LOCUS       NM_027802               1217 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus oocyte specific homeobox 1 (Obox1), mRNA.
ACCESSION   NM_027802
VERSION     NM_027802.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1217)
  AUTHORS   Ji,S., Chen,F., Stein,P., Wang,J., Zhou,Z., Wang,L., Zhao,Q.,
            Lin,Z., Liu,B., Xu,K., Lai,F., Xiong,Z., Hu,X., Kong,T., Kong,F.,
            Huang,B., Wang,Q., Xu,Q., Fan,Q., Liu,L., Williams,C.J.,
            Schultz,R.M. and Xie,W.
  TITLE     OBOX regulates mouse zygotic genome activation and early
            development
  JOURNAL   Nature 620 (7976), 1047-1053 (2023)
   PUBMED   37459895
REFERENCE   2  (bases 1 to 1217)
  AUTHORS   Wu,L., Wu,Y., Peng,B., Hou,Z., Dong,Y., Chen,K., Guo,M., Li,H.,
            Chen,X., Kou,X., Zhao,Y., Bi,Y., Wang,Y., Wang,H., Le,R., Kang,L.
            and Gao,S.
  TITLE     Oocyte-Specific Homeobox 1, Obox1, Facilitates Reprogramming by
            Promoting Mesenchymal-to-Epithelial Transition and Mitigating Cell
            Hyperproliferation
  JOURNAL   Stem Cell Reports 9 (5), 1692-1705 (2017)
   PUBMED   29033306
  REMARK    GeneRIF: Obox1 serves as a strong activator for somatic cell
            reprogramming through promoting the mesenchymal-to-epithelial
            transition and mitigating cell hyperproliferation.
REFERENCE   3  (bases 1 to 1217)
  AUTHORS   Brici,D., Zhang,Q., Reinhardt,S., Dahl,A., Hartmann,H., Schmidt,K.,
            Goveas,N., Huang,J., Gahurova,L., Kelsey,G., Anastassiadis,K.,
            Stewart,A.F. and Kranz,A.
  TITLE     Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a
            maternal effect gene required for the oogenic gene expression
            program
  JOURNAL   Development 144 (14), 2606-2617 (2017)
   PUBMED   28619824
REFERENCE   4  (bases 1 to 1217)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 1217)
  AUTHORS   Chung,Y.C., Tsai,Y.J., Shiu,T.Y., Sun,Y.Y., Wang,P.F. and Chen,C.L.
  TITLE     Screening large numbers of expression patterns of transcription
            factors in late stages of the mouse thymus
  JOURNAL   Gene Expr Patterns 11 (1-2), 84-92 (2011)
   PUBMED   20932939
REFERENCE   6  (bases 1 to 1217)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 1217)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 1217)
  AUTHORS   Cheng,W.C., Hsieh-Li,H.M., Yeh,Y.J. and Li,H.
  TITLE     Mice lacking the Obox6 homeobox gene undergo normal early embryonic
            development and are fertile
  JOURNAL   Dev Dyn 236 (9), 2636-2642 (2007)
   PUBMED   17676645
REFERENCE   9  (bases 1 to 1217)
  AUTHORS   Rajkovic,A., Yan,C., Yan,W., Klysik,M. and Matzuk,M.M.
  TITLE     Obox, a family of homeobox genes preferentially expressed in germ
            cells
  JOURNAL   Genomics 79 (5), 711-717 (2002)
   PUBMED   11991721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC189859.1.
            
            On Nov 17, 2006 this sequence version replaced NM_027802.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018362.1, AK136061.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AC189859.1         124218-124276
            60-321              AC189859.1         132078-132339
            322-521             AC189859.1         132466-132665
            522-1217            AC189859.1         133112-133807
FEATURES             Location/Qualifiers
     source          1..1217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.5 cM"
     gene            1..1217
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /note="oocyte specific homeobox 1"
                     /db_xref="GeneID:71468"
                     /db_xref="MGI:MGI:1918718"
     exon            1..59
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            60..321
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    87..89
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /note="upstream in-frame stop codon"
     CDS             105..719
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /codon_start=1
                     /product="oocyte-specific homeobox protein 1"
                     /protein_id="NP_082078.1"
                     /db_xref="CCDS:CCDS20837.1"
                     /db_xref="GeneID:71468"
                     /db_xref="MGI:MGI:1918718"
                     /translation="

MAEGPSLHPKLQVDSNIPIEISSQIPQEPARNLAFQMRQSPLVTPGSTTKSSLSVPERNLLKQESQGPSRQSGCMLLSDKYVNKQTGPMASRKFRKERTVYTKEQQGLLQKHFDECQYPNKKKIVELALSVGVTKREIKIWFKNNRAKYRRMNLQNIEQVLPESNGSSKAVSESTHFPVVASDNGESMCSGTFGEDSIPKFNCS"

     misc_feature    186..323
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D350.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    387..557
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            322..521
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            522..1217
                     /gene="Obox1"
                     /gene_synonym="7420700M11Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tgagtagaattaaaacagccagaggatttagcaagttacagcaaccctctggattcctggttatccagtacaggaacatactccaataaattcagaacacacaaatggcggaaggtccctccttgcatccaaaactccaagtggattcgaatatacccatagaaataagttcccaaatacctcaagaaccggcaaggaacctagcttttcaaatgcgtcagagtcccctagtgaccccaggaagtacaacgaaatcaagtctttcagtccctgaaaggaacctacttaagcaagagtctcaaggaccatcaagacaatcaggttgtatgctactgtcagataaatatgttaacaaacaaactggcccaatggcttcaagaaagtttcgaaaagaacgaactgtgtacaccaaagaacagcagggcctgctgcaaaaacattttgatgagtgccagtacccaaacaagaagaaaattgtggagctggcactatcagttggtgttacaaagagggagattaagatctggttcaagaacaaccgagctaagtacaggcggatgaacctccagaatattgaacaagtactgccagagtcaaatggaagctctaaagcggtttctgagtcaacccattttcctgttgttgcctctgacaatggagagtccatgtgttcaggcacatttggtgaggattccattcccaaattcaactgcagctaggaatcttccctgcattgttttcaggcctgagatggggccatgtgttgtacgcaagaatacgtgcttgatggccatacccctgttacagcttggaactctggtcaatcagcagcagttgaatatcacacttacttagcagtagctgaagctccagtcgggctggcatatgctgcccaagccccagaggatgctcacaattcagctccatctgcagacaagctctagcaaaggatccttgaagacttttgacacatcagatgactggcttgccatgagaaacccctccactccagcttacacctctcaggtccttgacgagtccaaccttacagccatgaagaagtgtgttatatacacctttattctctgtatttggagaaataaccagtcttatctgtagaagcatcataccactgtgttttatgtagtgcgattgtttgaaattcagtttaggtcttaattttttattgttagagtatatgttcattaaataaaagg

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