LOCUS       NM_001114909            1293 bp    mRNA    linear   VRT 10-AUG-2025
DEFINITION  Danio rerio acetylserotonin O-methyltransferase (asmt), mRNA.
ACCESSION   NM_001114909 XM_009305018
VERSION     NM_001114909.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Aranda-Martinez,P., Fernandez-Martinez,J., Diaz-Casado,M.E.,
            Ramirez-Casas,Y., Martin-Estebane,M., Lopez-Rodriguez,A.,
            Escames,G. and Acuna-Castroviejo,D.
  TITLE     Lack of asmt1 or asmt2 Yields Different Phenotypes and
            Malformations in Larvae to Adult Zebrafish
  JOURNAL   Int J Mol Sci 26 (8), 3912 (2025)
   PUBMED   40332753
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Lee,J.H., Hwang,S.J., Ham,S.L., Kim,J., Bang,H.J., Park,J.S.,
            Jang,H.H., Kim,T.Y., Park,J.W., Seo,Y.R., Kim,B.S., Kim,G.S.,
            Lee,H.J. and Kim,C.S.
  TITLE     Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce
            Melatonin Synthesis and Extend Sleep Duration in Mice
  JOURNAL   ACS Omega 9 (43), 43875-43883 (2024)
   PUBMED   39493976
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Dekens,M.P.S., Fontinha,B.M., Gallach,M., Pflugler,S. and
            Tessmar-Raible,K.
  TITLE     Melanopsin elevates locomotor activity during the wake state of the
            diurnal zebrafish
  JOURNAL   EMBO Rep 23 (5), e51528 (2022)
   PUBMED   35233929
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Khan,Z.A., Yumnamcha,T., Rajiv,C., Sanjita Devi,H., Mondal,G.,
            Devi,S.D., Bharali,R. and Chattoraj,A.
  TITLE     Melatonin biosynthesizing enzyme genes and clock genes in ovary and
            whole brain of zebrafish (Danio rerio): Differential expression and
            a possible interplay
  JOURNAL   Gen Comp Endocrinol 233, 16-31 (2016)
   PUBMED   27179881
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000009.1.
            
            On or before Jul 28, 2025 this sequence version replaced
            XM_009305018.5, NM_001114909.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01001685.1,
                                           SRR32588730.14768938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01765705 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               JBMGRA010000009.1  58074251-58074352   c
            103-274             JBMGRA010000009.1  58073675-58073846   c
            275-404             JBMGRA010000009.1  58073006-58073135   c
            405-473             JBMGRA010000009.1  58071710-58071778   c
            474-592             JBMGRA010000009.1  58071440-58071558   c
            593-733             JBMGRA010000009.1  58065821-58065961   c
            734-856             JBMGRA010000009.1  58062595-58062717   c
            857-1293            JBMGRA010000009.1  58059672-58060108   c
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="9"
                     /map="9"
     gene            1..1293
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /note="acetylserotonin O-methyltransferase"
                     /db_xref="GeneID:100141344"
                     /db_xref="ZFIN:ZDB-GENE-080220-43"
     exon            1..102
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1068
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /EC_number="2.1.1.4"
                     /codon_start=1
                     /product="acetylserotonin O-methyltransferase"
                     /protein_id="NP_001108381.2"
                     /db_xref="GeneID:100141344"
                     /db_xref="ZFIN:ZDB-GENE-080220-43"
                     /translation="

MAEEAELYPKKILEYMEGFLVSKTLFSACELGVFELLQSACLSAGQVSAALSTSVDGTERLLSACVGLQLLNTHTHTDGTVLYSNTEMSNVFLVKSSPKSLYHSIEYSSRTIYLCWHYLSDAVRDGKNQYEKAFGVNSKDLFEALYRSDDEMVKFMHLMNSVWNICGRDVITAFDLTPYKTICDLGGCSGALAKQCVSAYPESSVTIFDLPRVVQNSQKHFMMDQDPRIAFCEGDFFKDELPQADLYILARILHDWTDQRSVELLTKIYQSCRPGGALLLAEALLHEDDSGPLTVQLYSLNMLVQTEGRERKASEYTRLLNAAGFTHVHTHTTGKIYDAVLAIK"

     misc_feature    67..330
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /note="dimerization domain; Region: dimerization2;
                     pfam16864"
                     /db_xref="CDD:465287"
     misc_feature    379..1008
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /note="O-methyltransferase domain; Region: Methyltransf_2;
                     pfam00891"
                     /db_xref="CDD:395719"
     exon            103..274
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            275..404
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            405..473
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            474..592
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            593..733
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            734..856
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1293
                     /gene="asmt"
                     /gene_synonym="hiomt; zgc:171885"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agacgaacaatcactgtgaacacacagaaaaacatggcagaagaagcggagctgtaccccaaaaagatcctcgaatacatggaggggttcctggtgtccaagactctgttctccgcctgtgagctgggtgtgtttgagctcctgcagtctgcgtgtctgtctgctggtcaggtttctgcagctctgagcaccagtgtggacgggacggagcgtctgctgtctgcgtgtgtggggctgcagctgctcaatacacacacacacaccgacggaaccgttctgtacagtaacacagagatgtcgaatgtgttcctggtcaagtccagcccgaagtctctgtatcactctatcgagtacagctccagaaccatctacctgtgctggcattacctgagcgacgccgtccgagacgggaagaaccagtatgagaaagcctttggagtcaactctaaagacctgtttgaagccctctacaggtctgatgatgagatggtgaagtttatgcacctgatgaactcggtctggaatatctgcgggcgcgacgtgatcacagccttcgacctgacgccgtacaagaccatctgtgacctcggaggctgcagtggagccctggccaaacagtgtgtgtcggcatacccagagtcttccgtcaccatctttgaccttcccagagtggtgcaaaactcacagaaacacttcatgatggaccaagacccgcgcattgccttctgtgaaggagacttcttcaaggacgagctcccgcaggccgatctctacattctggcccggattctgcatgactggactgaccagcggagtgtggaactgctgaccaagatataccagtcctgtagaccaggtggagcgctgctgctggctgaagctcttcttcatgaggatgactctggtcctctgacggttcagctttattccctcaatatgttggtccagacggagggtcgcgagcgcaaggcttcagaatacacacgtctgctgaacgccgccggcttcacacacgtacacacacacaccaccggcaagatctatgacgctgttttggccatcaaataaatgaaaacacaaacacatacacactcatatacacacacacacacacacacacacacacacacacacacacacacacacacacacacacagacacacacacacactgatcagctggctctgaggctgtaaggcagttgttgctcagtttctgtttagtttacagcacaaatatctaaacctgatgtgtgtaaaattaagtataaataaataaaataaaataaaaaa

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