LOCUS       NM_200297               1638 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio monoglyceride lipase (mgll), mRNA.
ACCESSION   NM_200297
VERSION     NM_200297.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1638)
  AUTHORS   Grepper,D., Tabasso,C., Aguettaz,A.K.F., Martinotti,A.,
            Ebrahimi,A., Lagarrigue,S. and Amati,F.
  TITLE     Methodological advancements in organ-specific ectopic lipid
            quantitative characterization: Effects of high fat diet on muscle
            and liver intracellular lipids
  JOURNAL   Mol Metab 68, 101669 (2023)
   PUBMED   36642092
REFERENCE   2  (bases 1 to 1638)
  AUTHORS   Hu,R., Xu,Y., Han,B., Chen,Y., Li,W., Guan,G., Hu,P., Zhou,Y.,
            Xu,Q. and Chen,L.
  TITLE     MiR-202-3p determines embryo viability during mid-blastula
            transition
  JOURNAL   Front Cell Dev Biol 10, 897826 (2022)
   PUBMED   36003151
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1638)
  AUTHORS   Zhang,W., Wu,C., Ni,R., Yang,Q., Luo,L. and He,J.
  TITLE     Formimidoyltransferase cyclodeaminase prevents the
            starvation-induced liver hepatomegaly and dysfunction through
            downregulating mTORC1
  JOURNAL   PLoS Genet 17 (12), e1009980 (2021)
   PUBMED   34941873
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1638)
  AUTHORS   Bian,W.P., Pu,S.Y., Xie,S.L., Wang,C., Deng,S., Strauss,P.R. and
            Pei,D.S.
  TITLE     Loss of mpv17 affected early embryonic development via mitochondria
            dysfunction in zebrafish
  JOURNAL   Cell Death Discov 7 (1), 250 (2021)
   PUBMED   34537814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1638)
  AUTHORS   Knuth,M.M., Stutts,W.L., Ritter,M.M., Garrard,K.P. and Kullman,S.W.
  TITLE     Vitamin D deficiency promotes accumulation of bioactive lipids and
            increased endocannabinoid tone in zebrafish
  JOURNAL   J Lipid Res 62, 100142 (2021)
   PUBMED   34673019
REFERENCE   6  (bases 1 to 1638)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1638)
  AUTHORS   Falcinelli,S., Picchietti,S., Rodiles,A., Cossignani,L.,
            Merrifield,D.L., Taddei,A.R., Maradonna,F., Olivotto,I.,
            Gioacchini,G. and Carnevali,O.
  TITLE     Lactobacillus rhamnosus lowers zebrafish lipid content by changing
            gut microbiota and host transcription of genes involved in lipid
            metabolism
  JOURNAL   Sci Rep 5, 9336 (2015)
   PUBMED   25822072
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1638)
  AUTHORS   Klee,E.W., Schneider,H., Clark,K.J., Cousin,M.A., Ebbert,J.O.,
            Hooten,W.M., Karpyak,V.M., Warner,D.O. and Ekker,S.C.
  TITLE     Zebrafish: a model for the study of addiction genetics
  JOURNAL   Hum Genet 131 (6), 977-1008 (2012)
   PUBMED   22207143
  REMARK    Review article
REFERENCE   9  (bases 1 to 1638)
  AUTHORS   McPartland,J.M., Glass,M., Matias,I., Norris,R.W. and
            Kilpatrick,C.W.
  TITLE     A shifted repertoire of endocannabinoid genes in the zebrafish
            (Danio rerio)
  JOURNAL   Mol Genet Genomics 277 (5), 555-570 (2007)
   PUBMED   17256142
REFERENCE   10 (bases 1 to 1638)
  AUTHORS   Song,H.D., Sun,X.J., Deng,M., Zhang,G.W., Zhou,Y., Wu,X.Y.,
            Sheng,Y., Chen,Y., Ruan,Z., Jiang,C.L., Fan,H.Y., Zon,L.I.,
            Kanki,J.P., Liu,T.X., Look,A.T. and Chen,Z.
  TITLE     Hematopoietic gene expression profile in zebrafish kidney marrow
  JOURNAL   Proc Natl Acad Sci U S A 101 (46), 16240-16245 (2004)
   PUBMED   15520368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC049487.1.
            
