LOCUS       NR_182209               4953 bp    RNA     linear   PRI 08-NOV-2022
DEFINITION  Homo sapiens polyhomeotic homolog 1 (PHC1), transcript variant 19,
            non-coding RNA.
ACCESSION   NR_182209
VERSION     NR_182209.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4953)
  AUTHORS   Chen L, Tong Q, Chen X, Jiang P, Yu H, Zhao Q, Sun L, Liu C, Gu B,
            Zheng Y, Fei L, Jiang X, Li W, Volpe G, Abdul MM, Guo G, Zhang J,
            Qian P, Sun Q, Neculai D, Esteban MA, Li C, Wen F and Ji J.
  TITLE     PHC1 maintains pluripotency by organizing genome-wide chromatin
            interactions of the Nanog locus
  JOURNAL   Nat Commun 12 (1), 2829 (2021)
   PUBMED   33990559
  REMARK    GeneRIF: PHC1 maintains pluripotency by organizing genome-wide
            chromatin interactions of the Nanog locus.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4953)
  AUTHORS   Luck K, Kim DK, Lambourne L, Spirohn K, Begg BE, Bian W, Brignall
            R, Cafarelli T, Campos-Laborie FJ, Charloteaux B, Choi D, Cote AG,
            Daley M, Deimling S, Desbuleux A, Dricot A, Gebbia M, Hardy MF,
            Kishore N, Knapp JJ, Kovacs IA, Lemmens I, Mee MW, Mellor JC,
            Pollis C, Pons C, Richardson AD, Schlabach S, Teeking B, Yadav A,
            Babor M, Balcha D, Basha O, Bowman-Colin C, Chin SF, Choi SG,
            Colabella C, Coppin G, D'Amata C, De Ridder D, De Rouck S,
            Duran-Frigola M, Ennajdaoui H, Goebels F, Goehring L, Gopal A,
            Haddad G, Hatchi E, Helmy M, Jacob Y, Kassa Y, Landini S, Li R, van
            Lieshout N, MacWilliams A, Markey D, Paulson JN, Rangarajan S,
            Rasla J, Rayhan A, Rolland T, San-Miguel A, Shen Y, Sheykhkarimli
            D, Sheynkman GM, Simonovsky E, Tasan M, Tejeda A, Tropepe V,
            Twizere JC, Wang Y, Weatheritt RJ, Weile J, Xia Y, Yang X,
            Yeger-Lotem E, Zhong Q, Aloy P, Bader GD, De Las Rivas J, Gaudet S,
            Hao T, Rak J, Tavernier J, Hill DE, Vidal M, Roth FP and Calderwood
            MA.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4953)
  AUTHORS   Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K,
            Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G,
            Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson
            BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP and
            Harper JW.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 4953)
  AUTHORS   Hauri S, Comoglio F, Seimiya M, Gerstung M, Glatter T, Hansen K,
            Aebersold R, Paro R, Gstaiger M and Beisel C.
