LOCUS       NM_131102               3443 bp    mRNA    linear   VRT 17-MAR-2024
DEFINITION  Danio rerio POU class 3 homeobox 3b (pou3f3b), transcript variant
            1, mRNA.
ACCESSION   NM_131102
VERSION     NM_131102.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3443)
  AUTHORS   England,S.J., Rusnock,A.K., Mujcic,A., Kowalchuk,A., de Jager,S.,
            Hilinski,W.C., Juarez-Morales,J.L., Smith,M.E., Grieb,G.,
            Banerjee,S. and Lewis,K.E.
  TITLE     Molecular analyses of zebrafish V0v spinal interneurons and
            identification of transcriptional regulators downstream of Evx1 and
            Evx2 in these cells
  JOURNAL   Neural Dev 18 (1), 8 (2023)
   PUBMED   38017520
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3443)
  AUTHORS   Tan,A.L., Mohanty,S., Guo,J., Lekven,A.C. and Riley,B.B.
  TITLE     Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate
            sensory-neural patterning in the inner ear
  JOURNAL   Dev Biol 492, 139-153 (2022)
   PUBMED   36244503
REFERENCE   3  (bases 1 to 3443)
  AUTHORS   Fabian,P., Tseng,K.C., Thiruppathy,M., Arata,C., Chen,H.J.,
            Smeeton,J., Nelson,N. and Crump,J.G.
  TITLE     Lifelong single-cell profiling of cranial neural crest
            diversification in zebrafish
  JOURNAL   Nat Commun 13 (1), 13 (2022)
   PUBMED   35013168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3443)
  AUTHORS   Xu,P., Yu,H.V., Tseng,K.C., Flath,M., Fabian,P., Segil,N. and
            Crump,J.G.
  TITLE     Foxc1 establishes enhancer accessibility for craniofacial cartilage
            differentiation
  JOURNAL   Elife 10, e63595 (2021)
   PUBMED   33501917
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3443)
  AUTHORS   Barske,L., Fabian,P., Hirschberger,C., Jandzik,D., Square,T.,
            Xu,P., Nelson,N., Yu,H.V., Medeiros,D.M., Gillis,J.A. and
            Crump,J.G.
  TITLE     Evolution of vertebrate gill covers via shifts in an ancient Pou3f3
            enhancer
  JOURNAL   Proc Natl Acad Sci U S A 117 (40), 24876-24884 (2020)
   PUBMED   32958671
REFERENCE   6  (bases 1 to 3443)
  AUTHORS   Pujic,Z., Omori,Y., Tsujikawa,M., Thisse,B., Thisse,C. and
            Malicki,J.
  TITLE     Reverse genetic analysis of neurogenesis in the zebrafish retina
  JOURNAL   Dev Biol 293 (2), 330-347 (2006)
   PUBMED   16603149
REFERENCE   7  (bases 1 to 3443)
  AUTHORS   Kwak,S.J., Phillips,B.T., Heck,R. and Riley,B.B.
  TITLE     An expanded domain of fgf3 expression in the hindbrain of zebrafish
            valentino mutants results in mis-patterning of the otic vesicle
  JOURNAL   Development 129 (22), 5279-5287 (2002)
   PUBMED   12399318
REFERENCE   8  (bases 1 to 3443)
  AUTHORS   Hauptmann,G. and Gerster,T.
  TITLE     Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU
            genes in the embryonic brain, pronephric primordium, and pharyngeal
            arches
  JOURNAL   Dev Dyn 218 (2), 345-358 (2000)
   PUBMED   10842361
REFERENCE   9  (bases 1 to 3443)
  AUTHORS   Spaniol,P., Bornmann,C., Hauptmann,G. and Gerster,T.
  TITLE     Class III POU genes of zebrafish are predominantly expressed in the
            central nervous system
  JOURNAL   Nucleic Acids Res 24 (24), 4874-4881 (1996)
   PUBMED   9016656
REFERENCE   10 (bases 1 to 3443)
  AUTHORS   Sampath,K. and Stuart,G.W.
  TITLE     Developmental expression of class III and IV POU domain genes in
            the zebrafish
  JOURNAL   Biochem Biophys Res Commun 219 (2), 565-571 (1996)
   PUBMED   8605028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU929521.7 and BC056320.1.
            
            On Aug 18, 2015 this sequence version replaced NM_131102.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               CU929521.7         2134-2380
            248-3443            BC056320.1         1-3196
FEATURES             Location/Qualifiers
     source          1..3443
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="6"
                     /map="6"
     gene            1..3443
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="POU class 3 homeobox 3b"
                     /db_xref="GeneID:30321"
                     /db_xref="ZFIN:ZDB-GENE-980526-140"
     exon            1..3406
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    799..801
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="upstream in-frame stop codon"
     CDS             859..2136
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="isoform 1 is encoded by transcript variant 1; POU
                     domain, class 3, transcription factor 3-B; ZP-23;
                     brain-1.0; zfbrn-1.0; POU domain protein 1; POU domain
                     protein 23; brain-specific homeobox/POU domain protein
                     1.0; POU domain gene 23; POU domain gene 1"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 3-B
                     isoform 1"
                     /protein_id="NP_571177.2"
                     /db_xref="GeneID:30321"
                     /db_xref="ZFIN:ZDB-GENE-980526-140"
                     /translation="

MATAASNPYLASSSILSSGSIVHSDSGGGMQQGSAAVTSVSGGYRGDPTVKMVQSDFMQGAMAASNGGHMLSHAHQWVTSLPHAAAAAAAAAVAAAEAGSPWSSSPVGMTGSPQQQDVKNNSGRDDLHSGTALHHRAPHLGPHQTHAGAWGSTTAAHIPSLTGSQQQQQSLIYSQPGGFTVNGMLSPPGSQSLVHPGLVRGDTPELDHSSHHHHHHHQHQHHQQAHHGVNSHDPHSDEDTPTSDDLEHFAKQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADNLQLEKEVVRVWFCNRRQKEKRMTPPGVPQTPEDVYSQVGNVSADTPPPSMDCKRMFSET"

     misc_feature    919..978
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="propagated from UniProtKB/Swiss-Prot (P79745.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1156..1308
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="propagated from UniProtKB/Swiss-Prot (P79745.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1402..1590
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="propagated from UniProtKB/Swiss-Prot (P79745.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
     misc_feature    1570..1794
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="Found in Pit-Oct-Unc transcription factors; Region:
                     POU; smart00352"
                     /db_xref="CDD:197673"
     misc_feature    1807..1809
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="Phosphoserine.
                     /evidence=ECO:0000269|PubMed:18307296; propagated from
                     UniProtKB/Swiss-Prot (P79745.1); phosphorylation site"
     misc_feature    1849..2019
                     /gene="pou3f3b"
                     /gene_synonym="fb92g06; pou1; pou23; wu:fb92g06; zfpou1;
                     zp23; zp23pou"
                     /note="Region: Homeodomain; pfam00046"
                     /db_xref="CDD:459649"
ORIGIN      

aatcaacgaaagccttacacccgacttcctcgcatttggggaaaagacgtggacgatgtacgcagcacagggtaaacactcgtgtgtcctcgagctctgagggagggacggagctaactgtcagagagagagagaaagagagggagggagagcgagcgagggagaggagagagaacaagcgaatgagaaagaaggcatgcaacactgctttgcactgtaatactggattgtacttcaactggagcggtttggcaggtttaaacacatcaaaacagaacaaagagacagactttacagcaccataaaagaatctgcaaaagaaaagaaataaagaaacggagcaagtgaaatcgctgcggctaaataacaaaagaattgaggaagaaccacgttcatatttttccactcggtaacggaacatacgtttggacttattatttttaagggcattacaacttcttcaagcgccagaactttttcgcgggacagtttttgaaacaattttgaatctatcattttttctctcttttggtttgttttcagacagacattttaaaaagaaaacacagactggaggacggtttgatttccgagggcttttcaacgctgtcataaaattggaatttatcgtttcaatcattcatgttcgaaatatatgaatccacaaattattcaagagacggatttcgtccactcgcctgcagatactttctctttgctttttgttgatggtgtttgccaaaacacaagccagacttttaaagtttgaataattcatgagatataatttgcctgcattaaaaaagtttttgcaaaagggagggggtgatcagcaaacatattcataaggttaacggaatggccacagcggcttccaacccttatctagccagcagtagtatattatcgtccggctcgatagtgcactcggactccgggggtgggatgcagcagggcagtgctgcagtaacctcagtgtccggtgggtacagaggagacccaacggttaaaatggtccaaagtgatttcatgcagggcgcaatggcagcgagcaacgggggacatatgctgagccacgctcaccagtgggtgacgtccttgcctcacgccgcagcggcggctgcagctgccgcagtggccgcagctgaagccggatcgccttggtcgtctagcccagttgggatgacaggcagtccgcagcagcaggacgtgaaaaataactctgggagagacgatttgcactctgggactgcgctgcatcacagggccccacatttaggtccccaccagactcacgcgggtgcctggggtagcacaactgctgcccacatcccttcgctaacagggagccagcagcagcagcagtctctcatatactcgcagcctggcggcttcacggtgaacggcatgctcagtccgccgggcagccaaagccttgtacacccgggtctggtgcgtggcgacaccccggagctcgatcacagcagccaccaccaccaccatcaccaccagcatcaacatcaccagcaagcacatcacggagtgaacagccacgacccgcactccgacgaggacacgccaacgtcggatgacttagagcactttgccaagcagttcaaacaacgccggatcaaactgggcttcacgcaggcggacgtgggcttggcgttgggcactctgtacgggaacgttttctcgcagaccacaatctgtcgattcgaagctctccagctcagctttaagaacatgtgcaaactgaagccgttgcttaacaaatggctcgaggaagcagactcttccacgggcagtcccaccagcatcgacaagatcgcggctcagggcagaaaacgcaagaagcgcacctccatcgaagtgagcgtcaaaggggctctggagagtcacttcttaaaatgtcccaagccttcggcccaagagataacctcgctggcggacaacctgcagctggagaaggaggtggtgagagtctggttttgcaatcggaggcagaaagagaaaaggatgacgcccccaggagtgccgcagacgccggaggatgtatattctcaggtcggcaatgtgagtgcagatacaccgcccccctccatggactgcaaacgaatgttcagtgagacatagaacagcatacaagactaaaaaatattttatatatgactaatctgataaaacacagactatcatcaagatagcaaaacattttgatactgtgattgtgagggattattgagactgcagatgtgttatatatttttttcacaagaaaaacaaaatcacccctctttctttcccaaccctaaaccgcccgctaatcttcttccaggcccttaaatgtcttaacctaaaaggttttgtctgctctttctttcagggacattttttagtagattacttaaaagatgcaagtttaactgggccgagcgaaccgggcgaccagagggtgacaactacaagttcgttccaccaggtaattttggcgcattaacttcaactgcaaataactgaaattagaaatgaacaacgcattcttttgccccctacccctttacacccatgtcttgtttgagaggcaaaaggcgcaggcaattgtgtatgttgttatgggacattaaacttcaaacaaagggatgaaattcagctgcaacaatgcgaagaacagtggcatccacgaagcttccatccaacttggcagagaagactgcatggtttgatattatccaaaaatatggaatggattttttttttggccttccaatccttacaaaaacaaaacaaagactgccctgatctccaagatcacatcttttgaaattgttgtttttttatgtaaaggactgaatcatacgtggatttttgaggacaaaattaaatcaaagatgacttttgaaaagacttaatattccgcagctgcacctctttgaaaaccttctgtgcgaacatccgttgccaagtgggccagagctggtgctgtggatgttttcatgtgctgccatttccaagcagtattctttggtaggttttaataaacaagactatgtaaagccggcaatatagattcattagatcagatgctgatcggaattatttacttaatatttttcattaaatgctttgttttaatattttattcgggatacatacgaactattccaaacagttatttatttcccccagacttgtgtaaaatgtcccccaccccctattttcgttgttgaccctttttgttttgtttaattttgtattctcatttataaaagagcacaaatctacacgagctgactttgacagtaggtaataagggtatattttgatgtgatgatttgattgtaatttaatttcagtagtgattccgtaagagatgatcgagaacaataaatttgttagaatgaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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