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Previous release (v1)
2025-08-21 21:06:27, GGRNA.v2 : RefSeq release 230 (May, 2025)
LOCUS NM_013869 4639 bp mRNA linear ROD 18-JUN-2024
DEFINITION Mus musculus tumor necrosis factor receptor superfamily, member 19
(Tnfrsf19), transcript variant 1, mRNA.
ACCESSION NM_013869
VERSION NM_013869.5
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4639)
AUTHORS Grommisch,D., Wang,M., Eenjes,E., Svetlicic,M., Deng,Q.,
Giselsson,P. and Genander,M.
TITLE Defining the contribution of Troy-positive progenitor cells to the
mouse esophageal epithelium
JOURNAL Dev Cell 59 (10), 1269-1283 (2024)
PUBMED 38565145
REFERENCE 2 (bases 1 to 4639)
AUTHORS Deacon,E., Li,A., Boivin,F., Dvorkin-Gheva,A., Cunanan,J. and
Bridgewater,D.
TITLE beta-Catenin in the kidney stroma modulates pathways and genes to
regulate kidney development
JOURNAL Dev Dyn 252 (9), 1224-1239 (2023)
PUBMED 37227110
REFERENCE 3 (bases 1 to 4639)
AUTHORS Lee,J.H., Kim,S., Han,S., Min,J., Caldwell,B., Bamford,A.D.,
Rocha,A.S.B., Park,J., Lee,S., Wu,S.S., Lee,H., Fink,J.,
Pilat-Carotta,S., Kim,J., Josserand,M., Szep-Bakonyi,R., An,Y.,
Ju,Y.S., Philpott,A., Simons,B.D., Stange,D.E., Choi,E., Koo,B.K.
and Kim,J.K.
TITLE p57Kip2 imposes the reserve stem cell state of gastric chief cells
JOURNAL Cell Stem Cell 29 (5), 826-839 (2022)
PUBMED 35523142
REFERENCE 4 (bases 1 to 4639)
AUTHORS Douchi,D., Yamamura,A., Matsuo,J., Melissa Lim,Y.H.,
Nuttonmanit,N., Shimura,M., Suda,K., Chen,S., Pang,S., Kohu,K.,
Abe,T., Shioi,G., Kim,G., Shabbir,A., Srivastava,S., Unno,M.,
Bok-Yan So,J., Teh,M., Yeoh,K.G., Chuang,L.S.H. and Ito,Y.
TITLE Induction of Gastric Cancer by Successive Oncogenic Activation in
the Corpus
JOURNAL Gastroenterology 161 (6), 1907-1923 (2021)
PUBMED 34391772
REFERENCE 5 (bases 1 to 4639)
AUTHORS Kretzschmar,K., Boonekamp,K.E., Bleijs,M., Asra,P., Koomen,M.,
Chuva de Sousa Lopes,S.M., Giovannone,B. and Clevers,H.
TITLE Troy/Tnfrsf19 marks epidermal cells that govern interfollicular
epidermal renewal and cornification
JOURNAL Stem Cell Reports 16 (9), 2379-2394 (2021)
PUBMED 34358453
REMARK GeneRIF: Troy/Tnfrsf19 marks epidermal cells that govern
interfollicular epidermal renewal and cornification.
REFERENCE 6 (bases 1 to 4639)
AUTHORS Naito,A., Yoshida,H., Nishioka,E., Satoh,M., Azuma,S., Yamamoto,T.,
Nishikawa,S. and Inoue,J.
TITLE TRAF6-deficient mice display hypohidrotic ectodermal dysplasia
JOURNAL Proc Natl Acad Sci U S A 99 (13), 8766-8771 (2002)
PUBMED 12060722
REFERENCE 7 (bases 1 to 4639)
AUTHORS Locksley,R.M., Killeen,N. and Lenardo,M.J.
TITLE The TNF and TNF receptor superfamilies: integrating mammalian
biology
JOURNAL Cell 104 (4), 487-501 (2001)
PUBMED 11239407
REMARK Review article
REFERENCE 8 (bases 1 to 4639)
AUTHORS Kojima,T., Morikawa,Y., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
Senba,E. and Kitamura,T.
