LOCUS       XM_046918636           10639 bp    mRNA    linear   VRT 01-MAR-2022
DEFINITION  PREDICTED: Gallus gallus dicer 1, ribonuclease III (DICER1),
            transcript variant X3, mRNA.
ACCESSION   XM_046918636
VERSION     XM_046918636.1
DBLINK      BioProject: PRJNA698614
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_052577.1) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI
            Annotation Status           :: Full annotation
            Annotation Name             :: Gallus gallus Annotation Release 106
            Annotation Version          :: 106
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 9.0
            Annotation Method           :: Best-placed RefSeq; Gnomon
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10639
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /isolate="bGalGal1"
                     /db_xref="taxon:9031"
                     /chromosome="5"
                     /sex="female"
                     /tissue_type="blood"
                     /geo_loc_name="USA: Fayetteville"
                     /lat_lon="36.0822 N 94.1719 W"
                     /collection_date="20-May-2019"
                     /collected_by="Nick Anthony"
     gene            1..10639
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dicer 1, ribonuclease III; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 5
                     mRNAs, 11 ESTs, 868 long SRA reads, 20 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 27 samples with support for all
                     annotated introns"
                     /db_xref="CGNC:8359"
                     /db_xref="GeneID:423437"
     misc_feature    1
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /experiment="COORDINATES: cap analysis [ECO:0007248]"
                     /note="transcription start site"
     CDS             266..6031
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /codon_start=1
                     /product="endoribonuclease Dicer isoform X1"
                     /protein_id="XP_046774592.1"
                     /db_xref="GeneID:423437"
                     /db_xref="CGNC:8359"
                     /translation="

MKSPALQSLSMAGLQLMTPASSPMGPFFGLPWQQEAIHDNIYTPRKYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELSYQIRGDFNKNGKRTVFLVNSANQVAQQVSAVRTHSDLKVGEYSSLEVTESWTKEKWSQEFSKHQVLVMTCHVALTVLRNEYLSLSNINLLVFDECHLAIQDHPYREIMKICEDYPSCPRILGLTASILNGKCDPAELEEKIKKLEKILKSNAETATDLVVLDRYTSQPCEIVVDCGPYTDKSGLYGRLLRELDEALHFLNDCNISVHSKERDSTLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFLLFTDTFLRKIHALCEEHFSPASLDLKFVTPKVIKLLEILRKYKPYERQQFESVEWYNNRNQDNYVSWSDSEDDDEDEEIEEKEKPETNFPSPFTNILCGIIFVERRYTAVVLNRLIKEAGKQDPELAYISSNFITGHGIGKNQPRNKQMEVEFRKQEEVLRKFRAHETNLLIATSIVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYIMLADTDKIKSFEEDLKTYKAIEKILRNKCSKSVDTSETETEPIVDDDDVFPPYVLRTDENSPRVTINTAIGHINRYCARLPSDPFTHLAPKCKTRELPDHTFYSTLYLPINSPLRASIVGPPMSCARLAERVVALICCEKLHKIGELDDHLMPVGKETVKYEEELDLHDEEETSVPGRPGSTKRRQCYPKAIPECLRDSYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAKPIPQIPHFPVYTRSGEVTISIELKKSGFTLSLQMLELITRLHQYIFSHILRLEKPALEFKPTEADSAYCVLPLNIVDDSSTLDIDFKFMEDIEKSEARTGIPSTQYTKEMPFIFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLSKFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLNQKGKALPLSSAEKRKAKWESLQNKQILVPELCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTATDAGVGVKSLPADFRYPNLDFGWKKSIDSKSFISIPSSSLVENENYCKHSTIVVPENAAHQGANRTSSAEKHDQMSVSYRTLLDESPSKLQIDVSAELAAINGVSYNKNLANGNCDLVNRDFCQGNQLNYCRQEIPVQPTTSYPIQNLYSSENQPKPSNECTLLSNKYLDGNANRSTSDGCPKMTLTTSTSTALNLSKDKVDSEKNTSSGYSSKTLGPNPGLILQALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSKKVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYIVNQDKSNTDKWEKDETTKENLLANGKLDYDDDDEEDEDLMWRLPKEETDFEDDFLEYDQEHIKFIDSMLMGSGAFVKKISLSHFSTTDSNYEWKAPKKSSLGNVPFSSDFDDFDYSSWDAMCYLDPSKAVEEDDFVVGFWNPSEENCGVDAGKQSISYDLHTEQCIADKSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIKKTDWESTLCATGENCNSEQKNLSPNSVSACIVNSEPSLYKDLEYGCLKIPPRCMFDHPDAEKTLNHLISGFENFEKKINYSFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDYLITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPELFHVIDDFVQFQMEKNEMQGMDSELRRSEEDEEKEEDIEVPKAMGDIFESLAGAIYMDSGMSLEMVWQVYYPMMRPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVGKGKFKGVGRSYRIAKSAAARRALRSLKANQPQVPNS"

     misc_feature    389..982
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="DEXH-box helicase domain of endoribonuclease Dicer;
                     Region: DEXHc_dicer; cd18034"
                     /db_xref="CDD:350792"
     misc_feature    order(389..400,407..409,458..481,602..604,791..793,
                     884..886)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350792"
     misc_feature    order(566..571,638..643,716..718,722..727,734..736,
                     809..817)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="nucleic acid binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:350792"
     misc_feature    1076..1360
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Partner-binding domain of the endoribonuclease
                     Dicer; Region: Dicer_PBD; cd15903"
                     /db_xref="CDD:277191"
     misc_feature    order(1091..1096,1103..1105,1109..1114,1289..1294,
                     1301..1306,1313..1315,1322..1327,1334..1336)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Trbp binding interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:277191"
     misc_feature    1379..1957
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="C-terminal helicase domain of the endoribonuclease
                     Dicer; Region: SF2_C_dicer; cd18802"
                     /db_xref="CDD:350189"
     misc_feature    order(1610..1618,1826..1828,1883..1885,1889..1891)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350189"
     misc_feature    order(1838..1840,1844..1846,1919..1921,1925..1927)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:350189"
     misc_feature    2153..2419
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Dicer dimerization domain; Region: Dicer_dimer;
                     pfam03368"
                     /db_xref="CDD:460900"
     misc_feature    2921..3289
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="PAZ domain, dicer_like subfamily. Dicer is an RNAse
                     involved in cleaving dsRNA in the RNA interference
                     pathway. It generates dsRNAs which are approximately 20 bp
                     long (siRNAs), which in turn target hydrolysis of
                     homologous RNAs. PAZ domains are named...; Region:
                     PAZ_dicer_like; cd02843"
                     /db_xref="CDD:239209"
     misc_feature    order(3110..3112,3149..3151,3167..3169,3179..3181,
                     3233..3235,3257..3259,3263..3265)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="nucleic acid-binding interface [nucleotide
                     binding]; other site"
                     /db_xref="CDD:239209"
     misc_feature    4154..>4429
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Ribonuclease III family; Region: RIBOc; smart00535"
                     /db_xref="CDD:197778"
     misc_feature    order(4205..4210,4217..4222,4229..4231,4238..4243,
