LOCUS       NM_001114416            1988 bp    mRNA    linear   VRT 03-APR-2024
DEFINITION  Danio rerio major facilitator superfamily domain containing 4Ab
            (mfsd4ab), mRNA.
ACCESSION   NM_001114416 XM_681331
VERSION     NM_001114416.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Perland,E., Bagchi,S., Klaesson,A. and Fredriksson,R.
  TITLE     Characteristics of 29 novel atypical solute carriers of major
            facilitator superfamily type: evolutionary conservation, predicted
            structure and neuronal co-expression
  JOURNAL   Open Biol 7 (9) (2017)
   PUBMED   28878041
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC155330.1.
            
            On Feb 10, 2008 this sequence version replaced XM_681331.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC155330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505372
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="23"
                     /map="23"
     gene            1..1988
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="major facilitator superfamily domain containing
                     4Ab"
                     /db_xref="GeneID:558146"
                     /db_xref="ZFIN:ZDB-GENE-060810-38"
     exon            1..282
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    23..25
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="upstream in-frame stop codon"
     CDS             53..1663
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="mfsd4b; major facilitator superfamily domain
                     containing 4b"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 4B"
                     /protein_id="NP_001107888.1"
                     /db_xref="GeneID:558146"
                     /db_xref="ZFIN:ZDB-GENE-060810-38"
                     /translation="

MLIEERLLTLFKRNCQHTLTYWSVFFSFGLSIAFLGPTILDLKCRTGSTLQEITWVFFAQQLCLLIGSSSGGAFTKTLFSALLALFLSSLIISVVFSIIPLCYNVLLLAIAMAVSGLAMGIIDTIANIQLVSIYKKDSPIFLQALHFFIGLGALLSPLIAEPFISGHCLRSNSTENATEIIHHFRSSFRSPVNLPESSPLSGPVEERNVSYAFWIMALINLPVPIAVFVLMYQEKLLPFCPNSSPRLLDKDELAMETKAPDNTEMAELDDEVFLHSGHGNIFSCCTDGALRGLPVTFFLIHIFGGMVLFMTEGIMGVYAGFVYTYAVSPPMSLQSKMAGNLNCIFWAAITAGRLVSIPLSYRFKTVHLLLTNMAGVIVTLLLLMILYTNRVFLFVGTTFLGLFISSVFPCLVAYTEDILEYRGCATTVLVTLSGMGEMTLQVLAGTLIQKKGSYSFLVCGLVIGCLGFIFLLSVILSNHFHRKITGASKKAEITDGPAAPAPEKTAPEHKTAVIQPECIKCDFGLDHNGSKPAENT"

     misc_feature    104..1462
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="Major Facilitator Superfamily; Region: MFS;
                     cl28910"
                     /db_xref="CDD:475125"
     misc_feature    107..169
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    order(134..139,146..151,158..160,254..256,407..412,
                     416..424,431..433,488..490,497..502,509..511,974..976,
                     983..988,995..1003,1010..1012,1097..1099,1109..1111,
                     1259..1264,1274..1276,1286..1288,1331..1333,1340..1345,
                     1352..1357,1364..1366)
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]; other site"
                     /db_xref="CDD:349949"
     misc_feature    209..271
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    293..355
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    365..427
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    470..532
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    683..745
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    941..1003
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    1073..1135
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    1148..1210
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    1223..1285
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    1334..1396
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     misc_feature    1418..1480
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /note="propagated from UniProtKB/Swiss-Prot (A9JTG4.1);
                     transmembrane region"
     exon            283..481
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            482..712
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            713..866
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            867..997
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1171
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1319
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1390
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1508
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1943
                     /gene="mfsd4ab"
                     /gene_synonym="im:7150270; mfsd4b2; zgc:175151"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

caaacgtcaacaattacagcagtgagtggaagagatcggagattttcacgctatgttaatagaggagcgcttactaacacttttcaaaaggaactgtcaacatacgctgacatactggagcgtgttcttcagctttggactgagcattgcttttctggggcctaccatcctggatctgaaatgccggacaggctccacgctgcaggagatcacctgggttttctttgcccaacagctctgtctacttatcggcagctccagtggaggagctttcaccaaaacgttgttcagcgctctgctcgctctcttcctctcgtccctcatcatctctgtggttttttccatcatcccactttgctataatgtgctgctgctggcgatagcgatggcagtgtcaggtctggccatgggcatcatcgacaccatcgcaaacatccaactggtgtccatttataaaaaggactctcctatctttctgcaggctctgcacttcttcattggtctcggtgctctattgagtcctctgattgcagagcctttcatatccggccactgcctgcgcagtaatagcacagaaaacgccaccgagataattcaccacttcagatccagcttcaggtcacctgtaaatctgcccgagagttcgccgctctcaggcccggtggaggagaggaacgtgtcctacgccttctggatcatggctctcattaatctgccggtgccgattgcagtttttgtgttgatgtatcaagagaagctgctgcccttttgcccaaacagcagcccacgactgctagacaaagatgagctggccatggagaccaaagcaccagacaacacagaaatggctgaattggatgacgaagtttttcttcactctggacatggaaacatcttcagctgctgtacggatggtgctctgcgtgggttacccgtcaccttctttctcatccacatttttggtggtatggtgctgtttatgacagagggcattatgggggtctatgcaggctttgtttacacgtacgccgtttcacctcccatgtctctgcaatctaaaatggcaggaaacctgaactgtatcttctgggcagccatcactgccggacgactggtgtcaatcccgctatcataccgctttaaaacagtacatctgctcctcactaacatggctggtgtgattgtgacattgctgctgttaatgatcctctacacaaacagagtgtttctgtttgttggaacaacctttctggggcttttcattagcagtgttttcccctgcttagtggcctacactgaggacattctggaataccgtggatgtgcaacaacggtcttagtgacattgtcagggatgggtgagatgacgctgcaggtgctggctggaacacttattcagaaaaaaggcagttacagttttttggtgtgtggtttggtcattggatgtctcggtttcatcttcctcctgagtgtgatcctgagcaaccacttccacagaaaaatcacaggagcatctaaaaaagcagaaattactgatggtccagcagctcctgctccagagaaaacagcaccagaacacaaaactgctgtaatacagcccgaatgcattaaatgtgactttggattagaccataatgggtcaaaacctgctgaaaatacttaacagtatgactaaactgtaaacggtgaatgtgtttttattatatttgtgtaaactaacaaaaggtttaaaaaaaacatacacagtgatgcaatatatttttatgtatttctgcaaagtttggtattaagttgtgttttgtaattgtttctagcaaaaaaaaccctgactgttcaattctaaacatttactgaactagcaaatgtttaacaattacaaaagtggaatgatgtaatttataacattcaatggctacatattataaataaagttttgtactttaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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