LOCUS       NM_001346962            3968 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus neurexin I (Nrxn1), transcript variant 8, mRNA.
ACCESSION   NM_001346962 XM_017317317
VERSION     NM_001346962.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3968)
  AUTHORS   Brockhaus,J., Kahl,I., Ahmad,M., Repetto,D., Reissner,C. and
            Missler,M.
  TITLE     Conditional Knockout of Neurexins Alters the Contribution of
            Calcium Channel Subtypes to Presynaptic Ca2+ Influx
  JOURNAL   Cells 13 (11), 981 (2024)
   PUBMED   38891114
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3968)
  AUTHORS   Chofflet,N., Naito,Y., Pastore,A.J., Padmanabhan,N., Nguyen,P.T.,
            Poitras,C., Feller,B., Yi,N., Van Prooijen,J., Khaled,H.,
            Coulombe,B., Clapcote,S.J., Bourgault,S., Siddiqui,T.J., Rudenko,G.
            and Takahashi,H.
  TITLE     Structural and functional characterization of the
            IgSF21-neurexin2alpha complex and its related signaling pathways in
            the regulation of inhibitory synapse organization
  JOURNAL   Front Mol Neurosci 17, 1371145 (2024)
   PUBMED   38571813
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3968)
  AUTHORS   Kolesova,H., Hrabalova,P., Bohuslavova,R., Abaffy,P.,
            Fabriciova,V., Sedmera,D. and Pavlinkova,G.
  TITLE     Reprogramming of the developing heart by Hif1a-deficient
            sympathetic system and maternal diabetes exposure
  JOURNAL   Front Endocrinol (Lausanne) 15, 1344074 (2024)
   PUBMED   38505753
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3968)
  AUTHORS   Yan,Q., Weyn-Vanhentenryck,S.M., Wu,J., Sloan,S.A., Zhang,Y.,
            Chen,K., Wu,J.Q., Barres,B.A. and Zhang,C.
  TITLE     Systematic discovery of regulated and conserved alternative exons
            in the mammalian brain reveals NMD modulating chromatin regulators
  JOURNAL   Proc Natl Acad Sci U S A 112 (11), 3445-3450 (2015)
   PUBMED   25737549
REFERENCE   5  (bases 1 to 3968)
  AUTHORS   Iijima,T., Wu,K., Witte,H., Hanno-Iijima,Y., Glatter,T., Richard,S.
            and Scheiffele,P.
  TITLE     SAM68 regulates neuronal activity-dependent alternative splicing of
            neurexin-1
  JOURNAL   Cell 147 (7), 1601-1614 (2011)
   PUBMED   22196734
  REMARK    GeneRIF: Findings uncover SAM68 as a key regulator of dynamic
            control of Nrxn1 molecular diversity and activity-dependent
            alternative splicing in the central nervous system.
REFERENCE   6  (bases 1 to 3968)
  AUTHORS   Tabuchi,K. and Sudhof,T.C.
  TITLE     Structure and evolution of neurexin genes: insight into the
            mechanism of alternative splicing
  JOURNAL   Genomics 79 (6), 849-859 (2002)
   PUBMED   12036300
REFERENCE   7  (bases 1 to 3968)
  AUTHORS   Geppert,M., Khvotchev,M., Krasnoperov,V., Goda,Y., Missler,M.,
            Hammer,R.E., Ichtchenko,K., Petrenko,A.G. and Sudhof,T.C.
  TITLE     Neurexin I alpha is a major alpha-latrotoxin receptor that
            cooperates in alpha-latrotoxin action
  JOURNAL   J Biol Chem 273 (3), 1705-1710 (1998)
   PUBMED   9430716
REFERENCE   8  (bases 1 to 3968)
  AUTHORS   Missler,M. and Sudhof,T.C.
  TITLE     Neurexins: three genes and 1001 products
  JOURNAL   Trends Genet 14 (1), 20-26 (1998)
   PUBMED   9448462
  REMARK    Review article
REFERENCE   9  (bases 1 to 3968)
  AUTHORS   Andres,C., Beeri,R., Friedman,A., Lev-Lehman,E., Henis,S.,
            Timberg,R., Shani,M. and Soreq,H.
  TITLE     Acetylcholinesterase-transgenic mice display embryonic modulations
            in spinal cord choline acetyltransferase and neurexin Ibeta gene
            expression followed by late-onset neuromotor deterioration
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 8173-8178 (1997)
   PUBMED   9223334
REFERENCE   10 (bases 1 to 3968)
  AUTHORS   Puschel,A.W. and Betz,H.
  TITLE     Neurexins are differentially expressed in the embryonic nervous
            system of mice
  JOURNAL   J Neurosci 15 (4), 2849-2856 (1995)
   PUBMED   7722633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CT486002.9.
            
