LOCUS       NM_001076560            2495 bp    mRNA    linear   VRT 16-SEP-2024
DEFINITION  Danio rerio fascin actin-bundling protein 1a (fscn1a), mRNA.
ACCESSION   NM_001076560 XM_679131 XM_702307
VERSION     NM_001076560.1
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Ruggiero C, Tamburello M, Rossini E, Zini S, Durand N, Cantini G,
            Cioppi F, Hantel C, Kiseljak-Vassiliades K, Wierman ME, Landwehr
            LS, Weigand I, Kurlbaum M, Zizioli D, Turtoi A, Yang S, Berruti A,
            Luconi M, Sigala S and Lalli E.
  TITLE     FSCN1 as a new druggable target in adrenocortical carcinoma
  JOURNAL   Int J Cancer 153 (1), 210-223 (2023)
   PUBMED   36971100
  REMARK    GeneRIF: FSCN1 as a new druggable target in adrenocortical
            carcinoma.
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Kondrychyn I, Kelly DJ, Carretero NT, Nomori A, Kato K, Chong J,
            Nakajima H, Okuda S, Mochizuki N and Phng LK.
  TITLE     Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic
            forces to control blood vessel shape and size
  JOURNAL   Nat Commun 11 (1), 5476 (2020)
   PUBMED   33127887
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Chestnut B, Casie Chetty S, Koenig AL and Sumanas S.
  TITLE     Single-cell transcriptomic analysis identifies the conversion of
            zebrafish Etv2-deficient vascular progenitors into skeletal muscle
  JOURNAL   Nat Commun 11 (1), 2796 (2020)
   PUBMED   32493965
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Witjes L, Van Troys M, Vandekerckhove J, Vandepoele K and Ampe C.
  TITLE     A new evolutionary model for the vertebrate actin family including
            two novel groups
  JOURNAL   Mol Phylogenet Evol 141, 106632 (2019)
   PUBMED   31560986
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Rutherford NE, Wong AH and Bruce AEE.
  TITLE     Spatiotemporal characterization of dynamic epithelial filopodia
            during zebrafish epiboly
  JOURNAL   Dev Dyn 248 (10), 997-1008 (2019)
   PUBMED   31390119
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I,
            Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y and
            Bobe J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2495)
  AUTHORS   van Boxtel AL, Chesebro JE, Heliot C, Ramel MC, Stone RK and Hill
            CS.
  TITLE     A Temporal Window for Signal Activation Dictates the Dimensions of
            a Nodal Signaling Domain
  JOURNAL   Dev Cell 35 (2), 175-185 (2015)
   PUBMED   26506307
REFERENCE   8  (bases 1 to 2495)
  AUTHORS   Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M,
            Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD,
            Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov
            GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W and
            Hertzano R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2495)
  AUTHORS   Boer EF, Howell ED, Schilling TF, Jette CA and Stewart RA.
  TITLE     Fascin1-dependent Filopodia are required for directional migration
            of a subset of neural crest cells
  JOURNAL   PLoS Genet 11 (1), e1004946 (2015)
   PUBMED   25607881
  REMARK    GeneRIF: These data show that fscn1a-dependent filopodia are
            required in a subset of NC cells to promote cell migration and NC
            derivative formation
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2495)
  AUTHORS   Liu Z, Lin X, Cai Z, Zhang Z, Han C, Jia S, Meng A and Wang Q.
  TITLE     Global identification of SMAD2 target genes reveals a role for
            multiple co-regulatory factors in zebrafish early gastrulas
  JOURNAL   J Biol Chem 286 (32), 28520-28532 (2011)
   PUBMED   21669877
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC124405.1.
            
            On or before Oct 4, 2006 this sequence version replaced
            XM_679131.1, XM_702307.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC124405.1, BC165613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="3"
                     /map="3"
     gene            1..2495
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="fascin actin-bundling protein 1a"
                     /db_xref="GeneID:558271"
                     /db_xref="ZFIN:ZDB-GENE-031009-1"
     exon            1..964
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1617
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="fascin homolog 1, actin-bundling protein a"
                     /codon_start=1
                     /product="fascin actin-bundling protein 1a"
                     /protein_id="NP_001070028.1"
                     /db_xref="GeneID:558271"
                     /db_xref="ZFIN:ZDB-GENE-031009-1"
                     /translation="

MTANGTSDMLKIQFGLINCGNKYLTAETFGFKINASATSMKKKQIWTLEQDGDDSNMFFLKSHLGRYIAADKDGNVTGDSETPGEDCRFIITAHDDGRWSLQSEPHKRYLGGTEDRITCFAQTISIAEKWSVHIAMHPQVNIFSVTRKRYAHLSSEQNEIAIDRDVPWGVDSLITLVFQDQRYHLQTSDNRFLKNDGSLSQTADKTTGYTLEFRSGKVAFRDCTGKYLAPSGPSGTMKSGKSMKVGKDELFVLEQSLPQVVLTAGNDRNVSTRQGMDLSANQDEEGDQETFQMEISKDTKKCAFRTCTGKYWTLTANGGLQCTASTKSANCYFDIEWRGKKITLRATNGKYVAAKKNGQLAATIDSAGETEEFLMKLINRPLIVLRGEHGFIGCRRVTGTLDSNRSSYDVFGLDFNDGAYSLRDCTGKYWMVGSESNVLSSSDTPVDFFLEFCNYNKVAIKTTEGKYLKGDHAGVLKANADDLDSSTMWEY"

