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Previous release (v1)
2026-01-17 21:54:11, GGRNA.v2 : RefSeq release 232 (Sep, 2025)
LOCUS NM_001031430 4444 bp mRNA linear VRT 01-MAY-2025
DEFINITION Gallus gallus spleen associated tyrosine kinase (SYK), mRNA.
ACCESSION NM_001031430 XM_424855
VERSION NM_001031430.2
KEYWORDS RefSeq.
SOURCE Gallus gallus (chicken)
ORGANISM Gallus gallus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
REFERENCE 1 (bases 1 to 4444)
AUTHORS Tang,H., Finn,R.D. and Thomas,P.D.
TITLE TreeGrafter: phylogenetic tree-based annotation of proteins with
Gene Ontology terms and other annotations
JOURNAL Bioinformatics 35 (3), 518-520 (2019)
PUBMED 30032202
REFERENCE 2 (bases 1 to 4444)
AUTHORS Stepanek,O., Draber,P., Drobek,A., Horejsi,V. and Brdicka,T.
TITLE Nonredundant roles of Src-family kinases and Syk in the initiation
of B-cell antigen receptor signaling
JOURNAL J Immunol 190 (4), 1807-1818 (2013)
PUBMED 23335753
REMARK GeneRIF: Analysis of controlled B cell receptor triggering ex vivo
and on primary murine B cells reveals that Src family kinases are
required for signal initiation and Syk activation.
REFERENCE 3 (bases 1 to 4444)
AUTHORS Losing,M., Goldbeck,I., Manno,B., Oellerich,T., Schnyder,T.,
Bohnenberger,H., Stork,B., Urlaub,H., Batista,F.D., Wienands,J. and
Engelke,M.
TITLE The Dok-3/Grb2 protein signal module attenuates Lyn
kinase-dependent activation of Syk kinase in B cell antigen
receptor microclusters
JOURNAL J Biol Chem 288 (4), 2303-2313 (2013)
PUBMED 23223229
REMARK GeneRIF: The Dok-3/Grb2 protein signal module attenuates Lyn
kinase-dependent activation of Syk kinase in B cell antigen
receptor microclusters
REFERENCE 4 (bases 1 to 4444)
AUTHORS Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
TITLE Manual GO annotation of predictive protein signatures: the InterPro
approach to GO curation
JOURNAL Database (Oxford) 2012, bar068 (2012)
PUBMED 22301074
REMARK Publication Status: Online-Only
REFERENCE 5 (bases 1 to 4444)
AUTHORS Chen,C.H., Martin,V.A., Gorenstein,N.M., Geahlen,R.L. and Post,C.B.
TITLE Two closely spaced tyrosines regulate NFAT signaling in B cells via
Syk association with Vav
JOURNAL Mol Cell Biol 31 (14), 2984-2996 (2011)
PUBMED 21606197
REMARK GeneRIF: Results suggest that the uncommon recognition determinant
of two closely spaced tyrosines is a limiting factor in NFAT
signaling via Syk association with Vav1.
REFERENCE 6 (bases 1 to 4444)
AUTHORS Oh,H., Ozkirimli,E., Shah,K., Harrison,M.L. and Geahlen,R.L.
TITLE Generation of an analog-sensitive Syk tyrosine kinase for the study
of signaling dynamics from the B cell antigen receptor
JOURNAL J Biol Chem 282 (46), 33760-33768 (2007)
PUBMED 17913708
REMARK GeneRIF: Syk tyrosine kinase has a role in signaling dynamics of
the B cell antigen receptor
REFERENCE 7 (bases 1 to 4444)
AUTHORS Chung,S.C., Limnander,A., Kurosaki,T., Weiss,A. and Korenbrot,J.I.
TITLE Coupling Ca2+ store release to Icrac channel activation in B
lymphocytes requires the activity of Lyn and Syk kinases
JOURNAL J Cell Biol 177 (2), 317-328 (2007)
PUBMED 17452533
REMARK GeneRIF: The simultaneous but not the independent suppression of
Lyn and Syk expression prevents the activation of Ca2+-release
activated Ca2+ current without interfering with
thapsigargin-sensitive Ca(2+) store release in DT40 B lymphocyte
cells.
REFERENCE 8 (bases 1 to 4444)
AUTHORS Caldwell,R.B., Kierzek,A.M., Arakawa,H., Bezzubov,Y., Zaim,J.,
Fiedler,P., Kutter,S., Blagodatski,A., Kostovska,D., Koter,M.,
Plachy,J., Carninci,P., Hayashizaki,Y. and Buerstedde,J.M.
TITLE Full-length cDNAs from chicken bursal lymphocytes to facilitate
gene function analysis
JOURNAL Genome Biol 6 (1), R6 (2005)
PUBMED 15642098
REFERENCE 9 (bases 1 to 4444)
AUTHORS Qin,S. and Chock,P.B.
