2024-11-24 10:34:14, GGRNA.v2 : RefSeq release 226 (Sep, 2024)
LOCUS NM_131721 7896 bp mRNA linear VRT 08-SEP-2024 DEFINITION Danio rerio mitogen-activated protein kinase 8b (mapk8b), mRNA. ACCESSION NM_131721 VERSION NM_131721.2 KEYWORDS RefSeq. SOURCE Danio rerio (zebrafish) ORGANISM Danio rerio Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio. REFERENCE 1 (bases 1 to 7896) AUTHORS Hong,Y., Sourander,C., Hackl,B., Patton,J.S., John,J., Paatero,I. and Coffey,E. TITLE Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen JOURNAL Sci Rep 14 (1), 11174 (2024) PUBMED 38750129 REMARK GeneRIF: Jnk1 and downstream signalling hubs regulate anxiety-like behaviours in a zebrafish larvae phenotypic screen. Publication Status: Online-Only REFERENCE 2 (bases 1 to 7896) AUTHORS Li,Y., Zhang,L., Mao,M., He,L., Wang,T., Pan,Y., Zhao,X., Li,Z., Mu,X., Qian,Y. and Qiu,J. TITLE Multi-omics analysis of a drug-induced model of bipolar disorder in zebrafish JOURNAL iScience 26 (5), 106744 (2023) PUBMED 37207274 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7896) AUTHORS Zhou,C., Chen,J., Liu,K., Maharajan,K., Zhang,Y., Hou,L., Li,J., Mi,M. and Xia,Q. TITLE Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation JOURNAL Biomed Pharmacother 160, 114315 (2023) PUBMED 36716661 REFERENCE 4 (bases 1 to 7896) AUTHORS Shao,G.J., Wang,X.L., Wei,M.L., Ren,D.L. and Hu,B. TITLE DUSP2 deletion with CRISPR/Cas9 promotes Mauthner cell axonal regeneration at the early stage of zebrafish JOURNAL Neural Regen Res 18 (3), 577-581 (2023) PUBMED 36018180 REFERENCE 5 (bases 1 to 7896) AUTHORS Wang,S., Bao,J., Li,J., Li,W., Tian,M., Qiu,C., Pang,F., Li,X., Yang,J., Hu,Y., Wang,S. and Jin,H. TITLE Fraxinellone Induces Hepatotoxicity in Zebrafish through Oxidative Stress and the Transporters Pathway JOURNAL Molecules 27 (9), 2647 (2022) PUBMED 35566003 REMARK Publication Status: Online-Only REFERENCE 6 (bases 1 to 7896) AUTHORS Hendricks,M. and Jesuthasan,S. TITLE PHR regulates growth cone pausing at intermediate targets through microtubule disassembly JOURNAL J Neurosci 29 (20), 6593-6598 (2009) PUBMED 19458229 REFERENCE 7 (bases 1 to 7896) AUTHORS Zhang,Y., Bai,X.T., Zhu,K.Y., Jin,Y., Deng,M., Le,H.Y., Fu,Y.F., Chen,Y., Zhu,J., Look,A.T., Kanki,J., Chen,Z., Chen,S.J. and Liu,T.X. TITLE In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury JOURNAL J Immunol 181 (3), 2155-2164 (2008) PUBMED 18641354 REMARK GeneRIF: JNK-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo REFERENCE 8 (bases 1 to 7896) AUTHORS Rui,Y., Xu,Z., Xiong,B., Cao,Y., Lin,S., Zhang,M., Chan,S.C., Luo,W., Han,Y., Lu,Z., Ye,Z., Zhou,H.M., Han,J., Meng,A. and Lin,S.C. TITLE A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida JOURNAL Dev Cell 13 (2), 268-282 (2007) PUBMED 17681137 REMARK GeneRIF: A dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis, is defined. REFERENCE 9 (bases 1 to 7896) AUTHORS Krens,S.F., He,S., Spaink,H.P. and Snaar-Jagalska,B.E. TITLE Characterization and expression patterns of the MAPK family in zebrafish JOURNAL Gene Expr Patterns 6 (8), 1019-1026 (2006) PUBMED 16774848 REFERENCE 10 (bases 1 to 7896) AUTHORS Amali,A.A., Rekha,R.D., Lin,C.J., Wang,W.L., Gong,H.Y., Her,G.M. and Wu,J.L. TITLE Thioacetamide induced liver damage in zebrafish embryo as a disease