LOCUS       NM_131289               2712 bp    mRNA    linear   VRT 15-MAY-2023
DEFINITION  Danio rerio POU class 3 homeobox 2a (pou3f2a), mRNA.
ACCESSION   NM_131289
VERSION     NM_131289.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Okada K, Aoki K, Tabei T, Sugio K, Imai K, Bonkohara Y and Kamachi
            Y.
  TITLE     Key sequence features of CRISPR RNA for dual-guide CRISPR-Cas9
            ribonucleoprotein complexes assembled with wild-type or HiFi Cas9
  JOURNAL   Nucleic Acids Res 50 (5), 2854-2871 (2022)
   PUBMED   35166844
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Zhang T, Guan P, Liu W, Zhao G, Fang Y, Fu H, Gui JF, Li G and Liu
            JX.
  TITLE     Copper stress induces zebrafish central neural system myelin
            defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b
            DNA methylation
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1863 (10), 194612 (2020)
   PUBMED   32745624
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Spikol ED and Glasgow E.
  TITLE     Separate roles for Med12 and Wnt signaling in regulation of
            oxytocin expression
  JOURNAL   Biol Open 7 (3) (2018)
   PUBMED   29530929
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Cosse-Etchepare C, Gervi I, Buisson I, Formery L, Schubert M, Riou
            JF, Umbhauer M and Le Bouffant R.
  TITLE     Pou3f transcription factor expression during embryonic development
            highlights distinct pou3f3 and pou3f4 localization in the Xenopus
            laevis kidney
  JOURNAL   Int J Dev Biol 62 (4-5), 325-333 (2018)
   PUBMED   29877572
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Kasher PR, Schertz KE, Thomas M, Jackson A, Annunziata S,
            Ballesta-Martinez MJ, Campeau PM, Clayton PE, Eaton JL, Granata T,
            Guillen-Navarro E, Hernando C, Laverriere CE, Lieden A,
            Villa-Marcos O, McEntagart M, Nordgren A, Pantaleoni C,
            Pebrel-Richard C, Sarret C, Sciacca FL, Wright R, Kerr B, Glasgow E
            and Banka S.
  TITLE     Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to
            Obesity and Variable Developmental Delay with Intellectual
            Disability
  JOURNAL   Am J Hum Genet 98 (2), 363-372 (2016)
   PUBMED   26833329
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Tseng WF, Jang TH, Huang CB and Yuh CH.
  TITLE     An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a
            operates in the formation of endoderm in zebrafish
  JOURNAL   Dev Biol 357 (2), 541-557 (2011)
   PUBMED   21756893
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC129152.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC129152.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     gene            1..2712
                     /gene="pou3f2a"
                     /gene_synonym="brn-1.2; brn1.2; id:ibd5088"
                     /note="POU class 3 homeobox 2a"
                     /db_xref="GeneID:30547"
                     /db_xref="ZFIN:ZDB-GENE-980526-139"
     exon            1..2672
                     /gene="pou3f2a"
                     /gene_synonym="brn-1.2; brn1.2; id:ibd5088"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1021
                     /gene="pou3f2a"
                     /gene_synonym="brn-1.2; brn1.2; id:ibd5088"
                     /note="brain POU domain gene 1.2"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2a"
                     /protein_id="NP_571364.1"
                     /db_xref="GeneID:30547"
                     /db_xref="ZFIN:ZDB-GENE-980526-139"
                     /translation="

MATAASNHYSILTSSAEPGSMQQTPPPAYRDAHSLLQSEYTTLQSSGGTLGHAHQWLTAALSHGGEGSPWPASPLGEQDIKPVEELQHSPRQAHLVPQSQHHETAAWRATTTAHMPSMSTSNGQSLIYSQPGYGEMHHEEHHSPHLSEHGHPQSLHSDEDTPTSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSTSGSPTSLDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPGASEINSLADSLQLEKEVVRVWFCNRRQKEKRMTPQNGPMAGSEDVYGDASPHHGAQTPVP"

     misc_feature    482..706
                     /gene="pou3f2a"
                     /gene_synonym="brn-1.2; brn1.2; id:ibd5088"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    761..931
                     /gene="pou3f2a"
                     /gene_synonym="brn-1.2; brn1.2; id:ibd5088"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