                     4250..4255,4259..4267,4295..4297)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5306..5800
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="Ribonuclease III C terminal domain. This group
                     consists of eukaryotic, bacterial and archeal ribonuclease
                     III (RNAse III) proteins. RNAse III is a double stranded
                     RNA-specific endonuclease. Prokaryotic RNAse III is
                     important in post-transcriptional...; Region: RIBOc;
                     cd00593"
                     /db_xref="CDD:238333"
     misc_feature    order(5366..5371,5378..5383,5390..5392,5399..5404,
                     5411..5416,5420..5428,5456..5458,5720..5722,5753..5755)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="dimerization interface [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238333"
     misc_feature    order(5366..5368,5375..5377,5387..5389,5690..5692,
                     5699..5701)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="active site"
                     /db_xref="CDD:238333"
     misc_feature    order(5375..5377,5690..5692,5699..5701)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="metal binding site [ion binding]; metal-binding
                     site"
                     /db_xref="CDD:238333"
     misc_feature    5813..6001
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="double-stranded RNA binding motif of
                     endoribonuclease Dicer and similar proteins; Region:
                     DSRM_DICER; cd10843"
                     /db_xref="CDD:380680"
     misc_feature    order(5813..5818,5822..5827,5834..5839,5846..5851,
                     5861..5863,5876..5884,5888..5890,5894..5896,5945..5956,
                     5963..5965)
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /note="putative RNA binding site [nucleotide binding];
                     other site"
                     /db_xref="CDD:380680"
     polyA_site      10639
                     /gene="DICER1"
                     /gene_synonym="dicer"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

gggggaaaggggggggaggagaaggaggaggaggccgtcgcgggcccaggttacctagggtgaaacaaaattacaggcttggaaactctggaaaagctcagcatcagtatttgagagccgaagcctgcaaattatgtgattaacctacaagctgatatcatgatgtcaaaatgcagtttggaaagcataagcacagaggctgcagagattaaaacgtaggctgtgctggaacaaaaacgcaatgacagaaacactggatgaatgaatgaaaagccctgctttgcaatccctcagcatggcgggactgcagctcatgacccctgcttcctccccaatgggtccattttttggactaccgtggcaacaagaagcaattcatgataacatttatacgccaagaaaatatcaggttgaactgcttgaagcagctttggatcataatacaatagtctgtttaaacactggctcagggaagacttttattgcagtactactcactaaagagctgtcctatcagatcaggggggatttcaacaaaaacggaaaaagaactgtgttcttggtcaactcagcaaatcaagttgctcagcaagtgtcagctgtcaggacacattcagatcttaaagtgggagagtattcaagtttagaggtaactgaatcatggacaaaagagaaatggagtcaggaattctctaagcatcaggttctggttatgacatgtcatgttgctttgactgttttgagaaatgagtatttatccctatcaaatattaatctactggtgtttgatgagtgccatcttgcaatccaggaccatccataccgtgaaattatgaagatctgtgaggattacccatcttgccctcgaatcttgggattaactgcttccattttaaatgggaagtgtgatcctgctgagttagaagaaaagataaagaaactggagaaaatactaaagagcaatgctgaaactgcaactgatttggtggtcttagatagatatacttctcagccatgtgagattgttgtagactgtggaccatatactgacaaaagtggattgtacggaagactattaagggaattagatgaagcacttcattttctaaatgactgcaacatatctgtacattcaaaggaaagagattctacgttaatttctaaacagatattgtcagactgtcgagctgtgttggttgttctgggaccctggtgtgcagataaggtagctgggatgatggtgagagagctacagaagtatatcaaacatgagcaagaggagctgcacaggaaatttttattgtttacagacactttccttaggaaaatacatgcactctgtgaagagcatttctcacctgcctcacttgacctgaaatttgtaactccaaaagtaataaagctgcttgaaatcttgcgcaaatacaaaccatatgaacggcagcagttcgaaagtgttgaatggtataacaatagaaatcaggataattatgtatcatggagtgattctgaagatgatgatgaagatgaagagattgaggagaaagagaagccagagactaatttcccatctccttttacgaatattttatgtggaattatttttgtggaaagaagatacacagcagttgtactaaataggttgataaaagaagctggcaaacaggatccagaactggcttacatcagtagcaatttcataactggacatggcattggcaagaatcagcctcgtaacaagcagatggaagtagaattcagaaagcaggaagaggttcttagaaaatttcgagcacacgagaccaatcttcttattgctaccagtattgtagaagagggtgttgacataccaaaatgcaatttggtggtgcgttttgatttgcccacagaataccgttcctatgtgcagtcaaaaggaagagctagagcaccaatttccaattatataatgttagcagatacagacaaaattaaaagttttgaggaagatcttaagacatataaagcaattgagaagatcctgagaaataaatgctcaaaatctgttgataccagcgaaactgaaactgaacccattgttgatgatgatgatgtgtttccaccctatgtgctgaggacagatgagaacagtccaagagttactatcaacactgcaattggacacataaataggtactgcgctagattaccaagtgatccatttacacacctagctcccaagtgtaaaacccgagaactacctgatcatacattctactctactctctacctgccaatcaactcacctcttcgagcatcaattgttggtcctccaatgagttgtgcaagattggctgagagagttgtagctcttatttgctgtgaaaaactgcacaaaatcggtgaactggatgaccatttgatgccagttggaaaagaaacggttaaatatgaggaagagcttgatttacatgatgaagaagaaaccagtgtgccaggaagaccaggctctacaaaaagacgacagtgctaccctaaagctattccagaatgtttgagggatagttatcccaaacctgatcagccctgttacctgtatgtaataggaatggtgttaactactccattgcctgatgagctcaactttaggagacgaaagctatatcctcctgaggatacgacgagatgttttggcatattgacagccaaacctatacctcagattcctcactttcctgtgtatactcgctctggagaggttacaatatctattgagcttaagaaatctggttttactttgtctttgcaaatgcttgagctgataacacgactccaccagtacattttctcacatattcttcgtcttgagaaacctgcactagagttcaaacccacagaagctgattcagcctattgtgttctacctcttaacattgttgatgactccagcactttggacattgactttaagtttatggaagacattgaaaagtctgaagcgcgtacaggcattcccagtacacagtatacaaaagaaatgccttttattttcaagttagaagactaccaggatgcagttatcattccacggtatcgaaattttgatcagcctcatcgattctatgtagctgatgtatacactgatcttactccactcagtaaattcccttcccctgaatatgaaacttttgctgaatattataaaacaaaatataatcttgacctgaccaatctcaaccagccgctgctggatgtggaccacacatcttcaagacttaatcttttgactcctcgccatttgaatcagaaggggaaagcacttccactaagcagtgctgagaagaggaaagcaaaatgggaaagtctgcagaataagcagatactggttcctgagctatgtgctatacatcctattccagcatcgttgtggagaaaagcagtttgcctccccagcatactttatcgcctgcactgccttttgacagcagaggaactaagagctcaaacagccactgatgctggcgtaggggttaaatcacttcctgcagatttcagatatcctaacctggacttcggatggaaaaaatctattgacagcaaatctttcatctccatacctagctcctctttggtagagaatgaaaattactgtaagcacagcacaattgtagtccctgaaaatgctgcacatcaaggtgctaatagaacctcttctgcagaaaaacatgaccaaatgtctgtgagttacagaacactgcttgatgagtcacccagtaaactccaaattgatgtctcagcagaacttgcagcaattaatggtgtttcttataataaaaatcttgccaatggcaattgtgatttagttaacagagacttttgccaaggaaatcagctgaattactgcaggcaggaaatacctgtacaaccaactacctcatatcccattcagaatttatacagcagtgagaaccagcccaagcccagcaatgaatgtactctactgagtaataaataccttgatggaaatgctaacagatctacctcagatggatgccccaaaatgacattgaccaccagtacttcaacagctcttaatctttcaaaagacaaagtggattctgaaaagaacacttccagtgggtactcctcaaaaactcttggtcctaatcctggtctcattcttcaggctttgactctttcaaatgctagtgatggatttaatttggagcggctagaaatgcttggtgattcatttttaaagcatgccatcactacatacttgttttgcacttaccctgatgcgcacgagggacggctgtcatacatgagaagtaaaaaagtcagcaactgtaacttgtatcgccttggaaaaaagaaaggactgcctagtcgaatggtggtatcgatttttgatcctcctgtcaattggcttcctcctggttacatagtaaaccaggacaagagcaacactgataaatgggagaaagacgaaacgacaaaggagaatttgttggctaatggtaaacttgattatgatgatgacgacgaagaggatgaagacctaatgtggaggttgcccaaggaagaaacagactttgaagatgattttttggagtatgatcaagagcatatcaaattcatagatagtatgttaatgggatcgggggcttttgtgaagaaaatttctctctctcacttttcaaccactgattcaaactatgaatggaaagcacccaaaaagtcatccctgggtaacgttccgttttcatcagattttgatgattttgactacagctcttgggatgctatgtgctatctggatcctagcaaggctgttgaagaggatgattttgtagtgggtttctggaatccatcagaagaaaactgtggtgtcgatgcaggaaaacagtctatctcatatgatttgcatacagagcagtgtattgctgacaaaagcattgcagactgtgtggaagccctgttgggctgctatctgaccagctgtggtgaaagagctgctc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