model for steatohepatitis JOURNAL J Biomed Sci 13 (2), 225-232 (2006) PUBMED 16456712 COMMENT VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR774192.15. On Feb 26, 2016 this sequence version replaced NM_131721.1. Sequence Note: This RefSeq record was created from genomic sequence data because no single transcript from the reference genome strain was available for the full length of the gene. The extent of this transcript is supported by partial transcript alignments and orthologous alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB030900.1, GFIL01025906.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END## PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-118 CR774192.15 96501-96618 c 119-298 CR774192.15 92172-92351 c 299-428 CR774192.15 90209-90338 c 429-487 CR774192.15 89366-89424 c 488-626 CR774192.15 89082-89220 c 627-792 CR774192.15 88453-88618 c 793-864 CR774192.15 86175-86246 c 865-1047 CR774192.15 83818-84000 c 1048-1172 CR774192.15 82088-82212 c 1173-1236 CR774192.15 81639-81702 c 1237-1314 CR774192.15 81343-81420 c 1315-7896 CR774192.15 73813-80394 c FEATURES Location/Qualifiers source 1..7896 /organism="Danio rerio" /mol_type="mRNA" /strain="Tuebingen" /db_xref="taxon:7955" /chromosome="12" /map="12" gene 1..7896 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="mitogen-activated protein kinase 8b" /db_xref="GeneID:65236" /db_xref="ZFIN:ZDB-GENE-010202-1" exon 1..118 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 119..298 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" CDS 177..1331 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /EC_number="2.7.11.24" /note="c-Jun N-terminal kinase 1; stress-activated protein kinase JNK1; MAPK 8; MAP kinase 8" /codon_start=1 /product="mitogen-activated protein kinase 8" /protein_id="NP_571796.1" /db_xref="GeneID:65236" /db_xref="ZFIN:ZDB-GENE-010202-1" /translation="
MNRNKREKEYYSIDVGDSTFTVLKRYQNLRPIGSGAQGIVCSAYDHVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERLSYLLYQMLCGIKHLHAAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAATGLLMTPYVVTRYYRAPEVILGMGYQANVDVWSIGCIMAEMVRGSVLFPGTDHIDQWNKVIEQLGTPSQEFMMKLNQSVRTYVENRPRYAGYSFEKLFPDVLFPADSDHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEVEAPPPAITDKQLDEREHSVEEWKELIYKEVLEWEERTKNGVIRGQPASLAQVQQ"
misc_feature 249..1256 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; Region: STKc_JNK; cd07850" /db_xref="CDD:270840" misc_feature order(270..290,294..296,333..335,339..341,390..392, 432..434,498..518,522..527,627..629,633..635,639..644, 648..650,678..683,690..692,723..725,729..740,744..746, 855..857) /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="active site" /db_xref="CDD:270840" misc_feature order(270..290,294..296,333..335,339..341,432..434, 498..518,648..650,678..680) /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270840" misc_feature order(390..392,522..524,627..629,633..635,690..692, 723..725,729..740,744..746,855..857) /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270840" misc_feature order(510..512,528..530,555..557,564..566,651..665, 1143..1148,1152..1154,1161..1163) /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="KIM docking site [polypeptide binding]; other site" /db_xref="CDD:270840" misc_feature order(678..710,720..746) /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="activation loop (A-loop); other site" /db_xref="CDD:270840" misc_feature 723..731 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="propagated from UniProtKB/Swiss-Prot (Q9DGD9.1); Region: TXY" misc_feature 723..725 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="Phosphothreonine. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (Q9DGD9.1); phosphorylation site" misc_feature 729..731 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /note="Phosphotyrosine. /evidence=ECO:0000250; propagated from UniProtKB/Swiss-Prot (Q9DGD9.1); phosphorylation site" exon 299..428 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 429..487 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 488..626 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 627..792 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 793..864 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 865..1047 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 1048..1172 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 1173..1236 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 1237..1314 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" exon 1315..7896 /gene="mapk8b" /gene_synonym="JNK; JNK1; jnk1a-1; jnk1b; mapk8; zgc:112379" /inference="alignment:Splign:2.1.0" ORIGIN
agtggacggaaacgcagtgcttgtgtcttgtgtggaaagacaaatacaacaacccgctgagaagaccccagtgtttttatgattctacacttgaattgtctgttcatcttttaggaggatttttgaaggtgaagctcttcttgaatgcccaggatacagtcagtacggttttcatcatgaacaggaataagcgcgagaaagaatattacagcatagatgtaggagattcaacgttcaccgttttgaagcgctatcagaatttaagaccaatcgggtccggagcacaaggcatcgtctgctcagcgtatgaccacgtcctcgatcgaaatgtggcaattaagaaactcagccgaccctttcaaaaccaaactcatgccaaacgggcctacagagaactggtcctgatgaaatgcgtcaaccacaaaaatataattggcttactaaacgtgttcacaccacagaagacacttgaagagttccaggatgtttatctggtgatggagctgatggatgcaaacctgtgtcaggtgattcagatggagctggaccacgagaggctgtcctacctgctctatcagatgctctgcggcattaaacacctgcacgctgctggcatcatacacagggatctgaaacccagtaatatagtagtgaaatcggactgcacgctgaagatcctggatttcggtctggcccgaacggctgcaaccggcctcctcatgactccttatgtcgtgacacgctattatcgggccccagaggtcatcctgggcatgggttatcaagctaacgttgatgtctggtctattggctgcatcatggctgaaatggtcagaggtagtgtgttgtttcctggcacagaccatattgaccagtggaataaagtgatcgagcagctgggcacgccgtcacaggagttcatgatgaagctgaatcagtctgtgaggacgtatgtggagaaccggcctcggtatgcgggatacagctttgagaagctcttcccagacgtgctcttccccgcagactcggaccacaacaaactcaaggcgagtcaggcacgagacttgttatccaaaatgctggtaatagatgcatccaagcggatctctgtagacgaggcgcttcagcacccctacatcaacgtttggtacgacccatcagaagtggaggcgccgccaccagcgatcacggataaacagctcgatgagagagaacactcagtggaagagtggaaagagctcatatacaaggaagtgctggaatgggaggagcgaacaaaaaatggagtgatcagaggacagccggcctcgctagcacaggtgcagcagtgagcagtgactcccatgagccctcgacgtcgtcctcctccataaacgatgtgtcgtccatgtccaccgaggtcacgctgacctcagacaccgacagcagtcaggagacgtccaacggagcgctgcactgctgcagatgaccatccttcttcaacctccgtcaccctctgaaatccttcatcaccttccattgtcttctgtcatgattcttcatcctccaaaatgcttcatcaccttccaaaatcatctattgttctctgtcatggttcttcatcctccaaaatcctcccattggccttttaaaatcctccatcctcccctgtcaccttccaaaatcctctagccccctcaaatatgctctgttaccctctaaaatcctccatccttctttgtttaccatccaaaatcctcaatcgccctccaaattcctccattctcctcagttaccttccaaaatcctccattgtcttcattcaccctccaaaatcctccactaccccgtaaatcctccattaccctccaaaatccctcattgtgtttgtcaggattcttcatcctctgtcgccctccaaaatccttcattttcctccaaaatcctctgtcaccggcaaaatcctcctacattatccttcaaaatccttaattgccctccattttcctccagagtcctctgtcacctccaaaatctcttcattcacccttcaaaatactcagttgccctctaaaatcctctattttcctctagaatcctctgtcacctcccaaatcctcctcaatcgccctccaaaatcctctatcaccctctaaaatcctccatcacccttcaaaattctccatcacgctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcctccataacccttcaaaatctcccattaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaattctccatcatcctccaaaattctccatcaccctccaaaattctccatcaccctccaaaattctccatcatcctccaaaattctccatcatcctccaaaattctccatcatcctccaaaatcctccattaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccattaccttccaaaatcctccatcaccctccaaaatcctccatcaccctccaaaatcatccatcaccctccaaaatcctccataacccttcaaaatctcccatcaccctccaaaatcatatatcaccctccaaaatcctccattaccctccaaaattctccatcatcctccaaaattctccatcatcctccaacattctccattaccctccaaaattctccatcaccctccagaatcgtccatcaccctccaaaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaattctccatcaccctccagaatcctcaaactttcaagctcttgtcaattcaaaagtgtaagagtggcggggatagtttttttgagggcatctcaaaggcttttacaccaaaccagcattactttcactgctttcctgtttttattttgaactttgcatcaaattgaagctactgctacgtcgtcttgccattcggaagtggaatgattcaagtttatttgtaaagataaatggtgaatatatttttttcgagatgttttatttttttgagagtcattttaatcactaatgagtggaggttcattaaatggcacgtccattttttttggacaagtgagtatttccacactgttactactgctttggagtataaaaggcatctgtatgtttgttttggtctgataagtggtttaatttatggcctgtgtaactaaatcacgattagttgaacgtttaattcggttgtcttacagaatcacattttaaagtgctttttcgggatctgtaagctgatttttcctctaatttccacacacaagatttacttcacataatattctctctgtaaaaacacgtttgggttttcagaattcacattatgtaatctagcctgtacatatttcatctacaaacacagaaaacatcccagcttaattccgcttcaactgtacagtcacagctcttcatgtctgaacacttcaatatatgatctgaagcccatgccaggtttttggcccatgcatacaaaatgctttcgatttttccagtactgattttgaatttataaccaatatgcatacagctttgttgtcttattgagtatgcgttaagacaccgaactgatttactggatgcagcactcttgctaaatgaatatagaatgaatattaatgaaacccaaaggagcatgaaaaatgaacgcaacgtttctcatttcttgtttgctttaagtggaaatgtgtaaacattgcttaaatgtgatggttttctacagtagcgttcaaaataatagcaggacaacatgactaaccagaataatccagattttcataataatttttattgctacatggcaaacaagttaccaggtgcagtaaattctcaaaaaacaaacacgagcatttatgatatgcacgctcttaaggatgtgcaattgggcaattagttgaagggggtgtgtttaaaaaaatagcagtgtggtatttcgatcagtgaggtcatcaattttgggataaaacaggtgtgaaccaggtgggcccctatttaaggacatgtttgttgaacatgcatttgaaaaaagcctcatggtgcgtttacaccgttgaaccttttgtgttttctcgcttcatccgcacgtcaaattcgactcatattcaaatagagtcaaattcgtgactctagtttcgatgctaaatggctaacatggattttattgaggtagtagctgtgctttatgaaggctgaaaaacagcgtagatttgtttggcgccattagtccactagatcctttcagaggtgcacccagaggttcatcaactccaccagaatctatatccggatgatggacgcttttagcagtgcatccgactgagccaagcccagtttgaggagctgttgtccggtgtcggcaagaggatttccccttgcaacaccaacaacattgccgcttcatttaaacgcgtcaagcctcattcacactactagtgactcacaccggcaaagcgagagagaagcgaccactcatttcaacggagaacaagctacttccggcaaccaccatctacgtccacatacagccacattttctccctctgtacctggatattgcctgcctgctgcacctaaggactctgaaagcgatgtttgtcttgccccagcagcgcctgtgcctcttctttcctcctcttctgaccacctagtcatattctgtcttgtgatttatatgtaggcgtttgaataggtttgtggtattaccacagtacctcattgttttgttacacgtgtcacaaaccgcattgtttgattttatggaagtgaagtagctccacacaaaacttcgcttgcggtcacccatatccaatgacagcacaactgaacaacatgtgccagcggactgactgagcgg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Creative Commons Attribution 4.0 International License (CC BY 4.0).
If you use GGRNA in your work, please cite:
Naito Y, Bono H. (2012)
GGRNA: an ultrafast, transcript-oriented search engine for genes and transcripts.
Nucleic Acids Res., 40, W592-W596.
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