TITLE Bruton's tyrosine kinase is essential for hydrogen peroxide-induced
calcium signaling
JOURNAL Biochemistry 40 (27), 8085-8091 (2001)
PUBMED 11434777
REMARK GeneRIF: In hydrogen peroxide-stimulated DT40 cells, BLNK is
phosphorylated by Syk and not by Btk.
REFERENCE 10 (bases 1 to 4444)
AUTHORS Fu,C., Turck,C.W., Kurosaki,T. and Chan,A.C.
TITLE BLNK: a central linker protein in B cell activation
JOURNAL Immunity 9 (1), 93-103 (1998)
PUBMED 9697839
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence was derived from
JAENSK010000094.1.
On Sep 23, 2021 this sequence version replaced NM_001031430.1.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: AJ720543.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMEA103992290, SAMEA103992323
[ECO:0000348]
##Evidence-Data-END##
PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP
1-170 JAENSK010000094.1 9714611-9714780
171-624 JAENSK010000094.1 9730942-9731395
625-785 JAENSK010000094.1 9731996-9732156
786-924 JAENSK010000094.1 9740979-9741117
925-1006 JAENSK010000094.1 9742925-9743006
1007-1053 JAENSK010000094.1 9743937-9743983
1054-1147 JAENSK010000094.1 9755778-9755871
1148-1325 JAENSK010000094.1 9756508-9756685
1326-1535 JAENSK010000094.1 9757803-9758012
1536-1725 JAENSK010000094.1 9758452-9758641
1726-1866 JAENSK010000094.1 9759933-9760073
1867-1979 JAENSK010000094.1 9760319-9760431
1980-4444 JAENSK010000094.1 9763932-9766396
FEATURES Location/Qualifiers
source 1..4444
/organism="Gallus gallus"
/mol_type="mRNA"
/db_xref="taxon:9031"
/chromosome="Z"
/map="Z"
gene 1..4444
/gene="SYK"
/note="spleen associated tyrosine kinase"
/db_xref="CGNC:53036"
/db_xref="GeneID:427272"
exon 1..170
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 171..624
/gene="SYK"
/inference="alignment:Splign:2.1.0"
misc_feature 175..177
/gene="SYK"
/note="upstream in-frame stop codon"
CDS 211..2052
/gene="SYK"
/EC_number="2.7.10.2"
/note="spleen tyrosine kinase"
/codon_start=1
/product="tyrosine-protein kinase SYK"
/protein_id="NP_001026601.2"
/db_xref="CGNC:53036"
/db_xref="GeneID:427272"
/translation="
MASNMANPANHLPYFFGNITREEAEEYLMQGGMSDGLYLLRQSRNYLGGFALSLAYGRKVHHYTIERELSGTYAIAGGKSHASPAELINYHSEEADGLICLLRKSFNRPPGVEPKTGPFEDLKENLIREYVKQTWNLQGHALEQAIISQKPQLEKLIATTAHEKMPWFHGRISREESEHRILIGSRNNGKFLIRERDSNGSYALCLLNDGKVLHYRIDRDKTGKLSIPDGKRFDTLWQLVEHYSYKPDGLLRVLSIPCPRHGSESDNVVFDTRPLPGTPSKLQTPIGAPSDDQTPFNPYVLQRARGLIGAEKGDQREALPMDTEVYESPYADPDEIKPKNVTLDRKLLTLEEGELGSGNFGTVKKGFYKMKKGAKPVAVKILKNESNDPAIKDELLREANVMQQLDNPYIVRMIGICEAEAWMLVMEMAELGPLNKFLQKNRHVTEKNITELVHQVSMGMKYLEENNFVHRDLAARNVLLVTQHYAKISDFGLSKALSADENYYKAQSHGKWPVKWYAPECMNFYKFSSKSDVWSFGVLMWEAFSYGQKPYKGMKGGEVAQMIERGERMECPEACPVEVYDLMKLCWTYNVDDRPGFVAVELRLRNYYYDISH"
misc_feature 244..555
/gene="SYK"
/note="N-terminal Src homology 2 (SH2) domain found in
Zeta-chain-associated protein kinase 70 (ZAP-70) and
Spleen tyrosine kinase (Syk) proteins; Region:
SH2_N-SH2_Zap70_Syk_like; cd09938"
/db_xref="CDD:198191"
misc_feature order(271..273,331..333,394..396,400..402)
/gene="SYK"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198191"
misc_feature order(397..399,433..438,442..444,499..504)
/gene="SYK"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198191"
misc_feature 529..708
/gene="SYK"
/note="propagated from UniProtKB/Swiss-Prot (F1N9Y5.2);
Region: Interdomain A"
misc_feature 697..993
/gene="SYK"
/note="C-terminal Src homology 2 (SH2) domain found in
