LOCUS       NM_001397733            3078 bp    mRNA    linear   VRT 08-APR-2024
DEFINITION  Gallus gallus scinderin (SCIN), transcript variant 2, mRNA.
ACCESSION   NM_001397733 XM_040681278
VERSION     NM_001397733.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3078)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 3078)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3078)
  AUTHORS   Nurminsky,D., Magee,C., Faverman,L. and Nurminskaya,M.
  TITLE     Regulation of chondrocyte differentiation by actin-severing protein
            adseverin
  JOURNAL   Dev Biol 302 (2), 427-437 (2007)
   PUBMED   17097081
  REMARK    GeneRIF: Adseverin-induced rearrangements of the actin cytoskeleton
            may mediate activation of MAP signaling pathways necessary for
            chondrocyte hypertrophy, as evidenced by changes in cell
            morphology, and expression of chondrocyte maturation markers.
REFERENCE   4  (bases 1 to 3078)
  AUTHORS   Caldwell,R.B., Kierzek,A.M., Arakawa,H., Bezzubov,Y., Zaim,J.,
            Fiedler,P., Kutter,S., Blagodatski,A., Kostovska,D., Koter,M.,
            Plachy,J., Carninci,P., Hayashizaki,Y. and Buerstedde,J.M.
  TITLE     Full-length cDNAs from chicken bursal lymphocytes to facilitate
            gene function analysis
  JOURNAL   Genome Biol 6 (1), R6 (2005)
   PUBMED   15642098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000036.1.
            
            On Nov 27, 2021 this sequence version replaced XM_040681278.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13267658.5464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992428, SAMEA103992470
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               JAENSK010000036.1  18814996-18815154
            160-252             JAENSK010000036.1  18823272-18823364
            253-385             JAENSK010000036.1  18824562-18824694
            386-474             JAENSK010000036.1  18826462-18826550
            475-690             JAENSK010000036.1  18826755-18826970
            691-812             JAENSK010000036.1  18828182-18828303
            813-903             JAENSK010000036.1  18828520-18828610
            904-1074            JAENSK010000036.1  18831052-18831222
            1075-1252           JAENSK010000036.1  18831702-18831879
            1253-1374           JAENSK010000036.1  18832346-18832467
            1375-1452           JAENSK010000036.1  18834004-18834081
            1453-1513           JAENSK010000036.1  18835430-18835490
            1514-3078           JAENSK010000036.1  18836407-18837971
FEATURES             Location/Qualifiers
     source          1..3078
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="2"
                     /map="2"
     gene            1..3078
                     /gene="SCIN"
                     /note="scinderin"
                     /db_xref="CGNC:8188"
                     /db_xref="GeneID:420588"
     exon            1..159
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    133..135
                     /gene="SCIN"
                     /note="upstream in-frame stop codon"
     exon            160..252
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1647
                     /gene="SCIN"
                     /note="isoform 2 is encoded by transcript variant 2;
                     adseverin"
                     /codon_start=1
                     /product="scinderin isoform 2"
                     /protein_id="NP_001384662.1"
                     /db_xref="CGNC:8188"
                     /db_xref="GeneID:420588"
                     /translation="

MADIANRKSAKLYMVSDASGSMKLSVVAEENPFSMAMLLSEECFILDNGAARKIFVWKGKDANPQERKAAMKNAETFVQQMNYPANTQIQVLPEGGETPIFKQFFKDWKDKDQSDGFGKVYVTERVAKIEQIEFDATKLHESPQMAAQHNMIDDGSGKVQIWRVESSGRVPVEPETYGQFYGGDCYIILYTYPKGQIIYTWQGACATKDELTASAFLTVQLDRSLNDQAVQIRVSQGKEPPHLLSLFKNKPLTVYKNGTSKKEGQKPAPPTRLFQIRRNLMSVTRIAEVDVDAMSLNSNDAFVLKLPNNTGYTWVGKGVNKEEEQGAQYIASVLKCQTAKINEGQEPEEFWKALGGKKKYQTSSQLLTKAEDHPPRLFGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQVFVWIGKEANETERQESVKSAKRYIETDPSGRDKGTPIVIVKQGHEPPTFTGWFLAWDSNKWKN"

