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Previous release (v1)
2026-01-17 21:54:13, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_205263 3730 bp mRNA linear VRT 30-APR-2025
DEFINITION Gallus gallus poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
ACCESSION NM_205263
VERSION NM_205263.3
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (bases 1 to 3730)
AUTHORS Diani-Moore,S., Zhang,S., Ram,P. and Rifkind,A.B.
TITLE Aryl hydrocarbon receptor activation by dioxin targets
phosphoenolpyruvate carboxykinase (PEPCK) for ADP-ribosylation via
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible
poly(ADP-ribose) polymerase (TiPARP)
JOURNAL J Biol Chem 288 (30), 21514-21525 (2013)
PUBMED 23770670
REMARK GeneRIF: Data indicate that aryl hydrocarbon receptor (AHR)
enhances phosphoenolpyruvate carboxykinase (PEPCK) ADP-ribosylation
through TiPARP TiPARP (TCDD-inducible poly(ADP-ribose) polymerase).
REFERENCE 2 (bases 1 to 3730)
AUTHORS Bueno,M.T., Reyes,D., Valdes,L., Saheba,A., Urias,E., Mendoza,C.,
Fregoso,O.I. and Llano,M.
TITLE Poly(ADP-ribose) polymerase 1 promotes transcriptional repression
of integrated retroviruses
JOURNAL J Virol 87 (5), 2496-2507 (2013)
PUBMED 23255787
REMARK GeneRIF: data indicate a novel role of PARP-1 in the
transcriptional repression of integrated retroviruses
REFERENCE 3 (bases 1 to 3730)
AUTHORS Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 4 (bases 1 to 3730)
AUTHORS Fisher,A.E., Hochegger,H., Takeda,S. and Caldecott,K.W.
TITLE Poly(ADP-ribose) polymerase 1 accelerates single-strand break
repair in concert with poly(ADP-ribose) glycohydrolase
JOURNAL Mol Cell Biol 27 (15), 5597-5605 (2007)
PUBMED 17548475
REMARK GeneRIF: PARG is identified as a novel and critical component of
single-strand break repair that accelerates this process in concert
with PARP-1.
REFERENCE 5 (bases 1 to 3730)
AUTHORS Saberi,A., Hochegger,H., Szuts,D., Lan,L., Yasui,A., Sale,J.E.,
Taniguchi,Y., Murakawa,Y., Zeng,W., Yokomori,K., Helleday,T.,
Teraoka,H., Arakawa,H., Buerstedde,J.M. and Takeda,S.
TITLE RAD18 and poly(ADP-ribose) polymerase independently suppress the
access of nonhomologous end joining to double-strand breaks and
facilitate homologous recombination-mediated repair
JOURNAL Mol Cell Biol 27 (7), 2562-2571 (2007)
PUBMED 17242200
REMARK GeneRIF: Higher-eukaryotic cells separately employ PARP1 and Rad18
to suppress the toxic effects of NHEJ during the HR reaction at
stalled replication forks.
REFERENCE 6 (bases 1 to 3730)
AUTHORS Mendoza-Alvarez,H. and Alvarez-Gonzalez,R.
TITLE The 40 kDa carboxy-terminal domain of poly(ADP-ribose) polymerase-1
forms catalytically competent homo- and heterodimers in the absence
of DNA
JOURNAL J Mol Biol 336 (1), 105-114 (2004)
PUBMED 14741207
REMARK GeneRIF: Results show that the 40 kDa carboxy terminus of
poly(ADP-ribose) polymerase-1 forms a competent catalytic dimer in
the absence of DNA, and that its automodification reaction is
intermolecular.
REFERENCE 7 (bases 1 to 3730)
AUTHORS Ruf,A., Rolli,V., de Murcia,G. and Schulz,G.E.
TITLE The mechanism of the elongation and branching reaction of
poly(ADP-ribose) polymerase as derived from crystal structures and
mutagenesis
JOURNAL J Mol Biol 278 (1), 57-65 (1998)
PUBMED 9571033
REFERENCE 8 (bases 1 to 3730)
AUTHORS Ruf,A., de Murcia,G. and Schulz,G.E.
TITLE Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as
derived from crystal structures and homology modeling
JOURNAL Biochemistry 37 (11), 3893-3900 (1998)
PUBMED 9521710
REFERENCE 9 (bases 1 to 3730)
AUTHORS Ruf,A., Mennissier de Murcia,J., de Murcia,G. and Schulz,G.E.
