ver.2
Home
|
Help
|
Advanced search
Previous release (v1)
2025-04-20 02:45:58, GGRNA.v2 : RefSeq release 229 (Mar, 2025)
LOCUS NM_001407215 4279 bp mRNA linear ROD 28-MAY-2024
DEFINITION Mus musculus protein-L-isoaspartate (D-aspartate)
O-methyltransferase 1 (Pcmt1), transcript variant 31, mRNA.
ACCESSION NM_001407215
VERSION NM_001407215.1
KEYWORDS RefSeq.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (bases 1 to 4279)
AUTHORS Ling,Z., Zhou,S., Zhou,Y., Zhong,W., Su,Z. and Qin,Z.
TITLE Protective role of madecassoside from Centella asiatica against
protein L-isoaspartyl methyltransferase deficiency-induced
neurodegeneration
JOURNAL Neuropharmacology 246, 109834 (2024)
PUBMED 38181970
REFERENCE 2 (bases 1 to 4279)
AUTHORS Kalailingam,P., Mohd-Kahliab,K.H., Ngan,S.C., Iyappan,R.,
Melekh,E., Lu,T., Zien,G.W., Sharma,B., Guo,T., MacNeil,A.J.,
MacPherson,R.E., Tsiani,E.L., O'Leary,D.D., Lim,K.L., Su,I.H.,
Gao,Y.G., Richards,A.M., Kalaria,R.N., Chen,C.P., McCarthy,N.E. and
Sze,S.K.
TITLE Immunotherapy targeting isoDGR-protein damage extends lifespan in a
mouse model of protein deamidation
JOURNAL EMBO Mol Med 15 (12), e18526 (2023)
PUBMED 37971164
REFERENCE 3 (bases 1 to 4279)
AUTHORS Zhang,C., Guo,Z.F., Liu,W., Kazama,K., Hu,L., Sun,X., Wang,L.,
Lee,H., Lu,L., Yang,X.F., Summer,R. and Sun,J.
TITLE PIMT is a novel and potent suppressor of endothelial activation
JOURNAL Elife 12, e85754 (2023)
PUBMED 37070640
REMARK GeneRIF: PIMT is a novel and potent suppressor of endothelial
activation.
Publication Status: Online-Only
REFERENCE 4 (bases 1 to 4279)
AUTHORS Qin,Z., Dimitrijevic,A. and Aswad,D.W.
TITLE Accelerated protein damage in brains of PIMT+/- mice; a possible
model for the variability of cognitive decline in human aging
JOURNAL Neurobiol Aging 36 (2), 1029-1036 (2015)
PUBMED 25465735
REMARK GeneRIF: PIMT levels may significantly influence the course of
age-related central nervous system dysfunction.
REFERENCE 5 (bases 1 to 4279)
AUTHORS Dimitrijevic,A., Qin,Z. and Aswad,D.W.
TITLE Isoaspartyl formation in creatine kinase B is associated with loss
of enzymatic activity; implications for the linkage of isoaspartate
accumulation and neurological dysfunction in the PIMT knockout
mouse
JOURNAL PLoS One 9 (6), e100622 (2014)
PUBMED 24955845
REMARK GeneRIF: Loss of normal CKB structure and function contributes to
the mechanisms by which isoaspartate accumulation leads to central
nervous system dysfunction in the PIMT-Knockout mouse.
Erratum:[PLoS One. 2014;9(12):e116556]
Publication Status: Online-Only
REFERENCE 6 (bases 1 to 4279)
AUTHORS MacLaren,D.C. and Clarke,S.
TITLE Rapid mapping of genomic P1 clones: the mouse
L-isoaspartyl/D-aspartyl methyltransferase gene
JOURNAL Genomics 35 (2), 299-307 (1996)
PUBMED 8661142
REFERENCE 7 (bases 1 to 4279)
AUTHORS Galus,A., Lagos,A., Romanik,E.A. and O'Connor,C.M.
