LOCUS       NM_001005616            3322 bp    mRNA    linear   VRT 06-OCT-2024
DEFINITION  Gallus gallus prospero homeobox 1 (PROX1), mRNA.
ACCESSION   NM_001005616 XM_419421
VERSION     NM_001005616.1
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Jourdeuil,K. and Franz-Odendaal,T.A.
  TITLE     Gene expression analysis during the induction and patterning of the
            conjunctival papillae in the chick embryonic eye
  JOURNAL   Gene Expr Patterns 22 (1), 30-36 (2016)
   PUBMED   27664768
  REMARK    GeneRIF: We show that b-catenin is expressed during the
            pre-patterning of the epithelium prior to papilla induction and
            second that b-catenin, Ednrb and Inhba are expressed during the
            induction and patterning of the conjunctival papillae. Furthermore,
            we identified two genes, b-catenin and Prox1, that may be involved
            in the induction of the underlying scleral bones
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Holzmann,J., Hennchen,M. and Rohrer,H.
  TITLE     Prox1 identifies proliferating neuroblasts and nascent neurons
            during neurogenesis in sympathetic ganglia
  JOURNAL   Dev Neurobiol 75 (12), 1352-1367 (2015)
   PUBMED   25788138
  REMARK    GeneRIF: Results define the neurogenesis period in the chick
            paravertebral sympathetic ganglia including an initial cell cycle
            withdrawal and identify Prox1 as a marker and regulator of
            proliferating sympathetic neuroblasts
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Freeman,S.D. and Daudet,N.
  TITLE     Artificial induction of Sox21 regulates sensory cell formation in
            the embryonic chicken inner ear
  JOURNAL   PLoS One 7 (10), e46387 (2012)
   PUBMED   23071561
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Verra,D.M., Contin,M.A., Hicks,D. and Guido,M.E.
  TITLE     Early onset and differential temporospatial expression of
            melanopsin isoforms in the developing chicken retina
  JOURNAL   Invest Ophthalmol Vis Sci 52 (8), 5111-5120 (2011)
   PUBMED   21676907
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Dudas,J., Papoutsi,M., Hecht,M., Elmaouhoub,A., Saile,B.,
            Christ,B., Tomarev,S.I., von Kaisenberg,C.S., Schweigerer,L.,
            Ramadori,G. and Wilting,J.
  TITLE     The homeobox transcription factor Prox1 is highly conserved in
            embryonic hepatoblasts and in adult and transformed hepatocytes,
            but is absent from bile duct epithelium
  JOURNAL   Anat Embryol (Berl) 208 (5), 359-366 (2004)
   PUBMED   15232737
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Wilting,J., Tomarev,S.I., Christ,B. and Schweigerer,L.
  TITLE     Lymphangioblasts in embryonic lymphangiogenesis
  JOURNAL   Lymphat Res Biol 1 (1), 33-40 (2003)
   PUBMED   15624319
  REMARK    Erratum:[Lymphat Res Biol. 2003;1(2):179]
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Duncan,M.K., Cui,W., Oh,D.J. and Tomarev,S.I.
  TITLE     Prox1 is differentially localized during lens development
  JOURNAL   Mech Dev 112 (1-2), 195-198 (2002)
   PUBMED   11850194
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Rodriguez-Niedenfuhr,M., Papoutsi,M., Christ,B., Nicolaides,K.H.,
            von Kaisenberg,C.S., Tomarev,S.I. and Wilting,J.
  TITLE     Prox1 is a marker of ectodermal placodes, endodermal compartments,
            lymphatic endothelium and lymphangioblasts
  JOURNAL   Anat Embryol (Berl) 204 (5), 399-406 (2001)
   PUBMED   11789987
REFERENCE   10 (bases 1 to 3322)
  AUTHORS   Tomarev,S.I., Sundin,O., Banerjee-Basu,S., Duncan,M.K., Yang,J.M.
            and Piatigorsky,J.
