LOCUS       NM_213430               1748 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio phospholipase A2, group XIIB (pla2g12b), mRNA.
ACCESSION   NM_213430 NM_213207
VERSION     NM_213430.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1748)
  AUTHORS   Feng,J., Chen,X., Wang,S., Zhang,J., Wang,Q., Guo,S. and Shen,Q.
  TITLE     Transcriptomics integrated with metabolomics reveals the
            ameliorating effect of mussel-derived plasmalogens on high-fat
            diet-induced hyperlipidemia in zebrafish
  JOURNAL   Food Funct 14 (8), 3641-3658 (2023)
   PUBMED   36961308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1748)
  AUTHORS   Jawahar,J., McCumber,A.W., Lickwar,C.R., Amoroso,C.R., de la Torre
            Canny,S.G., Wong,S., Morash,M., Thierer,J.H., Farber,S.A.,
            Bohannan,B.J.M., Guillemin,K. and Rawls,J.F.
  TITLE     Starvation causes changes in the intestinal transcriptome and
            microbiome that are reversed upon refeeding
  JOURNAL   BMC Genomics 23 (1), 225 (2022)
   PUBMED   35317738
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1748)
  AUTHORS   White,R.J., Mackay,E., Wilson,S.W. and Busch-Nentwich,E.M.
  TITLE     Allele-specific gene expression can underlie altered transcript
            abundance in zebrafish mutants
  JOURNAL   Elife 11, e72825 (2022)
   PUBMED   35175196
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1748)
  AUTHORS   Feng,J., Song,G., Wu,Y., Chen,X., Pang,J., Xu,Y., Shen,Q., Guo,S.
            and Zhang,M.
  TITLE     Plasmalogens improve swimming performance by modulating the
            expression of genes involved in amino acid and lipid metabolism,
            oxidative stress, and ferroptosis in an Alzheimer's disease
            zebrafish model
  JOURNAL   Food Funct 12 (23), 12087-12097 (2021)
   PUBMED   34783821
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1748)
  AUTHORS   Thierer,J.H., Ekker,S.C. and Farber,S.A.
  TITLE     The LipoGlo reporter system for sensitive and specific monitoring
            of atherogenic lipoproteins
  JOURNAL   Nat Commun 10 (1), 3426 (2019)
   PUBMED   31366908
  REMARK    Erratum:[Nat Commun. 2020 Jul 21;11(1):3707. PMID: 32694507]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1748)
  AUTHORS   Anderson,J.L., Mulligan,T.S., Shen,M.C., Wang,H., Scahill,C.M.,
            Tan,F.J., Du,S.J., Busch-Nentwich,E.M. and Farber,S.A.
  TITLE     mRNA processing in mutant zebrafish lines generated by chemical and
            CRISPR-mediated mutagenesis produces unexpected transcripts that
            escape nonsense-mediated decay
  JOURNAL   PLoS Genet 13 (11), e1007105 (2017)
   PUBMED   29161261
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1748)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1748)
  AUTHORS   Kessels,M.Y., Huitema,L.F., Boeren,S., Kranenbarg,S.,
            Schulte-Merker,S., van Leeuwen,J.L. and de Vries,S.C.
  TITLE     Proteomics analysis of the zebrafish skeletal extracellular matrix
  JOURNAL   PLoS One 9 (3), e90568 (2014)
   PUBMED   24608635
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1748)
  AUTHORS   Jima,D.D., Shah,R.N., Orcutt,T.M., Joshi,D., Law,J.M., Litman,G.W.,
            Trede,N.S. and Yoder,J.A.
  TITLE     Enhanced transcription of complement and coagulation genes in the
            absence of adaptive immunity
  JOURNAL   Mol Immunol 46 (7), 1505-1516 (2009)
   PUBMED   19200601
REFERENCE   10 (bases 1 to 1748)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC052113.1.
            
