LOCUS       NM_001114466            2414 bp    mRNA    linear   VRT 10-JAN-2022
DEFINITION  Danio rerio saxiphilin (sxph), mRNA.
ACCESSION   NM_001114466 XM_001340560
VERSION     NM_001114466.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2414)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC155640.1.
            
            On Feb 10, 2008 this sequence version replaced XM_001340560.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC155640.1 [ECO:0000331]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2414
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="6"
                     /map="6"
     gene            1..2414
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="saxiphilin"
                     /db_xref="GeneID:100000381"
                     /db_xref="ZFIN:ZDB-GENE-080204-110"
     exon            1..82
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    10..12
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="upstream in-frame stop codon"
     CDS             19..2220
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /codon_start=1
                     /product="Saxiphilin-like precursor"
                     /protein_id="NP_001107938.1"
                     /db_xref="GeneID:100000381"
                     /db_xref="ZFIN:ZDB-GENE-080204-110"
                     /translation="

MMKLVSVIVVLLLLLCSITSWGKKMRWCAVSEAEQKKCAELAKALVAVLPPAAVTAFARLSCVKAYSTADCINKIRDNKADLVTLDAGEVYSAVKQFGLTVVAKEIYRDGGCILAVAVVRNSSSLDMRSLQGSRSCHSGARWTAGWSLPLGHLLSRNLLPWAEDEPISQAVSAFFNASCVPGATTMAANLCSLCKGQRSYIRQKNFHCETSHSEPFYHNQGALRCLQSGAGDIAFVDHTALDGIDEREKDELRLLCTDGSLAPLSSFRTCNLGRGPGGGVVTRMNIRKIARKFLVAAQMSFGWRGRERRRFQLFESASFGGSDLLFRDVTEKLSVLMEDMDMSQVLGLDYVALLKGLGHEGSSLEDSVVRWCCISHAEQKKCEQWAISIKSDPLVCVKASSMSDCIEKIKRDEVDAVSLDATHAFIAGKCGLVPVVTEYYGEKCETSAGAGGHFESNELPPVYGVAVVRRSSKSLFFGSLADRRSCHSHMYSPAGWVLPVRHTLSTEHNNSAPCEPNKVYSEVFWKGCLPGGQGNLCKVCMGGTEEAATKRCADNHNERYYGNMGALRCLVGDPTGKSFGDVAFMEHHNLESNIERLNTSGWAEGWVTWDFELLCSDGSRAPLSQWKSCNLGAVPPNIVMTRPVLTARIYDLLMKSQDTTEARPHSGFHLFESQQYGESDLLFKDVTKCLVHTSHMDYRTILGNEFCSQAESIFNCTHSNILQFCNQDVCSIF"

     sig_peptide     19..84
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
     misc_feature    91..1089
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="Transferrin family of the type 2
                     periplasmic-binding protein superfamily; Region:
                     PBP2_transferrin; cd13529"
                     /db_xref="CDD:270247"
     misc_feature    order(274..276,355..357,430..432,451..453,850..852)
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="active site"
                     /db_xref="CDD:270247"
     misc_feature    1123..2157
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="Transferrin family of the type 2
                     periplasmic-binding protein superfamily; Region:
                     PBP2_transferrin; cd13529"
                     /db_xref="CDD:270247"
     misc_feature    order(1276..1278,1402..1404,1480..1482,1501..1503,
                     1927..1929)
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /note="active site"
                     /db_xref="CDD:270247"
     exon            83..246
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            247..346
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            347..526
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            527..689
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            690..754
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            755..912
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1099
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1248
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1339
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1390
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1573
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1721
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1804
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1989
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2176
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2279
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2377
                     /gene="sxph"
                     /gene_synonym="zgc:172271"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agagatttctgacggactatgatgaagctcgtgagtgttattgttgtgctcttgctgctgttgtgctccatcaccagctggggtaagaagatgcgctggtgtgcagtatcagaggcagagcagaagaagtgtgcagaactggccaaagctcttgtcgctgtccttccacctgcagcagtcactgcgttcgctcgtctgtcatgtgtgaaagcttacagcaccgcagactgcattaataagataagggataataaagctgacctggtgaccctggacgccggagaggtttattctgctgtcaaacagtttgggctcacagtagttgcaaaggaaatctacagagatggtggctgtattcttgcagttgctgtggtcaggaacagcagttctttagacatgcgctctctgcagggcagtaggagctgtcacagtggagctcgctggactgcaggctggagtctgcctttgggacacttactgtctcgaaaccttctgccctgggctgaggatgagcccatcagtcaggcggtcagtgctttcttcaatgctagctgtgttcctggagcaactacaatggctgcaaacctttgttccttatgcaaaggccaaaggtcttacattcgtcagaagaacttccactgtgagacgtctcacagcgaaccattctatcacaaccaaggagcactcagatgtttgcagtcaggagctggagatattgcttttgtggatcacacagctctggacggcattgatgagagggagaaggatgagctgcgcctgctgtgtacagatgggtctctggctccgctcagcagctttaggacgtgtaatcttggacgaggtcctggaggcggtgtggtcacacggatgaacataaggaaaattgctcgaaagttcttggttgctgcccagatgtcttttggttggaggggaagggagcgtcggcgtttccagctgtttgaatctgcatcctttggtgggagtgaccttctcttcagagatgtgacggagaaattatctgttctgatggaggatatggatatgagccaggttctgggactcgactatgtggccttgctcaagggtcttggacatgaaggtagttcgctggaggacagtgtggtgaggtggtgctgtataagtcacgccgaacagaagaaatgtgagcagtgggctattagtataaaatcagaccctctggtgtgtgtaaaagcctcatctatgagtgactgcattgagaagatcaagagggatgaagtggatgccgtgtctctggacgccactcatgcttttatagctggaaaatgcggccttgtccctgttgtgactgaatattatggagagaaatgtgagacttctgcaggagctggaggccattttgaaagtaacgaattgccgccagtgtacggtgtggcagttgtgcgtcggtcaagcaagagtttattttttggaagtctggccgacagacgctcctgccacagtcacatgtacagtcctgcaggctgggttttacctgtaagacacacacttagcacagaacacaacaacagcgctccctgtgagcccaataaagtgtactctgaggtgttttggaaaggctgtttgcctgggggtcagggtaatctgtgtaaggtgtgtatgggtggaactgaggaagctgccacgaaacgttgtgctgacaaccataatgagcgctactacggcaacatgggtgcattaaggtgcctggttggagacccaactgggaaaagttttggagatgtggcctttatggagcaccacaatctagaaagcaacattgaacgtctgaacaccagtggctgggcagaaggttgggtcacttgggactttgagttactctgcagcgatggcagtcgggctcctctgtcgcaatggaaaagctgtaatttaggcgcagtccctccaaatattgttatgacacgtcctgttcttaccgctcgcatttatgacctcttaatgaagtcacaggataccacagaggctcgccctcattctgggtttcatctgtttgagtctcagcagtacggagagagtgacctgctttttaaagatgttacaaagtgtctagttcacaccagtcacatggactaccggaccatactgggaaatgagttctgttcacaggcggagagcatcttcaactgcacacactccaatatcctacagttctgcaatcaagatgtatgcagcatattctaatcaatctagatgaaataacatatatatatatatatatatatatatatatatatatatatatatatatatatatatatgactgttaaaaagcagcatgggtcatgttttgtattttatgtatctctcatgacatacaataaaatataatttgattataaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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