LOCUS       NM_001310078            1719 bp    mRNA    linear   VRT 23-SEP-2023
DEFINITION  Danio rerio ALX homeobox 4b (alx4b), mRNA.
ACCESSION   NM_001310078
VERSION     NM_001310078.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1719)
  AUTHORS   Jang HS, Chen Y, Ge J, Wilkening AN, Hou Y, Lee HJ, Choi YR, Lowdon
            RF, Xing X, Li D, Kaufman CK, Johnson SL and Wang T.
  TITLE     Epigenetic dynamics shaping melanophore and iridophore cell fate in
            zebrafish
  JOURNAL   Genome Biol 22 (1), 282 (2021)
   PUBMED   34607603
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1719)
  AUTHORS   Mitchell JM, Sucharov J, Pulvino AT, Brooks EP, Gillen AE and
            Nichols JT.
  TITLE     The alx3 gene shapes the zebrafish neurocranium by regulating
            frontonasal neural crest cell differentiation timing
  JOURNAL   Development 148 (7) (2021)
   PUBMED   33741714
REFERENCE   3  (bases 1 to 1719)
  AUTHORS   Pini J, Kueper J, Hu YD, Kawasaki K, Yeung P, Tsimbal C, Yoon B,
            Carmichael N, Maas RL, Cotney J, Grinblat Y and Liao EC.
  TITLE     ALX1-related frontonasal dysplasia results from defective neural
            crest cell development and migration
  JOURNAL   EMBO Mol Med 12 (10), e12013 (2020)
   PUBMED   32914578
  REMARK    Erratum:[EMBO Mol Med. 2022 Jul 7;14(7):e16289. PMID: 35795978]
REFERENCE   4  (bases 1 to 1719)
  AUTHORS   Saunders LM, Mishra AK, Aman AJ, Lewis VM, Toomey MB, Packer JS,
            Qiu X, McFaline-Figueroa JL, Corbo JC, Trapnell C and Parichy DM.
  TITLE     Thyroid hormone regulates distinct paths to maturation in pigment
            cell lineages
  JOURNAL   Elife 8, e45181 (2019)
   PUBMED   31140974
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1719)
  AUTHORS   Sharma PP, MacLean AL, Meinecke L, Clouthier DE, Nie Q and
            Schilling TF.
  TITLE     Transcriptomics reveals complex kinetics of dorsal-ventral
            patterning gene expression in the mandibular arch
  JOURNAL   Genesis 57 (1), e23275 (2019)
   PUBMED   30561090
REFERENCE   6  (bases 1 to 1719)
  AUTHORS   Liu C, Hu J, Qu C, Wang L, Huang G, Niu P, Zhong Z, Hong F, Wang G,
            Postlethwait JH and Wang H.
  TITLE     Molecular evolution and functional divergence of zebrafish (Danio
            rerio) cryptochrome genes
  JOURNAL   Sci Rep 5, 8113 (2015)
   PUBMED   25630924
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1719)
  AUTHORS   Lours-Calet C, Alvares LE, El-Hanfy AS, Gandesha S, Walters EH,
            Sobreira DR, Wotton KR, Jorge EC, Lawson JA, Kelsey Lewis A, Tada
            M, Sharpe C, Kardon G and Dietrich S.
  TITLE     Evolutionarily conserved morphogenetic movements at the vertebrate
            head-trunk interface coordinate the transport and assembly of
            hypopharyngeal structures
  JOURNAL   Dev Biol 390 (2), 231-246 (2014)
   PUBMED   24662046
REFERENCE   8  (bases 1 to 1719)
  AUTHORS   Dee CT, Szymoniuk CR, Mills PE and Takahashi T.
  TITLE     Defective neural crest migration revealed by a Zebrafish model of
            Alx1-related frontonasal dysplasia
  JOURNAL   Hum Mol Genet 22 (2), 239-251 (2013)
   PUBMED   23059813
REFERENCE   9  (bases 1 to 1719)
  AUTHORS   McGonnell IM, Graham A, Richardson J, Fish JL, Depew MJ, Dee CT,
            Holland PW and Takahashi T.
  TITLE     Evolution of the Alx homeobox gene family: parallel retention and
            independent loss of the vertebrate Alx3 gene
  JOURNAL   Evol Dev 13 (4), 343-351 (2011)
   PUBMED   21740507
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CU929116.4, EH456049.1, CU929277.10 and EH481782.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH456048.1, EH456049.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               CU929116.4         23708-24139         c
            433-629             EH456049.1         27-223
            630-656             CU929277.10        15815-15841
            657-799             EH456049.1         252-394
            800-1519            CU929277.10        24429-25148
            1520-1679           EH481782.1         71-230              c
            1680-1719           CU929277.10        25309-25348
FEATURES             Location/Qualifiers
     source          1..1719
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="18"
                     /map="18"
     gene            1..1719
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /note="ALX homeobox 4b"
                     /db_xref="GeneID:497424"
                     /db_xref="ZFIN:ZDB-GENE-050208-140"
     exon            1..606
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    243..245
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /note="upstream in-frame stop codon"
     CDS             273..1052
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /note="aristaless-like homeobox 4b"
                     /codon_start=1
                     /product="homeobox protein aristaless-like 4b"
                     /protein_id="NP_001297007.1"
                     /db_xref="GeneID:497424"
                     /db_xref="ZFIN:ZDB-GENE-050208-140"
                     /translation="

