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2025-08-21 21:57:06, GGRNA.v2 : RefSeq release 230 (May, 2025)

LOCUS       NM_144881               2857 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus hedgehog acyltransferase (Hhat), mRNA.
ACCESSION   NM_144881
VERSION     NM_144881.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2857)
  AUTHORS   Asciolla,J.J. and Resh,M.D.
  TITLE     Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across
            the Endoplasmic Reticulum Membrane
  JOURNAL   Cell Rep 29 (13), 4608-4619 (2019)
   PUBMED   31875564
  REMARK    GeneRIF: Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA
            across the Endoplasmic Reticulum Membrane.
REFERENCE   2  (bases 1 to 2857)
  AUTHORS   Iulianella,A., Sakai,D., Kurosaka,H. and Trainor,P.A.
  TITLE     Ventral neural patterning in the absence of a Shh activity gradient
            from the floorplate
  JOURNAL   Dev Dyn 247 (1), 170-184 (2018)
   PUBMED   28891097
REFERENCE   3  (bases 1 to 2857)
  AUTHORS   Yun,K. and Perantoni,A.O.
  TITLE     Hydronephrosis in the Wnt5a-ablated kidney is caused by an abnormal
            ureter-bladder connection
  JOURNAL   Differentiation 94, 1-7 (2017)
   PUBMED   27923152
REFERENCE   4  (bases 1 to 2857)
  AUTHORS   Kurosaka,H., Trainor,P.A., Leroux-Berger,M. and Iulianella,A.
  TITLE     Cranial nerve development requires co-ordinated Shh and canonical
            Wnt signaling
  JOURNAL   PLoS One 10 (3), e0120821 (2015)
   PUBMED   25799573
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2857)
  AUTHORS   Callier,P., Calvel,P., Matevossian,A., Makrythanasis,P.,
            Bernard,P., Kurosaka,H., Vannier,A., Thauvin-Robinet,C., Borel,C.,
            Mazaud-Guittot,S., Rolland,A., Desdoits-Lethimonier,C.,
            Guipponi,M., Zimmermann,C., Stevant,I., Kuhne,F., Conne,B.,
            Santoni,F., Lambert,S., Huet,F., Mugneret,F., Jaruzelska,J.,
            Faivre,L., Wilhelm,D., Jegou,B., Trainor,P.A., Resh,M.D.,
            Antonarakis,S.E. and Nef,S.
  TITLE     Loss of function mutation in the palmitoyl-transferase HHAT leads
            to syndromic 46,XY disorder of sex development by impeding Hedgehog
            protein palmitoylation and signaling
  JOURNAL   PLoS Genet 10 (5), e1004340 (2014)
   PUBMED   24784881
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2857)
  AUTHORS   Abe,Y., Kita,Y. and Niikura,T.
  TITLE     Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol
            uptake/transporter 1, acts as a negative regulator for N-terminal
            palmitoylation of Sonic hedgehog
  JOURNAL   FEBS J 275 (2), 318-331 (2008)
   PUBMED   18081866
REFERENCE   7  (bases 1 to 2857)
  AUTHORS   Li,C., Xu,X., Nelson,D.K., Williams,T., Kuehn,M.R. and Deng,C.X.
  TITLE     FGFR1 function at the earliest stages of mouse limb development
            plays an indispensable role in subsequent autopod morphogenesis
  JOURNAL   Development 132 (21), 4755-4764 (2005)
   PUBMED   16207751
REFERENCE   8  (bases 1 to 2857)
  AUTHORS   Coumoul,X., Shukla,V., Li,C., Wang,R.H. and Deng,C.X.
  TITLE     Conditional knockdown of Fgfr2 in mice using Cre-LoxP induced RNA
            interference
  JOURNAL   Nucleic Acids Res 33 (11), e102 (2005)
   PUBMED   15987787
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2857)
  AUTHORS   Chen,M.H., Li,Y.J., Kawakami,T., Xu,S.M. and Chuang,P.T.
  TITLE     Palmitoylation is required for the production of a soluble
            multimeric Hedgehog protein complex and long-range signaling in
            vertebrates
  JOURNAL   Genes Dev 18 (6), 641-659 (2004)
   PUBMED   15075292
REFERENCE   10 (bases 1 to 2857)
  AUTHORS   Nelson,D.K. and Williams,T.
  TITLE     Frontonasal process-specific disruption of AP-2alpha results in
            postnatal midfacial hypoplasia, vascular anomalies, and nasal
            cavity defects
  JOURNAL   Dev Biol 267 (1), 72-92 (2004)
   PUBMED   14975718
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365317.22, AC115917.11 and AC105325.11.
            
