LOCUS       NM_131232               3334 bp    mRNA    linear   VRT 04-DEC-2023
DEFINITION  Danio rerio even-skipped homeobox 2 (evx2), mRNA.
ACCESSION   NM_131232
VERSION     NM_131232.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3334)
  AUTHORS   England SJ, Rusnock AK, Mujcic A, Kowalchuk A, de Jager S, Hilinski
            WC, Juarez-Morales JL, Smith ME, Grieb G, Banerjee S and Lewis KE.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    GeneRIF: Molecular analyses of zebrafish V0v spinal interneurons
            and identification of transcriptional regulators downstream of Evx1
            and Evx2 in these cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3334)
  AUTHORS   Habicher J, Manuel R, Pedroni A, Ferebee C, Ampatzis K and Boije H.
  TITLE     A new transgenic reporter line reveals expression of protocadherin
            9 at a cellular level within the zebrafish central nervous system
  JOURNAL   Gene Expr Patterns 44, 119246 (2022)
   PUBMED   35427788
REFERENCE   3  (bases 1 to 3334)
  AUTHORS   Kawano K, Kato K, Sugioka T, Kimura Y, Tanimoto M and Higashijima
            SI.
  TITLE     Long descending commissural V0v neurons ensure coordinated swimming
            movements along the body axis in larval zebrafish
  JOURNAL   Sci Rep 12 (1), 4348 (2022)
   PUBMED   35288598
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3334)
  AUTHORS   Wang T, Zhou M, Zhang Q, Zhang C and Peng G.
  TITLE     ubtor Mutation Causes Motor Hyperactivity by Activating mTOR
            Signaling in Zebrafish
  JOURNAL   Neurosci Bull 37 (12), 1658-1670 (2021)
   PUBMED   34309811
REFERENCE   5  (bases 1 to 3334)
  AUTHORS   Matharu NK, Yadav S, Kumar M and Mishra RK.
  TITLE     Role of vertebrate GAGA associated factor (vGAF) in early
            development of zebrafish
  JOURNAL   Cells Dev 166, 203682 (2021)
   PUBMED   33994355
REFERENCE   6  (bases 1 to 3334)
  AUTHORS   Lavoie H, Debeane F, Trinh QD, Turcotte JF, Corbeil-Girard LP,
            Dicaire MJ, Saint-Denis A, Page M, Rouleau GA and Brais B.
  TITLE     Polymorphism, shared functions and convergent evolution of genes
            with sequences coding for polyalanine domains
  JOURNAL   Hum Mol Genet 12 (22), 2967-2979 (2003)
   PUBMED   14519685
REFERENCE   7  (bases 1 to 3334)
  AUTHORS   Avaron F, Thaeron-Antono C, Beck CW, Borday-Birraux V, Geraudie J,
            Casane D and Laurenti P.
  TITLE     Comparison of even-skipped related gene expression pattern in
            vertebrates shows an association between expression domain loss and
            modification of selective constraints on sequences
  JOURNAL   Evol Dev 5 (2), 145-156 (2003)
   PUBMED   12622731
REFERENCE   8  (bases 1 to 3334)
  AUTHORS   Becker KA and Hart NH.
  TITLE     Reorganization of filamentous actin and myosin-II in zebrafish eggs
            correlates temporally and spatially with cortical granule
            exocytosis
  JOURNAL   J Cell Sci 112 (Pt 1), 97-110 (1999)
   PUBMED   9841907
REFERENCE   9  (bases 1 to 3334)
  AUTHORS   Brulfert A, Monnot MJ and Geraudie J.
  TITLE     Expression of two even-skipped genes eve1 and evx2 during zebrafish
            fin morphogenesis and their regulation by retinoic acid
  JOURNAL   Int J Dev Biol 42 (8), 1117-1124 (1998)
   PUBMED   9879709
REFERENCE   10 (bases 1 to 3334)
  AUTHORS   Herault Y, Hraba-Renevey S, van der Hoeven F and Duboule D.
  TITLE     Function of the Evx-2 gene in the morphogenesis of vertebrate limbs
  JOURNAL   EMBO J 15 (23), 6727-6738 (1996)
   PUBMED   8978698
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC057443.1.
            
            On Jan 25, 2004 this sequence version replaced NM_131232.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057443.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3334
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="9"
                     /map="9"
     gene            1..3334
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /note="even-skipped homeobox 2"
                     /db_xref="GeneID:30479"
                     /db_xref="ZFIN:ZDB-GENE-980526-215"
     exon            1..765
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    300..302
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /note="upstream in-frame stop codon"
     CDS             363..1619
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /codon_start=1
                     /product="homeobox even-skipped homolog protein 2"
                     /protein_id="NP_571307.2"
                     /db_xref="GeneID:30479"
                     /db_xref="ZFIN:ZDB-GENE-980526-215"
                     /translation="

