LOCUS       NM_001442038            2309 bp    mRNA    linear   VRT 21-JUL-2025
DEFINITION  Danio rerio phospholipase A2, group XIIB (pla2g12b), transcript
            variant 1, mRNA.
ACCESSION   NM_001442038 XM_005156519
VERSION     NM_001442038.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2309)
  AUTHORS   Feng,J., Chen,X., Wang,S., Zhang,J., Wang,Q., Guo,S. and Shen,Q.
  TITLE     Transcriptomics integrated with metabolomics reveals the
            ameliorating effect of mussel-derived plasmalogens on high-fat
            diet-induced hyperlipidemia in zebrafish
  JOURNAL   Food Funct 14 (8), 3641-3658 (2023)
   PUBMED   36961308
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2309)
  AUTHORS   Jawahar,J., McCumber,A.W., Lickwar,C.R., Amoroso,C.R., de la Torre
            Canny,S.G., Wong,S., Morash,M., Thierer,J.H., Farber,S.A.,
            Bohannan,B.J.M., Guillemin,K. and Rawls,J.F.
  TITLE     Starvation causes changes in the intestinal transcriptome and
            microbiome that are reversed upon refeeding
  JOURNAL   BMC Genomics 23 (1), 225 (2022)
   PUBMED   35317738
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2309)
  AUTHORS   White,R.J., Mackay,E., Wilson,S.W. and Busch-Nentwich,E.M.
  TITLE     Allele-specific gene expression can underlie altered transcript
            abundance in zebrafish mutants
  JOURNAL   Elife 11, e72825 (2022)
   PUBMED   35175196
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2309)
  AUTHORS   Feng,J., Song,G., Wu,Y., Chen,X., Pang,J., Xu,Y., Shen,Q., Guo,S.
            and Zhang,M.
  TITLE     Plasmalogens improve swimming performance by modulating the
            expression of genes involved in amino acid and lipid metabolism,
            oxidative stress, and ferroptosis in an Alzheimer's disease
            zebrafish model
  JOURNAL   Food Funct 12 (23), 12087-12097 (2021)
   PUBMED   34783821
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2309)
  AUTHORS   Thierer,J.H., Ekker,S.C. and Farber,S.A.
  TITLE     The LipoGlo reporter system for sensitive and specific monitoring
            of atherogenic lipoproteins
  JOURNAL   Nat Commun 10 (1), 3426 (2019)
   PUBMED   31366908
  REMARK    Erratum:[Nat Commun. 2020 Jul 21;11(1):3707. doi:
            10.1038/s41467-020-17532-7. PMID: 32694507]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2309)
  AUTHORS   Anderson,J.L., Mulligan,T.S., Shen,M.C., Wang,H., Scahill,C.M.,
            Tan,F.J., Du,S.J., Busch-Nentwich,E.M. and Farber,S.A.
  TITLE     mRNA processing in mutant zebrafish lines generated by chemical and
            CRISPR-mediated mutagenesis produces unexpected transcripts that
            escape nonsense-mediated decay
  JOURNAL   PLoS Genet 13 (11), e1007105 (2017)
   PUBMED   29161261
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2309)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2309)
  AUTHORS   Kessels,M.Y., Huitema,L.F., Boeren,S., Kranenbarg,S.,
            Schulte-Merker,S., van Leeuwen,J.L. and de Vries,S.C.
  TITLE     Proteomics analysis of the zebrafish skeletal extracellular matrix
  JOURNAL   PLoS One 9 (3), e90568 (2014)
   PUBMED   24608635
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2309)
  AUTHORS   Jima,D.D., Shah,R.N., Orcutt,T.M., Joshi,D., Law,J.M., Litman,G.W.,
            Trede,N.S. and Yoder,J.A.
  TITLE     Enhanced transcription of complement and coagulation genes in the
            absence of adaptive immunity
  JOURNAL   Mol Immunol 46 (7), 1505-1516 (2009)
   PUBMED   19200601
REFERENCE   10 (bases 1 to 2309)
  AUTHORS   Woods,I.G., Wilson,C., Friedlander,B., Chang,P., Reyes,D.K.,
            Nix,R., Kelly,P.D., Chu,F., Postlethwait,J.H. and Talbot,W.S.
  TITLE     The zebrafish gene map defines ancestral vertebrate chromosomes
  JOURNAL   Genome Res 15 (9), 1307-1314 (2005)
   PUBMED   16109975
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000013.1.
            