TITLE TROY, a newly identified member of the tumor necrosis factor
receptor superfamily, exhibits a homology with Edar and is
expressed in embryonic skin and hair follicles
JOURNAL J Biol Chem 275 (27), 20742-20747 (2000)
PUBMED 10764796
REFERENCE 9 (bases 1 to 4639)
AUTHORS Eby,M.T., Jasmin,A., Kumar,A., Sharma,K. and Chaudhary,P.M.
TITLE TAJ, a novel member of the tumor necrosis factor receptor family,
activates the c-Jun N-terminal kinase pathway and mediates
caspase-independent cell death
JOURNAL J Biol Chem 275 (20), 15336-15342 (2000)
PUBMED 10809768
REFERENCE 10 (bases 1 to 4639)
AUTHORS Hu,S., Tamada,K., Ni,J., Vincenz,C. and Chen,L.
TITLE Characterization of TNFRSF19, a novel member of the tumor necrosis
factor receptor superfamily
JOURNAL Genomics 62 (1), 103-107 (1999)
PUBMED 10585776
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
CF727607.1, AK083283.1, AK028146.1 and BY637570.1.
On Aug 20, 2009 this sequence version replaced NM_013869.4.
Transcript Variant: This variant (1) represents the longer
transcript. Both variants 1 and 2 encode the same protein.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660811.2373.1, AK083283.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164131 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on conservation, expression,
longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-386 CF727607.1 1-386
387-998 AK083283.1 2-613
999-2478 AK028146.1 306-1785
2479-4437 AK083283.1 2094-4052
4438-4623 AK028146.1 3745-3930
4624-4639 BY637570.1 398-413
FEATURES Location/Qualifiers
source 1..4639
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="14"
/map="14 32.06 cM"
gene 1..4639
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="tumor necrosis factor receptor superfamily, member
19"
/db_xref="GeneID:29820"
/db_xref="MGI:MGI:1352474"
exon 1..741
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 742..834
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
misc_feature 745..747
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="upstream in-frame stop codon"
CDS 766..2016
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="Toxicity and JNK inducer"
/codon_start=1
/product="tumor necrosis factor receptor superfamily
member 19 precursor"
/protein_id="NP_038897.4"
/db_xref="CCDS:CCDS36941.1"
/db_xref="GeneID:29820"
/db_xref="MGI:MGI:1352474"
/translation="
MALKVLPLHRTVLFAAILFLLHLACKVSCETGDCRQQEFKDRSGNCVLCKQCGPGMELSKECGFGYGEDAQCVPCRPHRFKEDWGFQKCKPCADCALVNRFQRANCSHTSDAVCGDCLPGFYRKTKLVGFQDMECVPCGDPPPPYEPHCTSKVNLVKISSTVSSPRDTALAAVICSALATVLLALLILCVIYCKRQFMEKKPSWSLRSQDIQYNGSELSCFDQPRLRHCAHRACCQYHRDSAPMYGPVHLIPSLCCEEARSSARAVLGCGLRSPTTLQERNPASVGDTMPAFFGSVSRSICAEFSDAWPLMQNPLGGDSSLCDSYPELTGEDTNSLNPENESAASLDSSGGQDLAGTAALESSGNVSESTDSPRHGDTGTVWEQTLAQDAQRTPSQGGWEDRENLNLAMPTAFQDA"
sig_peptide 766..852
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="COORDINATES: ab initio prediction:SignalP:6.0"
mat_peptide 853..2013
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/product="Tumor necrosis factor receptor superfamily
member 19. /id=PRO_0000034598"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2)"
misc_feature 862..1212
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="Tumor necrosis factor receptor superfamily member
19 (TNFRSF19), also known as TROY; Region: TNFRSF19;
cd13418"
/db_xref="CDD:276923"
misc_feature 862..981
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2);
Region: TNFR-Cys 1"
misc_feature 865..981
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="CRD1 [structural motif]; Region: CRD1"
/db_xref="CDD:276923"
misc_feature 985..1107
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2);
Region: TNFR-Cys 2"
misc_feature 988..1107
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="CRD2 [structural motif]; Region: CRD2"
/db_xref="CDD:276923"
misc_feature 1078..1080
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="N-linked (GlcNAc...) asparagine.