            On Mar 29, 2022 this sequence version replaced NM_001346962.1.
            
            Summary: This gene encodes a single-pass type I membrane protein
            that belongs to the neurexin family. Neurexins are synaptic
            transmembrane receptors that bind endogenous ligands that include
            neuroligins, dystroglycan, and neurexophilins. Neurexin complexes
            are required for efficient neurotransmission and are involved in
            synaptogenesis. In vertebrates, alternate promoter usage results in
            multiple isoform classes, of which the alpha and beta classes are
            the best characterized. In humans, allelic variants in this gene
            are associated with Pitt-Hopkins-like syndrome-2, while deletions
            have been associated with autism and schizophrenia. Mouse knockouts
            display decreased spontaneous and evoked vesicle release resulting
            in impaired synaptic transmission. In addition, knockout mice show
            altered social approach, reduced social investigation, reduced
            locomotor activity, and in males, increased aggression. Alternative
            splicing and promoter usage result in multiple transcript variants.
            [provided by RefSeq, Nov 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219379.35692.1,
                                           ERR3363660.228900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               CT486002.9         62501-62648
            149-227             CT486002.9         91250-91328
            228-3968            CT486002.9         113429-117169
FEATURES             Location/Qualifiers
     source          1..3968
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 59.73 cM"
     gene            1..3968
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="neurexin I"
                     /db_xref="GeneID:18189"
                     /db_xref="MGI:MGI:1096391"
     exon            1..148
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..535
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="isoform 8 is encoded by transcript variant 8;
                     alpha-latrotoxin receptor (calcium-dependent); neurexin-1;
                     neurexin 1 NRXN1+7a; neurexin 1 NRXN1-7"
                     /codon_start=1
                     /product="neurexin-1 isoform 8"
                     /protein_id="NP_001333891.1"
                     /db_xref="CCDS:CCDS84339.1"
                     /db_xref="GeneID:18189"
                     /db_xref="MGI:MGI:1096391"
                     /translation="

MDMRWHCENSQTTDDILVASAECPSDDEDIDPCEPSSANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV"

     misc_feature    305..>412
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="Syndecan domain; Region: Syndecan; pfam01034"
                     /db_xref="CDD:460035"
     misc_feature    365..421
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="putative band 4.1 homologues' binding motif;
                     Region: 4.1m; smart00294"
                     /db_xref="CDD:128590"
     exon            149..227
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /inference="alignment:Splign:2.1.0"
     exon            228..3968
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3639..3644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="hexamer: AATAAA"
     polyA_site      3660
                     /gene="Nrxn1"
                     /gene_synonym="1700062G21Rik; 9330127H16Rik;
                     A230068P09Rik; mKIAA0578"
                     /note="major polyA site"
ORIGIN      

