LOCUS       NM_205249               1332 bp    mRNA    linear   VRT 17-FEB-2024
DEFINITION  Gallus gallus homeobox D12 (HOXD12), mRNA.
ACCESSION   NM_205249
VERSION     NM_205249.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Kamiyama,N., Seki,R., Yokoyama,H. and Tamura,K.
  TITLE     Heterochronically early decline of Hox expression prior to
            cartilage formation in the avian hindlimb zeugopod
  JOURNAL   Dev Growth Differ 54 (6), 619-632 (2012)
   PUBMED   22708793
  REMARK    GeneRIF: Expression of Hoxd11/Hoxd12 in the chick hindlimb
            decreased and disappeared from the presumptive zeugopod region
            before cartilage formation.
REFERENCE   3  (bases 1 to 1332)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1332)
  AUTHORS   Kataoka,K., Yoshitomo-Nakagawa,K., Shioda,S. and Nishizawa,M.
  TITLE     A set of Hox proteins interact with the Maf oncoprotein to inhibit
            its DNA binding, transactivation, and transforming activities
  JOURNAL   J Biol Chem 276 (1), 819-826 (2001)
   PUBMED   11036080
REFERENCE   5  (bases 1 to 1332)
  AUTHORS   Mackem,S. and Mahon,K.A.
  TITLE     Ghox 4.7: a chick homeobox gene expressed primarily in limb buds
            with limb-type differences in expression
  JOURNAL   Development 112 (3), 791-806 (1991)
   PUBMED   1682126
REFERENCE   6  (bases 1 to 1332)
  AUTHORS   Izpisua-Belmonte,J.C., Tickle,C., Dolle,P., Wolpert,L. and
            Duboule,D.
  TITLE     Expression of the homeobox Hox-4 genes and the specification of
            position in chick wing development
  JOURNAL   Nature 350 (6319), 585-589 (1991)
   PUBMED   1673231
REFERENCE   7  (bases 1 to 1332)
  AUTHORS   Nohno,T., Noji,S., Koyama,E., Ohyama,K., Myokai,F., Kuroiwa,A.,
            Saito,T. and Taniguchi,S.
  TITLE     Involvement of the Chox-4 chicken homeobox genes in determination
            of anteroposterior axial polarity during limb development
  JOURNAL   Cell 64 (6), 1197-1205 (1991)
   PUBMED   1672266
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAENSK010000236.1.
            
            On Sep 23, 2021 this sequence version replaced NM_205249.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X62019.1, HAEL01007512.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992604, SAMEA3109051
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               JAENSK010000236.1  8580089-8580657     c
            570-1332            JAENSK010000236.1  8579055-8579817     c
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="7"
                     /map="7"
     gene            1..1332
                     /gene="HOXD12"
                     /note="homeobox D12"
                     /db_xref="CGNC:7046"
                     /db_xref="GeneID:396178"
     exon            1..569
                     /gene="HOXD12"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..808
                     /gene="HOXD12"
                     /note="Ghox 4.7; homeo box D12; chox-4F; chox-4.7;
                     ghox-4.7; homeobox protein Hox-4F; homeobox protein
                     Hox-4.7; Hox D12"
                     /codon_start=1
                     /product="homeobox protein Hox-D12"
                     /protein_id="NP_990580.1"
                     /db_xref="CGNC:7046"
                     /db_xref="GeneID:396178"
                     /translation="

MCDRSLYRSGYVGSLLNLQSPDSFYFPNLRANGSQLAALPTISYPRSSIPWTCPSPCAAQPQGHAFGGAAQPYLPGSVPISISSNSNKECLEENSKYYAHDASSKQEERCRQRQSFANDPTITHAANLKPAKYDHSSLPRSLHGSAALFEVNSCTSSLKEDIKNSVNLNLTVQPAAVQSCLRPSVQDGLPWCPTQGRSRKKRKPYTKQQIAELENEFLLNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVMREQALSMY"

     misc_feature    602..772
                     /gene="HOXD12"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            570..1332
                     /gene="HOXD12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gttggaaatgtgtgatcgcagtctctacagatctggctacgttggttctctcttgaacttgcaatctccagattccttttattttcccaatttgcgggctaatggcagtcagttggcggctctgcccaccatttcctacccccggagctcgatcccgtggacgtgccccagtccgtgcgcagctcagccgcagggccacgcgttcggcggcgcggcgcagccgtacctccccggctccgttccaatcagcatcagctccaacagcaacaaagagtgcctggaagaaaacagtaaatattacgcccacgacgcgagctccaaacaagaggaaagatgcaggcagaggcaatctttcgcaaatgacccaactattactcacgcagccaacttaaagcccgcaaagtatgaccactcgagcctgccgaggagcttgcacggctcggccgctctttttgaagtgaattcctgcacttccagcctaaaggaggacatcaagaattcggtcaacttgaacctgacagttcagcccgcggcagtccagtcatgcctcagaccttcagtgcaggatggtttgccttggtgccccacccaggggagatcgcgaaagaaacggaaaccgtacacaaaacagcaaatcgccgaattggaaaacgagtttctcctcaatgagtttattaaccgacagaagaggaaagaactatcaaacagactgaatttaagcgaccagcaagtgaaaatttggtttcagaaccgacgaatgaaaaagaaaagagtggtaatgcgcgagcaggcgctctctatgtactagcgcggcgcccgcccgttcccgcatgaacttgcgttcgccccgtagagtagcgtgtggtcgcggctgcgaggcgggagctgggtgggttttcccctttaagccgagctctcggaacgcgtaggatccccgcgtgcgtcggcaaccgctgagctcttaggcagagcgaagaagacgagccagcccagcactgaaacccgtattatcagcttttccccctttctttctccttttatatagatcttctccctcttctaaccccctctttccccggagaacgtgcggcgctaaactaaaatcgatgcctttttaactgtatgtaaacaccactttgcaggaaaaaaaaaaaaaaaaaagaataaaagaataatgcctagtaaagacgtctgtaaatgccggctggtcccttcatgtgttccccgcttctgaaggcgagcatgcggcgctcgcgtgttttgtggtttggaataacctgttggagcacagatcgcacaaagcggttaccaaataaacctttttagttttca

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