     misc_feature    238..531
                     /gene="SCIN"
                     /note="Gelsolin sub-domain 3-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S3_like; cd11292"
                     /db_xref="CDD:200448"
     misc_feature    order(514..516,529..531)
                     /gene="SCIN"
                     /note="putative nucleotide binding site [chemical
                     binding]; other site"
                     /db_xref="CDD:200448"
     misc_feature    661..951
                     /gene="SCIN"
                     /note="Gelsolin sub-domain 4-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S4_like; cd11293"
                     /db_xref="CDD:200449"
     misc_feature    order(709..714,814..816,832..837,841..849,853..861,
                     865..870,901..903,907..909)
                     /gene="SCIN"
                     /note="putative actin binding interface [polypeptide
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    922..924
                     /gene="SCIN"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200449"
     misc_feature    1015..1287
                     /gene="SCIN"
                     /note="Gelsolin sub-domain 5-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S5_like; cd11288"
                     /db_xref="CDD:200444"
     misc_feature    1039..1041
                     /gene="SCIN"
                     /note="putative nucleotide binding residue [chemical
                     binding]; other site"
                     /db_xref="CDD:200444"
     misc_feature    1330..1626
                     /gene="SCIN"
                     /note="Gelsolin sub-domain 6-like domain found in
                     gelsolin, severin, villin, and related proteins; Region:
                     gelsolin_S6_like; cd11291"
                     /db_xref="CDD:200447"
     exon            253..385
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            386..474
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            475..690
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            691..812
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            813..903
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1074
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1252
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1374
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1452
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1513
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..3078
                     /gene="SCIN"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agactgcacatggcttggatcttccactgagttgacttcagtatcgcttagcagatttcacaagctcatcacttggcccagtgttttccccaggcctaaatcagcaggggttctgccctgaagagcagaggctgaccaggaggagtcttaaggaacgttgtcttaggggaaaagccagagcttcctgaatgtagtgatgatgacgatgagatggctgatattgcaaatcggaagagtgctaaactctatatggtgtcagatgcaagtggatccatgaagttgtcagtggtagcagaggaaaaccctttctctatggctatgcttttgtcagaggaatgcttcatcctggacaatggtgctgcaaggaagatctttgtgtggaaaggcaaagatgctaacccacaggaaagaaaggctgccatgaagaatgctgaaacattcgtacagcagatgaattatcctgccaacacacagattcaagtgcttccagaaggaggtgaaacgccaattttcaaacaatttttcaaagactggaaggataaagatcaaagcgatggcttcggcaaagtatatgtcacagagagagtggctaaaattgagcagattgaatttgatgctaccaagttacatgagtctccacaaatggctgcacagcataacatgatagatgatggctcagggaaagtacagatctggcgtgtggaaagcagtggcagagttcctgtggaacccgaaacgtatggacagttctatggtggtgactgttacatcatcctatacacatatcctaaagggcagatcatctacacatggcaaggagcctgtgctacaaaagatgaactgactgcatctgcatttctgactgttcagctcgaccggtcattgaatgatcaggctgtgcagattcgagtcagtcaaggcaaagaacctccccatttactgagcctgttcaaaaataaaccacttactgtctacaagaatggaacatccaagaaggaaggtcagaaacctgctccacccacacggctcttccaaatacgcaggaacctaatgtccgttaccaggattgctgaggttgatgttgatgcaatgtcactgaattccaatgatgcctttgttctgaaacttccaaacaacactggttacacctgggtgggaaaaggagtaaacaaagaagaggaacaaggagctcaatacattgccagtgttcttaagtgccagactgctaagattaatgaaggccaggaaccagaggaattctggaaagcacttggaggtaaaaaaaaatatcagacttcatctcagcttttgacaaaggctgaagatcatcctcctcgcctgtttggttgttctaataagaccggcagatttattattgaggaggtcccaggagaattcactcaggatgatttggctgaagatgatgtcatgttactagatgcttgggagcaggtttttgtctggattgggaaagaagctaatgaaactgaacgacaggaatccgttaaatctgccaaacgctatattgaaacagacccttctggcagagataaggggacccccatcgttatagtgaagcaggggcatgagcccccaaccttcacgggctggttcctggcttgggattccaacaaatggaaaaactgagctacccaagagagcttcagcttcaagccaaagaatcatgagtgcacaactattttctagtatttttaagcataagcttatgcaacaacatgatgcagatcttgttaccctttgctgagctttgatatctttatatgaataacttagcggttctcagtgctggataggatgaatgataattgtcaagtgaggtgggtggggcttttcacgtaggaaatatgcaacctatgaattcttcacaaaagtggaccagtttattttactttgcaaagatgggccaaattctgccttcccttaacaattcaaaccaatgccaaagaaactcctttagtgtaaagacagcataattttgtgcataatttggctggtgtagaatttcagacaatgcctgatgcagagctttgtcttgcaaggggcaaacaagagatgagtattttgacacagctgttcttaacatgtctgtttgctgtccttggtctagatattataattggagcttaggattgtacacttgtaagaatatgaaggtgttttgtggtgcgtagggtttttttttttttttagattctatctaaatcattttaatggattttaggtttctctatgcaaaccagcctccagctccacatctttttaactgaagctctcacgcacattttagggaactacttttcagtggaagcagaagtaacagcttcaaaaatacttactctgccttaaccagaccgcacttaagccatactttgccttgattgccttactcagcagtccctcgtgctttcatggcatgtaatttgttcacattgtcaggtacaggatatgtttccaactcattttctaaacaggtctcagtcaaatatcagcatggaaactgcttttttcagcagcattcctgggaatttggagtatgaggaagcaccacataagtttctctcagacacagctatttgggatttctttttttgtattctggtgaatttaagagcatatcttcaaagtatgtttttttaagttgtagctttgccagaaaagtctccttaagggcattaggaaaaatcctgctacaaatctatagcgctgctttaagcatttatcctagaatgcttgttttaaacaatttgtacagcagtaaatcatgttaatgtggctttttaacgaaggcttttcaacacttttgttgttctcataagatagtttggaaagtgaacattttagttattttttactttttatgattgtgattttgaatctgagttatgcaaaagagtgaattttatctgagctcataataacattgacaaaaactaaagagaagctaagtcaattaattcagggagttttttcagccttaaacattcatttagatcctttcttaaataactgggctgtatctggatgtcatttcatttaaaataaaattatgaaacagta

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