LOCUS       NM_001165925            1283 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus claudin 14 (Cldn14), transcript variant 2, mRNA.
ACCESSION   NM_001165925
VERSION     NM_001165925.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Higashi,A.Y., Higashi,T., Furuse,K., Ozeki,K., Furuse,M. and
            Chiba,H.
  TITLE     Claudin-9 constitutes tight junctions of folliculo-stellate cells
            in the anterior pituitary gland
  JOURNAL   Sci Rep 11 (1), 21642 (2021)
   PUBMED   34737342
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Krohs,C., Korber,C., Ebbers,L., Altaf,F., Hollje,G., Hoppe,S.,
            Dorflinger,Y., Prosser,H.M. and Nothwang,H.G.
  TITLE     Loss of miR-183/96 Alters Synaptic Strength via Presynaptic and
            Postsynaptic Mechanisms at a Central Synapse
  JOURNAL   J Neurosci 41 (32), 6796-6811 (2021)
   PUBMED   34193555
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Frische,S., Alexander,R.T., Ferreira,P., Tan,R.S.G., Wang,W.,
            Svenningsen,P., Skjodt,K. and Dimke,H.
  TITLE     Localization and regulation of claudin-14 in experimental models of
            hypercalcemia
  JOURNAL   Am J Physiol Renal Physiol 320 (1), F74-F86 (2021)
   PUBMED   33283646
  REMARK    GeneRIF: Localization and regulation of claudin-14 in experimental
            models of hypercalcemia.
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Claussen,M., Schulze,J. and Nothwang,H.G.
  TITLE     Loss of inner hair cell ribbon synapses and auditory nerve fiber
            regression in Cldn14 knockout mice
  JOURNAL   Hear Res 391, 107950 (2020)
   PUBMED   32251970
  REMARK    GeneRIF: Loss of inner hair cell ribbon synapses and auditory nerve
            fiber regression in Cldn14 knockout mice.
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Schluter,T., Berger,C., Rosengauer,E., Fieth,P., Krohs,C.,
            Ushakov,K., Steel,K.P., Avraham,K.B., Hartmann,A.K., Felmy,F. and
            Nothwang,H.G.
  TITLE     miR-96 is required for normal development of the auditory hindbrain
  JOURNAL   Hum Mol Genet 27 (5), 860-874 (2018)
   PUBMED   29325119
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Elkouby-Naor,L., Abassi,Z., Lagziel,A., Gow,A. and Ben-Yosef,T.
  TITLE     Double gene deletion reveals lack of cooperation between claudin 11
            and claudin 14 tight junction proteins
  JOURNAL   Cell Tissue Res 333 (3), 427-438 (2008)
   PUBMED   18663477
  REMARK    GeneRIF: We generated claudin 11/claudin 14 double-deficient mice,
            which exhibit deafness, neurological deficits, and male sterility.
            Kidney function and ion balance are not significantly affected.
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Krause,G., Winkler,L., Mueller,S.L., Haseloff,R.F., Piontek,J. and
            Blasig,I.E.
  TITLE     Structure and function of claudins
  JOURNAL   Biochim Biophys Acta 1778 (3), 631-645 (2008)
   PUBMED   18036336
  REMARK    Review article
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Nunes,F.D., Lopez,L.N., Lin,H.W., Davies,C., Azevedo,R.B., Gow,A.
            and Kachar,B.
  TITLE     Distinct subdomain organization and molecular composition of a
            tight junction with adherens junction features
  JOURNAL   J Cell Sci 119 (Pt 23), 4819-4827 (2006)
   PUBMED   17130295
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Ben-Yosef,T., Belyantseva,I.A., Saunders,T.L., Hughes,E.D.,
            Kawamoto,K., Van Itallie,C.M., Beyer,L.A., Halsey,K., Gardner,D.J.,
            Wilcox,E.R., Rasmussen,J., Anderson,J.M., Dolan,D.F., Forge,A.,
            Raphael,Y., Camper,S.A. and Friedman,T.B.
  TITLE     Claudin 14 knockout mice, a model for autosomal recessive deafness
            DFNB29, are deaf due to cochlear hair cell degeneration
  JOURNAL   Hum Mol Genet 12 (16), 2049-2061 (2003)
   PUBMED   12913076
  REMARK    GeneRIF: To explore the role of claudin 14 in the inner ear and in
            other tissues we created a mouse model by a targeted deletion of
            Cldn14.
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Wilcox,E.R., Burton,Q.L., Naz,S., Riazuddin,S., Smith,T.N.,
            Ploplis,B., Belyantseva,I., Ben-Yosef,T., Liburd,N.A., Morell,R.J.,
            Kachar,B., Wu,D.K., Griffith,A.J., Riazuddin,S. and Friedman,T.B.
  TITLE     Mutations in the gene encoding tight junction claudin-14 cause
            autosomal recessive deafness DFNB29
  JOURNAL   Cell 104 (1), 165-172 (2001)
   PUBMED   11163249
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC168220.1, BX522097.1 and
            AI851731.1.
            
