LOCUS       NM_001100046            1183 bp    mRNA    linear   VRT 03-APR-2025
DEFINITION  Danio rerio wingless-type MMTV integration site family, member 16
            (wnt16), mRNA.
ACCESSION   NM_001100046 NM_207096 XM_001331630
VERSION     NM_001100046.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1183)
  AUTHORS   Diamond,K.M., Burtner,A.E., Siddiqui,D., Alvarado,K., Leake,S.,
            Rolfe,S., Zhang,C., Kwon,R.Y. and Maga,A.M.
  TITLE     Examining craniofacial variation among crispant and mutant
            zebrafish models of human skeletal diseases
  JOURNAL   J Anat 243 (1), 66-77 (2023)
   PUBMED   36858797
REFERENCE   2  (bases 1 to 1183)
  AUTHORS   Liu,W., Lin,S., Li,L., Tai,Z. and Liu,J.X.
  TITLE     Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via
            regulating gata1a expression and WNT signaling to facilitate
            hypoxia tolerance
  JOURNAL   Cell Regen 12 (1), 10 (2023)
   PUBMED   37002435
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1183)
  AUTHORS   Watson,C.J., Tang,W.J., Rojas,M.F., Fiedler,I.A.K., Morfin Montes
            de Oca,E., Cronrath,A.R., Callies,L.K., Swearer,A.A., Ahmed,A.R.,
            Sethuraman,V., Addish,S., Farr,G.H. 3rd, Gomez,A.E., Rai,J.,
            Monstad-Rios,A.T., Gardiner,E.M., Karasik,D., Maves,L., Busse,B.,
            Hsu,Y.H. and Kwon,R.Y.
  TITLE     wnt16 regulates spine and muscle morphogenesis through parallel
            signals from notochord and dermomyotome
  JOURNAL   PLoS Genet 18 (11), e1010496 (2022)
   PUBMED   36346812
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1183)
  AUTHORS   Wada,Y., Tsukatani,H., Kuroda,C., Miyazaki,Y., Otoshi,M. and
            Kobayashi,I.
  TITLE     Jagged 2b induces intercellular signaling within somites to
            establish hematopoietic stem cell fate in zebrafish
  JOURNAL   Development 149 (7) (2022)
   PUBMED   35388409
REFERENCE   5  (bases 1 to 1183)
  AUTHORS   Qu,X., Liao,M., Liu,W., Cai,Y., Yi,Q., Long,J., Tan,L., Deng,Y.,
            Deng,H. and Chen,X.
  TITLE     Loss of Wnt16 Leads to Skeletal Deformities and Downregulation of
            Bone Developmental Pathway in Zebrafish
  JOURNAL   Int J Mol Sci 22 (13), 6673 (2021)
   PUBMED   34206401
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1183)
  AUTHORS   Moore,F.E., Reyon,D., Sander,J.D., Martinez,S.A., Blackburn,J.S.,
            Khayter,C., Ramirez,C.L., Joung,J.K. and Langenau,D.M.
  TITLE     Improved somatic mutagenesis in zebrafish using transcription
            activator-like effector nucleases (TALENs)
  JOURNAL   PLoS One 7 (5), e37877 (2012)
   PUBMED   22655075
REFERENCE   7  (bases 1 to 1183)
  AUTHORS   Ramachandran,R., Zhao,X.F. and Goldman,D.
  TITLE     Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen
            synthase kinase-3beta inhibition is sufficient for zebrafish retina
            regeneration
  JOURNAL   Proc Natl Acad Sci U S A 108 (38), 15858-15863 (2011)
   PUBMED   21911394
REFERENCE   8  (bases 1 to 1183)
  AUTHORS   Lu,F.I., Thisse,C. and Thisse,B.
  TITLE     Identification and mechanism of regulation of the zebrafish dorsal
            determinant
  JOURNAL   Proc Natl Acad Sci U S A 108 (38), 15876-15880 (2011)
   PUBMED   21911385
REFERENCE   9  (bases 1 to 1183)
  AUTHORS   Clements,W.K., Kim,A.D., Ong,K.G., Moore,J.C., Lawson,N.D. and
            Traver,D.
  TITLE     A somitic Wnt16/Notch pathway specifies haematopoietic stem cells
  JOURNAL   Nature 474 (7350), 220-224 (2011)
   PUBMED   21654806
  REMARK    GeneRIF: Wnt16 controls a novel genetic regulatory network required
            for HSC specification
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1183)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Comparative genomics on Wnt16 orthologs
  JOURNAL   Oncol Rep 13 (4), 771-775 (2005)
   PUBMED   15756456
  REMARK    GeneRIF: genomic analysis of conserved sequences between human,
            rat, and zebrafish WNT16
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CT025718.7.
            