            On Dec 21, 2021 this sequence version replaced NM_144881.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028230.1, SRR7345562.2403635.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AL365317.22        1786-2044
            260-389             AL365317.22        13224-13353
            390-457             AL365317.22        24076-24143
            458-571             AL365317.22        31401-31514
            572-766             AL365317.22        45546-45740
            767-1000            AL365317.22        46671-46904
            1001-1172           AL365317.22        55896-56067
            1173-1323           AL365317.22        79075-79225
            1324-1359           AC115917.11        160126-160161       c
            1360-1561           AC115917.11        93557-93758         c
            1562-1706           AC115917.11        51609-51753         c
            1707-2857           AC105325.11        114657-115807       c
FEATURES             Location/Qualifiers
     source          1..2857
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 97.55 cM"
     gene            1..2857
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="hedgehog acyltransferase"
                     /db_xref="GeneID:226861"
                     /db_xref="MGI:MGI:2444681"
     exon            1..259
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    155..157
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="upstream in-frame stop codon"
     exon            260..389
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1798
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="skinny hedgehog protein"
                     /codon_start=1
                     /product="protein-cysteine N-palmitoyltransferase HHAT"
                     /protein_id="NP_659130.2"
                     /db_xref="CCDS:CCDS15628.1"
                     /db_xref="GeneID:226861"
                     /db_xref="MGI:MGI:2444681"
                     /translation="
MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL"
     misc_feature    314..364
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    500..550
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    569..763
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     Region: Essential for palmitoylation of SHH.
                     /evidence=ECO:0000250|UniProtKB:Q5VTY9"
     misc_feature    692..742
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    752..1642
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="membrane-bound O-acyltransferase family; Region:
                     MBOAT; cl00738"
                     /db_xref="CDD:445070"
     misc_feature    785..847
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1046..1129
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1160..1246
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1406..1456
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1466..1513
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1598..1660
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     misc_feature    1703..1759
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BMT9.1);
                     transmembrane region"
     exon            390..457
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            458..571
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            572..766
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1000
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1172
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1323
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1359
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1561
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1706
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..2857
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2836..2841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="hexamer: AATAAA"
     polyA_site      2857
                     /gene="Hhat"
                     /gene_synonym="2810432O22Rik; AP-2CRE; Skn;
                     Tg(TFAP2A-cre)1Will"
                     /note="major polyA site"
ORIGIN      
attcctttggggaccggaagaatcctggagcctgaggttctggtgggaccctgtgtaatgattcggctccagtaaatgtacagagccctggccaatcctgcgttcgggaacccgggcacaacatctcaggccaggcgctcacccccgcggcctctgacccgcgctgtgctcgcgagtccctcccgggccgcggctcagcgcggcggggtgcagggacgccttctctcccgctcgcccagctctgcacactgcgatccagaaactctccacactacactgggaagcagagactccagctatgctgcccgggtgggaactgactctctgcctgcttgtttccttgggtttccacttccgctctttctatgaagtttacaaagtctccagagagcatgaagaggaactggatcaagaatttgagctggagatggacactctatttggaggactgaagaaggacccgactgattttgagtggaacttctggatggaatgggggaagcggaggctggtgtggctcttcattggccatatggctgtgtctcagttggccacgttactcacaaagaagcacagaccctggattgtcatggtctatggaatgtgggcctgctggtgtgtgctgggggcgccaggcgtggtcatggtccttctccacagcaccatcgcgttctgcgtggctcagttccgatccgtgctcctgtcctggctgtgttctctccttctgctctccaccctaaggctgcaaagtgtggaggaagttaagagaaggtggtacaagacagagaacgagtattacctgctccagtttacgctcactgttcgctgcctgtactacaccagcttcagcctggagctgtgccggcagcctccgtctgcacaacctactccatctgcgcaaggtgcctcccattcctacccgtggctgctgacctacgtcttctattatcccgtcttccacaacgggcccatccttaacttcccggagttcttcagacagatgcagcagccagagctcaactctctgcagcacagcctctgcattgtagccaagggcctgggtcgtctgctctgctggtggtggctggctgaactgatggtacacctcatgtacatgcatgccctctacagcagcgcccccctcctggagagcgtttcctgctggaccttaggaggactggcgctggcccaagtgctcttcttctatgtgaagtacctggtgctctttggtgtcccggctctgctcatgcgcctggatggactcacgccaccacctcttccccgctgcgtgagcaccatgttcagttttaccgggatgtggaggtattttgatgttggactacacaatttcttaatcaggtatgtgtacatcccactgggcgggtcccagcatggcctgttggggacactgctttctactgcaacaacgtttgcgttcgtgagctactggcatggtagctatgaggacctctggtgctgggcagcgctcaactggctgggagtcactgtggagagtggggtccggaggctgctagagacaccctgtgtccgggagactttggcccggcacctctccccacaagcccaccatcgactgcacgctctgcttgccgcctgctctacctccatgctcatcctcttcaacctggtgttcctcgggggaattcaagttgggaaaacctactggaacaggatcttcctgcaagggtggccatgggtgactctgtctgtcctgggattcctgtactgctattctcacgtggacattgcttgggctcagacatacacagttctttaactgtgtatggctgctgggccagctcagcctccaagggacatggcatttcatcctgatctctcattctgagaccatcctcaaaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggaccaccctccactccaggacagtccctgagggactaccttccactcatcttctaatgaagacgcttcattccaggactggcagcttcatcaatcacagtaaatacacaactcaaacttctagctctggagcctcagagatttgtcgcgtcccccccagaagcttcctgacgcacaaggtacagtccagagcagtctcaggttttcctgactatacctgtgatatttgttcccatgaacctgcttgtttttttttttttttcttctctaccaaagcttaggtgtggcagatgtgtgttttgatatggaagtcctggttagggataggcttgccatccttgggatgtctttctgagaaattctgagatactttgatgtctcctttctatgtgctgccctgggggctctggactaaccttcgcatgaatggtccttagacaggggatcagcagaaccatttcacatttcaagtggcccagctagagtgggtgatgtgcagctggggctttacaaagagttctgtaacttgaactttattggagagtccacacagggctgctgctttctgagacttgtagccatggaggaacatggtggttcctctcacagctgttctgcacagaagtggagtttaaaagccagagaataagatgtccacatgcaggtggtgttgcgcaaggcctctggggagagtgacatcccaaggtcccatgacttttactcagtgggttttattgccttattctcatttaaaaaaaaaaaaaacagaacctgtttttgctacatagataattctgatttttttgtggtcttattttggatattttttaaataaaaattttgagatctaaa
//

by @meso_cacase at DBCLS
This page is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596. [Full Text]