LOCUS       NM_001098265            3734 bp    mRNA    linear   VRT 23-MAR-2025
DEFINITION  Danio rerio ADNP homeobox 2a (adnp2a), mRNA.
ACCESSION   NM_001098265 XM_001345830
VERSION     NM_001098265.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 3734)
  AUTHORS   Wang,Y., Sun,X., Xiong,B., Duan,M. and Sun,Y.
  TITLE     Genetic and Environmental Factors Co-Contributing to Behavioral
            Abnormalities in adnp/adnp2 Mutant Zebrafish
  JOURNAL   Int J Mol Sci 25 (17), 9469 (2024)
   PUBMED   39273418
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3734)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3734)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3734)
  AUTHORS   Dresner,E., Malishkevich,A., Arviv,C., Leibman Barak,S., Alon,S.,
            Ofir,R., Gothilf,Y. and Gozes,I.
  TITLE     Novel evolutionary-conserved role for the activity-dependent
            neuroprotective protein (ADNP) family that is important for
            erythropoiesis
  JOURNAL   J Biol Chem 287 (48), 40173-40185 (2012)
   PUBMED   23071114
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC139614.1.
            
            On May 25, 2007 this sequence version replaced XM_001345830.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC139614.1, EV758900.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA4476745, SAMEA4476758
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3734
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Singapore"
                     /db_xref="taxon:7955"
                     /chromosome="16"
                     /map="16"
     gene            1..3734
                     /gene="adnp2a"
                     /gene_synonym="adnp2; im:6912290; wu:fc45g06; znf508"
                     /note="ADNP homeobox 2a"
                     /db_xref="GeneID:100007394"
                     /db_xref="ZFIN:ZDB-GENE-040914-55"
     misc_feature    246..248
                     /gene="adnp2a"
                     /gene_synonym="adnp2; im:6912290; wu:fc45g06; znf508"
                     /note="upstream in-frame stop codon"
     CDS             261..3149
                     /gene="adnp2a"
                     /gene_synonym="adnp2; im:6912290; wu:fc45g06; znf508"
                     /note="ADNP homeobox 2; zinc finger protein 508; ADNP
                     homeobox protein 2a; activity-dependent neuroprotector
                     homeobox protein 2a"
                     /codon_start=1
                     /product="activity-dependent neuroprotective protein 2a"
                     /protein_id="NP_001091735.1"
                     /db_xref="GeneID:100007394"
                     /db_xref="ZFIN:ZDB-GENE-040914-55"
                     /translation="

MYQIPVKNLTKLRRPRKRVKSILCDIGMQQCQDMLETYKCFDAGDASFDNTEWDDFTDGHVGKKKKKYPYRSQSLCCSLCWYSSRSVPTFRSHIHRCHWKNLDGACLLMCPYCPFVSSPKVTEQHIQFFHMLPSRAHQSHPSHTLAHTPKTISVTVSADAADDRYTCATCGYHDSLLYVMKKHVLVNHFATLLDRYFGLGSESAPMAGPQIRDGTPVKYHCKLCKLPAETIEHLLYHILSSEKHKELHWQIMPCIIEKECMNQMVGLQNLLNLAPKSMQPVTLFARPNYMPQQTQQTNGNGTVLLAGPSNAAALFCSPGAGQMFLSPQTQALLSGTTVAALQNAPHPQSPGGMSQVLPTSPVVKPLNMVMPNMPQNTPKTLPLTMTVPRLPPPQQGPQVLLPPGVQVNLPGEMGVHSPFLVTQGLQLNQSVPRAPLITSQSVRFIPTGNKVNGVPTYTLAPVQVTVPVHGGPPQMVLAQNQISQPPNSAVVTPGLMPPVQRAMNKNSRPNELAVQAPFLKKHDNQTVKCLRCKILLTEQGIFQHLLHGLKCLFCPQMFYSFKQIMEHSKKEHSLKVKDNRLYIKEQFSLDCDDEGNLIFSTFNLNTDVPKDLLDNRELNLALVTSTKDKIYIKMYPDKAEYTTMLKSAPNACPFCQVKLQNPEDYELHLQTKHHIVPTIHAILKTPAYKCIYCFGVYTEKSTPKTISIHVQRCRCAPKAVKEAERKLNPDTSESHDGDVCSSVQMPASEVTFQGAPEFPKPKKEAVTPRNRRRNTKASKTGTLVPETPVTLVLEPMGMERTSFEDRKDFLSQYFHRKPYVTKTEIELLASRLWINKADVKAHFNSKLTKCLKAIQKKRVCVRLGFKMIEVNKLKHNLFIPEVKPVKRKDPNEVNLSSLVPGVTVKTEQVDATTQHPLFIPEVPVTIKKEEEVCEIDHGFIIQEVTVKQEEVDEMEDALCTNG"

     misc_feature    261..2639
                     /gene="adnp2a"
                     /gene_synonym="adnp2; im:6912290; wu:fc45g06; znf508"
                     /note="Activity-dependent neuroprotector homeobox protein
                     N-terminal; Region: ADNP_N; pfam19627"
                     /db_xref="CDD:466132"
     misc_feature    2517..2603
                     /gene="adnp2a"
                     /gene_synonym="adnp2; im:6912290; wu:fc45g06; znf508"
                     /note="propagated from UniProtKB/Swiss-Prot (A4QP16.1);
                     Region: Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite"
ORIGIN      

