LOCUS       NM_207095               1276 bp    mRNA    linear   VRT 23-MAR-2025
DEFINITION  Danio rerio SIX homeobox 1b (six1b), mRNA.
ACCESSION   NM_207095
VERSION     NM_207095.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1276)
  AUTHORS   Bell,J.M., Turner,E.M., Biesemeyer,C., Vanderbeck,M.M.,
            Hendricks,R. and McGraw,H.F.
  TITLE     foxg1a is required for hair cell development and regeneration in
            the zebrafish lateral line
  JOURNAL   Biol Open 13 (9) (2024)
   PUBMED   39301848
REFERENCE   2  (bases 1 to 1276)
  AUTHORS   Miller,B.M. and Goessling,W.
  TITLE     The proteasome subunit psmb1 is essential for craniofacial
            cartilage maturation and morphogenesis
  JOURNAL   JCI Insight 9 (16), e181723 (2024)
   PUBMED   39171526
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1276)
  AUTHORS   Yan,C.Y., Wu,F.Y., Sun,F., Fang,Y., Zhang,R.J., Zhang,C.R.,
            Zhang,C.X., Wang,Z., Yang,R.M., Yang,L., Dong,M., Zhang,Q.Y.,
            Ye,X.P., Song,H.D. and Zhao,S.X.
  TITLE     The isl2a transcription factor regulates pituitary development in
            zebrafish
  JOURNAL   Front Endocrinol (Lausanne) 14, 920548 (2023)
   PUBMED   36824359
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1276)
  AUTHORS   Sugasawa,T., Komine,R., Manevich,L., Tamai,S., Takekoshi,K. and
            Kanki,Y.
  TITLE     Gene Expression Profile Provides Novel Insights of
            Fasting-Refeeding Response in Zebrafish Skeletal Muscle
  JOURNAL   Nutrients 14 (11), 2239 (2022)
   PUBMED   35684038
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1276)
  AUTHORS   Hsu,J.Y., Danis,E.P., Nance,S., O'Brien,J.H., Gustafson,A.L.,
            Wessells,V.M., Goodspeed,A.E., Talbot,J.C., Amacher,S.L.,
            Jedlicka,P., Black,J.C., Costello,J.C., Durbin,A.D., Artinger,K.B.
            and Ford,H.L.
  TITLE     SIX1 reprograms myogenic transcription factors to maintain the
            rhabdomyosarcoma undifferentiated state
  JOURNAL   Cell Rep 38 (5), 110323 (2022)
   PUBMED   35108532
  REMARK    GeneRIF: SIX1 reprograms myogenic transcription factors to maintain
            the rhabdomyosarcoma undifferentiated state.
REFERENCE   6  (bases 1 to 1276)
  AUTHORS   Pogoda,H.M. and Hammerschmidt,M.
  TITLE     How to make a teleost adenohypophysis: molecular pathways of
            pituitary development in zebrafish
  JOURNAL   Mol Cell Endocrinol 312 (1-2), 2-13 (2009)
   PUBMED   19728983
  REMARK    Review article
REFERENCE   7  (bases 1 to 1276)
  AUTHORS   Lin,C.Y., Chen,W.T., Lee,H.C., Yang,P.H., Yang,H.J. and Tsai,H.J.
  TITLE     The transcription factor Six1a plays an essential role in the
            craniofacial myogenesis of zebrafish
  JOURNAL   Dev Biol 331 (2), 152-166 (2009)
   PUBMED   19409884
REFERENCE   8  (bases 1 to 1276)
  AUTHORS   Bessarab,D.A., Chong,S.W., Srinivas,B.P. and Korzh,V.
  TITLE     Six1a is required for the onset of fast muscle differentiation in
            zebrafish
  JOURNAL   Dev Biol 323 (2), 216-228 (2008)
   PUBMED   18789916
REFERENCE   9  (bases 1 to 1276)
  AUTHORS   Bricaud,O. and Collazo,A.
  TITLE     The transcription factor six1 inhibits neuronal and promotes hair
            cell fate in the developing zebrafish (Danio rerio) inner ear
  JOURNAL   J Neurosci 26 (41), 10438-10451 (2006)
   PUBMED   17035528
  REMARK    GeneRIF: six1 promotes inner hair cell fate and inhibits neuronal
            fate during development.
REFERENCE   10 (bases 1 to 1276)
  AUTHORS   Nica,G., Herzog,W., Sonntag,C., Nowak,M., Schwarz,H., Zapata,A.G.
            and Hammerschmidt,M.
  TITLE     Eya1 is required for lineage-specific differentiation, but not for
            cell survival in the zebrafish adenohypophysis
  JOURNAL   Dev Biol 292 (1), 189-204 (2006)
   PUBMED   16458879
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC066396.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066396.1, AY254196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1276
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="20"
                     /map="20"
     gene            1..1276
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="SIX homeobox 1b"
                     /db_xref="GeneID:404627"
                     /db_xref="ZFIN:ZDB-GENE-040426-2308"
     exon            1..704
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    127..129
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="upstream in-frame stop codon"
     CDS             145..999
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="six1a; sine oculis homeobox homolog 1; homeodomain
                     transcription factor six1; homeobox protein six1a; sine
                     oculis homeobox homolog 1a; sine oculis homeobox homolog
                     1b"
                     /codon_start=1
                     /product="homeobox protein six1b"
                     /protein_id="NP_996978.1"
                     /db_xref="GeneID:404627"
                     /db_xref="ZFIN:ZDB-GENE-040426-2308"
                     /translation="

MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENNNTGANKQNQLSPLDGGKSLMSSSEDEFSPPQSPDQNSVLLLQGNMSHPGASAYSMTGLGAAQSVHGMQGHPHQLQDSLLGPLTSSLVDLGS"

     misc_feature    169..498
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="Transcriptional regulator, SIX1, N-terminal SD
                     domain; Region: SIX1_SD; pfam16878"
                     /db_xref="CDD:465293"
     misc_feature    529..684
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="Homeodomain; DNA binding domains involved in the
                     transcriptional regulation of key eukaryotic developmental
                     processes; may bind to DNA as monomers or as homo- and/or
                     heterodimers, in a sequence-specific manner; Region:
                     homeodomain; cd00086"
                     /db_xref="CDD:238039"
     misc_feature    order(532..534,652..654,661..666,673..675)
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    643..858
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6NZ04.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     exon            705..1262
                     /gene="six1b"
                     /gene_synonym="six1; zgc:77345"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cgcgcgcagaggacatctccaaccccaaaaaacttgtcaagtgacttggtcgctctcattaatcgaaggcaaacggggtgtcgcccattccgcttccttcgtagcatccagaggagagcggtttggtagcgggagtcaggcgtcatgtcaatgttgccttctttcgggtttacgcaggagcaagtcgcgtgtgtgtgtgaggtgcttcaacaaggggggaacctcgagcgtctcggacgatttctgtggtctctcccggcttgcgatcatctccacaaaaacgaaagcgtcctcaaagccaaggctgtcgtcgccttccatcgtggaaacttcagggaactttataagatactagagagccaccagttctctccgcacaaccacccgaagctgcagcagctgtggcttaaggcccattacattgaggctgagaagctgagggggcgaccgctgggagccgtggggaaataccgagtgcgcaggaaatttcctctgcctcgcacaatatgggacggagaggagaccagctactgttttaaggagaagtcccgcggggtgctgcgagagtggtacacgcacaacccctatccatctcctcgggaaaagagggagctggccgaggccacaggactgactaccacacaagtgagcaactggtttaaaaacagacggcagagggatcgcgcagcggaggcgaaagaaagggaaaacagcgagaacaacaacacgggcgctaacaaacagaaccagctgtcaccgctggacggcgggaagtccctgatgtcgagctcggaggacgaattctcgcccccgcagagtcctgaccagaactccgtgctcctgctccagggtaatatgagccaccccggcgcgtccgcgtactccatgaccggtctcggcgccgcacagtcggtacacggcatgcaaggacacccacatcagctccaggattcattactgggacctttaacttcaagtctagtggacctaggctcttaagtgattgcgactaagcttttatttatttttgtttattttgtaccaaatatagactatgatctgccacttttactgtatatataagggaaaatgaacattaaaatataagtaaaaatcctagtttttctctggttttcagagaaatactcagtggtacactttaccgtggtagactattacggactgacatttgccaagtcgttaaactggtcagaagacaaaccaaaaagcagttaataaaactattctttccttcaaactcaaaaaaaaaaaaaaa

//