LOCUS       NM_001001530            3324 bp    mRNA    linear   VRT 01-MAY-2025
DEFINITION  Gallus gallus prolyl 3-hydroxylase 2 (P3H2), transcript variant 1,
            mRNA.
ACCESSION   NM_001001530 XM_422721
VERSION     NM_001001530.2
KEYWORDS    RefSeq.
SOURCE      Gallus gallus (chicken)
  ORGANISM  Gallus gallus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
            Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
            Phasianidae; Phasianinae; Gallus.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Tang,H., Finn,R.D. and Thomas,P.D.
  TITLE     TreeGrafter: phylogenetic tree-based annotation of proteins with
            Gene Ontology terms and other annotations
  JOURNAL   Bioinformatics 35 (3), 518-520 (2019)
   PUBMED   30032202
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Burge,S., Kelly,E., Lonsdale,D., Mutowo-Muellenet,P., McAnulla,C.,
            Mitchell,A., Sangrador-Vegas,A., Yong,S.Y., Mulder,N. and Hunter,S.
  TITLE     Manual GO annotation of predictive protein signatures: the InterPro
            approach to GO curation
  JOURNAL   Database (Oxford) 2012, bar068 (2012)
   PUBMED   22301074
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Fernandes,R.J., Farnand,A.W., Traeger,G.R., Weis,M.A. and Eyre,D.R.
  TITLE     A role for prolyl 3-hydroxylase 2 in post-translational
            modification of fibril-forming collagens
  JOURNAL   J Biol Chem 286 (35), 30662-30669 (2011)
   PUBMED   21757687
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Hubbard,S.J., Grafham,D.V., Beattie,K.J., Overton,I.M.,
            McLaren,S.R., Croning,M.D., Boardman,P.E., Bonfield,J.K.,
            Burnside,J., Davies,R.M., Farrell,E.R., Francis,M.D.,
            Griffiths-Jones,S., Humphray,S.J., Hyland,C., Scott,C.E., Tang,H.,
            Taylor,R.G., Tickle,C., Brown,W.R., Birney,E., Rogers,J. and
            Wilson,S.A.
  TITLE     Transcriptome analysis for the chicken based on 19,626 finished
            cDNA sequences and 485,337 expressed sequence tags
  JOURNAL   Genome Res 15 (1), 174-183 (2005)
   PUBMED   15590942
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Vranka,J.A., Sakai,L.Y. and Bachinger,H.P.
  TITLE     Prolyl 3-hydroxylase 1, enzyme characterization and identification
            of a novel family of enzymes
  JOURNAL   J Biol Chem 279 (22), 23615-23621 (2004)
   PUBMED   15044469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAENSK010000240.1.
            
            On Dec 16, 2021 this sequence version replaced NM_001001530.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY463529.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA103992393, SAMEA103992415
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-511               JAENSK010000240.1  13680910-13681420
            512-658             JAENSK010000240.1  13722668-13722814
            659-848             JAENSK010000240.1  13723666-13723855
            849-980             JAENSK010000240.1  13726305-13726436
            981-1123            JAENSK010000240.1  13726978-13727120
            1124-1213           JAENSK010000240.1  13728316-13728405
            1214-1254           JAENSK010000240.1  13728633-13728673
            1255-1349           JAENSK010000240.1  13729067-13729161
            1350-1477           JAENSK010000240.1  13731344-13731471
            1478-1573           JAENSK010000240.1  13731818-13731913
            1574-1724           JAENSK010000240.1  13731998-13732148
            1725-1842           JAENSK010000240.1  13732595-13732712
            1843-1918           JAENSK010000240.1  13733103-13733178
            1919-2059           JAENSK010000240.1  13733370-13733510
