LOCUS       NM_214734               1617 bp    mRNA    linear   VRT 08-JUN-2024
DEFINITION  Danio rerio paired related homeobox 1a (prrx1a), mRNA.
ACCESSION   NM_214734
VERSION     NM_214734.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1617)
  AUTHORS   Letelier,J., Buono,L., Almuedo-Castillo,M., Zang,J., Mounieres,C.,
            Gonzalez-Diaz,S., Polvillo,R., Sanabria-Reinoso,E., Corbacho,J.,
            Sousa-Ortega,A., Diez Del Corral,R., Neuhauss,S.C.F. and
            Martinez-Morales,J.R.
  TITLE     Mutation of vsx genes in zebrafish highlights the robustness of the
            retinal specification network
  JOURNAL   Elife 12, e85594 (2023)
   PUBMED   37227126
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1617)
  AUTHORS   Okeke,C., Paulding,D., Riedel,A., Paudel,S., Phelan,C., Teng,C.S.
            and Barske,L.
  TITLE     Control of cranial ectomesenchyme fate by Nr2f nuclear receptors
  JOURNAL   Development 149 (23) (2022)
   PUBMED   36367707
REFERENCE   3  (bases 1 to 1617)
  AUTHORS   Liu,Y., Kossack,M.E., McFaul,M.E., Christensen,L.N., Siebert,S.,
            Wyatt,S.R., Kamei,C.N., Horst,S., Arroyo,N., Drummond,I.A.,
            Juliano,C.E. and Draper,B.W.
  TITLE     Single-cell transcriptome reveals insights into the development and
            function of the zebrafish ovary
  JOURNAL   Elife 11, e76014 (2022)
   PUBMED   35588359
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1617)
  AUTHORS   de Bakker,D.E.M., Bouwman,M., Dronkers,E., Simoes,F.C., Riley,P.R.,
            Goumans,M.J., Smits,A.M. and Bakkers,J.
  TITLE     Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte
            proliferation during zebrafish heart regeneration
  JOURNAL   Development 148 (19) (2021)
   PUBMED   34486669
REFERENCE   5  (bases 1 to 1617)
  AUTHORS   Tessadori,F., de Bakker,D.E.M., Barske,L., Nelson,N., Algra,H.A.,
            Willekers,S., Nichols,J.T., Crump,J.G. and Bakkers,J.
  TITLE     Zebrafish prrx1a mutants have normal hearts
  JOURNAL   Nature 585 (7826), E14-E16 (2020)
   PUBMED   32968253
REFERENCE   6  (bases 1 to 1617)
  AUTHORS   Itou,J., Taniguchi,N., Oishi,I., Kawakami,H., Lotz,M. and
            Kawakami,Y.
  TITLE     HMGB factors are required for posterior digit development through
            integrating signaling pathway activities
  JOURNAL   Dev Dyn 240 (5), 1151-1162 (2011)
   PUBMED   21384471
REFERENCE   7  (bases 1 to 1617)
  AUTHORS   Murata,Y., Tamura,M., Aita,Y., Fujimura,K., Murakami,Y., Okabe,M.,
            Okada,N. and Tanaka,M.
  TITLE     Allometric growth of the trunk leads to the rostral shift of the
            pelvic fin in teleost fishes
  JOURNAL   Dev Biol 347 (1), 236-245 (2010)
   PUBMED   20692249
REFERENCE   8  (bases 1 to 1617)
  AUTHORS   Luesch,H., Chanda,S.K., Raya,R.M., DeJesus,P.D., Orth,A.P.,
            Walker,J.R., Izpisua Belmonte,J.C. and Schultz,P.G.
  TITLE     A functional genomics approach to the mode of action of apratoxin A
  JOURNAL   Nat Chem Biol 2 (3), 158-167 (2006)
   PUBMED   16474387
REFERENCE   9  (bases 1 to 1617)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   10 (bases 1 to 1617)
  AUTHORS   Kawakami,Y., Esteban,C.R., Matsui,T., Rodriguez-Leon,J., Kato,S.
            and Izpisua Belmonte,J.C.
  TITLE     Sp8 and Sp9, two closely related buttonhead-like transcription
            factors, regulate Fgf8 expression and limb outgrowth in vertebrate
            embryos
  JOURNAL   Development 131 (19), 4763-4774 (2004)
   PUBMED   15358670
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC053228.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053228.1, EE300653.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505388, SAMEA4476739
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1617
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1617
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /note="paired related homeobox 1a"
                     /db_xref="GeneID:406431"
                     /db_xref="ZFIN:ZDB-GENE-020905-5"
     exon            1..373
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    94..96
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /note="upstream in-frame stop codon"
     CDS             127..864
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /note="paired related homeobox 1; prx1; paired mesoderm
                     homeo box 1"
                     /codon_start=1
                     /product="paired mesoderm homeobox protein 1a"
                     /protein_id="NP_999899.1"
                     /db_xref="GeneID:406431"
                     /db_xref="ZFIN:ZDB-GENE-020905-5"
                     /translation="

