LOCUS       NM_016674               3263 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus claudin 1 (Cldn1), mRNA.
ACCESSION   NM_016674 XM_358828
VERSION     NM_016674.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3263)
  AUTHORS   Siegerist,F., Kliewe,F., Hammer,E., Schakau,P., Chi Soh,J.E.,
            Weber,C., Lindenmeyer,M., Reichelt-Wurm,S., Drenic,V.,
            Chatziantoniou,C., Chadjichristos,C.E., Zhang,Y., Simm,S.,
            Banas,M.C., Nauck,M., Volker,U. and Endlich,N.
  TITLE     The role of the tricellular junction protein ILDR2 in
            glomerulopathies: Expression patterns and functional insights
  JOURNAL   iScience 27 (12), 111329 (2024)
   PUBMED   39640577
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3263)
  AUTHORS   Zhu,L., Tang,N., Hang,H., Zhou,Y., Dong,J., Yang,Y., Mao,L.,
            Qiu,Y., Fu,X. and Cao,W.
  TITLE     Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic
            cancer progression
  JOURNAL   Cancer Lett 586, 216611 (2024)
   PUBMED   38309617
  REMARK    GeneRIF: Loss of Claudin-1 incurred by DNMT aberration promotes
            pancreatic cancer progression.
REFERENCE   3  (bases 1 to 3263)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3263)
  AUTHORS   Mak,S. and Hammes,A.
  TITLE     Canonical and Non-Canonical Localization of Tight Junction Proteins
            during Early Murine Cranial Development
  JOURNAL   Int J Mol Sci 25 (3), 1426 (2024)
   PUBMED   38338705
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3263)
  AUTHORS   Cazorla-Vazquez,S., Kosters,P., Bertz,S., Pfister,F., Daniel,C.,
            Dedden,M., Zundler,S., Jobst-Schwan,T., Amann,K. and Engel,F.B.
  TITLE     Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish,
            Mouse, and Human Kidney
  JOURNAL   Cells 12 (15), 1988 (2023)
   PUBMED   37566066
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3263)
  AUTHORS   Kubota,K., Furuse,M., Sasaki,H., Sonoda,N., Fujita,K., Nagafuchi,A.
            and Tsukita,S.
  TITLE     Ca(2+)-independent cell-adhesion activity of claudins, a family of
            integral membrane proteins localized at tight junctions
  JOURNAL   Curr Biol 9 (18), 1035-1038 (1999)
   PUBMED   10508613
REFERENCE   7  (bases 1 to 3263)
  AUTHORS   Morita,K., Furuse,M., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin multigene family encoding four-transmembrane domain protein
            components of tight junction strands
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 511-516 (1999)
   PUBMED   9892664
REFERENCE   8  (bases 1 to 3263)
  AUTHORS   Citi,S. and Cordenonsi,M.
  TITLE     Tight junction proteins
  JOURNAL   Biochim Biophys Acta 1448 (1), 1-11 (1998)
   PUBMED   9824655
  REMARK    Review article
REFERENCE   9  (bases 1 to 3263)
  AUTHORS   Furuse,M., Sasaki,H., Fujimoto,K. and Tsukita,S.
  TITLE     A single gene product, claudin-1 or -2, reconstitutes tight
            junction strands and recruits occludin in fibroblasts
  JOURNAL   J Cell Biol 143 (2), 391-401 (1998)
   PUBMED   9786950
REFERENCE   10 (bases 1 to 3263)
  AUTHORS   Furuse,M., Fujita,K., Hiiragi,T., Fujimoto,K. and Tsukita,S.
  TITLE     Claudin-1 and -2: novel integral membrane proteins localizing at
            tight junctions with no sequence similarity to occludin
  JOURNAL   J Cell Biol 141 (7), 1539-1550 (1998)
   PUBMED   9647647
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK036780.1 and CK626537.1.
            
            On Aug 3, 2010 this sequence version replaced NM_016674.3.
            
            Summary: This gene encodes a member of the claudin family. Claudins
            are integral membrane proteins and components of tight junction
            strands. Tight junction strands serve as a physical barrier to
            prevent solutes and water from passing freely through the
            paracellular space between epithelial or endothelial cell sheets,
            and also play critical roles in maintaining cell polarity and
            signal transductions. The knockout mice lacking this gene die soon
            after birth as a consequence of dehydration from trandermal water
            loss, indicating that this gene is indispensable for creating and
            maintaining the epidermal barrier. The protein encoded by this gene
            also has gastric tumor suppressive activity, and is a key factor
            for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008536.1, AK036780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3236              AK036780.1         2-3237
            3237-3263           CK626537.1         1-27                c
FEATURES             Location/Qualifiers
     source          1..3263
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 18.0 cM"
     gene            1..3263
                     /gene="Cldn1"
                     /note="claudin 1"
                     /db_xref="GeneID:12737"
                     /db_xref="MGI:MGI:1276109"
     exon            1..436
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..849
                     /gene="Cldn1"
                     /codon_start=1
                     /product="claudin-1"
                     /protein_id="NP_057883.1"
                     /db_xref="CCDS:CCDS28087.1"
                     /db_xref="GeneID:12737"
                     /db_xref="MGI:MGI:1276109"
                     /translation="

MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFLISGLATLVATAWYGNRIVQEFYDPLTPINARYEFGQALFTGWAAASLCLLGGVLLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV"

     misc_feature    226..759
                     /gene="Cldn1"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; pfam00822"
                     /db_xref="CDD:395662"
     misc_feature    235..297
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     transmembrane region"
     misc_feature    457..519
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     transmembrane region"
     misc_feature    559..621
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     transmembrane region"
     misc_feature    703..765
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     transmembrane region"
     misc_feature    781..846
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    841..846
                     /gene="Cldn1"
                     /note="propagated from UniProtKB/Swiss-Prot (O88551.1);
                     Region: Interactions with TJP1, TJP2, TJP3 and PATJ"
     exon            437..601
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            602..686
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..3242
                     /gene="Cldn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn1"
                     /note="hexamer: AATAAA"
     polyA_site      3242
                     /gene="Cldn1"
                     /note="major polyA site"
ORIGIN      

ctcagagaactctgccacttctcacttccagactccaccaccgcctacccggaccagaagccaggagcctcgccccgcagctgcacagagagcaagggtataggcactaacttgtttgcagagaccccatcaccttcgggagctcaggtgcgcaccttgcaaactccactttctgcatctgccactgagcccgcgggagcctcggaaagagccatggccaacgcggggctgcagctgctgggtttcatcctggcttctctgggatggatcggctccatcgtcagcactgccctgccccagtggaagatttactcctatgctggggacaacatcgtgaccgctcaggccatctacgagggactgtggatgtcctgcgtttcgcaaagcaccgggcagatacagtgcaaagtcttcgactccttgctgaatctgaacagtactttgcaggcaacccgagccttgatggtaattggcatcctgctggggctgatcgcaatctttgtgtccaccattggcatgaagtgcatgaggtgcctggaagatgatgaggtgcagaagatgtggatggctgtcattgggggcataatatttttaatttcaggtctggcgacattagtggccacagcatggtatggaaacagaattgttcaagaattctatgaccccttgacccccatcaatgccaggtatgaatttggccaggccctctttactggctgggccgctgcctccctctgccttctgggaggtgtcctactttcctgctcctgtccccggaaaacaacctcttacccaacaccacggccttatcccaagccaacaccttctagtgggaaagactatgtgtgacagaggcaaaggaagagatcttcctggagcaaatacaaaatggacattgaacctaggattgacattaacgccttagactgttgatgatggttatcggaactgtggtagaacagaaggaagcatatttttatacatccccatggctatgcaggccttggctgtaccttaccatcttccctgagcacaggagggaaggcttttgcctgtgaactgctgcttccctctgagaaatcacactcaaacggggataaggtgctccttgcatgtgtatagatatgtacagatacatagtttctattaaaaatagacaagttacaaatcccttattctcctcatactgtaccagcacactttaaatgactctacaatatatacaattatgttttgattaaataagcctttttgatgtattattcctttttctctatgaacatatgtgatcagtcaaatatcacccctttgatcagcatttagtaactttgccataagaccagacttccttatgaactcagactgtgttctttttaaccccatgtgtcttctttacatcaaaatatttaatttttttactctgaaacacactttttcagactgttactctgaggtttgattctaactcccaaatctaataatgaatttggagcccacattttgaagcgtaaaaccagtaagaatcccatagtcctcctgtttctgagctgtggtgaccaacattctagtcagatgatgttttcccgatgacctttctggacggtctttgcactttggtctggagctgtcttgtttgctttaaaaatatttgtttccctgagtggctgtgctgctaaccctgttgttgaaacagttttattgcctgcattttttaggtacttattttccatcccagatcctgcaaactgtgcttctcctctccccccaccccagctgtctagtttccccacatataattatctgacagtttagctcttttcagataggtgtggtctgtttatctacacaaactgctagacttgccagagtggtaatctagtgacaaatattccctaggtagccgtgaacaatttacaatctttatacctcgttttcccatctgtcaaattgagataattatacttaagcagctggtagaggtaatgtgagtattaattagttgatatgactctcattctttgaacatgaaatatgcctaagtagtgtttttccttgctcaattagcagttttgaagacactgaataagatctatgcacatgccttcaactgttctgtatctctctttgtcatgagttgatttcctcccatccagctgtgcatggcctcttgttggtgctgttttgttttgaccagtgctcttaatatactctcatccataggaaaggcccttcagcagagcaaggttttgtaatacaaagggtgttgccattgacattggtagacctggatttgcatcttggtgctatcacttaattagtgagcttgggcaaaggcacttggttgccctacatgtattgctacatctagacaacgggttcattaactcttgtcctgcctatgttgcatgagtcaagagggggcacaggctaacatggttttatattggaaaacatgttactctacaaattaatggcttttgtgtttattttttcaaacaactggaaagagaaaaatgttaagtgagtttcattccttaagaactctctcaaatgaggagttcctaaagcttactaagttaaactgatcttaagtctttaaggcttttggttgggagtcagtgtttcagcctatggtccaaactggccaagagcccctatgtcactcaaagatccttcttcctcaacctcccaactgttaagatgagaggcatgaacccttcctactgttacaccctagtttcagttgtttggcctggaacttctgttgctaagcaaatgtaatggtgaaagtctatgtatactctaaaagcaaatgaagtgctctttgtgaagtgatactttcaaaattaaatggaagctgacagttataggagaggttaagaattataattcatggtaaaaccacatggatgaagttatagacagaatggagtcttatgtgaatttgtactatgtaagttttactatatttgtgtgtgtaaagtaatcatgcaaagatgttttgccacagaatctgtgcttaatatgtaatgtaaatgcatagaaatgatacttgccaaactacacaaatctatatattctaaaataatcccatagaaatcttacatcagaacttacctagttttgatatttttataccctactaccaaagctggaaagagatcagttgatatctgggggctgcaatgggaatttgtacaaagcactactctttttcaataaattgttttttaattaataaaaaaaaaaaaaaaaaaaaaaaa

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