TITLE Structure of the catalytic fragment of poly(AD-ribose) polymerase
from chicken
JOURNAL Proc Natl Acad Sci U S A 93 (15), 7481-7485 (1996)
PUBMED 8755499
REFERENCE 10 (bases 1 to 3730)
AUTHORS Ittel,M.E., Garnier,J.M., Jeltsch,J.M. and Niedergang,C.P.
TITLE Chicken poly(ADP-ribose) synthetase: complete deduced amino acid
sequence and comparison with mammalian enzyme sequences
JOURNAL Gene 102 (2), 157-164 (1991)
PUBMED 1840535
COMMENT VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
JAENSK010000062.1.
On Dec 3, 2021 this sequence version replaced NM_205263.2.
Sequence Note: The RefSeq transcript and protein were derived from
genomic sequence to make the sequence consistent with the reference
genome assembly. The genomic coordinates used for the transcript
record were based on alignments.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: X52690.1, SRR13267655.22632.1
[ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA103992290, SAMEA103992323
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-221 JAENSK010000062.1 4799635-4799855
222-384 JAENSK010000062.1 4800745-4800907
385-503 JAENSK010000062.1 4801577-4801695
504-718 JAENSK010000062.1 4802749-4802963
719-815 JAENSK010000062.1 4810132-4810228
816-932 JAENSK010000062.1 4811553-4811669
933-1109 JAENSK010000062.1 4812176-4812352
1110-1251 JAENSK010000062.1 4812794-4812935
1252-1392 JAENSK010000062.1 4814450-4814590
1393-1635 JAENSK010000062.1 4814967-4815209
1636-1704 JAENSK010000062.1 4816001-4816069
1705-1837 JAENSK010000062.1 4816848-4816980
1838-2033 JAENSK010000062.1 4818146-4818341
2034-2162 JAENSK010000062.1 4819539-4819667
2163-2246 JAENSK010000062.1 4822033-4822116
2247-2369 JAENSK010000062.1 4823064-4823186
2370-2498 JAENSK010000062.1 4823564-4823692
2499-2597 JAENSK010000062.1 4824212-4824310
2598-2750 JAENSK010000062.1 4824800-4824952
2751-2878 JAENSK010000062.1 4825251-4825378
2879-2940 JAENSK010000062.1 4825769-4825830
2941-3055 JAENSK010000062.1 4826888-4827002
3056-3730 JAENSK010000062.1 4828963-4829637
FEATURES Location/Qualifiers
source 1..3730
/organism="Gallus gallus"
/mol_type="mRNA"
/db_xref="taxon:9031"
/chromosome="3"
/map="3"
gene 1..3730
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="poly(ADP-ribose) polymerase 1"
/db_xref="CGNC:7010"
/db_xref="GeneID:396199"
exon 1..221
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
CDS 102..3137
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/EC_number="2.4.2.30"
/note="ADP-ribosyltransferase NAD(+); ADPRT 1;
poly[ADP-ribose] synthetase 1; NAD(+)
ADP-ribosyltransferase 1; poly[ADP-ribose] synthase 1;
poly (ADP-ribose) polymerase family, member 1;
ADP-ribosyltransferase diphtheria toxin-like 1; DNA
ADP-ribosyltransferase PARP1; protein
poly-ADP-ribosyltransferase PARP1; TCDD-inducible
poly(ADP-ribose) polymerase"
/codon_start=1
/product="poly [ADP-ribose] polymerase 1"
/protein_id="NP_990594.3"
/db_xref="CGNC:7010"
/db_xref="GeneID:396199"
/translation="