  TITLE     Chicken homeobox gene Prox 1 related to Drosophila prospero is
            expressed in the developing lens and retina
  JOURNAL   Dev Dyn 206 (4), 354-367 (1996)
   PUBMED   8853985
  REMARK    Erratum:[Dev Dyn 1996 Sep;207(1):120]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U46563.1.
            
            On Dec 23, 2004 this sequence version replaced XM_419421.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U46563.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA103992290,
                                           SAMEA103992323 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="3"
                     /map="3"
     gene            1..3322
                     /gene="PROX1"
                     /note="prospero homeobox 1"
                     /db_xref="CGNC:7438"
                     /db_xref="GeneID:395802"
     exon            1..1789
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    41..43
                     /gene="PROX1"
                     /note="upstream in-frame stop codon"
     CDS             68..2278
                     /gene="PROX1"
                     /note="PROX-1; homeobox prospero-like protein PROX1;
                     prospero-related homeobox 1"
                     /codon_start=1
                     /product="prospero homeobox protein 1"
                     /protein_id="NP_001005616.1"
                     /db_xref="CGNC:7438"
                     /db_xref="GeneID:395802"
                     /translation="

MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKPNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDVCSNSSRDSPQECLSPFGRPTMSQFDVDRLCDEHLRAKRARVENIIRGMSHSPRVALRGNENEREIRPQSVSPRESYRENKRKQNWPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEEFYQIYDSTDSENDEDGNLSEDRMRSETVDAQAGDSVGRSDNEMCELDPGQFIDRARALIREQEIGENKPKREGPKEKDQGPNSFHPEGKHLAETLKQELNTAMSQVVDTVVKVFSSKPSRQLPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFSSVPMPGATDQTDALPLVVRKNSSDQPASAPPAGGHHASLHQSPLSATAGFSTSSFRHPFPLPLMAYPFQSPLGAPSASFPGKERASPESLDLTRETTSLRTKMSSHHMNHHPCSPAHPPSAAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE"

     misc_feature    374..505
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    554..571
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Nuclear localization signal.
                     /evidence=ECO:0000255"
     misc_feature    605..727
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    848..970
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1022..1099
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1400..1462
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1562..1621
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1793..2269
                     /gene="PROX1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q91018.1);
                     Region: Homeo-Prospero.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01162"
     misc_feature    1799..2260
                     /gene="PROX1"
                     /note="Homeo-prospero domain; Region: HPD; pfam05044"
                     /db_xref="CDD:461534"
     exon            1790..1897
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2092
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..3322
