LOCUS       NM_001004618            1275 bp    mRNA    linear   VRT 25-JUN-2025
DEFINITION  Danio rerio nicotinamide riboside kinase 2 (nmrk2), transcript
            variant 2, mRNA.
ACCESSION   NM_001004618
VERSION     NM_001004618.3
KEYWORDS    RefSeq.
SOURCE      Danio rerio (zebrafish)
  ORGANISM  Danio rerio
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Actinopterygii; Neopterygii; Teleostei; Ostariophysi;
            Cypriniformes; Danionidae; Danioninae; Danio.
REFERENCE   1  (bases 1 to 1275)
  AUTHORS   Horzmann,K.A., Lin,L.F., Taslakjian,B., Yuan,C. and Freeman,J.L.
  TITLE     Anxiety-related behavior and associated brain transcriptome and
            epigenome alterations in adult female zebrafish exposed to atrazine
            during embryogenesis
  JOURNAL   Chemosphere 308 (Pt 3), 136431 (2022)
   PUBMED   36126741
REFERENCE   2  (bases 1 to 1275)
  AUTHORS   Keller,R.M., Beaver,L.M., Reardon,P.N., Prater,M.C., Truong,L.,
            Robinson,M.M., Tanguay,R.L., Stevens,J.F. and Hord,N.G.
  TITLE     Nitrate-induced improvements in exercise performance are coincident
            with exuberant changes in metabolic genes and the metabolome in
            zebrafish (Danio rerio) skeletal muscle
  JOURNAL   J Appl Physiol (1985) 131 (1), 142-157 (2021)
   PUBMED   34043471
REFERENCE   3  (bases 1 to 1275)
  AUTHORS   Sullivan,C., Lage,C.R., Yoder,J.A., Postlethwait,J.H. and Kim,C.H.
  TITLE     Evolutionary divergence of the vertebrate TNFAIP8 gene family:
            Applying the spotted gar orthology bridge to understand ohnolog
            loss in teleosts
  JOURNAL   PLoS One 12 (6), e0179517 (2017)
   PUBMED   28658311
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1275)
  AUTHORS   Pasquier,J., Cabau,C., Nguyen,T., Jouanno,E., Severac,D.,
            Braasch,I., Journot,L., Pontarotti,P., Klopp,C., Postlethwait,J.H.,
            Guiguen,Y. and Bobe,J.
  TITLE     Gene evolution and gene expression after whole genome duplication
            in fish: the PhyloFish database
  JOURNAL   BMC Genomics 17, 368 (2016)
   PUBMED   27189481
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1275)
  AUTHORS   Elkon,R., Milon,B., Morrison,L., Shah,M., Vijayakumar,S.,
            Racherla,M., Leitch,C.C., Silipino,L., Hadi,S., Weiss-Gayet,M.,
            Barras,E., Schmid,C.D., Ait-Lounis,A., Barnes,A., Song,Y.,
            Eisenman,D.J., Eliyahu,E., Frolenkov,G.I., Strome,S.E., Durand,B.,
            Zaghloul,N.A., Jones,S.M., Reith,W. and Hertzano,R.
  TITLE     RFX transcription factors are essential for hearing in mice
  JOURNAL   Nat Commun 6, 8549 (2015)
   PUBMED   26469318
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JBMGRA010000002.1.
            
            On Jun 25, 2025 this sequence version replaced NM_001004618.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO933265.1, SRR32588717.29180134.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA3505370, SAMEA3505371
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               JBMGRA010000002.1  59322793-59322947
            156-246             JBMGRA010000002.1  59323021-59323111
            247-412             JBMGRA010000002.1  59324621-59324786
            413-484             JBMGRA010000002.1  59327812-59327883
            485-591             JBMGRA010000002.1  59327964-59328070
            592-677             JBMGRA010000002.1  59329557-59329642
            678-1275            JBMGRA010000002.1  59330017-59330614
FEATURES             Location/Qualifiers
     source          1..1275
                     /organism="Danio rerio"
                     /mol_type="mRNA"
                     /strain="Tuebingen"
                     /db_xref="taxon:7955"
                     /chromosome="2"
                     /map="2"
     gene            1..1275
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="nicotinamide riboside kinase 2"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
     exon            1..155
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            156..246
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     misc_feature    234..236
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="upstream in-frame stop codon"
     exon            247..412
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..677
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /note="isoform 2 is encoded by transcript variant 2;
                     integrin beta 1 binding protein 3"
                     /codon_start=1
                     /product="nicotinamide riboside kinase 2 isoform 2"
                     /protein_id="NP_001004618.3"
                     /db_xref="GeneID:447879"
                     /db_xref="ZFIN:ZDB-GENE-040912-44"
                     /translation="

MDAMVNTVKGWMENPVKFARSHGVSVSTTSDPDSDIHILIVEGFLLYNYKPLIDVYNKCFYVTIPYEECKRRRSTRTYTVPDPPGLFDGHVWPMYLKHRTEMENSSLDIQYLDGMSSKDELYNQVYEDIQNSLLNIL"

     exon            413..484
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            485..591
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            592..677
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
     exon            678..1275
                     /gene="nmrk2"
                     /gene_synonym="itgb1bp3; zgc:103408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      

aatgaaatagtaaaaagagggagattctgggagaaaggaaaggagagagaggctgaaagcattcccaaggaagcgattcctttgctagtgtcctatcgcgaagaccaagaacaaacaaagaggatcagaatgaagtttattattggaatagggggtgtgaccaatggaggaaagacaactttgactggaagactcataaagaacctaccaaactgttgtgtggttcatcaagatgattttttcaagtcattaccgccttagacatggacgccatggtgaacactgttaaaggatggatggagaacccggtgaagtttgcacgatcccatggcgtgagcgtttccaccacatctgaccctgatagtgacatccacatactcattgtggagggatttctgctttataactacaagcctttaattgacgtctataacaagtgcttctacgtcaccattccatatgaagagtgcaaaaggagaagaagtacgagaacgtacaccgttcctgacccacccggtctgtttgacggccatgtttggccaatgtacttgaaacacaggacagaaatggagaacagcagcttggatatccaatatctggacggcatgagctctaaggacgagctctataaccaagtttatgaagacattcagaactctctgttgaacatcttatagcatctccaatcggattgaagatgtgtttgtgtatagaactgtaaataggatcttaagtagattcggcttctgccactagatgaactttgtaaatacgatgaagcactaacttatttgaaaacttgtggctagtgcctttgattttatattgctctgtgtaacttgttttatttaaaatcacgcctcactctctgggctgatcagagatgtacagttttcatgtatactgtaattgaagaacttcaatcaaaacacacatttgaactctttatctgttgtgttttcattcttagcattgagacgtgcatgcatttaaaccatcttgtgcatgtttatggattatgatgaaggaatataataaaaatataaaataaataacacataactcaagaaataaatatgaatgtattgggcaagatataacatatatacattttaattaaaacatttcacagagtttaagtaaatactgtaaaattccagggcttttaatgtaaagattgttcatttacatgaaaatgcattagatattatgtatgcgctttcattctcagcattaaaacatgcatgttattttaaaaaacatgcaaatatttcc

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