LOCUS       NM_131161               2885 bp    mRNA    linear   VRT 03-APR-2024
DEFINITION  Danio rerio POU class 3 homeobox 1 (pou3f1), mRNA.
ACCESSION   NM_131161
VERSION     NM_131161.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2885)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2885)
  AUTHORS   Petratou,K., Spencer,S.A., Kelsh,R.N. and Lister,J.A.
  TITLE     The MITF paralog tfec is required in neural crest development for
            fate specification of the iridophore lineage from a multipotent
            pigment cell progenitor
  JOURNAL   PLoS One 16 (1), e0244794 (2021)
   PUBMED   33439865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2885)
  AUTHORS   Lu,S., Lyu,Z., Wang,Z., Kou,Y., Liu,C., Li,S., Hu,M., Zhu,H.,
            Wang,W., Zhang,C., Kuan,Y.S., Liu,Y.W., Chen,J. and Tian,J.
  TITLE     Lipin 1 deficiency causes adult-onset myasthenia with motor neuron
            dysfunction in humans and neuromuscular junction defects in
            zebrafish
  JOURNAL   Theranostics 11 (6), 2788-2805 (2021)
   PUBMED   33456573
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2885)
  AUTHORS   Barske,L., Fabian,P., Hirschberger,C., Jandzik,D., Square,T.,
            Xu,P., Nelson,N., Yu,H.V., Medeiros,D.M., Gillis,J.A. and
            Crump,J.G.
  TITLE     Evolution of vertebrate gill covers via shifts in an ancient Pou3f3
            enhancer
  JOURNAL   Proc Natl Acad Sci U S A 117 (40), 24876-24884 (2020)
   PUBMED   32958671
REFERENCE   5  (bases 1 to 2885)
  AUTHORS   Zhang,T., Guan,P., Liu,W., Zhao,G., Fang,Y., Fu,H., Gui,J.F., Li,G.
            and Liu,J.X.
  TITLE     Copper stress induces zebrafish central neural system myelin
            defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b
            DNA methylation
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1863 (10), 194612 (2020)
   PUBMED   32745624
REFERENCE   6  (bases 1 to 2885)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
REFERENCE   7  (bases 1 to 2885)
  AUTHORS   Hauptmann,G., Soll,I. and Gerster,T.
  TITLE     The early embryonic zebrafish forebrain is subdivided into
            molecularly distinct transverse and longitudinal domains
  JOURNAL   Brain Res Bull 57 (3-4), 371-375 (2002)
   PUBMED   11922991
REFERENCE   8  (bases 1 to 2885)
  AUTHORS   Hauptmann,G. and Gerster,T.
  TITLE     Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU
            genes in the embryonic brain, pronephric primordium, and pharyngeal
            arches
  JOURNAL   Dev Dyn 218 (2), 345-358 (2000)
   PUBMED   10842361
REFERENCE   9  (bases 1 to 2885)
  AUTHORS   Hauptmann,G. and Gerster,T.
  TITLE     Regulatory gene expression patterns reveal transverse and
            longitudinal subdivisions of the embryonic zebrafish forebrain
  JOURNAL   Mech Dev 91 (1-2), 105-118 (2000)
   PUBMED   10704836
REFERENCE   10 (bases 1 to 2885)
  AUTHORS   Levavasseur,F., Mandemakers,W., Visser,P., Broos,L., Grosveld,F.,
            Zivkovic,D. and Meijer,D.
  TITLE     Comparison of sequence and function of the Oct-6 genes in
            zebrafish, chicken and mouse
  JOURNAL   Mech Dev 74 (1-2), 89-98 (1998)
   PUBMED   9651490
  REMARK    GeneRIF: The expression of the zebrafish Oct-6 protein is
            consistent with the notion that it functions as a 'competence
            factor' in promyelin cells to execute the myelination program.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X96422.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X96422.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2885
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..2885
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="POU class 3 homeobox 1"
                     /db_xref="GeneID:30398"
                     /db_xref="ZFIN:ZDB-GENE-980526-372"
     exon            1..2869
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    101..103
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="upstream in-frame stop codon"
     CDS             113..1219
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="POU domain protein ZP-50; POU domain protein 50;
                     Oct-6; POU domain gene 50"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 1"
                     /protein_id="NP_571236.1"
                     /db_xref="GeneID:30398"
                     /db_xref="ZFIN:ZDB-GENE-980526-372"
                     /translation="