                     /gene="PROX1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ggtcccaggattcttgagctgagcccagctgacaagcttttgaagatggcacaataacagtccagtgatgcctgaccatgacagcacagccctcttaagcaggcaaaccaagagaagaagagttgacattggagtgaaaaggacggtagggacagcatctgcattttttgcaaaggcaagagcgacgttttttagtgccatgaatccccaaggttcagagcaggatgttgagtattcagtggtgcagcatgcagatggggaaaagccaaatgtactccgcaagctgctgaagagggcgaactcgtatgaagatgccatgatgccttttccaggagcaaccataatttcccagctgttgaaaaataacatgaacaaaaatggtggcaccgagcccagtttccaagccagcggtctctctagtacaggctcagaagtacatcaggaggatgtatgcagcaactcttcaagagacagcccccaagagtgtctttccccttttggcaggccgactatgagccagtttgatgtggatcggttatgcgatgagcacctgagagctaaacgcgcccgagttgagaatatcattcggggtatgagccattcccccagggtggcattaaggggcaatgaaaatgaaagagaaatacgtccgcagtccgtcagccctcgagaaagttaccgagaaaacaagcgcaagcagaactggccgcagcagcagcagcagagcttccagcagctggtttcggccaggaaggagcagaagcgagaggagcgccgacagctgaagcagcagctggaggacatgcagaagcagctgcgccagctgcaggaggagttctaccagatctacgacagcaccgactctgaaaatgatgaagatggcaacctgtctgaagacaggatgcgctccgagaccgtggatgcccaggctggtgactccgtcggcaggtcagacaacgagatgtgcgagctggacccagggcagttcatcgaccgggcgcgggctctcatacgggagcaggagatcggggagaacaagccgaaaagagaaggtcccaaggagaaggaccaagggccaaattccttccatcctgaaggtaaacacttggctgagacgctgaagcaggaactgaacactgccatgtcacaagttgtggacacagtggtgaaagttttctcgtccaagccctcccgccagcttccccaggtcttcccacctctccagatcccccaggccaggtttgctgtcaatggggagaaccacaacttccacacggccaaccagcgcctgcagtgctttggggacgtcatcattccaaaccccctcgacaccttcagcagcgtccccatgcctggtgccactgaccagactgacgcgctgcccctcgtcgtccgcaagaactcctccgaccagcccgcctcggcccctccagccggtggccaccacgcctcactgcaccagtccccactctcggccactgccggcttctccacctcctccttccgccaccccttcccgctgcccctcatggcctaccccttccagagccctctgggcgccccgtcagcctccttcccggggaaagagcgtgcctcccctgagtccctggacttgacccgggagaccaccagcctgaggaccaagatgtcgtcgcaccacatgaaccaccatccctgctcacctgcacacccccccagtgctgccgaaggcctctccttgtccctcataaagtctgagtgtggtgacctgcaagacatgtctgaaatctcgccctactcgggaagtgcaatgcaggaaggcttgtcgccgaaccacttgaaaaaggccaagctcatgttcttttacacccggtacccaagttccaatatgctgaaaacctacttctcagatgtaaagttcaacagatgcattacctctcagctcatcaagtggtttagcaatttccgtgagttttactacattcagatggagaagtatgcgcggcaagccatcaacgacggggtcacgagcacggaggagctgtctataaccagagactgtgagctgtacagggccctgaacatgcactacaataaagcgaatgactttgaggttccagagagattcctggaagtggctcagatcacgttacgggagtttttcaatgccattatcgcaggcaaagatgttgatccttcctggaagaaggccatatacaaggtcatctgtaagctggacagtgaggtccctgagattttcaaatcccccaactgcctacaagagcttcttcatgagtagagagttcagcagctatttatgaatgtatgaaagtagcagtccccttctgatgcccaagtcatgtgtgtctctattttaatttcatatatatgtgtattgcatacatatatatgtatatgaaattagactgtgatccctcctggtatatctttgggttttcgtttggttccaaggggatggttattttacttcagcctttggtttacttttgcccgagacccttaacatttggagaataaattgagttaattttcagggagaagagtttggaagcgtgtaaaagcctgtcttagcaagttagggcattatgtttaaaaatgctttgtcagatttattgcttgctgcaaagtggcattttgtcttagtgagactaatgtcatggcacaatactacagacaatgaagtttatattatgtttatactgctaaaggtctgaactctgtggagtcacttcataagcttggagctttttttttttaattattattattttatatactttttaaccaataactagattttctttcatacttcaaaaagctacaacatctatttcaggttctacctccaaggagtgataccgaaaaagcaaaccctattcttcatgctttcccttacagaaacaataaataacctgcgccagtaatcgacatgccaggttgttgtttttctaaattgcagcaagggacgtttgcacaaatcaaacaccactcgtgcaggttgaggccagtaattcatgcacagtgttgtatcaaccacacgaattgtagagtacggtcagcttgttaaaacggaagcatttcactctccatagagtaaaaatgaaacctgcagagtactaaattgccacgtcttggtcttactttaagtggcatcggtccctgatttttttcctctcagtcgattctgcccctagaaatcccctttcaaatatacgcagttttctgtctgtatttgacatctgtcctgaaaagcactttttgaatgatctgatatacagtcaaagaaagcatcttcacctcacagtgctgaggcaaaggaaag

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