            On Jul 21, 2025 this sequence version replaced XM_005156519.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH488985.1, EH494228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               JBMGRA010000013.1  4636849-4637246
            399-487             JBMGRA010000013.1  4639602-4639690
            488-653             JBMGRA010000013.1  4644221-4644386
            654-2309            JBMGRA010000013.1  4646611-4648266
FEATURES             Location/Qualifiers
     source          1..2309
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="13"
                     /map="13"
     gene            1..2309
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="phospholipase A2, group XIIB"
                     /db_xref="GeneID:406739"
                     /db_xref="ZFIN:ZDB-GENE-040426-2771"
     exon            1..398
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    56..58
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="upstream in-frame stop codon"
     CDS             65..772
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /EC_number="3.1.1.4"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="group XIIB secretory phospholipase A2-like
                     protein isoform 1 precursor"
                     /protein_id="NP_001428967.1"
                     /db_xref="GeneID:406739"
                     /db_xref="ZFIN:ZDB-GENE-040426-2771"
                     /translation="

MFPRALPLLLLCISAGLAATLIQASVDAASVDSPAGESPDVNQENQAEHVLMADAPVEGKPAPSATEESEDDDDWGFGSIRGSLQSVNGYFDSILELMGGRDGVCQFRCRYGKAPQPRPGYQMSEPDGCSTSLLGFQVPNSFDMGVPAMTKCCNQLDICYETCGSNKYRCDTKFRWCLHSICGDLKKSLGLMSKVEACETFADTMYNTVWTLGCRPFMNGQRASCYCEGEEKDEL"

     sig_peptide     65..148
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    242..769
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /note="Group XII secretory phospholipase A2 precursor
                     (PLA2G12); Region: PLA2G12; pfam06951"
                     /db_xref="CDD:399731"
     exon            399..487
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     exon            488..653
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
     exon            654..2309
                     /gene="pla2g12b"
                     /gene_synonym="wu:fb26d02; wu:fb99g06; wu:fc91d12;
                     zgc:111897; zgc:56487; zgc:77746"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

actctttttccttcgagcccttcaacttcgtcggtctccctggactgtactgtaataggacatcatgtttcctcgcgcactacccctgctcctgctgtgtatctctgcaggcttggctgcgactcttatccaggcttcagtagatgcggcctcagtagattcgcctgctggtgaaagcccagatgttaatcaggagaatcaggcagagcatgttttaatggcagatgcccctgttgagggaaaacctgcaccgagtgccacagaagaatctgaggacgatgatgactgggggttcggctctatccgaggaagtttacagtcagtcaatggctattttgactcaatactggagttgatgggaggccgtgatggtgtatgtcagttccgctgcagatatggtaaagctcctcagcctcgtcctggctatcagatgtcagaacctgatggttgtagcacgtccctgcttggcttccaggtaccgaatagttttgatatgggtgtcccagccatgaccaaatgttgcaaccagttagatatttgctacgaaacctgtggatccaacaagtaccgctgtgacaccaaattccgctggtgcctccacagcatctgcggtgacctgaagaagagtctgggccttatgtccaaagttgaagcatgtgagacctttgcagacaccatgtacaacactgtgtggactttgggctgcagacccttcatgaacggccaaagggcgtcctgctattgcgaaggagaagagaaggatgagctctgaagaccaacaaaatcacaaaacacaccaccttcagcacatataaacacttcatagctttaaactataccacacaaggcacgagtcacattcaaacaagtcacatttcactacaaacattgagtagaaactattgatcgacattaatttgaagtgaaatgtgaccttcacacgttgtggagattcatccactaacccttgaactggtgctattggattttgtcagacaagaaaaagtttatatggtatatgggtgtcattatcgcatatgtattgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgattgtgtataggtttcacacacagaaatctgatatatggcaatatatgcaaatttcatatataacatacaagtttatatttgaatttcacatatagtaaaatcggtgactcactccactgtggcaacctctaaaataaagactaagctgaagggaaatgaaaatatatagaaaaacagatgcccgtttatgtgtatattttaagtttcaaccattttaattacagatgtgtacattgcatatgcgtgtgtgtcatttatgaacacaaaatgattgctaatatattgtaacctatacggtgtgtacatatttgcaattataatggttgacaaactatatatgtaaacagccatttttgctatatacacttgtatgtcatataattcatttgcatacttgtatgtcatataattcgtttccatatgtcagatttctatatgggttgttatatgggaagacaacattcaacttcttatgaccatatatgaagccattaagatgtagagacttcacacaagtattggtaccgaactagtatttaatacattaaggaacttttgtttggtgatgatctaaatatcatggtaatatttatgtaatattactgcattactattattttcttcaaatgtaattaaatgtagaatcggtgctcagcaaaaacacgcaggaatgtttttcattgtgagtaaagactgaacgaaaaagactcggctgtaacatcactttatttcgcccagtaaaagtctgctaatcatatatgcaaatgagccattcaagcttttttatttattctgtgcttccatgcttgttaattgtacacattacagtactacaaatgaatgcagatgaaaatgcatttttcttttcagtttaggtgagaataatatgacagagtaggattagaagcagtggagatgggataggcttcaacagagcctcctcttatcaattcatgtatgattattactgactaaaccgtaaaatatctataaattagtggatttccatattttgtgattcatgtttttatttatccttttgagttgcattatgggatgtatgggttctttcttccaacaacgtttagccttgaaaagtttggtaaaagtgactttataaacattaataatagtttaaagtgctatattgtctgggttggtgttgtatattacgctacatacaccttgtaataaactgccagcccattttc

//