LOCUS       NM_001098733            2945 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio mohawk homeobox a (mkxa), mRNA.
ACCESSION   NM_001098733 XM_678274
VERSION     NM_001098733.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2945)
  AUTHORS   Nie,C.H., Wan,S.M., Chen,Y.L., Huysseune,A., Wu,Y.M., Zhou,J.J.,
            Hilsdorf,A.W.S., Wang,W.M., Witten,P.E., Lin,Q. and Gao,Z.X.
  TITLE     Single-cell transcriptomes and runx2b-/- mutants reveal the genetic
            signatures of intermuscular bone formation in zebrafish
  JOURNAL   Natl Sci Rev 9 (11), nwac152 (2022)
   PUBMED   36478733
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2945)
  AUTHORS   Song,Y., Chen,W., Zhu,B. and Ge,W.
  TITLE     Disruption of Epidermal Growth Factor Receptor but Not EGF Blocks
            Follicle Activation in Zebrafish Ovary
  JOURNAL   Front Cell Dev Biol 9, 750888 (2022)
   PUBMED   35111746
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2945)
  AUTHORS   Adachi,Y., Higuchi,A., Wakai,E., Shiromizu,T., Koiwa,J. and
            Nishimura,Y.
  TITLE     Involvement of homeobox transcription factor Mohawk in
            palatogenesis
  JOURNAL   Congenit Anom (Kyoto) 62 (1), 27-37 (2022)
   PUBMED   34816492
REFERENCE   4  (bases 1 to 2945)
  AUTHORS   Giffen,K.P., Liu,H., Kramer,K.L. and He,D.Z.
  TITLE     Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse
            Inner Ear Non-sensory Supporting Cells
  JOURNAL   Front Neurosci 13, 1117 (2019)
   PUBMED   31680844
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2945)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2945)
  AUTHORS   Chuang,H.N., Hsiao,K.M., Chang,H.Y., Wu,C.C. and Pan,H.
  TITLE     The homeobox transcription factor Irxl1 negatively regulates MyoD
            expression and myoblast differentiation
  JOURNAL   FEBS J 281 (13), 2990-3003 (2014)
   PUBMED   24814716
  REMARK    GeneRIF: Irxl1/Mkx can repress myoD expression through direct
            binding to its promoter and may thus play a negative regulatory
            role in muscle differentiation.
REFERENCE   7  (bases 1 to 2945)
  AUTHORS   Briolat,V., Jouneau,L., Carvalho,R., Palha,N., Langevin,C.,
            Herbomel,P., Schwartz,O., Spaink,H.P., Levraud,J.P. and Boudinot,P.
  TITLE     Contrasted innate responses to two viruses in zebrafish: insights
            into the ancestral repertoire of vertebrate IFN-stimulated genes
  JOURNAL   J Immunol 192 (9), 4328-4341 (2014)
   PUBMED   24683187
REFERENCE   8  (bases 1 to 2945)
  AUTHORS   Chuang,H.N., Cheng,H.Y., Hsiao,K.M., Lin,C.W., Lin,M.L. and Pan,H.
  TITLE     The zebrafish homeobox gene irxl1 is required for brain and
            pharyngeal arch morphogenesis
  JOURNAL   Dev Dyn 239 (2), 639-650 (2010)
   PUBMED   20014404
  REMARK    GeneRIF: observations suggest that irxl1 may regulate factors
            involved in brain and pharyngeal arch development
REFERENCE   9  (bases 1 to 2945)
  AUTHORS   Anderson,D.M., Beres,B.J., Wilson-Rawls,J. and Rawls,A.
  TITLE     The homeobox gene Mohawk represses transcription by recruiting the
            sin3A/HDAC co-repressor complex
  JOURNAL   Dev Dyn 238 (3), 572-580 (2009)
   PUBMED   19235719
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from EF457976.1.
            
            On Apr 10, 2008 this sequence version replaced NM_001098733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF457976.1, EU280785.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA3505388,
                                           SAMEA4476730 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2945
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="12"
                     /map="12"
     gene            1..2945
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="mohawk homeobox a"
                     /db_xref="GeneID:799136"
                     /db_xref="ZFIN:ZDB-GENE-080513-1"
     exon            1..104
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            105..385
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    132..134
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="upstream in-frame stop codon"
     CDS             210..1259
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="homeobox protein mohawk A; iroquois homeobox-like
                     protein 1b; irxl1"
                     /codon_start=1
                     /product="mohawk homeobox a"
                     /protein_id="NP_001092203.2"
                     /db_xref="GeneID:799136"
                     /db_xref="ZFIN:ZDB-GENE-080513-1"
                     /translation="