  TITLE     A High-Density Map for Navigating the Human Polycomb Complexome
  JOURNAL   Cell Rep 17 (2), 583-595 (2016)
   PUBMED   27705803
REFERENCE   5  (bases 1 to 4953)
  AUTHORS   Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni
            S, Ganna A, Chen J, Buchkovich ML, Mora S, Beckmann JS,
            Bragg-Gresham JL, Chang HY, Demirkan A, Den Hertog HM, Do R,
            Donnelly LA, Ehret GB, Esko T, Feitosa MF, Ferreira T, Fischer K,
            Fontanillas P, Fraser RM, Freitag DF, Gurdasani D, Heikkila K,
            Hypponen E, Isaacs A, Jackson AU, Johansson A, Johnson T, Kaakinen
            M, Kettunen J, Kleber ME, Li X, Luan J, Lyytikainen LP, Magnusson
            PKE, Mangino M, Mihailov E, Montasser ME, Muller-Nurasyid M, Nolte
            IM, O'Connell JR, Palmer CD, Perola M, Petersen AK, Sanna S, Saxena
            R, Service SK, Shah S, Shungin D, Sidore C, Song C, Strawbridge RJ,
            Surakka I, Tanaka T, Teslovich TM, Thorleifsson G, Van den Herik
            EG, Voight BF, Volcik KA, Waite LL, Wong A, Wu Y, Zhang W, Absher
            D, Asiki G, Barroso I, Been LF, Bolton JL, Bonnycastle LL,
            Brambilla P, Burnett MS, Cesana G, Dimitriou M, Doney ASF, Doring
            A, Elliott P, Epstein SE, Ingi Eyjolfsson G, Gigante B, Goodarzi
            MO, Grallert H, Gravito ML, Groves CJ, Hallmans G, Hartikainen AL,
            Hayward C, Hernandez D, Hicks AA, Holm H, Hung YJ, Illig T, Jones
            MR, Kaleebu P, Kastelein JJP, Khaw KT, Kim E, Klopp N, Komulainen
            P, Kumari M, Langenberg C, Lehtimaki T, Lin SY, Lindstrom J, Loos
            RJF, Mach F, McArdle WL, Meisinger C, Mitchell BD, Muller G,
            Nagaraja R, Narisu N, Nieminen TVM, Nsubuga RN, Olafsson I, Ong KK,
            Palotie A, Papamarkou T, Pomilla C, Pouta A, Rader DJ, Reilly MP,
            Ridker PM, Rivadeneira F, Rudan I, Ruokonen A, Samani N, Scharnagl
            H, Seeley J, Silander K, Stancakova A, Stirrups K, Swift AJ, Tiret
            L, Uitterlinden AG, van Pelt LJ, Vedantam S, Wainwright N, Wijmenga
            C, Wild SH, Willemsen G, Wilsgaard T, Wilson JF, Young EH, Zhao JH,
            Adair LS, Arveiler D, Assimes TL, Bandinelli S, Bennett F, Bochud
            M, Boehm BO, Boomsma DI, Borecki IB, Bornstein SR, Bovet P, Burnier
            M, Campbell H, Chakravarti A, Chambers JC, Chen YI, Collins FS,
            Cooper RS, Danesh J, Dedoussis G, de Faire U, Feranil AB, Ferrieres
            J, Ferrucci L, Freimer NB, Gieger C, Groop LC, Gudnason V,
            Gyllensten U, Hamsten A, Harris TB, Hingorani A, Hirschhorn JN,
            Hofman A, Hovingh GK, Hsiung CA, Humphries SE, Hunt SC, Hveem K,
            Iribarren C, Jarvelin MR, Jula A, Kahonen M, Kaprio J, Kesaniemi A,
            Kivimaki M, Kooner JS, Koudstaal PJ, Krauss RM, Kuh D, Kuusisto J,
            Kyvik KO, Laakso M, Lakka TA, Lind L, Lindgren CM, Martin NG, Marz
            W, McCarthy MI, McKenzie CA, Meneton P, Metspalu A, Moilanen L,
            Morris AD, Munroe PB, Njolstad I, Pedersen NL, Power C, Pramstaller
            PP, Price JF, Psaty BM, Quertermous T, Rauramaa R, Saleheen D,
            Salomaa V, Sanghera DK, Saramies J, Schwarz PEH, Sheu WH, Shuldiner
            AR, Siegbahn A, Spector TD, Stefansson K, Strachan DP, Tayo BO,
            Tremoli E, Tuomilehto J, Uusitupa M, van Duijn CM, Vollenweider P,
            Wallentin L, Wareham NJ, Whitfield JB, Wolffenbuttel BHR, Ordovas
            JM, Boerwinkle E, Palmer CNA, Thorsteinsdottir U, Chasman DI,
            Rotter JI, Franks PW, Ripatti S, Cupples LA, Sandhu MS, Rich SS,
            Boehnke M, Deloukas P, Kathiresan S, Mohlke KL, Ingelsson E and
            Abecasis GR.
  CONSRTM   Global Lipids Genetics Consortium
  TITLE     Discovery and refinement of loci associated with lipid levels
  JOURNAL   Nat Genet 45 (11), 1274-1283 (2013)
   PUBMED   24097068
REFERENCE   6  (bases 1 to 4953)
  AUTHORS   Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P and
            Kingston RE.