TITLE Structural analysis of transcripts for the protein L-isoaspartyl
methyltransferase reveals multiple transcription initiation sites
and a distinct pattern of expression in mouse testis:
identification of a 5'-flanking sequence with promoter activity
JOURNAL Arch Biochem Biophys 312 (2), 524-533 (1994)
PUBMED 8037467
REFERENCE 8 (bases 1 to 4279)
AUTHORS Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
TITLE Linkage mapping of 40 randomly isolated liver cDNA clones in the
mouse
JOURNAL Genomics 18 (2), 295-307 (1993)
PUBMED 8288233
REFERENCE 9 (bases 1 to 4279)
AUTHORS MacLaren,D.C., O'Connor,C.M., Xia,Y.R., Mehrabian,M., Klisak,I.,
Sparkes,R.S., Clarke,S. and Lusis,A.J.
TITLE The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1)
maps to human chromosome 6q22.3-6q24 and the syntenic region of
mouse chromosome 10
JOURNAL Genomics 14 (4), 852-856 (1992)
PUBMED 1478665
REFERENCE 10 (bases 1 to 4279)
AUTHORS Romanik,E.A., Ladino,C.A., Killoy,L.C., D'Ardenne,S.C. and
O'Connor,C.M.
TITLE Genomic organization and tissue expression of the murine gene
encoding the protein beta-aspartate methyltransferase
JOURNAL Gene 118 (2), 217-222 (1992)
PUBMED 1511895
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
AC156391.6.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR14995048.2119050.1,
SRR17253011.1196778.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN01164135, SAMN01164139
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
##RefSeq-Attributes-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-522 AC156391.6 112794-113315
523-627 AC156391.6 127235-127339
628-659 AC156391.6 128769-128800
660-764 AC156391.6 131961-132065
765-885 AC156391.6 135575-135695
886-971 AC156391.6 136260-136345
972-1147 AC156391.6 138165-138340
1148-4279 AC156391.6 145414-148545
FEATURES Location/Qualifiers
source 1..4279
/organism="Mus musculus"
/mol_type="mRNA"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="10"
/map="10 2.26 cM"
gene 1..4279
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="protein-L-isoaspartate (D-aspartate)
O-methyltransferase 1"
/db_xref="GeneID:18537"
/db_xref="MGI:MGI:97502"
exon 1..522
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
misc_feature 141..143
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="upstream in-frame stop codon"
misc_feature 294..296
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="upstream_AUG_codon; putative N-terminal extension:
MPGARIGGSGSDGSNSGRSSGDTSGAVTVWEVVSLLGKLLGTVAALKVVLYLLRVCFA
"
CDS 468..1160
/gene="Pcmt1"
/gene_synonym="PIMT"
/EC_number="2.1.1.77"
/note="isoform 11 is encoded by transcript variant 31;
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
protein-beta-aspartate methyltransferase; L-isoaspartyl
protein carboxyl methyltransferase; protein
L-isoaspartyl/D-aspartyl methyltransferase"
/codon_start=1
/product="protein-L-isoaspartate(D-aspartate)
O-methyltransferase isoform 11"
/protein_id="NP_001394144.1"
/db_xref="GeneID:18537"
/db_xref="MGI:MGI:97502"
/translation="
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKSNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGNSGKVIGIDHIKELVDDSITNVKKDDPMLLSSGRVRLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSVKMKPLMGVIYVPLTDKEKQWSRWKDEL"
mat_peptide 471..1148
/gene="Pcmt1"
/gene_synonym="PIMT"
/product="Protein-L-isoaspartate(D-aspartate)
O-methyltransferase. /id=PRO_0000111876"
/note="propagated from UniProtKB/Swiss-Prot (P23506.3)"
misc_feature 471..473
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="N-acetylalanine.