MNTIVFNKLSSQVLFEEKANEVERSSRNYLEVIDGQHPDLLSSSPVLKDSSAIRHRRSGSRQNPGKVRHKRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQPDLSWALRIKLYNKYVQGNAERLSVSSDDSCSDDADPATRAQVGEFSKPMYQSVIKKEGGGMGAGLRAASDASLADDYVSPPKYKSSLLHRYLNDSLRHVMGANGVMDARKRNHSGSFSSNEYDEDLLSPSSSEAEANFIYRTETVEHGSNKCDRSLQKEKGQRKDETYWREINAAMAPTNLAQPKGTATAGTTTSCIIQKSSHIAEIKTVKVPLLHKY"

     misc_feature    order(411..425,429..431,486..488,504..506,543..545,
                     549..554,561..566,570..578,582..587)
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238039"
     misc_feature    order(417..419,426..428,552..554,561..566,573..575)
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="specific DNA base contacts [nucleotide binding];
                     other site"
                     /db_xref="CDD:238039"
     misc_feature    462..578
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /note="Homeobox KN domain; Region: Homeobox_KN; pfam05920"
                     /db_xref="CDD:428673"
     exon            386..545
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            546..699
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1029
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1063
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..2945
                     /gene="mkxa"
                     /gene_synonym="irxl1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gtggtttgcgcgcaggatcttagagcggagaacatgtgagagggaatgggaaactggaaactggattacactttacagaaagacgcagaaggaggaacacacaggattttgacagggcgctgcggctccgttgagtaggacatccgcacggctgccaagcactttcagcggaaacacgggggaaaaggagttggactaatataccaaagatgaacacaattgtgtttaataagttaagcagccaggtcttattcgaggagaaggcgaatgaggtggaaagaagcagtcgcaattatctagaggtgatagacgggcagcatccggacctgctctccagcagcccagtcctcaaagacagctccgctatacggcacaggagatcagggtctcgtcaaaacccaggaaaggtacggcataaacggcaagctttacaggacatggcccggcctctgaaacagtggctctacaaacacagggacaatccttaccccactaaaacagagaaaattcttctcgcgcttggctcacaaatgacacttgtgcaggtgtctaactggtttgcaaatgctcgacggcgactgaagaacacagttaggcagcctgacttgagttgggcgcttaggatcaaactctacaacaaatacgtccagggcaatgcagaaaggctgagcgtcagcagtgatgactcctgctctgatgatgctgacccagcaacacgagctcaggtcggggagttcagtaaacccatgtaccagagcgtcatcaagaaggaaggtggcggcatgggggcgggtcttcgagcagcttcagacgcctcattggctgacgactatgtgtcaccgcctaaatacaagagcagcctgttgcatcgttacctcaatgactcgctccgtcatgtaatgggggccaatggcgtaatggacgcacggaagaggaaccactcgggctcgttcagctcaaatgagtatgatgaagacctgctgtcaccatcctcttcagaagcagaagccaactttatctacaggactgagactgtggagcatggatcaaataaatgtgacaggagtctgcagaaggagaagggacagaggaaagatgagacgtactggagggagatcaacgctgccatggctcccactaacctggctcagcctaaaggcacggccaccgctggcaccaccaccagctgcatcatccagaaatcctcacatatagccgagatcaagactgttaaagtgcctctcctccacaaatactaatgcgcgcacacacagtgacagaagaccccgctcctctacttttggaatattctacattactttgtggtactggtttgttattataagtacaatgaagtgccctgaaatgcagcacttgtttagttcaccaatgtgtgcatttctttttctccttttggataagtgttgacgaaacagcagtatttctgaacgagacacttttgcaatgttaacttattttgatattaatcagaaatttgtattgtatcgcaccaaagtgccttgatgcgtctcgaaggagagatgaatgagaatgtacagttggatgaaatgacaaaggagtgtgtgtgtgtgtatacgcgtgtataatacacactcttctctcaccgccgatgaccttcagatccaatcatcatcgcccacataaggccatttgtgcatgttttgtcttgatatctcctctggctgtgactacaacagtgttttgtctccaaaatttgaaaacttcaactgtcacctgccaacaatagccgtgagctgagagataagttcaaactctgcttcctctcgtttgcccacgtttctcagacacagtgagaaagatagaaacagacttcaaggttttttgtttttttttcctgtatctgttttgagacgaggactgggacccaaagggatatttatgaagttggtattattgcttaaaagccaacgtgttgccatcttttttcagaacaacgtacttcagtggaagcagaaaataatttagccagtcatgttttatcccccttttttccctctcagctggacagaattactctcgaattgttgtttacaaaaagtacaaaagatacttccattttaaaacacacacacacacacacacacatgcacccacgcacgcacgcacacacgcgcacacacacacgcgcgcacacacacacacaaagataaaaagtatagcagtattaccacatctcagattcagtgagcaatctcattttgtttgttttgcggtttttgcctttggttgtgttgaaggaatggaaagaaactatgttggatgcagtgttatttacagtagagtcgagttttactccatttacagaattaaaagagcaattttgagtgtcgcaataagcaagtatgtctgtttaaaggaaaggccaaagagacttattgaaaaagcagtatgcacttatctgactgcacccaatcccatttttaatatcagttagcactatgcccctgcttttctgctcggcagagcactgtagcacattttatttggtaaattttctattaaaaatggggaaatgtatgatctgatctgcttttggaatctcctttccctttgttttccctcttgaatcacatgtgaatgtcttttggcctttacggtgaacaaagagatgagaaagttacccgagtttcactaactgtgttcaaaaggacgctgacagacaaagttattttgtgcacattttagaacctttgaaatgattaaagactgtaaaaagaaacgagtaataatagtctgttttttattgttaagttatattcttttttttattgtagagactggatgtttatccaatgaaggaatgcataatatctcatttattctctaattttcttttaatgttcagtttttacatcaggaaccttgtttacttcaacggaacgttaaataaaacattttgatga

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