            On or before Apr 24, 2008 this sequence version replaced
            NM_207096.1, XM_001331630.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA4476729,
                              SAMEA4476735 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               CT025718.7         38831-39034
            205-431             CT025718.7         39199-39425
            432-718             CT025718.7         41402-41688
            719-1183            CT025718.7         44378-44842
FEATURES             Location/Qualifiers
     source          1..1183
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="4"
                     /map="4"
     gene            1..1183
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /note="wingless-type MMTV integration site family, member
                     16"
                     /db_xref="GeneID:791563"
                     /db_xref="ZFIN:ZDB-GENE-040426-2330"
     exon            1..204
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1183
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /codon_start=1
                     /product="protein Wnt-16 precursor"
                     /protein_id="NP_001093516.1"
                     /db_xref="GeneID:791563"
                     /db_xref="ZFIN:ZDB-GENE-040426-2330"
                     /translation="

MDNTGCGIHAVHHLFLIWLSVYPLCSQGSWMWLGITSVGVPEKLGCAHLPLSHKQKELCARKPHLLPSVKEGARLGITECQTQFRHERWNCSTRRDPNVFGYELTSGTKETAFIHAVMAAGLVHAVTRSCSAGNMTECSCDTSLLGSGSPTEGWHWGGCSDDIAFGTSFSRRFIDSAAKNTSTRGEEALLIMKQHNSEAGRQAVAKTMLTDCRCHGVSGSCAVKTCWRTMAAFERVGAYLKDRYETSVHVVDRSKRKVRRKDKEQRHVPITKDELIFFNKSPNYCLEDRRLGVTGTRGRKCNRTSAGPDGCNLLCCGRGYNTHVVRHVERCECKFVWCCYVRCRRCETMNDMHTCK"

     sig_peptide     113..196
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
     misc_feature    263..1180
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /note="Wnt domain found in protein Wnt-16 and similar
                     proteins; Region: Wnt_Wnt16; cd19344"
                     /db_xref="CDD:381718"
     misc_feature    order(749..754,761..769,791..793,1115..1117,1121..1123,
                     1127..1129,1133..1135)
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /note="Frizzled receptor binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:381718"
     exon            205..431
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /inference="alignment:Splign:2.1.0"
     exon            432..718
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1183
                     /gene="wnt16"
                     /gene_synonym="zgc:77293"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

agacttaaaagcgtcgtttgtggattacaggtgctacatattagatgcagtggaccggcatgaatcgtctttgtcaaaacgttcagttcgggacttgttaaatgaagtggacatggataataccggttgtgggatacatgcagttcatcatttattccttatatggctctccgtttaccctttgtgctctcagggaagttggatgtggttgggcatcacatctgtaggagtgcccgagaagttgggttgcgcgcatttgcccctgtcgcacaagcagaaggagctgtgcgcgcgcaaaccgcatcttctaccgagcgttaaagagggcgcgcgcctgggcatcaccgagtgccaaactcagttcagacacgaacgctggaactgctcgacccgacgggacccgaacgtgttcggctacgagctcacgagcgggactaaagagacagcgttcatccatgcagtaatggctgccggcctggttcatgcagtcacccgctcttgcagtgcaggaaatatgacagagtgttcatgtgacacaagcctgttgggcagcgggtcgcccaccgagggctggcattggggcggctgctctgatgacatcgccttcgggacttcattcagccgccgctttattgacagtgcagcgaaaaacacctcgacccgtggtgaggaggccctgctcattatgaagcagcataacagtgaggctgggagacaggcggtggccaaaacaatgttgacagactgccgctgtcatggcgtatcgggttcatgtgcggtaaagacgtgttggcgcacaatggctgcatttgagcgtgtgggcgcctacctgaaggatcgctatgaaaccagcgttcatgttgtggaccgttccaaacgtaaggtgcgacgcaaggataaagagcaacgccatgtgcctatcaccaaagatgagttaatcttcttcaacaaatcgcccaattattgcttggaggaccggcggctgggcgtgacggggaccaggggccgcaagtgtaacagaacttcggccgggcccgacggctgcaacctgctgtgctgcggacggggatacaacacacatgtggtgcgacatgtagagcgctgcgagtgtaagttcgtctggtgctgttatgttcgctgcagacgctgcgagacaatgaatgacatgcacacctgcaagtaa

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