            On Aug 31, 2012 this sequence version replaced NM_200297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049487.1, AY398382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505372
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1638              BC049487.1         2-1639
FEATURES             Location/Qualifiers
     source          1..1638
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="8"
                     /map="8"
     gene            1..1638
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /note="monoglyceride lipase"
                     /db_xref="GeneID:378960"
                     /db_xref="ZFIN:ZDB-GENE-031006-9"
     exon            1..119
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    71..73
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /note="upstream in-frame stop codon"
     exon            120..264
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1042
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /EC_number="3.1.1.23"
                     /codon_start=1
                     /product="monoglyceride lipase"
                     /protein_id="NP_956591.1"
                     /db_xref="GeneID:378960"
                     /db_xref="ZFIN:ZDB-GENE-031006-9"
                     /translation="

MPEPEGTRRSPQGVPYSDLPHIVNADGLHLFCRYWEPDGPPKALVYVAHGAGEHCGGYADIAHSLTQHGILVFAHDHVGHGQSEGERMELKNFQIYVRDSLQHIDIMKARYPKLAVFIVGHSMGGAISILTACERPQDFTGVVLIGPMVQMSAESATPFKVFMAKVLNRLAPKLTLGPIDPKFVSRDPKQVEAYEKDELNYHGGLRVSFGMQMLDATSRIERELPDIRWPFYILHGDADKLCDIRGSRLLYNEAKSTDKKLKVYEEAYHALHHDLPETIESVLKEVSTWILERVPAPQTS"

     misc_feature    254..964
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /note="Serine aminopeptidase, S33; Region: Hydrolase_4;
                     pfam12146"
                     /db_xref="CDD:463473"
     exon            265..371
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     exon            372..508
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     exon            509..619
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     exon            620..709
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     exon            710..925
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1622
                     /gene="mgll"
                     /gene_synonym="cb909; wu:fc66g01; zgc:56561"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agtgcgggaaacagcagcaggctgaacgccgctgtcaaacgccggcttcgttagcggaccactcactccataacctgaattgatttctgcctccagcattcagcctgtagcaggttctgactcaaccctcagcggggacatgccggaacccgaggggactcgtcggtcaccgcaaggtgttccttacagcgacctgccgcacatcgtcaacgccgacggactgcacttgttctgtcgttactgggagcccgacggtcctccgaaggcgctggtgtatgttgcccatggagcgggagagcattgtgggggatacgctgacattgctcacagtctgacccagcatggcattctggtgttcgcccacgaccacgttggtcatggtcaaagtgaaggtgagaggatggagctcaaaaacttccagatttacgtcagagactccctccagcacattgacatcatgaaggctcggtatcccaagctggccgtcttcatcgttggacattcaatgggaggagccatttccattctgaccgcatgcgagaggccgcaggattttacaggtgtggttctcattggccctatggttcagatgagtgctgaatctgctacacccttcaaggttttcatggccaaagttctaaaccgcttggctcctaaactcactctcggcccaatcgatccaaaatttgtctcacgggatcccaaacaggtggaggcatatgaaaaggatgagctgaattatcatggggggctacgcgtctcgttcgggatgcagatgttggatgcgacgtctcgcatcgagagagagttaccagacatcaggtggcccttttacattctacatggagacgccgacaaactgtgtgacatcagaggctctcgattattgtataatgaagccaagagcactgataaaaaactgaaggtatatgaagaagcttaccatgccctacatcacgacttacctgaaacaatcgagtctgtattaaaggaggtgagcacctggatcctggagagagtccctgcccctcaaacctcttagctgtcaatcacagcatacacacacacatgcctaagctccgcccctgtccaatcacatctctactttacagagagatatcagcctgcactacatgcaaacaatactatcctctgtttaattaacctagaggtctttactaagtgacctttgagcataaggcaaagcactggagatgaaaaaggtgaaaaatgatcaccatacttcaccagttgaccaattacttaaagaaataaattttttataacaagatttgatatgctatgtttaaatatgaaacgaggctcataaaaatatatttcaagcataaaaatctgaactgaagtcaggtttaaaaaagatctttttgacaccacagggtcttttttatcactccataattcagaaactacaacgaacagccagcaaaaatattataataacaatattttttaagaataaaagtttatatgcaatcagataaattatgtatagacatatatcccttggtagaaactttcaacatatagatacaactgacaaattggtgtaaaaatgtgatgaatgtaagatctgaaagctgctgaaatggaaatatagtgcaaaagaaaaaaaaaaaa

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