tctgtacgccatgttttttcagcaggagtgggctgatgtttcagtgagatttcatcaaaagtgggcaatcctgcgctcggttcgtatttcagcagaccatcgtcagtccatcgggaaaggcgggtcgagcgctacctggacgctccggacgatgaagtagacgcttcagagcgcgcgccttactagtgacgccggaagaaaacggacgcgcgcagacatttatccactcatctgtgccagaacactgaaggttgagcaaaatgtatcagattccagtgaagaaccttacaaaactcagacgaccgaggaaacgggtcaaaagtattttgtgtgacatcgggatgcagcagtgccaggatatgctggagacatataaatgttttgatgctggggatgcaagctttgacaacacagaatgggatgatttcactgacggtcatgttggcaaaaagaaaaaaaagtatccataccgaagccaaagtctgtgctgcagtctgtgttggtactccagccggtcggtgcccacattcagaagccacatccatcgctgtcactggaaaaatctggatggggcctgtttgttaatgtgcccctactgcccatttgtcagctctccaaaagtcacagagcaacacattcagtttttccacatgctgccatcaagagcccatcagagccaccctagccacactttggcccacacaccgaaaaccatatcagttacagtttctgctgatgctgctgacgacagatacacttgcgcgacctgtggttatcatgactctttattgtatgtgatgaagaagcacgtcctggtaaaccactttgctacgttgctggatcgctacttcggtcttgggtcggaaagtgcaccaatggctggtccgcagatacgtgatggcacacctgtcaaatatcactgcaaactgtgcaaacttccagcagagaccattgaacatttactgtaccatatcttgagttcagagaagcacaaggaactacactggcagataatgccttgtataattgaaaaagaatgcatgaaccaaatggttgggctacagaatctgctgaaccttgcacctaaatcgatgcagccggtcacgctgtttgcaagaccgaactatatgccacaacagactcaacaaaccaatggaaatggcacagttcttctggccggcccaagcaacgcggctgctctgttttgctctcctggtgcaggccagatgtttctgtctccacaaactcaagctctgctttcaggcacgactgtggctgcgcttcagaatgctccgcatccacagtcccctggcgggatgtcccaagttctgcctacctctccagtagtcaaacccctcaatatggtaatgccaaacatgccgcagaacacacccaagacgttacccctcactatgactgtgcccaggctaccaccgccccagcaaggaccgcaggttcttcttcctcctggtgtccaggtcaacctccctggcgaaatgggtgtacattcaccatttcttgttactcaaggtcttcagctgaaccagtcggttccaagagctcctctcatcacctcgcagtctgtgcgtttcattcccacaggcaacaaagtcaacggtgtcccaacctacactctagcacccgttcaagtgactgttcccgtccatggcgggcccccccaaatggtactagcgcaaaaccagattagccagcctccaaattcagcagtggtaaccccagggcttatgcctccagttcagagggcgatgaataaaaattccagaccaaatgaacttgctgtgcaggcgccgtttttaaaaaaacatgataatcaaactgtcaagtgcctgaggtgcaagattttactgacagagcagggtattttccagcatttgttgcacggcttgaagtgtctgttctgccctcagatgttctactccttcaagcagataatggagcacagcaagaaagagcacagtctgaaagtcaaagacaaccgactttacataaaggaacagtttagtcttgactgtgatgatgagggcaacctcatatttagcacttttaatctgaacacggatgtgcctaaagatctgcttgacaaccgagagcttaaccttgcactggtcaccagcactaaagacaagatttacataaaaatgtatccagataaggcagagtacacaactatgttgaagtcggcaccaaacgcctgtccgttttgtcaagtaaagctccagaaccctgaagactacgagctgcatcttcaaacgaaacaccatatcgttcccaccatccatgcaatactaaaaacacctgcatacaaatgtatatattgtttcggggtgtatactgaaaaatcaacacctaaaaccatctccattcacgtgcaacggtgtcgttgtgctcctaaagccgtcaaggaagcagagaggaaactgaatcctgatacatctgaatctcatgacggtgatgtatgcagctctgttcagatgcctgcttcagaagtgaccttccagggggcacctgaatttcccaagccaaagaaagaagctgtcacgccgaggaacagaagaaggaacacaaaggcttccaagacaggaactctagtccccgaaaccccagttacactggtcttggaaccaatgggaatggagaggacgtcgtttgaggacagaaaagactttctttcacagtacttccacagaaagccatacgtgacaaagacagaaatcgaactgctcgcttcccgtttgtggataaacaaggcggacgtgaaggcgcactttaacagcaagctcactaagtgcttgaaagcgattcagaaaaagagggtttgcgtacgtctcgggttcaaaatgattgaagtgaacaaactcaagcacaatctcttcattcctgaggtaaagcctgttaaaagaaaagacccaaacgaggtaaacctcagcagccttgttccaggggtgactgttaaaacagaacaagtggatgcaacgacacaacatcccctcttcatcccagaggtaccagtaactattaaaaaagaggaggaagtgtgtgaaattgatcatggcttcatcatccaagaggtgactgttaaacaagaagaagtggatgaaatggaagatgcgctctgtacaaatggctgatggtgtttttaggttaattatgtttgtatgcagcatgttgcgaaatgtttatttaaaaatacttgattcacgcttataaggtggtttgcctctaggcattggagtatgtaaaaagaggaacctacagcaaagactttacagttttgtatttttgttgtatatagttcatatgatgatgacattaaaagtttttttattatatatctctattgcaaggaaaaaaacaacactcgggtttcctatcttttatagtcatccttgtttaaaacacctgtaatttaaatttgaggacatcagtagtgataaagttctgcatttaacattttatgagtactgtacagagaatgaagtaattattattactaacttgcggattaggcagcatttcatagctgtatcactgtgtccctgtaaaagggacactttgttgttttcatgttaattttccccctatataatatacactgtattaatttcagacatgtggaaaaaaaacaagtgcctccgtcttatttaaagtttgcagttgtatttggctgttggaataaacgtgaccaaaaaaaaaaaaaaaaaaaaaaaaaaaaa

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