/evidence=ECO:0000255; propagated from
UniProtKB/Swiss-Prot (Q9JLL3.2); glycosylation site"
misc_feature 1111..1212
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2);
Region: TNFR-Cys 3, truncated"
misc_feature 1114..1212
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="CRD3 [structural motif]; Region: CRD3"
/db_xref="CDD:276923"
misc_feature 1276..1338
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2);
transmembrane region"
misc_feature 1726..2013
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="propagated from UniProtKB/Swiss-Prot (Q9JLL3.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 835..945
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 946..1124
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 1125..1210
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 1211..1375
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 1376..1501
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 1502..1604
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 1605..2007
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
exon 2008..4639
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/inference="alignment:Splign:2.1.0"
regulatory 4599..4604
/regulatory_class="polyA_signal_sequence"
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="hexamer: AATAAA"
polyA_site 4624
/gene="Tnfrsf19"
/gene_synonym="TAJ; TAJ-ALPHA; TRADE; Troy"
/note="major polyA site"
ORIGIN
cggagaaacggcctaattaaacactgctgtgccgctctgctgcgtttcggactaccctgctctggtagggacttcgtgctttttgtcacaggcagcggcttgatgctgtctactggaacctgcaacgatccaggaccttacaggcccggagcacagaggcccagagcagtcctggtgtgtccctcccagccaagagacacactgcagggctgtcgcgggcgaggcacagaccaacgcgactagaaatcaggctgactggcttctcccggccagccccacggcacggcatgatgtcatgggagctgccactcagcgagatgaaagggatgcggcgcagcagcgctggcactaggcagcccagctggggcaccgcgagagagagctgcagatccagccgctcagcccaggctggggaagcctgctctccagagctggggcagaacaacgtggcccacgtttaacaaaagaaccagacggtagcgaactttctagatctgcgcgcgtagcgagtaaactcagccttgcctttgatgcgcagcaactgatcggcgatcagattacaggcactccatctcctagttcgcctgcctttgatctgcgcgggtaatccattttcctggatttgaagtttgtctgggcttgcgcccacacacatttttgggaaggtaaaagcgtttggcgcggaagtgctaccaagctgcggaaagcgtgagtctggagcacagcactggcgagtagcaggaataaacacgtttggtgagagccatggcactcaaggtcctacctctacacaggacggtgctcttcgctgccattctcttcctactccacctggcatgtaaagtgagttgcgaaaccggagattgcaggcagcaggaattcaaggatcgatctggaaactgtgtcctctgcaaacagtgcggacctggcatggagttgtccaaggaatgtggcttcggctatggggaggatgcacagtgtgtgccctgcaggccgcaccggttcaaggaagactggggtttccagaagtgtaagccatgtgcggactgtgcgctggtgaaccgctttcagagggccaactgctcacacaccagtgatgctgtctgcggggactgcctgccaggattttaccggaagaccaaactggttggttttcaagacatggagtgtgtgccctgcggagacccacctcctccctacgaaccacactgtaccagcaaggtgaaccttgtgaagatctcctccaccgtctccagccctcgggacacggcgctggctgccgtcatctgcagtgctctggccacggtgctgctcgccctgctcatcctgtgtgtcatctactgcaagaggcagttcatggagaagaaacccagctggtctctgcggtcacaggacattcagtacaatggctctgagctgtcatgctttgaccagcctcggctccgccactgtgcccatagagcatgctgtcagtatcaccgggactcagccccaatgtatgggcctgttcacctgattccgtccttgtgctgtgaagaggcccgcagctctgcccgagctgtgcttggctgtgggctgcgttctcccactaccctccaggagagaaacccggcttctgtgggggacacgatgccagccttcttcgggtctgtttcccgttccatctgcgctgaattttctgatgcctggcctctgatgcagaatcctctgggtggtgacagctctctctgtgactcttatcctgaactcactggagaagataccaattccctcaatcccgaaaacgaaagcgcagcatctctggattccagtggcggccaggatctggctgggacagctgctctagagtcttctgggaatgtttcagaatctactgactcacctagacatggtgacactggtacagtctgggagcagacgctagctcaggatgctcaaaggactccaagccaaggaggctgggaagacagggaaaacctgaatctagccatgcccacagccttccaggatgcctgaaggccatcttcctgacgtggaggtgtgggtctggacaagcctgtgatgaggcctacagactgagcagtcttggtgtctggaagcaaaaataaatctgaaccaaactgacaacatttccatcctttcagccactagcttctgagccagaccagctgtaagctgaaaccccagcaagaagcaaggagagactgactgtaggcggccttgggacatgtgcttcttccctaagcgagaaccttagctggggccaatttgaaggacccatgggtggaatgtgctgcctgtgagcttgtgggcacagcaggacccagcctggctccttcttatgtccacggtgaatgtggtttcacaagacccagagtataaactttcatagacattctcttttagaaataatccattaccctgtgaaaaagccttagcagattcctttcttagattttaggcagagctctggcggtttctgttgaagaaaggcactttctaatcagcagaatgctatacttcagtggtttaaaggggcttcgtagccctgcctgagtcgtagtttggtgaagtcgactggcctatctgttatgagcagttctggcctcttccccacgaaggtacaacagcactggcaggagaggaggcctgagttattgaaagtggcggtgaatgtggttaagaatttagcaggttggggggagggaagatagaaaaggagagggcaatgctttaaagttaaaaccacctactatgcatatcctgaagcctggctgtgaatgttaggactggtgactgtggatgcgtgtgttagtattgctctgtgctgaacttccaaggcccagatttcttatataaaaaggagacatttatgagtctagtaatctgtgatcgacacccgagcttgtacaaaaggcttcagcacaccaagctcacttctggagaatccttcagtgagaacacaatgctcattagacccggacatggaagagcatggttgacccagtttgggagaatagaatgcctgtgccaactagtctaaccaaggctttgtaatacggcattctgatataggggtgctgtgtaaggtatcccctcttcttccgtgacagcatttaccttccagaacaatctctaaggctaaagaaaacctggggctcattttctcttcatccttcgccctatggcttcactgagcagaatgtctttgttttccagtttgaagtgacttgagcagatccgacctcagtctttcaaccctctgctagtgctctgttccactcgaactttaaaaggagcccgatctgtgagcatcagtgtgagaggattcaccagcatatttgttctgaggctgccctggttaaatcaggctcttaccgaacactgaaaccaaacatcaagatgctaccttcctagactttttaaaatcttctgtttacccacagtgttttctcattataagacatgagtagatttaatgagccctcttcctgtagcttctctccattcctaattatagctttttgatgtgtgtcttctggcttggccatatctattgcttctcatgccgtctgttcctttaccagatgtaggaagaacactgccatacagcatcccgtggtagcccacatctgcttttatgtccccatggtgcccagtcataacctattggcatttttgtttgtatgtccccaaccgttattatgagaactgactttagggaagtcgtaaagtatttaggatgtaagcaacaggcatccatgaggatgcaagctgagctcccctgagtggcctcctcctcgtgcacatgtgtgtgtcattgcttgcaacccaatcatctctgttatgacagggatgatcaaagccagcagggttgtgttcctttgtgtaacctgaagatattttccacatgccgagccctgatggacttcaaagacagacacagctggggaaagtcaatctgatggaagggagactctagcccccaaatcctgaaacatcacttttaatcagaagagaaatcctgggggttaaaaattgatttcatttgatactgcatttggacgatcctggattatcatcaaaaaggagacatcctcccaccagacactctagaaacatgtaatggtgttttacagttcacattctttggaaacaagagggaaaatctacaacctgcacttcacattattggaacatcttaaaaggctgtttacataggagctggcattctgatatcagacactggtatagagaggcatctaggcatagggggcaccagtgccacctttcctgtggcagaagccaggacaagatggaggagacaaggacttttgaatcagtcaggtcaagtcatgtgttttcgattttgaatatatggaatatattttgaatcgcaggattttctactctaaagagtgctgctgtctgtgttagaagaaaaagaacagaaaaggaaagagacacaatcatggctcttaagagagtttgtttcagcttagattttatcacaactgttttacatactgaatttattattaatagtatgttatcgctttccaatacaaacctttttttagtgctttttaaaaattgtgaataaaattgatacttgttattcttagttatgtgtcaagtc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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