MAETGDKPYRAEYAKSGRASCKKCGESIAKDSLRLALMVQSPMFDGKVPHWHHYSCFWKRARIVSHTDIDGFPELRWEDQEKIKKAIETGGPAGGKGGDQEGGGKAEKSLTDFAAEYAKSNRSTCKGCEQKIEKGQIRISKKMVHPEKPQLGMIDNWYHPDCFVSRRAELGFLPAYGATQLLGFSILKAEDKETLKKQLPATKTEGKRKGEEVDGNVVAKKKSRKEKEKESKQEKQLKEQTELIWGIKDELRKVCSTNDLKELLIANKQEVPSGENAILDRVADGMAFGALLPCEECKGQFVFKSDAYYCSGDITAWTKCVAKTQTPNRKDWVIPKEFREIPYLKKFKCKKQDRIFPPEAATVNSAPPPSASAPLTETVTAPQDKPLTNMKILTLGKLSKNKEEVKNIVEELGGKMTTTANKATLCISTQKEVEKMSKKMEEVKDAKVRVVSEEFLKDVKSSSKGFQELLSLHAISPWGAEVKTEHQEVAVDGKCSKPANMKSAGKVKEEQGPSKSEKKMKLTVKGGAAVDPDSGLEDSAHVFEKGGKIFSATLGLVDIVKGTNSYYKLQLLEDDRESRYWVFRSWGRVGTVIGSNKLEQMPSKEDAVEHFLNLYEEKTGNSWHSKNFTKYPKKFYPLEIDYGQDEEAVRKLTVSAGTKSKLAKPIQDLIKMIFDVESMKKAMVEFEIDLQKMPLGKLSKRQIQSAYSILNEVQQAVSDGGSESQILDLSNRFYTLIPHDFGMKKPPLLSNLEYIQAKVQMLDNLLDIEVAYSLLRGGNEDGDKDPIDINYEKLRTDIKVVDKDSEEAKIIKQYVKNTHAATHNAYDLKVVEIFRIEREGESQRYKPFKQLHNRQLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQADPIGLILLGEVALGNMYELKNASHITKLPKGKHSVKGLGKTAPDPTATTTLDGVEVPLGNGISTGINDTCLLYNEYIVYDVAQVNLKYLLKLKFNYKTSLW"
misc_feature 117..3122
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="poly [ADP-ribose] polymerase; Provisional; Region:
PLN03123"
/db_xref="CDD:215590"
misc_feature 693..806
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 720..728
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Nuclear localization signal.
/evidence=ECO:0000250|UniProtKB:P09874"
misc_feature 759..776
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Nuclear localization signal.
/evidence=ECO:0000250|UniProtKB:P09874"
misc_feature 966..1094
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Zinc ribbon.
/evidence=ECO:0000255|PROSITE-ProRule:PRU01351"
misc_feature 1176..1235
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
misc_feature 1212..1667
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Automodification domain.
/evidence=ECO:0000250|UniProtKB:P09874"
misc_feature 1587..1658
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/note="propagated from UniProtKB/Swiss-Prot (P26446.2);
Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
exon 222..384
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 385..503
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 504..718
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 719..815
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 816..932
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 933..1109
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1110..1251
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1252..1392
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1393..1635
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1636..1704
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1705..1837
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 1838..2033
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2034..2162
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2163..2246
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2247..2369
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2370..2498
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2499..2597
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2598..2750
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2751..2878
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2879..2940
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 2941..3055
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
exon 3056..3730
/gene="PARP1"
/gene_synonym="ADPRT; ARTD1; PARP-1"
/inference="alignment:Splign:2.1.0"
ORIGIN