  TITLE     The core of the polycomb repressive complex is compositionally and
            functionally conserved in flies and humans
  JOURNAL   Mol Cell Biol 22 (17), 6070-6078 (2002)
   PUBMED   12167701
REFERENCE   7  (bases 1 to 4953)
  AUTHORS   Ohta H, Tokimasa S, Zou Z, Funaki S, Kurahashi H, Takahashi Y,
            Kimura M, Matsuoka R, Horie M, Hara J, Shimada K and Takihara Y.
  TITLE     Structure and chromosomal localization of the RAE28/HPH1 gene, a
            human homologue of the polyhomeotic gene
  JOURNAL   DNA Seq 11 (1-2), 61-73 (2000)
   PUBMED   10902910
REFERENCE   8  (bases 1 to 4953)
  AUTHORS   Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema
            MJ, Saurin AJ, Freemont PS, van Driel R and Otte AP.
  TITLE     RING1 is associated with the polycomb group protein complex and
            acts as a transcriptional repressor
  JOURNAL   Mol Cell Biol 17 (7), 4105-4113 (1997)
   PUBMED   9199346
REFERENCE   9  (bases 1 to 4953)
  AUTHORS   Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D,
            Alkema MJ, van Lohuizen M, van Driel R and Otte AP.
  TITLE     Identification and characterization of interactions between the
            vertebrate polycomb-group protein BMI1 and human homologs of
            polyhomeotic
  JOURNAL   Mol Cell Biol 17 (4), 2326-2335 (1997)
   PUBMED   9121482
REFERENCE   10 (bases 1 to 4953)
  AUTHORS   Verloes,A., Drunat,S., Gressens,P. and Passemard,S.
  TITLE     Primary Autosomal Recessive Microcephalies and Seckel Syndrome
            Spectrum Disorders - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Everman DB, Mirzaa GM, Pagon RA, Wallace SE, Bean
            LJH, Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS((R));
            (1993)
   PUBMED   20301772
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006581.16.
            
            Summary: This gene is a homolog of the Drosophila polyhomeotic
            gene, which is a member of the Polycomb group of genes. The gene
            product is a component of a multimeric protein complex that
            contains EDR2 and the vertebrate Polycomb protein BMH1. The gene
            product, the EDR2 protein, and the Drosophila polyhomeotic protein
            share 2 highly conserved domains, named homology domains I and II.
            These domains are involved in protein-protein interactions and may
            mediate heterodimerization of the protein encoded by this gene and
            the EDR2 protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.44404.1,
                                           SRR14038196.2538327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC006581.16        62800-62907
            109-270             AC006581.16        66587-66748
            271-381             AC006581.16        68713-68823
            382-462             AC006581.16        69942-70022
            463-612             AC006581.16        70558-70707
            613-768             AC006581.16        71590-71745
            769-1261            AC006581.16        79392-79884
            1262-2049           AC006581.16        81520-82307
            2050-2197           AC006581.16        82822-82969
            2198-2409           AC006581.16        83224-83435
            2410-2524           AC006581.16        84081-84195
            2525-2633           AC006581.16        85813-85921
            2634-2784           AC006581.16        86133-86283
            2785-3016           AC006581.16        86786-87017
            3017-4729           AC006581.16        88262-89974
            4730-4953           AC006581.16        90201-90424