            Summary: This gene encodes a member of the claudin family of tight
            junction proteins. The encoded protein is an integral membrane
            protein that may function in maintaining apical membrane
            polarization in tight junctions located between outer hair cells
            and supporting cells. Loss of function of this gene is associated
            with hearing problems. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF531828.1, AI043125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC168220.1         68586-68661
            77-548              BX522097.1         45-516
            549-832             AC168220.1         78405-78688
            833-1283            AI851731.1         1-451               c
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 54.99 cM"
     gene            1..1283
                     /gene="Cldn14"
                     /note="claudin 14"
                     /db_xref="GeneID:56173"
                     /db_xref="MGI:MGI:1860425"
     exon            1..259
                     /gene="Cldn14"
                     /inference="alignment:Splign:2.1.0"
     exon            260..1266
                     /gene="Cldn14"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    323..325
                     /gene="Cldn14"
                     /note="upstream in-frame stop codon"
     CDS             341..1060
                     /gene="Cldn14"
                     /codon_start=1
                     /product="claudin-14"
                     /protein_id="NP_001159397.1"
                     /db_xref="CCDS:CCDS28345.1"
                     /db_xref="GeneID:56173"
                     /db_xref="MGI:MGI:1860425"
                     /translation="

MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPRDLQAARALMVISCLLSGMACACAVVGMKCTRCAKGTPAKTTFAVLGGALFLLAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYPPQSRAGATTTATAPAYRPPAAYKDNRAPSVTSAAHSGYRLNDYV"

     misc_feature    362..424
                     /gene="Cldn14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S3.2);
                     transmembrane region"
     misc_feature    407..883
                     /gene="Cldn14"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
     misc_feature    584..646
                     /gene="Cldn14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S3.2);
                     transmembrane region"
     misc_feature    686..748
                     /gene="Cldn14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S3.2);
                     transmembrane region"
     misc_feature    827..889
                     /gene="Cldn14"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z0S3.2);
                     transmembrane region"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cldn14"
                     /note="hexamer: AATAAA"
     polyA_site      1266
                     /gene="Cldn14"
                     /note="major polyA site"
ORIGIN      

cttctaaccagagggcatgtgtgcccacgcaggcccgactcagagaccgtaattgaccagacaactctctctcaaacacactggccttagagcttccattcggcgaatgaggcaaagccagaagactgtggtgtccttgctgtgtctccgtggtctacctgagagcatcaaggtggatgggactggagctgttctgtatgtgagtggagtggctgcagccggcaggcatttatctccaaagctgggccctgcctgtcaggcttcctgcgggcacctaaggaccagatccatccctggggacctgggcactgctcagcgcggctagcaggggcccttagccatggccagcacagcggtccagctcctaggcttcctgcttagcttcctgggcatggtaggaacgctcatcaccaccatcctgccacactggcggaggacggcccatgtgggcaccaacatcctgactgccgtatcctacctgaagggactgtggatggaatgtgtgtggcacagcacaggcatctaccagtgtcagatctaccgctcactgctggcgctgccccgggacttgcaggccgcccgggcgctcatggtcatctcctgcctgttgtcgggcatggcctgcgcctgcgcagtagtgggcatgaagtgcacacgctgcgccaaaggcacacccgccaagaccacctttgcagtgctggggggcgcgctcttcctgctggccggcctgctgtgcatggtggccgtgtcctggaccacgaatgacgtggtgcagaatttttataacccgctgctgcccagtggcatgaagtttgaaatcggccaggccctgtacctgggcttcatctcctcatccctgtctctcatcgggggcaccctgctctgcttatcctgccaggacgaggccccctacagaccctacccgccccagtccagggccggagctaccaccacggctaccgcccctgcctaccgcccaccagcggcctacaaggacaaccgtgccccctcggtgacctcagccgcgcacagtgggtacaggctgaatgactacgtgtgagttccttccccgggcttctgccagggatgctgggccccaaaggaccaatgatggatgtgggaaggatgcagagagcaagcccggaacacagggaaggaggtgctcttcaaagcaaagacttctaaaaagtgctggttttttatttattatatgtatttatgcgggtggcttaataagagctcaataaagagtgtcttggaagcgtgaaaaaaaaaaaaaaaaa

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