gagtcagggagctctcctgtcaccagtattgatttcagaggatggactaaatttcctaggatttccattaagaattaagaaaaaagctctaagcacgcagggtagccagacagacatggatatgagatggcactgtgaaaactcgcagaccacagatgacatccttgtggcctcggcagagtgtcccagtgacgatgaggacattgacccctgtgagccgagctcagccaaccccaccagagtaggtggccgtgaaccatacccaggctctgcagaggtgattcgggagtccagcagtaccactggcatggtggtggggattgtcgcagcagccgctctgtgcatcctcatcctcctctatgccatgtacaagtacaggaaccgggatgaagggtcgtaccacgtggatgagagtcgaaactacatcagtaactcagcacagtccaatggggctgtggtcaaggagaagcaacccagcagtgctaaaagcgccaacaaaaacaagaaaaacaaggataaggagtattacgtctgatatcaagatttgaaacggacacttgtatagaaatagtcttcattttatctgagacataatataaacttttactttcctttttatgaagcacatacaaaagaagacagggaatgcgatcaggagggaaaactctttttaaaaaaaaaaacaaacaagtatctcatgctcttgtttctcaaaagaaaaaaaaaacatacacaaaaaaaaaaaagaaagaaagagagaagaaaggaaggaaaaaatactaaaacaaaaacaggggccaataaaattccctaacatccgcagtgttttcatttactctgcttgtctttatgttgctgggacgttctaaaagacggtgaggaccgcacgcattcataaagcaaaggagtattacatcgaggcacaacacaaaaccaacacaaaacacaacacacacaaagaagctacctatgatcctggattcagccaaagtgctagcgctttcctgaggagccagtcagtgggcgtgccagagaagaagtcttcttatgggaccatctgcagattatgaggagttggtcagctggcacaactggagcaggggttggaacttgcatttgagacaaagtgctggctttttttttctttttttcttttcttttctttttcttttttttgaagactaatgcaggaaagcgtttttaaaaagcccctttctgtttgtgagagagtaacaattaaaaaaaatattatggaggccttatttttcaaaatgtgaaatataaggcacatgttcacactaaaattacaaaacaaaaatgagagggcatagatgcaatcattgggaaattttcatgcacgcttactatgttattacatatgtttatataaacccatctctgtgtgctttctggactgtgataagtgacgttttatagcctgttgtatagaaaatgcaaaatatatctctgctcttcagccatttttggtaaattcaatgttataagtgttgctaagtatagggagttttatgacatcggagcaacaattatttcagacagatttttttgccgacattataaattgccacaattacttacttttttaaactaaaattacagtgtagtgtttattctaagaaagatatgtatgaatgtatataaaaagactcagctacttcttttcttacatatatagccttcattctgttgcattattaagttttagtaattgtatgaaaggtgtgaattagaaggtgaaatatatacctaagtatcagataaaactttctctttcccaaatactcatatgtctatatgtgtttaacattcacacacatacacacacacacacacacacacacacacacacacaaatacacatacacaggcagccatcagatatgatggaataccaaaacacacaaatactgacaaattgaaaatgtgaagttagacagttgtgccaaggtattataacaaatcggtgatttgcttcattgagattctgattccaggagaccttgaattcttagtccctagtaaaatggaacgtttattttaaacgaaagagatccatcaccatacatggctgcataaatatgcatcactcaacaggcattacataaataatgttggtttactctggctgctgcaatggaaaacatttttcccataaatttatagatattctctgaacatggtgtgtgtgatcaagctttatggaaagtaagcattttctcaactaaaaaagtattctcagtaatttttgattctgtattactacccactaaaatcattctctatttgttgactattgacttaattttaacttttctggttttacatctatatacttaaacatagttttagtttaacacacactgtgtagtagtgaagtataggttactcacttgttttgcataatgtttgaatgatgttcatagcaataaattatcaaggtgagaaaataatttttaggttgcagggtgatgcctctgtaaaaattgatcacatgacataaacatctaaaagaataattcttggtttcataaaagagaaagatatcactaatctgctttaatcaacaaggcaaaaaaatgcaaaacatcttttgtgataatttagttgatgaaaaacatgccgagatgtggcctggatttcagacacaacactaccttagaaatacatagatatcatagcaaatcactatgaggtacagctgccaagaaattgtgtaataagtcttaaaggcttttcatcacccaaaaaatagatggcacgaagttaaaattcagtacccatttcttctctttcaagtcttcatatatatttaatttgccaggttaaaagatcttacaagtctttttacctacccctctcattcagtcttactcaggaaaagccagagaaataaaaaggaacataaaaccaccaatttacatatctatattgatatagatagaaatatatattccattgtatctatttaacataaactagtttcatctgaacagattataaaagatggtggaaaactaaattgaattgttactttttaaatggtatatctgggaggcttgttgtttaaaattgatttcagtgtttcttcccagcaagaaatttaaaatctcattcattgataaaaactgataatgctggtaaaaaatatgtatctaattttactgacctacacaaaacttagcaggattccccccccaacccccccccccccgaatgtagaaggcaaagagaggatgctgatgttttgaaggaaaaagacttgaatccaacccaagtatctttatactaaacatatcaggttccgtgtgtcacttgcagctcacagaagttttcacactacctggcataaactgactacatcgattgtaacatttttgtttgagtatgcttctttttttatccatgtaatgtgttgcctttaaaaacaaaaatgatgactaaaataatgtgtgaggtggttcatccctaagaagtcaacggaaggtcacttcaatcgtacccttctagtgcttctaatgactgaatatctaaggggtttgttttgttttgtttttctgttgcaaggccaatttatccattattggaaatgctaaacaagtggaatttactgttttgttaataaaatatttcttaatacaactgtggtttgttgactttaaaaattgcacatgacagcaatttgccactgaatataacaatgaagaagaatgcatttgaaaggagatcttatccccagacacacacaggaaaagatgctgtcacacccctttcagcattttactacttaatcagtccctctgcttgtacacttaagatgcaggcactccatgtagctttcatggaaaattacagaactagcagagaataatacgaatatatgctgatgtcataaatacactctctgtaagttacaatgggattaaagttaaatacacctgtaattaact

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