/evidence=ECO:0000250|UniProtKB:P22061; propagated from
UniProtKB/Swiss-Prot (P23506.3); acetylation site"
misc_feature 489..1115
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="Protein-L-isoaspartate(D-aspartate)
O-methyltransferase (PCMT); Region: PCMT; pfam01135"
/db_xref="CDD:395902"
exon 523..627
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 628..659
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 660..764
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 765..885
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 886..971
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 972..1147
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
exon 1148..4279
/gene="Pcmt1"
/gene_synonym="PIMT"
/inference="alignment:Splign:2.1.0"
regulatory 1414..1419
/regulatory_class="polyA_signal_sequence"
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="hexamer: AAGAAA"
polyA_site 1439
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="major polyA site"
regulatory 2727..2732
/regulatory_class="polyA_signal_sequence"
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="hexamer: AATAAA"
polyA_site 2744
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="major polyA site"
regulatory 4257..4262
/regulatory_class="polyA_signal_sequence"
/gene="Pcmt1"
/gene_synonym="PIMT"
/note="hexamer: AATAAA"
polyA_site 4279
/gene="Pcmt1"
/gene_synonym="PIMT"
ORIGIN
gcggagcccaagaaggcggcacacgtcggacccgccatcccgcatcagccagagccgcggctaggaaggagcctcatcacgcagaacaccagctcgccggccgcaggacggaggcaggtgcaggcctcaggaaggggaactgagcagcgttcgtttgtgcgacctcgctgcggccaccgagcactggttatcgcccccgctcgctactgggctccaggactcccccgccgcgggccccgcctggccgcaccccggactgcgcggcgtcacagagcgcatgcgtgccgcgggggatgccgggagcgcgcattggcggcagtggcagcgacggcagtaacagcggccgctcgagcggggacaccagcggggcggtgaccgtgtgggaggtggtctcactcttggggaaactgctagggaccgtcgccgcgctgaaggtggttctgtacctgctccgggtgtgcttcgcgatggcctggaaatccggcggcgccagccactcggagctaatccacaacctccgcaagaatggaatcatcaagacagataaagtatttgaagtgatgctggctacagaccgttcccactatgcaaaatctaacccttacatggattctccacaatcaataggtttccaggcaacaatcagtgcccctcatatgcacgcatatgcactagaacttctgtttgaccagctgcatgaaggtgctaaagccctggacgtgggctctggaagtggaatcctcaccgcctgttttgcacggatggttggaaatagtggaaaagtcattggaattgatcacattaaagaactagtagatgactcaataactaatgtcaaaaaggatgacccaatgctcctgtcctcggggcgagtgcggctggtggtgggtgatggaagaatgggatacgctgaagaagccccttacgacgctattcatgtgggagctgcagccccagttgtgccccaggcattaatagaccagttaaagcctggtggaagattgatattgccagtcggtcctgcaggaggaaaccaaatgttggagcagtatgacaagctacaagatggcagtgtcaaaatgaaacctctcatgggggtgatatacgtgcctttaacagataaagaaaagcagtggtccaggtggaaggatgaactgtgaaagcaacgtgagcttgaccagtctataaaccgcagtgggccgctcctctcggtccttacagcatttgagaaccaacagcatcacagcttgttttggactttgttacactcttactttcagcatgaaaacgtgtggttttgtaggatttcctaattccaaacggcgcggagccaaactgatagaggaaggctgcagagcgttaactgcgtgtgttgttttaacatgcccacatttcactttaaaaaaatattaaaagaaagagttctccaactggaaaaattagttttgaagagtggctttgcttttcttgggcacttaattctgttccaatattaattcatcagatttattttgtgcatcagataacaccacattcacaagtttagcttctttggtagccaatgtctgttagatgctactaagaaaacagagatgagctttcttcttaaaagcctttgatgtggcgtcataggatagcatgtcgtagatacaatcagctgctgttaccttaaaactaggtgtttgtaaatactgaaacttgagacgacgatgatggcaggtggtgtcccaaaaacactcagctgttccgattggaaattttgatgtaaatttcctctctctaaaaatgctaggaggcttgtagctcaatatcatttatttgtttctagtttgctgctggtaatgtatctgcatctaacattctgtgtaagcggtcgtgtctttgcacagtttatgcagcgctgctttgccaaataaaattaaaagcaaaagaagcattggtggcctttgaatctagaaggacacaggtctgctaggtccagatgctgcccacagtcctggggaagcgtcgtagtcttatgatattctaggaggtagatatgcatagcattcgtccactctatgtggctgcatttcttcaggatggagactctgtgttcattgtttctctctgccttcctagcccaaggcttgctttttaatagctctgtagtaaatgctcaatgagtgactgggtgaatgtagtatgaggaagaatgtggttgagagtaaacatactgaaatccatgtctcatctataaatagattcattaatttaataactgtaaaatgtctgtgaaggcaatggcactttgaagatcttatttaaatatggttttatattttctaataagactttagttttttgtgaagatcctagaacttgagagaagattagaagctcccggtaaatggggctaagcaaagcgaagccttccctctatgtgtaagggcacatgattctgacaagaagactcttagtgtctgagaagcccatccccactcttcacatcttaaattactgatttaaaagtcatgcagacatcacctgacaagtgtctcttcttggcttaggtctcagtcccaggaaactagcattactgtggtcccgcagacttgaaaaccttaaccagctttggtttgctgctggttgttgctttggaatcctgtcagtgaccccctggagtccaggatgcatggtcatttgaaatatgtgtaaagtcaaatgttcactcaggctttaaagcaaataaattcttaaacttacccaccagtctggatccttggtagtcattgcacattacagcacgcaaatctctgtgctgggcttcaggacggaagaggtgcttccaggtcagtttgccgtccagtggcggggacagtttataaataggcaccatacacttcacccagtttgtacagaaactctgtgcccaagccttgctcttagacttgacacttttaggaggtgaaactttaggatgttgaatgaacagccagtttgaacagcagcactaagtgggtagagatagaagaatggtgttaatgaggtctaagccctttaaaagagttgaatttatatatgtgtttaagacaggtaagaaatgcctgattttcagtgtgcataatttccagagcattttattttcctcatagaaagtacatctgaatacacataatgtaaagggcaatgaagatacttcgagtcattataggtagtgtgatcttgtgaataaactcttcctataaatttgctcttcctagaagctaaatctagttgtcagacttgggttgcagcaataagcttatgtcagggttgagtttctcttcagggctgcttgctctttcccagccaggaacaggacaaatcggcacccagggaaataactactactggccacaccaatacttaggacttcatcccccttgcagctgccatgttttattgtttgtttgtttatttgtggcaggtgggggtggatagcaagatggctcggggtaaagaggcttgctgccaaacctgaagacctgagtttcacccctcccccctcccagacccacagagtagaaggacagctgacacctgcagattgttctctgaccttcaggcatggtagcacttgcctgaaatcccagcacttggaagcaggaagggtcagaagtcatcctaggttacacaagttcaaggccagcccgaatttcatgagagcctgccttaaaggaaagaaaaaaccaaaaagtttctacagtgcatctcttcactaaagcatcgtaagcattgagtggattctaaaggagccatttttaaagtaataactttgtaaactcttcaagctgttcttgaaggaattcctcagagtgtttaaggccttttatctctctagagttttctaatttctggtagtttagtgtggcatcaaagaaagtcatgacagtgttgtcacccagcactgatagacaaatagtaagcatgagtcatcttataaattgttgtagaactcaaccggctgataacttattttaggtaagcacttaaactcttgtagcatacagatcatttcttatcgaatgctgtgttcctgatgccctaatatcttaatgtattctgtagtggagatgggccctgactggactttggttgcatctctgagcttccaccatctttcagaaagatggtagtattttgcccttagcattgttaaaggttctcactcagtaaggggacccacttgaaaagggtactggcccaaggaagcctgggactgtgcactggaatataataaagtggaaatgaagtctaa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]