MNADTCVSYCDMTSMDSYYSPAAPGQGRVQQANPYRTFQSSDSKYSPTFLPAKGQTYGEKPRSPFHQDCPTLDDSTAEGAYSKYHLFMQRPACKSPSEDSKLEDGALISCYGVVSESPGKWRKRERFGQMQQVRTHFSTAYELPLLTRPENYAQIQNPSWLSGSSSASPVPGCVVPCDTVSSCMTPHPHSASGVSDFLGMPSPGGSMAQTHMGSLFGSSGVGGTINGYDLSVEPDRKSSSIASLRMKAKEHSAAISWAT"

     misc_feature    975..1031
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /note="OAR motif; Region: OAR; pfam03826"
                     /db_xref="CDD:461067"
     exon            607..734
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1719
                     /gene="alx4b"
                     /gene_synonym="im:7142878; si:ch73-220n21.1; zgc:162606"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

atcatgacaggacctccgactctagtggacatcaggacagcatcctccttttactctctctcctcctctctcttcttaaccttaaagacgctttctagcctttgcctattctctggaaaacatctgaatcattttaaccaactccagctgtcgccttggtgtgggtgtgtgagaaagtgcatggccatctctgaatgaggggagactagagcgagggtgacgtttagatttacggaaaaagttaggatatttttgcttcttgttttgtcggtatgaacgcagatacgtgcgtctcatactgcgacatgacctccatggactcatattattcgccagcagcaccagggcaagggagagtccaacaggccaatccttacagaactttccagtcgagcgactccaaatacagtcccactttcttgcccgccaaaggccagacttatggggagaagccgcggagtccattccatcaggattgtccgacactggatgatagcacagccgagggcgcttatagcaaatatcacctttttatgcagagacccgcgtgcaaatctccttctgaagacagcaaactggaggacggcgcgctgatctcatgctacggtgtggtttcagaatcgccgggcaaatggagaaaacgagaacgctttggtcaaatgcagcaggttcggacacacttctcaacagcctatgagcttcctcttcttacacggccagaaaactatgcacagattcagaacccgtcttggctaagcggcagcagttcggcctctccagtgccaggctgtgtggtaccttgtgatactgtttcttcctgcatgactcctcatcctcactctgccagcggcgtgtctgatttcctcggtatgccaagtccaggtggcagcatggcgcagacacacatgggcagtctttttgggagctcaggagtaggtggaaccattaacggttatgatctcagcgtcgagcccgatcgcaaatcctccagcatcgccagcctgcgcatgaaggcgaaggagcacagcgccgccatctcttgggcaacatgatgccttcatctgggaaacagaagaaccagataacctcagccccaagccgtcagcactaatgaggtgaaagtttatggcatctggagccaatatggacatgagaaatggaggctggaagctttaaaacacttgtaggagatttaatattaaggttctgtaaaggaagtggattgtgcagtgggacattgtgctagaataagaggaaactgatgggccagtttgaacagagagatgtttggttaaaataactttttatgtaacattaaaaaaaaaaaatctatatgcactattttcccctattattcatagacatttgcactgccatttaaagaaaaacaaggttgcatttatttaatcaaaagaatacaaacattgaagctttataaatatatccaatggatccttggttaatacagatcttgacctgtagtagtgacctttactgaccccaaatggtagatatcctaaagaagaatatattctagggctgcacgatattggaaaaatttgatattgtgattttttattgttctgcgataaataatgcgatatgaaaatctgatgctttagaaaatagcactaaataaatagcactatttgacagctttctggggagtaattgagcaaatgaatgatcacaatacaacaataaatacttgtcttactt

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