LOCUS       NM_001346180            2687 bp    mRNA    linear   VRT 09-DEC-2025
DEFINITION  Danio rerio RNA polymerase II subunit M (polr2m), mRNA.
ACCESSION   NM_001346180 XM_001343168
VERSION     NM_001346180.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2687)
  AUTHORS   Xu,Q.H., Guan,P., Zhang,T., Lu,C., Li,G. and Liu,J.X.
  TITLE     Silver nanoparticles impair zebrafish skeletal and cardiac
            myofibrillogenesis and sarcomere formation
  JOURNAL   Aquat Toxicol 200, 102-113 (2018)
   PUBMED   29729476
REFERENCE   2  (bases 1 to 2687)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000007.1.
            
            On Dec 9, 2025 this sequence version replaced NM_001346180.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01015103.1, GDQH01028624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505380, SAMEA3505382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JBMGRA010000007.1  30258443-30258670
            229-795             JBMGRA010000007.1  30259294-30259860
            796-1003            JBMGRA010000007.1  30260698-30260905
            1004-2687           JBMGRA010000007.1  30261136-30262819
FEATURES             Location/Qualifiers
     source          1..2687
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="7"
                     /map="7"
     gene            1..2687
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /note="RNA polymerase II subunit M"
                     /db_xref="GeneID:100003720"
                     /db_xref="ZFIN:ZDB-GENE-160728-95"
     exon            1..228
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    65..67
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /note="upstream in-frame stop codon"
     CDS             119..1147
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /note="polymerase (RNA) II (DNA directed) polypeptide M;
                     polymerase (RNA) II subunit M"
                     /codon_start=1
                     /product="protein GRINL1A"
                     /protein_id="NP_001333109.2"
                     /db_xref="GeneID:100003720"
                     /db_xref="ZFIN:ZDB-GENE-160728-95"
                     /translation="

MLPSWVARQGEVGDLRNKSKDELLEILSRQEKILSNKRFIQTLPDKGKKIAEFVEKVHLALGHLEEEERKQAGLISVRTEFQSKYQQALAKRSKDNHLDSKLDTVIPSHDKKEANVNTDVVSVQENGDLFGQEEFLTARLQAAETLETAGVNAAASLLKDTELVKAFGRVTFAESNNGSNKDNIKTQPPSKPFLDTKPLKKPHYIEVLEKTEESVNMKKSRFKPNQLIAKSESPSSSQASGSTTPLTAEARKQQDRKHLDDITAAKLPPLHHSPAQLLSLEESAALLQEQTRKQLEMQAKQAAQKLADGLSIRMESYNPEGGPLAAYREVHDDGALLSSEED"

     misc_feature    194..760
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /note="Putative GRINL1B complex locus protein 2; Region:
                     GCOM2; pfam15328"
                     /db_xref="CDD:464649"
     exon            229..795
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1003
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..2687
                     /gene="polr2m"
                     /gene_synonym="si:ch211-94n14.3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gcacattttgacaaatggcggcacaagttgatatctagcatcccctgtcagttatgaatttttatagcgtgtcattgtgaaacttttactaatctatttattcttcacatatttgatcatgttgccgtcgtgggtagcgcgacagggggaagtgggtgatctgagaaacaaaagtaaagatgagctccttgaaatactttcacgacaagaaaagatactgtctaataagagatttattcaaaccctcccagataaggggaagaagattgctgagtttgtggagaaagtgcatcttgcactcgggcatctggaggaggaggagagaaagcaagcaggtttaatctctgtccggacagagtttcagtcgaaatatcagcaagcccttgccaagcgaagcaaagataatcatttagactcaaaattggacacagttatcccatcccatgacaaaaaggaagccaatgtcaatactgacgtggttagcgtacaggaaaatggtgatctgtttggccaggaggagtttttgacagcccgtctgcaggctgctgaaacactagaaacagccggtgtgaatgcagcagcctcattgctgaaagacacagagcttgtgaaggcatttggacgagtaacatttgctgaaagcaataatggctctaacaaagacaatatcaaaactcagcctccaagtaagccctttctggacactaagccactgaagaaaccacattacatagaagtcctggagaagacagaggaaagtgtgaatatgaagaaatctagattcaaaccaaaccagttaattgcaaaatctgagtctccatcatctagtcaggcgtctggcagcaccacaccactaactgcagaagccagaaaacaacaagaccgaaaacacctggatgacatcaccgcagctaaacttccaccactgcaccacagtccagcccagttactgtcattagaggagtcggcagcccttctgcaagagcagaccagaaagcagctggagatgcaggccaaacaagctgcccagaagctggcagatggtcttagtatcaggatggagagttacaacccagaaggaggcccactggcagcctatagagaggtgcatgatgatggggccctgctttcttcagaggaggactgatcgtggggccctatagggaggatactggcttgttgatatgtttggccccttgccctggaccagctctcggcctagagcccatgcttcaggaccctggagagagtctttcagcttgaggacaagagaaaggcccagaatcggcaaatcaagatgaataatagcaggttgcatctagctattctgtaaaaactagactgtttttgcatgtggaaatgttagtttctctcagtaaccgcttatcttggcaagctgataccaaaaaaacttacctcgacaggtccacacctgttgtcttttacagaataatataatttgaagctcttatcagccataccttcaagggtgtagttgatatgttattgcgaagatggtaatagaatatttttgtatgacctttcttagtgtttgttcaagcaaaatcccctgattcgagccctcaagcttgtgattggttctttgaatcggataacagaaaccgcagtttcataaactaaaggtggaagcacttaatgttttgtcacttgagcgcaacagctttggaaacgtctgtctccctcccttttgtagcattgttttgataaccacccactggttgattggagtgagtcagccatcgtttgaagggtgggatgttgttatcagtgcagaaatctgtgacatgcctcagatgattaatatatgtaatgtgaaatatcgaggcttgaaggaattacaccaattggtggaatacatctggattgtatttagatcatgtttctgtatggcagtgcattctgggatggcagtggatagacagacggaacatatggtaaattcagtttccaaagtcatcagcattgataaagcattcataaaactgacttcaactctcaggatgtaaacaacgtgtttctttcttgcatatgattcaggaatctttatatttaaatggagagtagggagtttgaagagggaggaaatccaaatctgcacttctccgcagtagatgacctgtgataacctctagtaattgcttctgcccgttgatgggaactgctgcctcagaaaaaaagagatcctaacacatctggcaggttagtgtttagacaccgtgtgtgacgaactccagagtgccttacccagacgtcctgtgataaatatgtcagtcttgttcagaaagaatctcttctctactggtattaattaagtctaccttgcataaagactgttatcaattacacactggattcctgcgctgatcagattcgctgctgagtacgtagatacgcttgagttggattcaagcatgcgttctgacagtgtctttaagttgttcttttttagctgcagtttttgctttccacatacctccacacccatcgtctcagatcaataaacggctcatggagtcatctgtaagtgctttacgagtgtgaaatcatgccctgagagaatgggcaaactttctgagctgtgagggggataaactatagattttcttttttttatcctggagaacccttccaactgacatcaataaaaacacattttctgcaatgca

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