            2060-3324           JAENSK010000240.1  13734283-13735547
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Gallus gallus"
                     /mol_type="mRNA"
                     /db_xref="taxon:9031"
                     /chromosome="9"
                     /map="9"
     gene            1..3324
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="prolyl 3-hydroxylase 2"
                     /db_xref="CGNC:49910"
                     /db_xref="GeneID:414143"
     exon            1..511
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2152
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /EC_number="1.14.11.7"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leprecan-like protein 1; leprecan-like 1"
                     /codon_start=1
                     /product="prolyl 3-hydroxylase 2 isoform 1 precursor"
                     /protein_id="NP_001001530.2"
                     /db_xref="CGNC:49910"
                     /db_xref="GeneID:414143"
                     /translation="

MAPGNRSWGAVLLLAAMLPAACGSCGADGGPLEPFDALYASGVEAYYGGDFAGAARCLEQALRSRRELRAERLRCRRRCRGQVRLAALGAGPAGELPFFGALLRRAGCLRSCEEPRLGAASRHRAAEEVRSDFQRRVPYSYLQRAYIQLNKLEEAANAAHTFFMANPEHMEIQQDIENYKTTAGKVSLIDLEAKPHMEDYSAGVRHYDKEEYGLAITFLERALEGYYAEDEDCQIMCEGPQRFEEHEYLEYKAGLYEAIADHYMQVLACKHDCIRELATRSGRISPIENFLPLHYDYLQFAYYRVGDYVKALECARSYLLFHPDDEDVLENAAYYEGLLEGTVDPATIKPRKEAKALLHRHKLESHLLRVAAVGLGFTYTEPNYWKRYGARQDEHSVPSSISSEPEDGPRLSLTKKPTPKPDRELKEGGPLLYSDVKFVYNSQQLNGTQRVLLDNVISEEQCRELHRVASGIMLAGDGYRGKTSPHTPNERFEGATVLKALKYGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHLVCRTALSGQQERRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNADFEGGEFIFTEMDAKTVTASIKPKCGRMVSFSSGGENPHGVKAVTKGQRCAVALWFTLDPLYRELERIQADEVIAMLDQEHVGRSEMNINPKDEL"

     sig_peptide     68..136
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6JHU7.1)"
     mat_peptide     137..2149
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /product="Prolyl 3-hydroxylase 2. /id=PRO_0000240359"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1)"
     misc_feature    170..271
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: TPR 1"
     misc_feature    473..574
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: TPR 2"
     misc_feature    653..754
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: TPR 3"
     misc_feature    941..1042
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: TPR 4"
     misc_feature    1250..1348
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1403..1405
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6JHU7.1); glycosylation site"
     misc_feature    1439..2035
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="Prolyl 4-hydroxylase alpha subunit homologues;
                     Region: P4Hc; smart00702"
                     /db_xref="CDD:214780"
     misc_feature    1670..1672
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6JHU7.1); glycosylation site"
     misc_feature    2138..2149
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6JHU7.1);
                     Region: Prevents secretion from ER.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU10138"
     exon            512..658
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            659..848
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            849..980
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1123
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1213
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1254
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1349
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1477
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1573
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1724
