LOCUS       NM_153651               1740 bp    mRNA    linear   VRT 07-DEC-2024
DEFINITION  Danio rerio T cell leukemia homeobox 2 (tlx2), mRNA.
ACCESSION   NM_153651
VERSION     NM_153651.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1740)
  AUTHORS   Sundaramoorthi,H., Fallatah,W., Mary,J. and Jagadeeswaran,P.
  TITLE     Discovery of seven hox genes in zebrafish thrombopoiesis
  JOURNAL   Blood Cells Mol Dis 104, 102796 (2024)
   PUBMED   37717409
REFERENCE   2  (bases 1 to 1740)
  AUTHORS   Lobbardi,R., Pinder,J., Martinez-Pastor,B., Theodorou,M.,
            Blackburn,J.S., Abraham,B.J., Namiki,Y., Mansour,M.,
            Abdelfattah,N.S., Molodtsov,A., Alexe,G., Toiber,D., de Waard,M.,
            Jain,E., Boukhali,M., Lion,M., Bhere,D., Shah,K., Gutierrez,A.,
            Stegmaier,K., Silverman,L.B., Sadreyev,R.I., Asara,J.M.,
            Oettinger,M.A., Haas,W., Look,A.T., Young,R.A., Mostoslavsky,R.,
            Dellaire,G. and Langenau,D.M.
  TITLE     TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell
            Acute Lymphoblastic Leukemia
  JOURNAL   Cancer Discov 7 (11), 1336-1353 (2017)
   PUBMED   28974511
REFERENCE   3  (bases 1 to 1740)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1740)
  AUTHORS   Petit,D., Teppa,E., Mir,A.M., Vicogne,D., Thisse,C., Thisse,B.,
            Filloux,C. and Harduin-Lepers,A.
  TITLE     Integrative view of alpha2,3-sialyltransferases (ST3Gal) molecular
            and functional evolution in deuterostomes: significance of
            lineage-specific losses
  JOURNAL   Mol Biol Evol 32 (4), 906-927 (2015)
   PUBMED   25534026
REFERENCE   5  (bases 1 to 1740)
  AUTHORS   Wang,J., Wu,Y., Zhao,F., Wu,Y., Dong,W., Zhao,J., Zhu,Z. and Liu,D.
  TITLE     Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural
            development in zebrafish
  JOURNAL   J Neurosci 35 (1), 234-244 (2015)
   PUBMED   25568117
REFERENCE   6  (bases 1 to 1740)
  AUTHORS   Kozlowski,D.J., Whitfield,T.T., Hukriede,N.A., Lam,W.K. and
            Weinberg,E.S.
  TITLE     The zebrafish dog-eared mutation disrupts eya1, a gene required for
            cell survival and differentiation in the inner ear and lateral line
  JOURNAL   Dev Biol 277 (1), 27-41 (2005)
   PUBMED   15572137
REFERENCE   7  (bases 1 to 1740)
  AUTHORS   Kaji,T. and Artinger,K.B.
  TITLE     dlx3b and dlx4b function in the development of Rohon-Beard sensory
            neurons and trigeminal placode in the zebrafish neurula
  JOURNAL   Dev Biol 276 (2), 523-540 (2004)
   PUBMED   15581883
REFERENCE   8  (bases 1 to 1740)
  AUTHORS   Park,H.C. and Appel,B.
  TITLE     Delta-Notch signaling regulates oligodendrocyte specification
  JOURNAL   Development 130 (16), 3747-3755 (2003)
   PUBMED   12835391
REFERENCE   9  (bases 1 to 1740)
  AUTHORS   Langenau,D.M., Palomero,T., Kanki,J.P., Ferrando,A.A., Zhou,Y.,
            Zon,L.I. and Look,A.T.
  TITLE     Molecular cloning and developmental expression of Tlx (Hox11) genes
            in zebrafish (Danio rerio)
  JOURNAL   Mech Dev 117 (1-2), 243-248 (2002)
   PUBMED   12204264
  REMARK    GeneRIF: identification and expression patterns of three members of
            the zebrafish Tlx family
REFERENCE   10 (bases 1 to 1740)
  AUTHORS   Bellipanni,G., Murakami,T., Doerre,O.G., Andermann,P. and
            Weinberg,E.S.
  TITLE     Expression of Otx homeodomain proteins induces cell aggregation in
            developing zebrafish embryos
  JOURNAL   Dev Biol 223 (2), 339-353 (2000)
   PUBMED   10882520
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128814.1.
            
