LOCUS       NM_131776               1773 bp    mRNA    linear   VRT 07-DEC-2024
DEFINITION  Danio rerio NK2 homeobox 1 (nkx2.1), mRNA.
ACCESSION   NM_131776
VERSION     NM_131776.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1773)
  AUTHORS   Umeda,K., Tanaka,K., Chowdhury,G., Nasu,K., Kuroyanagi,Y. and
            Yamasu,K.
  TITLE     Evolutionarily conserved roles of foxg1a in the developing
            subpallium of zebrafish embryos
  JOURNAL   Dev Growth Differ 66 (3), 219-234 (2024)
   PUBMED   38378191
REFERENCE   2  (bases 1 to 1773)
  AUTHORS   Chowdhury,G., Umeda,K., Ohyanagi,T., Nasu,K. and Yamasu,K.
  TITLE     Involvement of nr2f genes in brain regionalization and eye
            development during early zebrafish development
  JOURNAL   Dev Growth Differ 66 (2), 145-160 (2024)
   PUBMED   38263801
REFERENCE   3  (bases 1 to 1773)
  AUTHORS   Vaz,R., Edwards,S., Duenas-Rey,A., Hofmeister,W. and Lindstrand,A.
  TITLE     Loss of ctnnd2b affects neuronal differentiation and behavior in
            zebrafish
  JOURNAL   Front Neurosci 17, 1205653 (2023)
   PUBMED   37465584
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1773)
  AUTHORS   Hernandez-Bejarano,M., Gestri,G., Monfries,C., Tucker,L.,
            Dragomir,E.I., Bianco,I.H., Bovolenta,P., Wilson,S.W. and
            Cavodeassi,F.
  TITLE     Foxd1-dependent induction of a temporal retinal character is
            required for visual function
  JOURNAL   Development 149 (24) (2022)
   PUBMED   36520654
REFERENCE   5  (bases 1 to 1773)
  AUTHORS   Wang,H., Dong,F., Zhao,Y., Fu,S., Zhao,H., Liu,S., Zhang,W. and
            Hu,F.
  TITLE     Exposure to diclofenac alters thyroid hormone levels and
            transcription of genes involved in the
            hypothalamic-pituitary-thyroid axis in zebrafish embryos/larvae
  JOURNAL   Comp Biochem Physiol C Toxicol Pharmacol 257, 109335 (2022)
   PUBMED   35351617
REFERENCE   6  (bases 1 to 1773)
  AUTHORS   Feng,J., White,B., Tyurina,O.V., Guner,B., Larson,T., Lee,H.Y.,
            Karlstrom,R.O. and Kohtz,J.D.
  TITLE     Synergistic and antagonistic roles of the Sonic hedgehog N- and
            C-terminal lipids
  JOURNAL   Development 131 (17), 4357-4370 (2004)
   PUBMED   15294867
REFERENCE   7  (bases 1 to 1773)
  AUTHORS   Elsalini,O.A., von Gartzen,J., Cramer,M. and Rohr,K.B.
  TITLE     Zebrafish hhex, nk2.1a, and pax2.1 regulate thyroid growth and
            differentiation downstream of Nodal-dependent transcription factors
  JOURNAL   Dev Biol 263 (1), 67-80 (2003)
   PUBMED   14568547
REFERENCE   8  (bases 1 to 1773)
  AUTHORS   Walshe,J. and Mason,I.
  TITLE     Unique and combinatorial functions of Fgf3 and Fgf8 during
            zebrafish forebrain development
  JOURNAL   Development 130 (18), 4337-4349 (2003)
   PUBMED   12900450
REFERENCE   9  (bases 1 to 1773)
  AUTHORS   Karlstrom,R.O., Tyurina,O.V., Kawakami,A., Nishioka,N.,
            Talbot,W.S., Sasaki,H. and Schier,A.F.
  TITLE     Genetic analysis of zebrafish gli1 and gli2 reveals divergent
            requirements for gli genes in vertebrate development
  JOURNAL   Development 130 (8), 1549-1564 (2003)
   PUBMED   12620981
REFERENCE   10 (bases 1 to 1773)
  AUTHORS   Shanmugalingam,S., Houart,C., Picker,A., Reifers,F., Macdonald,R.,
            Barth,A., Griffin,K., Brand,M. and Wilson,S.W.
  TITLE     Ace/Fgf8 is required for forebrain commissure formation and
            patterning of the telencephalon
  JOURNAL   Development 127 (12), 2549-2561 (2000)
   PUBMED   10821754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF321112.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF321112.1, BC162657.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1773
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="17"
                     /map="17"
     gene            1..1773
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /note="NK2 homeobox 1"
                     /db_xref="GeneID:81883"
                     /db_xref="ZFIN:ZDB-GENE-010404-1"
     exon            1..494
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /note="upstream in-frame stop codon"
     CDS             128..1168
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /note="thyroid transcription factor 1b; NK2 homeobox 1b"
                     /codon_start=1
                     /product="homeobox protein Nkx-2.1"
                     /protein_id="NP_571851.1"
                     /db_xref="GeneID:81883"
                     /db_xref="ZFIN:ZDB-GENE-010404-1"
                     /translation="