MMERIRKEMILMERGLHSPVAGKRLSNLTDSAGNAVLEALENSQHAGRLSPRITSASLHGDIPTKGKFEIDSLFGNHHNDNTSSTEVSSSESRKKINLYPEVSPDSDMNSDVEVGCPSHRSPGSISQHKENNNKGFSDSNSGGSNTSSSSLSNLNGNSMGNSSSSSDQVRRYRTAFTREQIGRLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHMPLHYYPHVGVTAAAAAAAASGAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQSPAGLNSSAAASAAAAAAAAAAAVSAPSATGPCSCLSCHSSQAASALGSRSSSSDFTCTATGQRSESGFLPYSAAVLSKTAVPSPDQREESALNR"

     misc_feature    870..1040
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
     exon            766..1004
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..3314
                     /gene="evx2"
                     /gene_synonym="Evx-2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

cctggatatacgcgtctggccgatcaagggccgactctatcaaccgatgacagtctctctcctatttatttgcttataaacctgttacaataaatgatcattcgagccgcgtcacgcgcacctttaacgacgaaggcgcaaaccactttttgatgaatgactttctggaccagagaggatgcgcgggtcattttgagcagtcattcgttgcccgcactggcattcctctgtttttttttgccttccagctcataaaggtgttatattatttagaggcggcagctgagctgaatgcggattagatccgccaccagtcatcggagcaccagccctgggactttggattttttctgcacgacttcatgatggagaggataagaaaagaaatgattctgatggaaaggggactacacagtccagtggcagggaagaggctctccaacctcaccgactcggccgggaacgcggtgctcgaggccctggaaaattcccagcacgcaggtcgcctcagcccgagaataacttccgcctcgctgcatggggatattcccaccaaaggcaagttcgagatcgacagcttatttgggaaccaccacaacgacaacacttcctcaacagaagtgtcgtcctccgaaagccggaagaaaataaacctgtatcctgaagtttctcctgactccgacatgaacagcgatgtggaagtgggctgcccgtctcatcgttccccgggcagcatcagccaacacaaggagaacaacaataaaggtttctcggacagcaattcaggaggctccaatacaagttcatcctctctatcgaatcttaacggtaattccatgggaaacagcagctcgagctcggaccaggtgaggaggtaccggactgcttttacccgagagcagattggaagactggagaaagaattttacagggaaaactacgtctcgagacccaggagatgtgaattagccgcagcattaaacctgcccgaaacaacaataaaggtgtggtttcagaatcgacgaatgaaggacaagcggcagcggcttgccatgtcctggccacatcccgccgatcccagcttctacacctatatgatgacgcacgccgccgccaccggaagtctgccttacccttttcattcccacatgccactacactattacccccatgtcggtgtcacggcagcagctgctgcggcagccgcctcaggagccgcatcctcaccttttgctacctctatacgtccccttgatactttccgtgcgctttctcatccatattcgcgcccagagctgctgtgtagctttcgacatccaggactgtaccagtcacccgctggtttaaacagctcggcggctgcgtcggcggcagcggcggcggcggcagcggctgcggcggtcagcgcgccctcggctaccgggccgtgctcgtgtctcagctgccacagcagtcaggccgccagcgcactgggctccaggagctccagctctgattttacctgcacggcgaccgggcaaaggtctgagagcggatttttgccatactcggcggcagtcctcagcaaaaccgcggtgccctcaccggaccagagagaagaaagcgcgcttaatagatagctcactactggcatacacacttcttttatttaaagcacatgcaattattaggattattgttattatttttaaattacaaaagggacagcattttcattccagtgtacgcccagaattattacaaaaatatctatttaaaatacactgttaaggcctttaagatcaccacacacacacacactattacatttgatcaaatacggttatttataccaacatgctttacttttcagtattactaggcacatgtttattttattttaagtattatttgacttatttgtattactaggcacatgtttaatttatttttaagtattatttggcttgtttgtaatactaggcactgtatgcaagtgttattttggttacatccacaccgtgtgcagtaaagagaatagctatacactggttgtgccactttagtagcatcagttataggggaccaggcgcgagatgtaacgatgctattctgaaagtgttgctgctcgagggactctccctgatgatctaggagtgaggcgcataaaatgtgcactactgctacaatgtcaattctgctgttaataatgtgaagattatgacgaaaattgccaatcatgtaccttgatggacctcctttgaatgtggaaatgtaagaaagttcccgttcagagactcgctgtcaaagcataacaacccgctgtgggaagtcattagacaagatagataaaagaccttgagcatttcgcattgttcttggtgtgtagattgtacagtattaaacgtggtattcgttacctgagatttttttatgattattatttaaaaaaaaatccctttccaccgagtcctatttccaatcttcttattggaaccttggccggcctgggtagacttttctctcagagatgttccgctgatgcgagcagtctcattaaatccaaaccgatatttccataatactcccagtagagactcttcactcacaatataatgggattatccacacaaccccaaacttcagacaaattgctcatgcatttctgtctgcatacatttttttttgtcactgggcggaattcttcctataaaacctcattttaaagatagcaaaatagcacttgtacagatcaaaatggtgaaatattttgttacgacacgcataggtttaaattgcattaagccaaatgcattttgactgccatccgaaatgattagcttttgcatattattattattctcataatttatgtgactgtctgggtgtttatttcagatgttaggattactcaatctgacattacctcaccactacagaaattaaatgcgaagaaataggcctcatgtcgcaagccaaaatgatctgatccattgtatataaaaagcatatcgcattgctgttaccgtttaaaatgaaagaagatttctttttttttttttttaaataaaatagataaataaatgttaccgagttggagaacagggctggttgccgtctgttcaataaatgacaatactaaaatcccagtgttttgctcctctcccaagggttgccgtgatacacgactctgtacattacgtctctgtattttacatattgccgactgtatgaattttcatattttcacttgagaaaaatgtgcaatataaaaaaatgtatattatgttatttattgatggtgttgttattgtaaaataaatatttaaaacgcaaaaaaaaaaaaaaaaaaaaa

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