            On Nov 30, 2007 this sequence version replaced NM_153651.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128814.1, AF398518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476774 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1740
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="14"
                     /map="14"
     gene            1..1740
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /note="T cell leukemia homeobox 2"
                     /db_xref="GeneID:170781"
                     /db_xref="ZFIN:ZDB-GENE-020208-1"
     exon            1..907
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    376..378
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /note="upstream in-frame stop codon"
     CDS             433..1338
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /note="T-cell leukemia, homeobox 3a"
                     /codon_start=1
                     /product="T-cell leukemia homeobox protein 2"
                     /protein_id="NP_705937.2"
                     /db_xref="GeneID:170781"
                     /db_xref="ZFIN:ZDB-GENE-020208-1"
                     /translation="

MEHTGIEEVNQTHQQHETISFGIDQILNGSDQSSSCMLPSRTGDPDYALTPNVYNGYNSMYPACSMAAGLAGSYNVNMNMNVSMNMNVNVNSGNAGGVIRVPAHRPMPPAPHQPTAGHPPSIAAGIPTMPTVPSMGSPHSFTFPWMESSRRFAKDRLTAALSPFSVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASAERATLAKALKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQANRLMLQLQQEAFQKTLSQPLQQDPLCLHNSSLYALQNLQPWAEDNKLPI"

     misc_feature    979..1149
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            908..1145
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1326
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1715
                     /gene="tlx2"
                     /gene_synonym="hox11l; Tlx-3a; tlx3a; tlxA"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cacgtatcggacagttaacacttcactttagataacagcgatgagctcaagtctgggccgtgcgcctttctgaggtactccagaaacgcgtcagttttctttgctacaacttggcaactcatcactccgggatttaaccgcggagcacggtcgagctgctttttaggcatcatcatggaactgagcaacagacagacgcagtgcaagaaagtgttggataacgccgatttgatcgcgagggagtgatttctgttcttattttttgtatgtgtgtgtggtgtggcattgatataaattgcatgggctctgagcactccaaggaagaatatttttttgtttttttgttttctaaataaacacctttgggaataaatctaagttttaggaattaaacaaccttccaagctgtgcgtaacagatagaaccgcggagatggagcacacggggatcgaagaggtgaaccagacccaccagcagcacgaaaccatcagctttggaatagatcagatcctcaatggctcggaccagtcgagtagttgcatgctgcccagccgaaccggcgacccggactacgcgctcacgccgaacgtctacaacggctacaacagcatgtatccggcctgttcgatggcggcaggactagcaggttcctacaacgtaaacatgaacatgaatgtgagcatgaatatgaacgttaatgtgaactcggggaacgctggaggtgtcatccgcgtcccggcccacagacccatgccacccgcacctcaccaaccgacggctggccatccaccgagcatcgcggcgggaattcccactatgcccacagtacccagtatgggcagcccccacagtttcacgttcccctggatggagagcagcagaaggtttgcgaaggatagactgacagctgctctgtccccgttctccgtcacacggcggatcggtcatccgtaccagaaccggacaccgccgaagcgaaaaaagccacgcacgtcgttcagccgcgtgcagatctgcgagctggagaaacgctttcaccggcagaaatatctggcgtccgcggagcgcgccacactcgccaaggccttgaagatgacagacgctcaagtcaaaacctggtttcaaaacagaagaacaaaatggaggaggcagacagcggaggagagggaggccgagcgacagcaagccaaccgtctgatgctgcagcttcagcaggaggcctttcagaagaccctgagtcagccgctccaacaagacccgctctgccttcacaactcctcgctttatgccctgcagaacttacagccctgggcagaggacaataagctacccatctaacagagggacgggctttgtcctttccaaccccaaaccgcaaagctgtctgatgaatttcacccatcaagacggctgtttgtctacgtgccatttggcatcgaggagactgactcaaccccagactcgttcattcttgttctttttatttgtgtttgttttgttctccccctttggactttgtaagatgtgtttgtgatgcatgttctctacatttcctgtatgaagagatggactaaaaacggttagttctgtcaaactggagtccttcctaaaacgcactttggaagcaattacagaggcgctctttctctctctctggattcttcatgacgtgacgtttaaaggtgttttatattaaaaagaattgtgacttctaaaaaaaaaaaaaaaaaaaaaaaaaaa

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