgttgcgcaaggcctctggggagagtgacatcccaaggtcccatgacttttactcagtgggttttattgccttattctcatttaaaaaaaaaaaaaacagaacctgtttttgctacatagataattctgatttttttgtggtcttattttggatattttttaaataaaaattttgagatctaaa
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If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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