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1842
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1918
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2059
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..3324
                     /gene="P3H2"
                     /gene_synonym="LEPREL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agggagccggactgggatacggccgtgtcgttcccacagccatcgagccggtgctcgtgcggcgggcatggcgccggggaaccggtcctggggggccgtgctgttgctagcggcgatgctgcccgcggcgtgcgggagctgcggagcggacggcggcccgctggagcccttcgacgcgctgtacgccagcggcgtggaagcgtactacggcggcgacttcgcgggcgcggcgcggtgcctggagcaagcgctgcgcagccggcgggagctgcgggcggagcggctgcggtgccggcggcgctgccgggggcaggtgcggctggcggcgctgggcgcggggcccgccggggagctgcccttcttcggggcgctgctgcggcgtgccggctgtctgcggagctgcgaggaaccgcgcctgggagccgcgtcccggcaccgcgccgccgaggaggtgcgctctgacttccagcgcagggtgccctacagctacctgcagcgcgcctacatccagctgaacaagctggaggaggcagcaaacgcagctcacaccttcttcatggcaaaccctgagcacatggagatacagcaggacattgagaactacaaaaccacagcagggaaagtcagcttgatcgacctggaggccaagccgcacatggaggattacagtgctggtgtcaggcactatgacaaggaggagtacgggttggccatcaccttcttggagcgtgcactggaagggtactatgctgaggatgaggattgccagatcatgtgcgaaggaccacagaggtttgaggaacacgaatacctggaatataaggctggcctctacgaagctattgcagatcactacatgcaagtcctggcctgcaaacacgactgcatccgagagctcgccacgcgctcgggccgcatctcacccatcgaaaacttccttcccctccactacgattacctgcagtttgcctattacagagtcggtgactacgtgaaagccctggagtgtgccaggtcctacctcctcttccacccggatgatgaagatgtcttggagaatgcagcttattatgagggcctcttggaaggtaccgtggatccggccactatcaagcccagaaaggaagcaaaagcattgctgcatcggcacaagctggagtcccacctcctgcgggtggctgcggttggcctggggttcacctacacggagccaaactactggaagaggtatggtgcccgccaagatgagcatagtgtcccatcgagtattagcagtgagccagaggatgggccccggctgtcactaacaaagaaacccacaccaaaaccagatcgagagctgaaggaggggggtccacttctctacagcgacgtgaagtttgtctacaactcacagcagctgaacggcacccagcgagtgctgctggacaacgtcatctcagaggagcagtgtcgggagcttcacagagtggccagtgggatcatgttggctggagatggctataggggcaaaacctctccccatactccaaatgagagatttgaaggagccacggtcctcaaagccctcaagtatggctatgagggccgtgtcccactgaagagcgcccggctcttctacgacatcagcgagaaggcccgcaggatcgtcgagtcctacttcatgctcaactccacactctacttctcctacactcacctggtgtgccgcaccgctctctctggccagcaggagaggaggaatgacctgagccaccccatccatgccgacaactgcctcctggaccccgaggccaatgagtgctggaaggagcctcctgcctacacctttcgggactacagtgccctcctctacatgaatgcagatttcgaaggcggcgaattcattttcactgagatggatgccaaaacagtgacggcatccatcaagcccaagtgtggacggatggtcagcttctcatccggtggtgagaacccacatggagtgaaggcggttaccaaagggcagcggtgcgctgtggctctatggtttaccttggacccactttacagagaactggagcgaatccaggcagatgaagtgatcgccatgttggaccaggagcacgtaggacgcagtgaaatgaacatcaacccaaaggatgagctatgaactaggccaaagacttttttttttttctattaaatatttatttaatattgttaatcttattagaacctttctatttttgtacagagatgctgtataaattaacaggttaatatgattgtggagttttcaggagtgcctcttctgtgtttagcacagctcttgctgggacccctcctccctgtgccagcatctcctgctgggcccgtctttgctgctggggttccctgtccttcttgagcgctgctgtaccccctccaaggaccctttttattttcctcagccagaagtagctgcttctctttagcctctgctagagaaatgtctcaggtgtgctgatggatctctctccctctccctcctgccaagctgtggctgcagacctagtgctgttgccctagaaagcacagccaggcccttggttggagcttaccttcctcaggagctttatttttgcttcctgctgcttcatctcagtgccttttcagtgcctttctgctaccctcagccagccctgccattatttctaggacttaaaactggcagtgggcgttgggctttgctcttcattgttgcagcttgtacccccacccatgtacccatgtacccatgggtactgctggttgacctcaggagcaagacagggaaccaagggcttagcatcattgcatggcttaagttgaaagggaccctaaagctctgtgccctctcgatgaacagttgcccaggctccggaggagatgccattaccccaggaagagtgagggaaggttgatttgctccacctcttcaactactgcacctgcaggggagaacactgtgagtgcctctgagccactggcatgccttggttcctggacgtcacctcccttgcctacaggccattcaagtgcttcagcaggttggcttcccaagaaaacactcctggtaattgcttacccaccctctgtttaacacagctgcaagagaagctggggagaagggggtggcagctggagagcagaaccaggggctctgttatcccctctgtgccccaccaaaactcagccagggcttggctcctgcactgcacccttggccctggtctgtgctgctcccaggggctgctttgctgctgtggtgataactggagctgtgtgttaatccaggggaaataaaacaagtgagacaccaca

//