Spleen tyrosine kinase (Syk) proteins; Region:
SH2_C-SH2_Syk_like; cd10401"
/db_xref="CDD:198264"
misc_feature order(730..732,790..792,796..798,850..852,856..858)
/gene="SYK"
/note="phosphotyrosine binding pocket [polypeptide
binding]; other site"
/db_xref="CDD:198264"
misc_feature order(853..855,889..891,898..900,955..957)
/gene="SYK"
/note="hydrophobic binding pocket [polypeptide binding];
other site"
/db_xref="CDD:198264"
misc_feature 985..1254
/gene="SYK"
/note="propagated from UniProtKB/Swiss-Prot (F1N9Y5.2);
Region: Interdomain B"
misc_feature 1267..2037
/gene="SYK"
/note="Catalytic domain of the Protein Tyrosine Kinase,
Spleen tyrosine kinase; Region: PTKc_Syk; cd05116"
/db_xref="CDD:133247"
misc_feature order(1273..1281,1288..1290,1297..1299,1342..1344,
1348..1350,1402..1404,1441..1443,1486..1500,1504..1509,
1624..1626,1636..1641,1645..1647,1675..1680,1735..1749,
1774..1776,1876..1878)
/gene="SYK"
/note="active site"
/db_xref="CDD:133247"
misc_feature order(1273..1281,1288..1290,1297..1299,1342..1344,
1348..1350,1402..1404,1441..1443,1486..1500,1504..1509,
1636..1641,1645..1647,1675..1680)
/gene="SYK"
/note="ATP binding site [chemical binding]; other site"
/db_xref="CDD:133247"
misc_feature order(1624..1626,1636..1638,1735..1749,1774..1776,
1876..1878)
/gene="SYK"
/note="polypeptide substrate binding site [polypeptide
binding]; other site"
/db_xref="CDD:133247"
misc_feature 1675..1755
/gene="SYK"
/note="activation loop (A-loop); other site"
/db_xref="CDD:133247"
exon 625..785
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 786..924
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 925..1006
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1007..1053
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1054..1147
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1148..1325
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1326..1535
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1536..1725
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1726..1866
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1867..1979
/gene="SYK"
/inference="alignment:Splign:2.1.0"
exon 1980..4444
/gene="SYK"
/inference="alignment:Splign:2.1.0"
ORIGIN
gaggaagtggccgcggctgcgagagaagacgaggaagcagcggctcccgcaacgcctagctcgggtacagctccactgttggcggagccgcgccgctctgctcgctcccgggagcggtaggagccgccggtgggcggcagtaggcagtgagcggaggagccgcggcagcggcattaaacattaattgactacttggaaagaaaaaaaatcatggcttccaacatggccaaccctgctaaccatttgccatacttctttggcaatattacacgtgaggaagctgaggagtatttgatgcaaggaggaatgagcgatggactatacctgcttcgccaaagccggaattacctagggggctttgccttgtccttggcctatggaaggaaggttcatcattacacaattgagagagagctgagtgggacatatgctattgcaggaggcaaatcacatgcaagtcctgctgaactcattaactatcattcagaagaagcagatggccttatctgtctactgagaaaatctttcaatcgaccgccaggcgttgagcccaaaacagggccctttgaagatttaaaagagaacctcatcagagagtatgtcaagcaaacgtggaatctgcagggtcatgctcttgaacaagctatcattagccaaaaacctcagctggagaaactgattgctactacagcccatgagaagatgccttggttccatgggaggatctctcgggaagagtcagagcaccgtatcctcattgggtcaagaaacaacggaaaatttttaatacgagaaagggacagcaatggttcctatgccctgtgtttgctcaatgatggaaaagtactgcattaccgtattgacagagataagacaggaaagctctccataccagatggaaaaagatttgacaccctctggcagttagttgagcattattcttacaaaccggatggattattaagggttctgtccattccctgtccacggcatggctcagaaagtgataatgttgtttttgacactcgtcctctccctggaaccccttctaagctccagacacctattggtgccccatctgatgaccaaacaccttttaatccttatgtactgcaaagggcaagaggtctaataggagcagagaaaggtgatcagagagaggccttacccatggacactgaggtttatgaaagtccatatgctgatccagatgaaattaaaccaaaaaatgtcactctcgacaggaaattgttaaccctggaggaaggagaacttggctctggaaactttggtactgtaaagaaagggttctataagatgaaaaagggggccaagccagtggctgtaaaaattcttaagaacgagagcaatgatccagccataaaggatgagttactgagagaagcaaatgtaatgcagcaactggacaatccatatattgtccgaatgataggtatatgtgaagcagaggcctggatgttagtaatggaaatggctgaacttgggccactgaacaagtttttgcaaaaaaataggcacgtcacagaaaagaatataacagagctggtacatcaggtttccatgggaatgaaatatctggaggagaataactttgtacatagggatctggctgcaaggaacgtgctattagtcacccagcattatgccaaaatcagtgacttcggactatctaaggctcttagtgctgatgaaaattattacaaggcacaaagtcatggaaaatggccagtcaagtggtatgctccagaatgtatgaatttctacaagttttccagcaaaagtgatgtctggagctttggagttttaatgtgggaagctttctcttatgggcaaaagccctataaaggaatgaaaggtggtgaagttgcacagatgattgaaagaggagaacgaatggaatgtcctgaagcctgtccagtggaagtctatgacttaatgaaattatgttggacatacaatgttgatgaccgaccaggattcgttgccgtggagctgcgattacggaactactattacgacatttcccactaacagtgtgaacagcagcttgcctttcttcagcaaagagaagcagttcagattctgaaactaagtgacatatttttgtactgtcaccttcaccatagtgaagagctcttcaccaaagtgaagagctaagccctgtgtgtgaggttgcgtttttttgtttgtttgtttgttttggttttttctggctttcttgtggagtaccaagctctgaagtagagcagcacaacataagtgcagatgcatagactgccattacattccattttatttacagctttattgtctttacattcttctgtcatgaacctatttaaagtctttcagccctcttcctcttatgtatttgagtgcagatggggatttaaatttttgttgttcatattcttagctctcaaattgtgtcattccagccttctccctatttgagaaagaatagcataaacatttttttttaggactagagggaatggcttcaagctgcgccagggaagattcaggctggacattaggaaatactacttctctgagagggtggtcaggcactggaatgggctgcccagagaggtggtggagtcaccgaccctggtggtgttcaaagagcgtttggatgttgtgttgagggacatggtttagcgagaaccattggtgaagggtgaatggttggactggatgatcctgtgggtcttttccaaccttagcgattctatgattctatgattctatgatttttcactgttaaaaaaaaaaatcactattgacagtgtcagtcactttgactgacagtgtgtttgattttacccccatcactttataaccaaatagtattcttcttgttagtaacatttgcagtcaggagctgggagatgtgaatttctaaaacgtagaaaaaaaaaggaatcatcaactccattaggtgttaccagcttctctcttttgtcacctcttgtggaatccccaacatggaattcactttattaatggtgaaaccagggaattcaagggcttgctctgaccttgggacaaaaggtatcagcacctaaggcaattactctgtcttttaacctgaagttcatcactgcagttcctgaaaagacaattgtgctttgaaagttgaaggagcagcaacttcccttcatgttgtttcagccttctctagatttatcttttccatgtatctctttggatataccaaagcttcttgtgttgtattttaagcagcagccatttctttttctaaacctttcttcaaaagcacctgtggttattcaccgcagcttataacttctgaagctcagtttcactcccagctcaaatattctgaaataggctcatggatattcactttacttttgccctctcctatatgttagtactattaatccttgtgaacatctcagaaaaaggtgtctgtcttaccacatttttcatgatgctccaagcagagtttccagtattgtgtaggtatagcagtgatatgtaatcaacttctgtccccagtttttacttgtatgtatttttgtccaatctcattttaaatattctagaaatcaaaatttcttcttgtgtgtttcccacaagcagggaacttgacaggcacctgtgtatatttcaggaatctactatacacagagattttagagaaatatgaaaagtaagatttagagttagatatacctattgcatacaaatgtttgaaacgtgtttttacttgttatgtgaacaggatattcttagcaacacagtgatatttttggggcagttgcactgagacagtgaaataatatgtataaaatacagctataacaatgttggatttactgtgaagcagtgtgtttcttgatactaattgaatagtttattttaaaataaaagccaggtgattttggtagtttaacttctgggaatccagtgcaggatacttcagaaagtacatgctactgaaagatactgagtgttacaggtcatgttttaaacatgattcagacatgacttacattgatgctgatttcattttttgatttatttttaacaaacatttttctacaagaactgcttgtgtagatgttgcttgtgattatatatagccattttttagcattatccctgttgcagataaactgtcaagctctaatgtgcaattagtacattcatggggatatcagttgtaaaacagttgcagaaatcaaaaccaattgtacatctagtgagtgacagcactatttccctgcaatatatgcgtgtgtttaagttctaccaaatacaagaaagctaaagaaaactggagaaatagttctccccctctctttgcagcagatgtctctttctagtcttacttaactgtttttagcttcactattctgtaattatattaagaataaaaaatattgtgaaataa
//
by
@meso_cacase at
DBCLS
This page is licensed under a
Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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