LOCUS       NM_001006044            1661 bp    mRNA    linear   VRT 05-OCT-2024
DEFINITION  Danio rerio claudin 5b (cldn5b), mRNA.
ACCESSION   NM_001006044
VERSION     NM_001006044.2
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1661)
  AUTHORS   O'Brown,N.M., Patel,N.B., Hartmann,U., Klein,A.M., Gu,C. and
            Megason,S.G.
  TITLE     The secreted neuronal signal Spock1 promotes blood-brain barrier
            development
  JOURNAL   Dev Cell 58 (17), 1534-1547 (2023)
   PUBMED   37437574
REFERENCE   2  (bases 1 to 1661)
  AUTHORS   Campbell,P.D., Lee,I., Thyme,S. and Granato,M.
  TITLE     Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental
            locus regulate neural stem and progenitor cell proliferation
  JOURNAL   Mol Psychiatry 28 (9), 3769-3781 (2023)
   PUBMED   37794116
REFERENCE   3  (bases 1 to 1661)
  AUTHORS   Deshwar,A.R., Cytrynbaum,C., Murthy,H., Zon,J., Chitayat,D.,
            Volpatti,J., Newbury-Ecob,R., Ellard,S., Allen,H.L., Yu,E.P.,
            Noche,R., Walker,S., Scherer,S.W., Mahida,S., Elitt,C.M.,
            Nicolas,G., Goldenberg,A., Saugier-Veber,P., Lecoquierre,F.,
            Dabaj,I., Meddaugh,H., Marble,M., Keppler-Noreuil,K.M., Drayson,L.,
            Baranano,K.W., Chassevent,A., Agre,K., Letard,P., Bilan,F., Le
            Guyader,G., Laquerriere,A., Ramsey,K., Henderson,L., Brady,L.,
            Tarnopolsky,M., Bainbridge,M., Friedman,J., Capri,Y., Athayde,L.,
            Kok,F., Gurgel-Giannetti,J., Ramos,L.L.P., Blaser,S., Dowling,J.J.
            and Weksberg,R.
  TITLE     Variants in CLDN5 cause a syndrome characterized by seizures,
            microcephaly and brain calcifications
  JOURNAL   Brain 146 (6), 2285-2297 (2023)
   PUBMED   36477332
REFERENCE   4  (bases 1 to 1661)
  AUTHORS   Vocking,O. and Famulski,J.K.
  TITLE     A temporal single cell transcriptome atlas of zebrafish anterior
            segment development
  JOURNAL   Sci Rep 13 (1), 5656 (2023)
   PUBMED   37024546
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1661)
  AUTHORS   Paulissen,E. and Martin,B.L.
  TITLE     Myogenic regulatory factors Myod and Myf5 are required for dorsal
            aorta formation and angiogenic sprouting
  JOURNAL   Dev Biol 490, 134-143 (2022)
   PUBMED   35917935
REFERENCE   6  (bases 1 to 1661)
  AUTHORS   Wang,Y., Pan,L., Moens,C.B. and Appel,B.
  TITLE     Notch3 establishes brain vascular integrity by regulating pericyte
            number
  JOURNAL   Development 141 (2), 307-317 (2014)
   PUBMED   24306108
REFERENCE   7  (bases 1 to 1661)
  AUTHORS   Baltzegar,D.A., Reading,B.J., Brune,E.S. and Borski,R.J.
  TITLE     Phylogenetic revision of the claudin gene family
  JOURNAL   Mar Genomics 11, 17-26 (2013)
   PUBMED   23726886
REFERENCE   8  (bases 1 to 1661)
  AUTHORS   Gomez,G., Lee,J.H., Veldman,M.B., Lu,J., Xiao,X. and Lin,S.
  TITLE     Identification of vascular and hematopoietic genes downstream of
            etsrp by deep sequencing in zebrafish
  JOURNAL   PLoS One 7 (3), e31658 (2012)
   PUBMED   22438865
REFERENCE   9  (bases 1 to 1661)
  AUTHORS   Xie,J., Farage,E., Sugimoto,M. and Anand-Apte,B.
  TITLE     A novel transgenic zebrafish model for blood-brain and
            blood-retinal barrier development
  JOURNAL   BMC Dev Biol 10, 76 (2010)
   PUBMED   20653957
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 1661)
  AUTHORS   Zhang,J., Piontek,J., Wolburg,H., Piehl,C., Liss,M., Otten,C.,
            Christ,A., Willnow,T.E., Blasig,I.E. and Abdelilah-Seyfried,S.
  TITLE     Establishment of a neuroepithelial barrier by Claudin5a is
            essential for zebrafish brain ventricular lumen expansion
  JOURNAL   Proc Natl Acad Sci U S A 107 (4), 1425-1430 (2010)
   PUBMED   20080584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC083368.1.
            