MSMSPKHTTPFSVSDILSPLEESYKKVSMEGNNLGAPLASYRQPQVTQAAMQQHHMGHNGTVPAAYHMTAAGVSQLSHTAMGGYCNGNLGNMSDLPAYQDGMRGSTTATSWYGTNPDPRFSTISRFMGSSSGMNMGSMSTLSSLADVGKGMGPLTSTPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKVSQQQMQQDNGSCQQQQQSPRRVAVPVLVKDGKPCQGSSHTPNTGVQNHHHQGGNVMFMTNTSLSMSQHQSQQVGSAGQSLDLGQHAASPPSLQTQVPGLSHLNSSGSEYGAALPCSALLYGRTW"

     misc_feature    605..775
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            495..1772
                     /gene="nkx2.1"
                     /gene_synonym="nk2.1b; nkx2.1b; nkx2.4b; titf1b;
                     wu:fc31g10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

tccagtgcgcactcatacgtttccatcctgctgcagcgacggtgaaacaacaggaacagaggagctggccaaaaaaagaaggagagattgccttgccttctaatttctccctttccaacacagaacaatgtcgatgagccctaagcatacgactcctttttctgtatccgatatcttaagtcctcttgaagagagctacaaaaaagtgagtatggaggggaacaacttgggggctcctcttgcctcgtacagacaaccccaagtcacgcaagcggcgatgcagcagcaccacatgggccacaatggaacagtacccgctgcctaccacatgactgcagctggagtttcccagctgtcacatacagccatggggggctactgtaacgggaatttgggcaacatgagcgacctgccggcctatcaagacgggatgagaggcagcacgacggccaccagctggtacggaacgaatcctgacccacgcttctctacaatctctcgcttcatgggctcctcgtctggtatgaacatgggcagcatgagcactctgagttcgttggcggatgttggtaaaggcatgggtccactgaccagcacacctcgcaggaagagacgggtactcttctcccaggcgcaggtgtatgagcttgagcggcggttcaagcagcagaagtacctctccgcgccggaaagggagcatctggccagcatgatacacctgactccgactcaagttaaaatttggtttcagaaccaccggtataaaatgaaaaggcaagccaaggacaaggtgtcccagcagcagatgcaacaagacaatggttcctgtcagcagcagcagcagtctccacggcgggtggcggtgcctgtgttggtgaaagacggaaagccatgccaaggcagcagtcacacacccaacactggtgtacaaaaccaccatcaccaggggggaaacgtcatgtttatgaccaataccagtctttcaatgagccagcatcaaagtcagcaggtaggcagcgccggtcagtcccttgatttgggtcaacatgctgcaagcccgccatccctccaaacccaggtacccggcctatcacacctgaactcttccggttccgaatatggagctgcgttgccctgctccgctctgctttatggcaggacgtggtgacagacaataatacaataacgaaagtacgacaggtggatgcagattatgtgtacactatgctctgctcaaaaagaccatgcgaactggggtggcgctccgaaatcattgtctcctttctcggagggagaagtgacaaggctgcaagcaacgcgaggattgccaaatgtcaaaggtatcaaatcttttattgtgaggatgagcgccaaaacatcattaagaagatggaattatttatatacactagattttaaatggagactgactaaaacactaaaacacaaatattctgtcatcctgatggatttttaaaaatgtccctttcaacaatgaagacgtcccccctcacatttagactgctaaatacatttcatgatttcttaaagatttcactgtaaaacgtagcttgtatatttctgtaaaaggtttggactgattacatagtttttagcgatgtgtatattgtacaaaatttttatcgatattaaggttcacaagtttttttcagttccattgttatttgtacgtttaattttcttgtaacttatatagatatttgacttaaacacagtcatacaatcatattaataaattatgacaataataaa

//