LOCUS       XM_017358485            3280 bp    mRNA    linear   VRT 08-SEP-2024
DEFINITION  PREDICTED: Danio rerio mitogen-activated protein kinase 8b
            (mapk8b), transcript variant X1, mRNA.
ACCESSION   XM_017358485
VERSION     XM_017358485.3
DBLINK      BioProject: PRJNA13922
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_007123.7) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 8, 2024 this sequence version replaced XM_017358485.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Full annotation
            Annotation Name             :: GCF_000002035.6-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/15/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3280
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="12"
     gene            1..3280
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="mitogen-activated protein kinase 8b; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 6 long SRA reads, 65 Proteins, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 43 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
     misc_feature    1
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /experiment="COORDINATES: cap analysis [ECO:0007248]"
                     /note="transcription start site"
     CDS             197..1483
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /codon_start=1
                     /product="mitogen-activated protein kinase 8 isoform X1"
                     /protein_id="XP_017213974.1"
                     /db_xref="GeneID:65236"
                     /db_xref="ZFIN:ZDB-GENE-010202-1"
                     /translation="

MNRNKREKEYYSIDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDHVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWSIGCIMAEMVRGSVLFPGTDHIDQWNKVIEQLGTPSQEFMMKLNQSVRTYVENRPRYAGYSFEKLFPDVLFPADSDHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEVEAPPPAITDKQLDEREHSVEEWKELIYKEVLEWEERTKNGVIRGQPASLGAAVSSDSHEPSTSSSSINDVSSMSTEVTLTSDTDSSQETSNGALHCCR"

     misc_feature    269..1276
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="Catalytic domain of the Serine/Threonine Kinase,
                     c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850"
                     /db_xref="CDD:270840"
     misc_feature    order(290..310,314..316,353..355,359..361,410..412,
                     452..454,518..538,542..547,647..649,653..655,659..664,
                     668..670,698..703,710..712,743..745,749..760,764..766,
                     875..877)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="active site"
                     /db_xref="CDD:270840"
     misc_feature    order(290..310,314..316,353..355,359..361,452..454,
                     518..538,668..670,698..700)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(410..412,542..544,647..649,653..655,710..712,
                     743..745,749..760,764..766,875..877)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(530..532,548..550,575..577,584..586,671..685,
                     1163..1168,1172..1174,1181..1183)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="KIM docking site [polypeptide binding]; other site"
                     /db_xref="CDD:270840"
     misc_feature    order(698..730,740..766)
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270840"
     polyA_site      3280
                     /gene="mapk8b"
                     /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8;
                     zgc:112379"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      

agctcaagtaaaggcctgccagtggacggaaacgcagtgcttgtgtcttgtgtggaaagacaaatacaacaacccgctgagaagaccccagtgtttttatgattctacacttgaattgtctgttcatcttttaggaggatttttgaaggtgaagctcttcttgaatgcccaggatacagtcagtacggttttcatcatgaacaggaataagcgcgagaaagaatattacagcatagatgtaggagattcaacgttcaccgttttgaagcgctatcagaatttaagaccaatcgggtccggagcacaaggcatcgtctgctcagcgtatgaccacgtcctcgatcgaaatgtggcaattaagaaactcagccgaccctttcaaaaccaaactcatgccaaacgggcctacagagaactggtcctgatgaaatgcgtcaaccacaaaaatataattggcttactaaacgtgttcacaccacagaagacacttgaagagttccaggatgtttatctggtgatggagctgatggatgcaaacctgtgtcaggtgattcagatggagctggaccacgagaggctgtcctacctgctctatcagatgctctgcggcattaaacacctgcacgctgctggcatcatacacagggatctgaaacccagtaatatagtagtgaaatcggactgcacgctgaagatcctggatttcggtctggcccgaacggctgcaaccggcctcctcatgactccttatgtcgtgacacgctattatcgggccccagaggtcatcctgggcatgggttatcaagctaacgttgatgtctggtctattggctgcatcatggctgaaatggtcagaggtagtgtgttgtttcctggcacagaccatattgaccagtggaataaagtgatcgagcagctgggcacgccgtcacaggagttcatgatgaagctgaatcagtctgtgaggacgtatgtggagaaccggcctcggtatgcgggatacagctttgagaagctcttcccagacgtgctcttccccgcagactcggaccacaacaaactcaaggcgagtcaggcacgagacttgttatccaaaatgctggtaatagatgcatccaagcggatctctgtagacgaggcgcttcagcacccctacatcaacgtttggtacgacccatcagaagtggaggcgccgccaccagcgatcacggataaacagctcgatgagagagaacactcagtggaagagtggaaagagctcatatacaaggaagtgctggaatgggaggagcgaacaaaaaatggagtgatcagaggacagccggcctcgctaggtgcagcagtgagcagtgactcccatgagccctcgacgtcgtcctcctccataaacgatgtgtcgtccatgtccaccgaggtcacgctgacctcagacaccgacagcagtcaggagacgtccaacggagcgctgcactgctgcagatgaccatccttcttcaacctccgtcaccctctgaaatccttcatcaccttccattgtcttctgtcatgattcttcatcctccaaaatgcttcatcaccttccaaaatcatctattgttctctgtcatggttcttcatcctccaaaatcctcccattggccttttaaaatcctccatcctcccctgtcaccttccaaaatcctctagccccctcaaatatgctctgttaccctctaaaatcctccatccttctttgtttaccatccaaaatcctcaatcgccctccaaattcctccattctcctcagttaccttccaaaatcctccattgtcttcattcaccctccaaaatcctccactaccccgtaaatcctccattaccctccaaaatccctcattgtgtttgtcaggattcttcatcctctgtcgccctccaaaatccttcattttcctccaaaatcctctgtcaccggcaaaatcctcctacattatccttcaaaatccttaattgccctccattttcctccagagtcctctgtcacctccaaaatctcttcattcacccttcaaaatactcagttgccctctaaaatcctctattttcctctagaatcctctgtcacctcccaaatcctcctcaatcgccctccaaaatcctctatcaccctctaaaatcctccatcacccttcaaaattctccatcacgctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcctccataacccttcaaaatctcccattaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcaccctccaaaattctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccattaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccattaccttccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccataacccttcaaaatctcccatcaccctccaaaatcatatatcaccctccaaaatcctccattaccctccaaaattctccatcatcctccaaaattctccatcatcctccaacattctccattaccctccaaaattctccatcaccctccagaatcgtccatcaccctccaaaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaatcctcaaactttcaagctcttgtcaattcaaaagtgtaagagtggcggggatagtttttttgagggcatctcaaaggcttttacaccaaaccagcattactttcactgctttcctgtttttattttgaactttgcatcaaattgaagctactgctacgtcgtcttgccattcggaagtggaatgattcaagtttatttgtaaagataaatggtgaatatatttttttcgagatgttttatttttttgagagtcattttaatcactaatgagtggaggttcattaaatggcacgtccattttttttggacaagtgagtatttccacactgttactactgctttggagtataaaaggcatctgtatgttt

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