            On Sep 30, 2011 this sequence version replaced NM_001006044.1.
            
            Sequence Note: This RefSeq record was created from a transcript of
            a different strain than the reference genome strain because no
            single transcript from the reference strain was available for the
            full length of the gene. The extent of this transcript is supported
            by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC083368.1 [ECO:0000345]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1661              BC083368.1         1-1661
FEATURES             Location/Qualifiers
     source          1..1661
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /db_xref="taxon:7955"
                     /chromosome="10"
                     /map="10"
     gene            1..1661
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="claudin 5b"
                     /db_xref="GeneID:450023"
                     /db_xref="ZFIN:ZDB-GENE-041010-140"
     exon            1..1646
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    82..84
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="upstream in-frame stop codon"
     CDS             88..750
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /codon_start=1
                     /product="claudin-5b"
                     /protein_id="NP_001006044.2"
                     /db_xref="GeneID:450023"
                     /db_xref="ZFIN:ZDB-GENE-041010-140"
                     /translation="

MANMISACLEIVGLCLTVTGTLLVMVACGLPMWKVSAFIEGNIVVAQNIWDGLWMSCVVQSTGQMQCKMHDSVLALTTDLQTARALTVISAVLGVLALMITIAGAQCTNCINTESIKSKVVNAGGVMYIVAGLFVLIPLCWMANNIISDFYDPQVPYAKKREIGAALYIGWAASAMLLVGGAILCFSRPHDEKSTYPLKYIPPPTKGTSINGDYDKRNYV"

     misc_feature    139..639
                     /gene="cldn5b"
                     /gene_synonym="zgc:103419"
                     /note="PMP-22/EMP/MP20/Claudin family; Region:
                     PMP22_Claudin; cl21598"
                     /db_xref="CDD:473919"
ORIGIN      

agaaactcctcaagcacttcatctgagcgatgtagagacacttctgctgcttctgacagatttagactttggagaaaaaaataaacaatggcaaatatgatttctgcatgtctggagattgttggactctgcttgaccgtcaccgggactcttttggtgatggtagcctgtgggttgcccatgtggaaagtgtccgccttcattgaaggcaacattgtggtggcgcaaaacatctgggacgggctgtggatgtcctgtgttgttcaaagcacaggtcagatgcaatgcaaaatgcacgactctgtcctggcgctgaccactgacctccagacagctcgggctctgactgtcatctctgcggttttgggggtcctggctctcatgataaccatcgccggtgctcaatgcaccaattgcatcaacacggagtctatcaaatccaaagtggtcaacgccggaggcgtgatgtacatcgtcgcaggcttgtttgttctgattcctctgtgctggatggccaataacatcatctcagacttctacgatcctcaagttccctacgccaaaaagagagaaatcggagctgcgctgtacatcggatgggcagcatctgcaatgcttctggtcggaggagcgattctgtgtttctcccgtccacatgatgagaaatccacatatccacttaaatatatccctccgccgacaaaaggcacatcgatcaatggggactatgataaacgaaactacgtctgatcaagaggctaactatatggacttttgcaggtgcaaatggacttttaaaacgataatgctgatgatacaccgtggacctactttgggaaatgatcccataggcaactaggtgttactaattaggtgcaatgggatccagatacaatattgttgcctattcttaatggaaaagcaactttacaacattgcaaaatcactcaaaaagtcgccctgtgtatcatcagcataagggtagcttaccgataagcatgttttttatgttttgtacacatttgtactgatcttcaattcttttatatgactgtacagtgtaagaattatttttaaagtgcaaatgttgcaggtcatattgataaaaatgccattttttttacatgcaacaagtcttgtattgaactagtcaacatttaaagtggatcaagagtgacccaagacaagagtgggtattgttctgaagtttttcctagtttttttaatccaattcaaatgtactgtagattcatttcagtgaaacagcattgcatacttgcatttgaaagctatttaaaatgctctattaaccgaaggtcgcggtaataacgaattaaatgcacacgggtatttttggtcttcgttaatgatattagggtcagcgacccacttgtttgtgttcgatttttatcactgtggctcaaggggggtgaagggagggtccatatttcttgtttttgttctgctttactaattagacacggtctgtgcttcaacgagacactgaataatgtctattgttctgcctgtaaacgtgcaggcaggctggtttgatcatctaaacctcctgattgtacataattgtatgaaactttttagtaaatttgtgcatatacaaagtaataaataaaatgtttttttgttaaaaaaaaaaaaaaaaa

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