LOCUS       NM_001114409            1873 bp    mRNA    linear   VRT 17-JUN-2024
DEFINITION  Danio rerio mohawk homeobox b (mkxb), mRNA.
ACCESSION   NM_001114409 XM_678904
VERSION     NM_001114409.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1873)
  AUTHORS   Nie,C.H., Wan,S.M., Chen,Y.L., Huysseune,A., Wu,Y.M., Zhou,J.J.,
            Hilsdorf,A.W.S., Wang,W.M., Witten,P.E., Lin,Q. and Gao,Z.X.
  TITLE     Single-cell transcriptomes and runx2b-/- mutants reveal the genetic
            signatures of intermuscular bone formation in zebrafish
  JOURNAL   Natl Sci Rev 9 (11), nwac152 (2022)
   PUBMED   36478733
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1873)
  AUTHORS   Adachi,Y., Higuchi,A., Wakai,E., Shiromizu,T., Koiwa,J. and
            Nishimura,Y.
  TITLE     Involvement of homeobox transcription factor Mohawk in
            palatogenesis
  JOURNAL   Congenit Anom (Kyoto) 62 (1), 27-37 (2022)
   PUBMED   34816492
REFERENCE   3  (bases 1 to 1873)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1873)
  AUTHORS   Hsu,C.H., Lin,J.S., Po Lai,K., Li,J.W., Chan,T.F., You,M.S.,
            Tse,W.K. and Jiang,Y.J.
  TITLE     A new mib allele with a chromosomal deletion covering foxc1a
            exhibits anterior somite specification defect
  JOURNAL   Sci Rep 5, 10673 (2015)
   PUBMED   26039894
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1873)
  AUTHORS   Briolat,V., Jouneau,L., Carvalho,R., Palha,N., Langevin,C.,
            Herbomel,P., Schwartz,O., Spaink,H.P., Levraud,J.P. and Boudinot,P.
  TITLE     Contrasted innate responses to two viruses in zebrafish: insights
            into the ancestral repertoire of vertebrate IFN-stimulated genes
  JOURNAL   J Immunol 192 (9), 4328-4341 (2014)
   PUBMED   24683187
REFERENCE   6  (bases 1 to 1873)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CABZ01071987.1, CABZ01071986.1 and CU694527.8.
            
            On Jun 17, 2024 this sequence version replaced NM_001114409.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GFIL01026544.1, EU280786.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476730, SAMEA4476731
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               CABZ01071987.1     10152-10276         c
            126-383             CABZ01071987.1     9272-9529           c
            384-531             CABZ01071987.1     7238-7385           c
            532-685             CABZ01071987.1     1685-1838           c
            686-1006            CABZ01071986.1     17217-17537         c
            1007-1040           CU694527.8         6063-6096
            1041-1873           CU694527.8         6191-7023
FEATURES             Location/Qualifiers
     source          1..1873
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1873
                     /gene="mkxb"
                     /note="mohawk homeobox b"
                     /db_xref="GeneID:556167"
                     /db_xref="ZFIN:ZDB-GENE-080513-2"
     exon            1..125
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     exon            126..383
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    202..204
                     /gene="mkxb"
                     /note="upstream in-frame stop codon"
     misc_feature    205..207
                     /gene="mkxb"
                     /note="upstream_AUG_codon; putative N-terminal extension:
                     ME"
     CDS             211..1224
                     /gene="mkxb"
                     /note="homeobox protein mohawk B"
                     /codon_start=1
                     /product="mohawk homeobox b"
                     /protein_id="NP_001107881.2"
                     /db_xref="GeneID:556167"
                     /db_xref="ZFIN:ZDB-GENE-080513-2"
                     /translation="

MNTAVFSKFDQLRFEESGQNVERSSRSYLELIDGQRSDLLTSHKVMDGNDALKHRRNGGGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSHMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSISSDDTASDDGENNLQMQASESDYNRAVHKSVIQDSRVKVGRNADPSVCDDYVSPPKYKNSLLNRYLNDSLRHVMASDKVMDSRKRNHSGSFSSNEYEDDFLSPSSEAEANFTYHTVTLDCGTRQSESGARKGGNNETYWKELHAAMALTNLAQVKESSAAGTTSCIIQKSSHIAEIKTVKVPIQPRH"

     exon            384..531
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     exon            532..685
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     exon            686..1006
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1040
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1873
                     /gene="mkxb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agactccagagctgctccatatagtggaaaagcgcagatgcagagcgcagagctgcaaatgaagatgagctgacaggatgctggacgactctgaaactacactatagcgacgcacagggaactttgttgcgtcctagtaatttcagggaaaatattccgtgcacagactttggaggtacatgtggatttggcacatggcagtgaatggagatgaacacggcagtcttcagtaagtttgaccagctgcgctttgaggaaagcggacaaaatgtggagagaagcagcaggagttatttagagctgattgatggacaacgttcagatttactcacaagccacaaagtgatggatggcaacgacgctctcaaacacaggagaaatggtggagggaaggtgcgtcacaagcgtcaggctcttcaggatatggctcgaccgctgaagcagtggctctacaagcaccgggacaatccttatcccaccaagactgagaagatactgctggctcttgggtcccacatgaccctggttcaggtgtcaaattggtttgcgaatgcaaggcgtagactcaagaacacagttcgacagccggacttgagctgggctttacgtataaaactgtacaacaaatatgtccaaggcaacgcagagagactgagcattagcagtgatgacacagcatcagatgatggggagaacaatttgcagatgcaggccagcgagtccgactataacagagccgtgcacaagagcgttattcaggacagcagagtcaaagtgggccgaaacgcagacccctcggtttgtgatgattatgtttcgccaccgaaatacaagaacagcttgctgaaccgctatctgaatgattcccttcggcatgtaatggcctctgataaagttatggactctcggaagaggaaccattcgggatcgtttagctccaacgagtatgaggatgattttctctcgccctcttcagaagctgaggcaaacttcacctaccacacagtgacgctggactgcggcacacgccagagcgagagcggcgctcgtaaaggaggaaataatgagacctactggaaagagctccacgccgccatggccctgaccaacctggctcaagtaaaggagagctccgcggcgggtacaaccagctgtatcatccagaagtcttcccatatagcggagattaagactgtcaaagtgcccatacaaccccgacattagcggctaacaggctggactgcggtcgtaatcgctaagactacctgaacacttgagtacgtacagtagcctacttcatgcaataatttagctgaaaatgatccacgacagccttttcggatacatgtcgattgaccagcgtgcctcttatttctttaaaccactgtctgatgaaaaagaataatgtttgatttatggagagtacagctatgtttccatacaaagacgcaaaactggaatatcgcataaaacgtttgcgaataaacgactttttttgtcatgagaatctaagagaaatttatttataaactaatttcacacttagctgatgattgattatggtttggcttgctgtcccgggagagagccctgagctcataagatcctcgagccctaggctccctcccgtttgcctggcaagaggggagtttgagctctggtagatctcgagaactcccctgctgtagtaactaatgaacttagtgattgctcttaagagataactacttactaggagcatctctatggtgtcgatttggattagtcaattaacttaagttgcgtgtttttggacggtgggagaaaatcagggaaatacacggggagaacgtgtaaactccagacagaagtgtcaactggcttggtaaggact

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