     misc_feature    172..549
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="first fascin-like domain, beta-trefoil fold, found
                     in fascin and similar proteins; Region:
                     beta-trefoil_FSCN1_rpt1; cd23344"
                     /db_xref="CDD:467452"
     misc_feature    order(172..174,181..183,187..189,283..285,289..291,
                     313..315,319..321,412..414,436..438,442..444,535..537)
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:467452"
     misc_feature    order(259..267,274..276,544..546)
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="putative actin-binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:467452"
     misc_feature    550..906
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="second fascin-like domain, beta-trefoil fold, found
                     in fascin and similar proteins; Region:
                     beta-trefoil_FSCN1_rpt2; cd23348"
                     /db_xref="CDD:467456"
     misc_feature    772..786
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="ligand binding site [chemical binding]; other site"
                     /db_xref="CDD:467456"
     misc_feature    910..1278
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="third fascin-like domain, beta-trefoil fold, found
                     in fascin and similar proteins; Region:
                     beta-trefoil_FSCN1_rpt3; cd23352"
                     /db_xref="CDD:467460"
     misc_feature    order(1156..1158,1264..1278)
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="putative actin-binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:467460"
     misc_feature    1279..1614
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="fourth fascin-like domain, beta-trefoil fold, found
                     in fascin and similar proteins; Region:
                     beta-trefoil_FSCN1_rpt4; cd23356"
                     /db_xref="CDD:467464"
     misc_feature    order(1279..1284,1378..1380,1384..1386,1393..1395,
                     1399..1401,1486..1491)
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="putative actin-binding site 2 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:467464"
     misc_feature    1297..1311
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /note="putative actin-binding site 1 [polypeptide
                     binding]; other site"
                     /db_xref="CDD:467464"
     exon            965..1121
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1243
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1411
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..2475
                     /gene="fscn1a"
                     /gene_synonym="fscn1; sb:cb589; zgc:153632"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

gctgtgaggctgcagagaaagagagaaagagagagagagagagaggcgcgcgcacgctcgctccagcaaacaaagagacccgtcaacatcatccacggtgcaccagcagatcccgctccagcaaggccacgagctgcaaccatgactgcaaacggaaccagcgacatgctcaaaatccaattcggattgatcaactgcgggaacaagtacctcacggccgagaccttcggcttcaagatcaatgcatcagccaccagcatgaagaagaagcagatttggaccctggagcaagacggagatgattcaaacatgttcttcttgaagagccacctgggacggtacatcgcagccgacaaagacggtaacgtgacgggtgacagcgagaccccgggcgaggactgtcgcttcataatcaccgcacatgatgatgggcgctggtcactgcagtccgagccgcacaagcgctacctgggcggcaccgaggacaggataacctgcttcgcccagaccatctccatcgcggagaaatggagcgtgcacatcgccatgcacccgcaggtcaacatcttcagcgtgactagaaaaaggtacgcgcacctgagctctgagcagaacgagatagccatcgaccgggatgtaccctggggcgtggattccctcatcaccctggtcttccaggaccagaggtaccaccttcagacctccgacaaccgcttcctgaagaacgacggcagcctgtcccagacggcggataagactacgggttacacgctggagttcaggtctgggaaggtggccttcagagactgcaccgggaagtacctagctccctctggtcccagtggaaccatgaagtccggcaagagcatgaaggttggcaaggatgagctcttcgttctggagcagagccttccgcaagtggtcctcaccgctggcaacgacaggaatgtgtccaccagacaaggcatggatctctctgctaaccaagatgaggaaggagaccaggagaccttccagatggagatcagtaaggacacaaagaagtgtgcctttaggacctgcactggtaaatactggaccctcacagccaacggtggcctccaatgcactgcctctaccaagtctgctaactgctactttgacattgagtggcgtgggaagaagataaccctgcgtgccaccaatggaaaatatgtggccgccaaaaagaatggacagctggctgccactattgactcagcaggtgagaccgaggagttcctgatgaagctcatcaataggcctcttattgtgctgagaggagaacatggcttcattggctgcaggagagtgactggaactctggactccaaccgctcctcatatgacgtttttgggttggactttaatgatggagcctacagcttacgagattgcacagggaagtactggatggtgggcagtgaatcaaacgtgctgagcagtagcgacaccccggtagacttcttcctggagttttgcaactacaacaaagttgcaatcaagacaacagaggggaaatacctgaagggcgatcacgctggtgttctgaaggccaacgccgatgatctggacagctccactatgtgggagtactaagagcactcaagtaaccactgtggctttatctttcagttttttcccttttctgttatgcgttttgaatggtttctgaatacaagcgagcacacggggctaatagcagagagaaacccaaaggtgaaggggcttacttttagtcacgtatactccagtctgtctaagtactttgggtgccatggttttcgatgacccgacgagtggccaaaatggggacttctgggacttaactggcatccaaatttgtgttgtgtggttaaagcacatctcatgtcatctcttaatctgtcctaatatttgactggcatgtctccacttctctggaagatcggctatgcgggcgccacaagatttttgatgtaccagattgtagcgtgatccttccccctcgtctttgcacagtcccgtacgagcctcacactcttaaatattaacacatatagtgaaatatgtcaaagaaaaacctcgtgactgtgagctattgatgtatgcctcctgttataatgccagtcacaagtacctaccctctcgatcagagggcgaaggcagtatttacaggtaaatgtatgaatgttttgcttttctttttccatacagagcaatgaaggatggctcttaaaccactgaaatgagctatattgttttgtttttgtgacgtttgaagtacggcagtgatctgatgtgtgctgccaaactatttgtgccattagaatcattttaatgtttcaaaagaggaaaaccgagacaaactggattggtactgtacagtccctcatctcaagattagagttaaacctagaattgtaaatgggtgtgggaaagaaatatagatattaaaatgagagatgctttctgcaaaaaaaaaaaaaaaaaaaaaa

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