MATTAQYIPRNNSLPSNPLMHPDSDRMHQGTTYREVQKMMHHEYLQGLATNTGHPMSLTHHQWLPTSNTDWTSGTHIGQAEHNKASVQSREDLGNGYHRSHLVHQPTQNSHHGSWAPTTTHHLSPLSPASNGHQSLVYSQTGYTMLSPQPSLHHGLRDPLHDDAGSHDNQMESPQQPFSHHQDHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSNTGSPTNLDKIAAQGRKRKKRTSIEVGVKGALENHFLKCPKPSAHEITTLAGTLQLEKEVVRVWFCNRRQKEKRMTPVGVPHPTMEDVYSQAETPPLHHTLQSPVQ"

     misc_feature    113..196
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90482.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    <248..>643
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="AF-4 proto-oncoprotein N-terminal region; Region:
                     AF-4; pfam05110"
                     /db_xref="CDD:461550"
     misc_feature    317..376
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90482.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    410..514
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90482.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    551..691
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="propagated from UniProtKB/Swiss-Prot (Q90482.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    671..895
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    950..1120
                     /gene="pou3f1"
                     /gene_synonym="pou50; wu:fc09d06; zp-50; zp50; zp50pou"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

aagggaggcgtgtcttagctgttctctaagacctcccagagcaggttgttgcgttttgggctctaaagctcaaagatctccgaagtgcttgtcagttttctaagtcggagccatggcgacaacagctcagtatattccgcggaataactcattgccttcgaacccgctaatgcatccggattcagacaggatgcaccaggggacgacctacagagaggtgcagaaaatgatgcaccacgagtacttacaagggctagcgaccaacacgggacatccgatgagcctaacgcaccaccagtggctgccaacctccaacaccgactggaccagcggcacccacatcggacaagcagagcacaacaaagccagcgtgcagagcagggaagacctgggcaacggctatcacagatcgcatctggtccatcagccgacgcaaaacagtcaccacggctcatgggcaccgaccacaacgcaccacttatccccgctctctcccgcctccaatggtcaccagtctctggtttactcgcagacgggctacaccatgctcagcccccagccttcgctgcaccacggcttgcgggacccgctccacgacgacgcgggcagccacgacaaccagatggagtcgccccagcagccgttcagccaccaccaggaccactcggacgaagacgcccccagctccgacgacctggagcagttcgccaaacagttcaagcagaggcgcatcaaacttgggtttacgcaggcggacgtgggcttagctctgggcacgctctacggaaacgtcttttcccagaccaccatctgtagatttgaggctctccaactgagtttcaagaacatgtgcaaacttaagcctctgctaaacaaatggctcgaggagacagattcaaacactggcagtcccacgaatttagacaagattgcagcacagggccggaaacgaaagaagaggacctccatcgaagtcggagtgaaaggggcactggagaaccatttcttaaagtgtcctaagccctcagcccacgaaatcaccactttagcgggcactctgcagttggaaaaagaggttgtgcgcgtgtggttttgcaacagaagacagaaagagaaaagaatgacaccggtgggggtccctcatccaaccatggaggacgtttactcacaagcggagacaccccctctccatcacacgctacagagtcctgtccagtgactgctatcataaacagtgtcattgtttgaaaagaaactaaactacaatggaatttgtttatcccctttgtttatcccaagtcacaagagacagaaagtttgggaagagttcgctgacagtgaccggacacgttacgggacaccaataatttctcaataacgcgaaaaattattcatttcccgcgtcagcattcgcgtgtacctatttattaaatcagtaccagtgtttacgaaagtcgtatcgtttgtgccactttggaaaaattcgattctttcaccgtcgatcaaagggagctacgagccacacaaaaaagggcaaaagtctccttggacaaaggagagtggacagtgattttaattaaatcaattaaccagattaattatcagaattatcatttatctgatattatttgtgttgtttactttatttggaatgtttaacattaagatctttttttctgtctagcgagtattttttctttatttttatctaagacagatgaaattcgtgatgtacaaaacaggcacttggtcagatcctccaatacaagcaagtgcaccagaaactgtttacaatgtttattcattagcacctgatatcgtctaaagatgcagagacgttaaaatggcaacatgaaaacactgtctgaaacaatatttagcaattttgagttacactggttttacttttttcctctttgcatgaggcacttataataatttaaattcaatttattgctttctttctttcgttttttttacaatgtatttgtttaaggtatgacattaatgctttaattgtttacattttttccagtttcatgttttttgaaccggcactatttcagcatgtctgctccagctaaacatagcctaatgagagtgatgagtcaaaatgaaaaagaaagaaatatctcaggtaatatcagtgcccaaaaaatcgtgctgtactcttagttcttcttgaatattggccaactcttgacactctccatgtcagctgtgcccgtttagtttatgttaattgcattttgcatcctactcttgagcctggacacggagaaaagtagttgttgtagtaaataagggaggttttcgggaattcttttcaagattttgggggggaaaaataagaggctggtaacgtttcgtgtcgtttctcatggtctggcattttttcattggacagcaggtgttcatttctgcaatgttatttgaaacagtgtgaatattacaacctttttccaaaaaaagtaataaaaataaaaataaattacaagagaaaagattttaaataaatagttgtcaggattatttccaatatgtaaatatgtcgaatatgtaaacatatgtatttgttctgggttcgttttgttttgttttgttttccgggcagttttgtacacttactaattccaagaagatattttaatatttcatttatgaccatttatatatctatatatttatttcctacgtgtgtttggagcttttttttttgttcagctctgttgattatgttgcagtggattacaaatgttttgtttactacattggttgtatgttgattgcgaaatgtagactgcaaagtcacgtttatatttatgttatagtaatattttattacttacataaaacatatatacaagaaaaaaaaaaaaaaaaaa

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