MTSSYAHVMDRQATLPNRLETAITANQDHLQAKKNFSVSHLLDLEEAREMVGAQAEESAGEAGRSMLESPGLTSGSDTTQQENEQLNAEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLASKNASLLKSFSGEVTAVEQPIVPRPAPRPNDYLSWGSSPSYSAMATYSPSCANNTTAQGMNMANSIANLRLKAKEYSLNQVPTVN"

     misc_feature    427..585
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     misc_feature    784..837
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     exon            374..549
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /inference="alignment:Splign:2.1.0"
     exon            550..731
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /inference="alignment:Splign:2.1.0"
     exon            732..1603
                     /gene="prrx1a"
                     /gene_synonym="cb329; pmx1; prrx1; wu:fa09h05; wu:fb52c01;
                     zgc:64055"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgccgatctacggatgtaaaaacagaaatcgatcaatttgtcgagtatagagtggttgtttatggtcgaaacgtaacccatgttggttgtaggtagaggatatcttgggtttcgtcaatttgcgtcatgacttccagctatgctcatgtaatggacagacaagccacactaccaaaccgactggagactgcgatcaccgcgaatcaggatcatttacaggctaaaaagaacttctccgtgagccacctgttggatctggaggaggcgcgggagatggtgggagctcaagcggaggaaagcgcaggggaggcgggcaggagtatgctggagtctccgggactcaccagcgggagcgacactacacagcaggagaacgagcagctcaacgcagaggagaagaagaagcgtaaacagaggcgaaacagaaccacgttcaacagcagtcagctgcaggccttagagagagtgtttgagaggacgcattaccccgatgctttcgtcagggaggacttggcacgacgggtcaacctcactgaagcacgagttcaggtatggtttcaaaatcgacgggctaagtttcgacgaaatgaacgtgcgatgctggcaagtaaaaatgcttcattgctcaagtctttctcaggagaagtaacagccgtagagcagcccattgtcccacgacccgcacccagacccaatgactacctgtcctggggaagctcaccgtcatacagtgccatggcaacttattctccctcgtgcgccaacaacaccacagcccagggcatgaatatggccaacagtatcgccaacctgagactgaaagccaaagaatacagcctgaaccaggtacccactgtcaactgaagcgggcagctgggctgtcaaagactctcagaacaatcccaatgtcccagccccaaatctattgacataaacaacgttttctgtcctcctctatgtgttttactcttatccatcaaagaacagaagcaaacgagaacagctccaaggtaccaagcttttctaaaaccaatgatttacattgaaccgtcatgttcctggtatgtggggaaatgacatgtgggaaaattgagttttggacagcacaaaatggaaagttttcactgttcacactcactgtggcagcgtaagcgtggtcaacccttttggagatcgtggcttactatagatttctttcttgagactcctgccgaccacagggatttgatgacctctgcggaatccatatactacaatcttgcggacatctggggagtttttaggatttcccctcgatttctcattggaactcgtaaatgcgcactgaggccacaaattgggatttggatattttggttatttgggaacagagtgaaatttggctttcctgttaccggactctaaaatcactcttcactgttgtctgttaaaaaaacatgcaagggggtattggttcattttggcatatacagaactctggccatgtatgtaagtgatgaattcagagctttgttgattataccccattatattttctaaatatatgcataaatatgtaacattactttgcaataaagatgtcctagcaatgtaatgtcatcaaaaaaaaaaaaaaaa

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