ggaaactatggcgaccgcggcgtccaaccactacagcatcctcacgtccagcgcggagcccggcagcatgcagcagacgccgccgccggcctacagggacgcgcacagcctgctgcagagcgagtacaccaccctgcagagcagcgggggcacgctcggccacgcgcaccagtggctgacggcggcgctgtctcacgggggagaggggtcgccgtggcccgccagcccgctgggcgagcaggacattaagccggtggaggagctgcagcactcgccgagacaagcgcatctggtgccgcagagccagcatcacgagacggccgcctggcgcgccacgaccaccgcgcacatgccgagcatgagcacctccaacgggcagagcctaatctactctcagcccggctacggcgagatgcaccacgaggagcaccacagcccgcatctgagcgagcacggccacccgcagagcctacactcggacgaggacacgccgacctccgacgacctggagcagttcgccaagcagttcaagcagcggcggatcaagctgggcttcacgcaggcggacgtggggctcgcgctggggaccctctacggcaacgtcttctcccagaccaccatctgcaggttcgaggcgctccagctgagcttcaagaacatgtgcaaactcaagccgctgctgaacaagtggctggaggaggcggactccacttcgggaagcccgaccagcctggataagatcgccgcgcagggcaggaaaaggaaaaagcgcacctccatcgaggtgagtgtcaaaggggccctggagagccatttcctcaagtgcccgaaaccaggcgcgtccgagatcaactcgctggcggacagcctgcagctggagaaggaggtggtgcgggtctggttctgcaaccggcggcagaaggagaagcggatgacgccccaaaatggaccgatggccgggagcgaggatgtgtacggggacgcctcgcctcaccacggggcgcagacacctgttccgtgagagaggggaggattgaacataaccgactgtctctttgtcccggtcataagcccgttctgggcggaccgacggtgatgaagcgtctctgtgtgtggcacctccgagcgcgcgtggttgcgcgaacaatatacgggcacgggcgcgagaaaacgcgagcaaaccggggcgcgcagaatctgaagaggaacgtatatattcttttatttaagagatttcttttcaagtccggggatctgtgaaagcatcatatcacttccaaccgaaagctgtgaaaaggcgtcaggggcgcgccatcttcccctcatgaccacaaaaggtttattcctgattgatattaatccggtgcagtgtctgctctctcttacgaatattaatggcaaatgcttcattattattattattattattattatttattattattattattattaattattataattattattatatgttccagaattccaaaatagtcgaatataataccaaacaaaatcacaaagggtttaacactaatcgaaattgtttaatttattcacctgcataattagactaaatgcaataaattaaaataataataataataattattattattattattattattattatatttattttaattatttaaataaaaggactcaacaattcaaactaatcgaaaaatgtaaattattattttattttacttgtctttttaaatattatttacatgcacataaaggtatcactgcaaaatattaatgcaattctctcatttcggtcacaacaaaggctgccaagtgctgctgtgtgtttttcacaggcaaagcagcccgatttcatgcagatcacggattcacactgctggtgcaaaacagaggcctgaggaaacattaaagcctctctagaatcgcgctgctgtggatcatcgaaatgactgttttaaaagaaatccaatgataccagcttcataattatccactcagttgttgtttttaaatcttttttttataagcatccaaaaaatgaggcaggggctcttttttaaatagcatttgtttaatcaatcatttttgttatttcgtttaatttttagtttctgtataatttatgatttcaaaaagaaaccaaaatagactcatgttgcatataaaaacaaaccaagtttaattaatttattttcctagaaacgcggaaataatgcagaaatcatgtccagatttgtaaaaacaaagactaataataataataataataataatacaggccattttattgccaattattattaaactgtgtgattttgtgcgtcaactaaatgtataagcctcaacatgtttgtatctgtttgctatttgtgtttatcccgaatttgtcttttcctttaacgagaactactattacaccagctgtgttacaattatctgatggcctgcatcgaaaaacaaggacattgtgcgttttcatttttatttttgatatatatatatattgctctgtgaatacttgtatatttgtgcacttaacctggcactgccaaagcacaagctgtcagtgtgccctattgagaccggtaatgtctttggttttgacagaaaaaaattgcacagtttttaaaagccttttgtcattaaatgaatacatttttatataaagaagtgccaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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