gcctgcggtgggcgcgcggcgcggctcggctcggctcggctcggctcggctcggcgtgcctgggctcggggctcggggctcggctctcgagctcggcggcgatggcggagacgggggacaagccgtaccgcgcggagtacgccaagagcgggcgggcgtcgtgcaagaagtgcggcgagagcatcgccaaggactcgctgcgcctggccctcatggtgcagtcgcccatgttcgatggcaaagtccctcactggcaccactacagctgcttctggaagcgggcacggatcgtgtcccacacagacatcgatggcttccctgagctccgctgggaggaccaggagaaaatcaagaaggccattgaaaccggaggccctgcaggaggaaaagggggggaccaggaaggaggtggcaaggctgagaagagcctaactgactttgctgcagagtatgccaagtctaacaggagtacttgcaaaggctgtgagcagaaaatagaaaagggccagattcggatttccaagaagatggtgcatcctgagaaaccacagctggggatgatcgataactggtaccacccggactgcttcgtcagccgccgggcagagctgggcttcctcccagcatatggggccacacagctcctgggtttcagcatcttgaaagctgaagataaagaaactctgaagaaacagctaccagctactaagactgaaggaaagagaaaaggagaagaggtagatggaaatgtggttgcaaaaaagaaatcaagaaaagaaaaagaaaaagaatcaaagcaggaaaaacagctgaaggagcagacagagctgatctggggcatcaaggatgagctgaggaaggtctgctccacgaatgacctcaaagagctgctgatcgccaacaagcaggaggtgccttcaggggagaatgcaatcttggacagagtggcagacgggatggcgtttggagctctgcttccttgtgaggagtgtaaagggcagtttgtgttcaagagcgatgcatactactgctcaggggacattactgcctggactaagtgtgtggctaaaacacagactcccaataggaaagactgggtaatcccgaaggaatttcgtgagattccttatctcaaaaaatttaagtgtaagaagcaggataggatattccctcctgaggctgcaactgtgaactctgcaccgcctccatctgcatccgctccattgacagagactgtcactgcaccccaagacaaaccactgaccaacatgaagatcctgactcttggaaagctgtccaagaacaaggaggaagtgaagaatattgtggaggagctgggaggaaagatgacaacaacagctaacaaggccaccctgtgcatcagcacacaaaaggaggtggagaaaatgagcaagaagatggaagaagtgaaggatgccaaagttcgtgtggtctcagaggagtttcttaaggatgtgaaatcttccagcaagggctttcaggagcttctctctctccatgcaatttcaccttggggtgcagaggtgaaaacggagcaccaggaggtggcggtggatgggaagtgcagcaagcctgcaaatatgaagagtgctgggaaggtcaaagaagaacaaggacctagcaagtctgagaagaaaatgaagctaacagttaaaggtggagcagcagtagatcctgattccggcttggaggattctgctcatgtctttgaaaaaggtgggaagattttcagtgcaactcttggcctagtggatattgtgaaaggaacaaattcctattacaaactgcagctgctggaggatgacagagagagcaggtactgggtgttcagatcctggggtcgtgtgggcactgtcattgggagtaacaagctggagcagatgccatcaaaagaagatgctgttgaacacttcctaaatttgtacgaagagaaaactggcaattcttggcattcaaagaacttcactaaatatcccaaaaaattctacccactggaaatagattatggacaggatgaagaagctgtcaggaaactgacagtgagtgctgggactaaatcgaagcttgctaagccaatccaagaccttattaagatgatttttgatgtggagagcatgaagaaagccatggtggaatttgagattgacctgcagaagatgccactggggaaactgagcaagcgacagatccaaagtgcatactccatccttaacgaggttcagcaggcggtttctgacggtggttctgaatcccagatcttggacctctcaaaccgcttctatactctgatccctcatgactttgggatgaagaaaccacctcttctcagtaacttggaatacattcaggctaaagtgcagatgttggacaacttgctcgatattgaggttgcttacagtcttctcagaggtggaaatgaagatggagacaaagacccaattgatatcaattatgaaaagctccgaactgatattaaggtggttgacaaagattcagaagaagccaagattattaaacaatacgtgaaaaatactcatgctgctactcacaatgcatatgacctcaaagttgtggaaatcttcaggattgaacgtgaaggagagagtcagcgttacaagccatttaagcagcttcataatcgccagctgctgtggcacggttcccgcaccaccaacttcgctggtatcctctcacagggtctccggatagctccccctgaagctcctgtgaccggctacatgtttgggaagggcatctactttgcagatatggtttccaagagtgccaactactgtcacacatctcaagctgatccaattgggttaatactactgggagaagttgccctcggaaatatgtatgagctaaagaatgcttctcacataacaaaattgcccaagggaaaacatagtgtgaaaggcttgggcaaaactgcacctgatcccacagccactacaacccttgatggtgtagaagttcccttagggaatgggatctcaacaggaattaatgatacttgtctgctgtacaatgaatatattgtgtatgatgttgctcaggtaaatctgaagtacctgctgaaactgaaattcaactataagacatcactctggtgaacagtagttaggagtcctgttagttatactgtagttacactatagagttgacttctgacttgcttaagcattgacttcacttatcaagataccaagagctaaactgcaagagcggttactaaatcctatttagtacaacagttagtgaaagtttttatataatgtggcaacacaaggacctgaattctgttgagaatgcttagttggttttgttttacaccgcttctatttgtgggggctatcaagtgtttcttttgattggccgaacaaaatagatgacaacaacagcaacagaagtgttttttagccagaggtgggcgatagcagagaaggaacttgagggtgtttgtgatgtttgctctgttagggttcccacttgtttaagataccccttttcagtttccattttgaataaatgataaatgtgcatttattttgaggttaaaaaaacaataaaagataatttcatactaacagctttacgtttcaaaatttccgaattgttctgctttgagtaatcattcaaacgtatctgctggcgttttcttgaagagatatatctctctgatggtcaaatgccaaacattaatatc
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
[Full Text]