            On Apr 30, 2008 this sequence version replaced NM_213207.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052113.1, BC065857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1748
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..1748
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="phospholipase A2, group XIIB"
                     /db_xref="GeneID:406739"
                     /db_xref="ZFIN:ZDB-GENE-040426-2771"
     exon            1..395
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    53..55
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="upstream in-frame stop codon"
     CDS             62..757
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /EC_number="3.1.1.4"
                     /codon_start=1
                     /product="group XIIB secretory phospholipase A2-like
                     protein precursor"
                     /protein_id="NP_998595.2"
                     /db_xref="GeneID:406739"
                     /db_xref="ZFIN:ZDB-GENE-040426-2771"
                     /translation="

MFPRALPLLLLCISAGLAATLIQASVDAASVDSPAGESPDVNQENQAEHVLMADAPVEGKPAPSATEESEDDDDWGFGSIRGSLQSVNGYFDSILELMGGRDGVCQFRCRYGKAPQPRPGYQMSEPDGCSTSLLGFQFDMGVPAMTKCCNQLDICYETCGSNKYRCDTKFRWCLHSICGDLKKSLGLMSKVEACETFADTMYNTVWTLGCRPFMNGQRASCYCEGEEKDEL"

     sig_peptide     62..145
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    239..754
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="Group XII secretory phospholipase A2 precursor
                     (PLA2G12); Region: PLA2G12; pfam06951"
                     /db_xref="CDD:399731"
     exon            396..472
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     exon            473..638
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     exon            639..1729
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

ctttttccttcgagcccttcaacttcgtcggtctccctggactgtactgtaataggacatcatgtttcctcgcgcactacccctgctcctgctgtgtatctctgcaggcttggctgcgactcttatccaggcttcagtagatgcggcttcagtagattcgcctgctggtgaaagcccagatgttaatcaggagaatcaggcagagcatgttttaatggcagatgcccctgttgagggaaaacctgcaccgagtgccacagaagaatctgaggacgatgatgactgggggttcggctctatccgaggaagtttacagtcagtcaatggctattttgactcaatactggagttgatgggaggccgtgatggtgtatgtcagttccgctgcagatatggtaaagctcctcagcctcgtcctggctatcagatgtcagaacctgatggttgtagcacgtcactgcttggcttccagtttgatatgggtgtcccagccatgaccaaatgttgcaaccagttagatatttgctacgaaacctgtggatccaacaagtaccgctgtgacaccaaattccgctggtgcctccacagcatctgcggtgacctgaagaagagtctgggccttatgtccaaagttgaagcatgtgagacctttgcagacaccatgtacaacactgtgtggactttgggctgcagacccttcatgaacggccaaagggcgtcctgctattgcgaaggagaagagaaggacgagctctgaagaccaacaaaatcacaaaacacaccaccttcagcacatataaacacttcatagctttaaactataccacacaaggcacgagtcacattcaaacaagtcacatttcactacaaacattgagtagaaactattgatcgacattaattgaagtgaaatgtgaccttcacacgttgtggagattcatccactaacccttgaactggtgctattggattttgtcagacaagaaaaagtttatatggtatatgggtgtcgttatcgcatatgtattgtgtgtgtgtgtgattgtgtataggtttcgcacacagaaatctgatatatggcaatatatgcaaatttcatatataacatacaagtttatatttgaatttcacatatagaaaaatcgatggttcattccactgtgtcaacctctaaaataaagactaagctgaagggaaatgactgaatatagaaaaatagatatccgtttatgtgtatattttaagtttcaaccattttaattacagatgtgtacattgcatatgtgtgtgtgtcatatatgaacacaaaatgattgctaatatatttgaacctatacggtatgtacatatttgtaattataatggttgtcaaactatatatgtaaacagccatttttgctacatacacttgtatgtcatataattcatttgcatatatttccgtatgtcggatttctatatgggttgttatatgggaagacaacattgaacttcttatgaccatagatgaagccattaagacgtagagaattcacacaagtatttgtaccgaactaatatttaatatattaaggaacttttgtttggtgatgatctatatatcatggtaatatttatgtaatattactgcattactattattttcttcaaatgtaactaaatgtagaatcagtgctcagcaaaaacacgcaggaatgtttttcattgtgagtaaagactgaacgaaaaaaaaaaaaaaaaaaaaaaaa

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