FEATURES             Location/Qualifiers
     source          1..4953
                     /organism="Homo sapiens"
                     /mol_type="transcribed RNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..4953
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="polyhomeotic homolog 1"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
     misc_RNA        1..4953
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /product="polyhomeotic homolog 1, transcript variant 19"
                     /db_xref="GeneID:1911"
                     /db_xref="HGNC:HGNC:3182"
                     /db_xref="MIM:602978"
     exon            1..108
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            109..270
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    157..3171
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="COORDINATES:
                     alignment:Blast2seq::RefSeq|NM_004426.3"
                     /note="primary ORF has stop codon >50 nucleotides from the
                     terminal splice site; nonsense-mediated decay (NMD)
                     candidate"
     exon            271..381
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            382..462
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            463..612
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            613..768
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            769..1261
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..2049
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2197
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2409
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2524
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2633
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2784
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..3016
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..4729
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     exon            4730..4953
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4932..4937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="hexamer: AAGAAA"
     polyA_site      4953
                     /gene="PHC1"
                     /gene_synonym="EDR1; HPH1; MCPH11; RAE28"
                     /note="major polyA site"
ORIGIN      

aaatgctatccaaaggaagttacattaggttgctgctttgaaaatgaagtcaactcctaatgggttagctgtttctgcagcattctttcccgccttcttggagttgaggtcttgagtcagacagagcaccagccttggggaccctggaccactatcatggagactgagagcgagcagaactccaattccaccaatgggagttctagctcagggggcagctctcggccccagatagctcaaatgtcactttatgaacgacaagcagtgcaggctctgcaagcactgcagcggcagcccaatgcagctcagtatttccaccagttcatgctccagcagcagctcagtaatgcccagctgcatagcctggctgccgtccagcaggccacaattgctgccagtcggcaggccagctccccaaacaccagcactacacagcagcagactaccaccacccaggcctcgatcaatctggccaccacatcggccgcccagctcatcagccgatcccagagtgtgagctctcccagtgctaccaccttgacccaatctgtgctactggggaacaccacctccccacccctcaaccagtctcaggcccagatgtatctacggccacagctgggaaacctattgcaggtaaaccgaaccctgggtcggaatgtgcctctagcctcccaactcatcctgatgcctaatggggcggtggctgcagtccagcaggaggtgccatctgctcagtctcctggagttcatgcagatgcagatcaggttcagaacttggcagtaaggaatcaacaggcctcagctcaaggacctcagatgcaaggctccactcagaaggccattcctccaggagcctcccctgtctctagcctctcccaggcctctagccaggccctagcggtggcacaggcttcctctggggccacaaaccagtccctcaaccttagtcaagctggtggaggcagtgggaatagcatcccagggtccatgggtccaggtggaggtgggcaggcacatggtggtttgggtcagttgccttcctcaggaatgggtggtgggagctgtcccagaaagggtacaggagtggtgcagcccttgcctgcagcccaaacagtgactgtgagccagggcagccagacagaggcagaaagtgcagcagccaagaaggcagaagcagatgggagtggccagcagaatgtgggcatgaacctgacacggacagccacacctgcgcccagccagacacttattagctcagccacctacacacagatccagccccattcactgattcagcaacagcaacagatccacctccagcagaaacaggtggtgatccagcagcagattgccatccaccaccagcagcagttccagcaccggcagtcccagctccttcacacagctacacacctccagttggcgcagcagcagcagcagcaacaacagcaacagcagcaacagcagcagccgcaagccaccaccctcactgcccctcagccaccacaggtcccacctactcagcaggtcccaccttcccagtcccagcagcaagcccaaaccctggtcgttcagcccatgcttcagtcttcacccttgtctcttccacctgatgcagcccctaagccaccaattcccatccaatccaaaccacctgtagcacctatcaagccgcctcagttaggggccgctaagatgtcagctgcccagcaaccaccaccccatatccctgtgcaagttgtaggcactcgacagccaggtacagcccaggcacaggctttggggttggcacagctggcagctgctgtacctacttcccgggggatgccaggtacagtgcagtctggtcaggcccatttggcctcctcgccaccttcatcccaggctcctggtgcactgcaggagtgccctcccacattggcccctgggatgacccttgctcctgtgcaggggacagcacatgtggtaaagggtggggctaccacctcctcacctgttgtagcccaggtccctgctgccttctatatgcagtctgtgcacttgccgggtaaaccccagacattggctgtcaaacgcaaggctgactctgaggaggagagagatgatgtctccacattgggttcaatgcttcctgccaaggcatctccagtagcagaaagcccaaaagtcatggacgagaagagcagtcttggagaaaaagctgaatcagtggctaatgtgaatgctaatactccaagcagtgaactagtagccttgacccccgccccttcagtaccgcctcctacactagccatggtgtctagacaaatgggtgactcaaaacccccacaggccatcgtgaagccccagattctcacccacatcattgaaggctttgttatccaggaaggagcagaacctttcccggtgggttgttctcagttactgaaggagtctgagaagccactacagactggccttccgacagggctgactgagaatcagtcaggtggccctttgggagtggacagcccatctgctgagttagataagaaggcgaatctcctgaagtgcgagtactgtgggaagtacgcccccgcagagcagtttcgtggctctaagaggttctgctccatgacttgcgctaagaggtacaatgtgagctgtagccatcagttccggctgaagaggaaaaaaatgaaagagtttcaagaagccaactatgctcgcgttcgcaggcgtggaccccgccgcagctcctctgacattgcccgtgccaagattcagggcaagtgccaccggggtcaagaagactctagccggggttcagataattccagttatgatgaagcactctctccaacatctcctgggcctttatcagtaagagctgggcatggagaacgtgacctggggaatcccaatacagctccacctacaccggaattacatggcatcaaccctgtgttcctgtccagtaatcccagccgttggagtgtagaggaggtgtacgagtttattgcttctctccaaggctgccaagagattgcagaggaatttcgctcacaggagattgatggacaggcccttttattacttaaagaagaacatcttatgagtgccatgaacatcaagctgggccctgccctcaagatctgcgccaagataaatgtcctcaaggagacctaaggtggccctcttgcacaaaccagcctaaggcagacactctccactgtccaggttataacctggtaccagcagactttgcagggaagaaagagttgttccaatcatgtaaccttctgtaggggattactgagacagggaagagaagtgcaagaattggttgctggtgctacatggcggcagctttgacattttctctgggttctactttattttttaaaatctttacagttctcaccatttcacgtaccttaatccaatctttataaaagaggcagtctagagaactaggactgctcagccttatcctggagtggagcatttagcccaggtcttaattctccaagaggaggaatacatagtatggtaaggcaaggaactgggtggaatgtcaggttgcctgcccaatgggagaggtagggtttttctagcttgtgtgacagaagtagcaaaatctggtcctcccccctcccagtgtagctgtggctcagagttttttctttttgttgtcacttactcccttgtgattgaattttttctcctgcatccatggcaggatccccagccagtatagagacttggttggcatcttctgctgcagggactaaaagtatttgactggggcacatgtggctgttgtcattctttctgcatcccactgttcccctccaatttatgttattttctaccctgtttttcagttccatctctgctctgtcctatagctttataaaaccagagtgtgtggggctgaggtcaggagtataagtacctgccttaggcactattccttatataacaaaaatattaaatatttttttcctcagtaaaaggatgaaaattggtttcagttgtcttactctattccagtctttgcccactttcacacaaatgacaaggccaatatgttttgtttgttttttaatcattaagagtttttgtacaaaaggtgatggttttttttcttcattttaaaacaccagggtgtgggggagggatgcaaacaaataacaaaaaagatgcttttgtaacattattttccctgtttagaaagaaaaaaatcactccaatagtattgaaaagtccaaagatgaaatagtttcattttcttttcctaaggcttataaaaggccccctgcctgttgattccatccctcttttgtgtccagtggagccatgttactcttcagtggcccaggggttcactattaaagaaagatcagtccaggtttctgggcacatggcctaaacaggaagatggaagcatcagaggattaaaaacctttccccacagaaatgtgggcaagaagacacttccctgagccagcagaagggacaggtgcagcagcattccacacccagcgcagaggacagcagagccctcgatgtcccacttctgcttccgttccctttctagaagattgaaaaaaaggtcaaaaccacatgcctgtggagaaagtgcgacatgtttagaaatactggtagggaaccaggagtaagaaaagctttaccagcttttactacaaatggatgaaagacatcaggatcccaccaccgcaagaggtgggagaagcaagtctagaacatctccaggctcagactaaacgagagtacttggactgcaaccaagtaatcactgcaaagtagttccaagcagcaagaaataccagattctcatggaggctactatagggtacagaataacaacatgaaagcaatcaaccctgtataaataatgtttcttggcattttttttttaattaaagaaatccagtgtctcaaaaa

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