LOCUS       NM_001396407            1452 bp    mRNA    linear   VRT 17-FEB-2024
DEFINITION  Gallus gallus gastrulation brain homeobox 1 (GBX1), mRNA.
ACCESSION   NM_001396407 XM_003640629 XM_040664937
VERSION     NM_001396407.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Obinata,A. and Akimoto,Y.
  TITLE     Effects of retinoic acid and Gbx1 on feather-bud formation and
            epidermal transdifferentiation in chick embryonic cultured dorsal
            skin
  JOURNAL   Dev Dyn 241 (9), 1405-1412 (2012)
   PUBMED   22826214
  REMARK    GeneRIF: Gbx1 was involved in the feather-bud formation and was one
            of target genes of retinoic acid and other signals in addition to
            Gbx1 were required for epidermal mucous transdifferentiation.
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1452)
  AUTHORS   Obinata,A., Akimoto,Y., Omoto,Y. and Hirano,H.
  TITLE     Increase in expression of the homeobox gene, GBX1, in
            retinol-induced epidermal mucous metaplasia
  JOURNAL   Biochem Biophys Res Commun 280 (4), 1055-1061 (2001)
   PUBMED   11162634
REFERENCE   5  (bases 1 to 1452)
  AUTHORS   Fainsod,A. and Greunbaum,Y.
  TITLE     A chicken homeo box gene with developmentally regulated expression
  JOURNAL   FEBS Lett 250 (2), 381-385 (1989)
   PUBMED   2473919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000035.1 and AB050015.1.
            
            On or before Oct 17, 2021 this sequence version replaced
            XM_003640629.5, XM_040664937.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB050015.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3109051, SAMN02738216
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-343               JAENSK010000035.1  195186-195528
            344-1348            AB050015.1         1-1005
            1349-1433           JAENSK010000035.1  201448-201532
            1434-1452           AB050015.1         1091-1109
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="2"
                     /map="2"
     gene            1..1452
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /note="gastrulation brain homeobox 1"
                     /db_xref="CGNC:49289"
                     /db_xref="GeneID:395377"
     exon            1..645
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             186..1166
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /note="transcription factor Gbx-1"
                     /codon_start=1
                     /product="homeobox protein CHOX-7"
                     /protein_id="NP_001383336.1"
                     /db_xref="CGNC:49289"
                     /db_xref="GeneID:395377"
                     /translation="

MQRPSGQGTAFSIDSLIGTPPPRSGHLLYTGYPMFMPYRPLVLPQALSHAPLQSGLPPLAPLASFAGRLTNTFCASLGQAVPSMVALTTALPSFSEPPDGFYPPQELPPPRATPDAGCRRGAEGLEPEELPPGRDKGPPEPPLHFPDPFPGLADAKAYSSDEEKLEVKSAATPCSEREEESSAGDSEEEPFLDGAAAAALGPKGKGKGGPAAEQPPPGSGAGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLSEVQVKIWFQNRRAKWKRIKAGNVSNRSGEPVRNPKIVVPIPVHVNRFAVRSQHQQIEQGARP"

     misc_feature    708..>1064
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /note="Homeodomain-containing transcription factor
                     [Transcription]; Region: COG5576"
                     /db_xref="CDD:227863"
     misc_feature    858..1028
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            646..1438
                     /gene="GBX1"
                     /gene_synonym="CHOX-7; CHox7; GBX-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctccactccgccgcgccgaggcagcgagcgggcgggcgggcggcagctctcgccgggcgccggagcccacgggaggcggcgggcgggggccggggccgcggcggggcccgggggtgcggcgagttggcggcggcccgagctcgccggaaagttggtgccggctgagccggcggcgcccgctcgccatgcagagacccagcggccaggggaccgccttttccatcgactcgctcatcgggacgccgccgccgcgctccgggcacctgctgtacaccgggtaccccatgttcatgccgtaccggccgctggtgctgccgcaggcgctgtcccacgcgccgctgcagtcggggctgccgccgctcgcaccgctggcctctttcgccggccgcctcaccaacacgttctgcgccagcctgggccaggccgtgccctccatggtggccctcaccacggcgctgcccagcttctccgagccccccgacggcttctacccaccgcaggagctgcccccgccgcgcgccacccccgacgccggctgccgacggggcgccgagggcctggagccggaggagctgcccccggggcgcgacaaagggccgcccgagccgccgctgcacttcccggaccccttcccaggcctggcagacgccaaggcgtacagctcggacgaggagaagctggaggtgaaatcggcagcgacgccgtgcagcgaacgggaggaggagagctcggcgggcgacagcgaggaggagcccttcctggacggggcggccgcggccgcgctgggccccaaggggaaggggaagggcggccccgcggccgagcagcctccgccgggctccggggccgggaagagccgccggcggcgcacggcctttacgagcgagcagctgctggagctggagaaggagttccactgcaagaagtacctctcgctgacggagcgctcgcagatcgcgcacgccctgaagctgagcgaggtgcaggtgaagatctggttccagaaccgccgcgctaagtggaaacgcatcaaggcgggcaacgtcagcaaccgctcgggagagcccgtccgcaaccccaagatcgtggtgcccatcccggtgcacgtcaatcgcttcgccgtgcgcagccagcaccagcagatcgagcagggggcccgaccctgagccgcggcggctcccggaccctggggcgggcggagcgccggcagcgggaggggcccggggccgctcgcactcctctgtacatgtcccttatttattccgtgtaaactctgtacatacggcggcgcgtccgtccgtccgagccgcggggagcgagggccgcctgcccaccgccacccgttcacgtctgctcctgccccgccgggccggggccgcgctgtccgccagcgcccgcccgtgtatagctgtgatttcaataaattattttctatggaaaaaaaaaaaaaaa

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